H Kunugi

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint [The hypothalamic-pituitary-adrenal axis and depressive disorder: recent progress]
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:203-9. 2012
  2. pmc Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia
    Akihito Uezato
    Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Behav Brain Funct 8:2. 2012
  3. pmc Possible association between interleukin-1β gene and schizophrenia in a Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Behav Brain Funct 7:35. 2011
  4. pmc Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Behav Brain Funct 7:23. 2011
  5. ncbi request reprint Prenatal underdevelopment and schizophrenia: a case report of monozygotic twins
    Hiroshi Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 57:271-4. 2003
  6. ncbi request reprint Combined DEX/CRH test among Japanese patients with major depression
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, 187 8502, Tokyo, Japan
    J Psychiatr Res 38:123-8. 2004
  7. ncbi request reprint A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 129:44-6. 2004
  8. ncbi request reprint No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
  9. doi request reprint Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 64:447-59. 2010
  10. ncbi request reprint Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study
    Hiroshi Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neuropsychopharmacology 31:212-20. 2006

Collaborators

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint [The hypothalamic-pituitary-adrenal axis and depressive disorder: recent progress]
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:203-9. 2012
    ....
  2. pmc Further evidence for a male-selective genetic association of synapse-associated protein 97 (SAP97) gene with schizophrenia
    Akihito Uezato
    Department of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Behav Brain Funct 8:2. 2012
    ..We have recently demonstrated nominally significant associations between SAP97 gene and schizophrenia among Japanese males. The present study aimed to replicate these findings using an independent and larger sample...
  3. pmc Possible association between interleukin-1β gene and schizophrenia in a Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Behav Brain Funct 7:35. 2011
    ..Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms...
  4. pmc Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Behav Brain Funct 7:23. 2011
    ..These findings prompted us to examine the possible association between IL-1β gene polymorphisms and HPA axis function assessed with the DEX/CRH test...
  5. ncbi request reprint Prenatal underdevelopment and schizophrenia: a case report of monozygotic twins
    Hiroshi Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 57:271-4. 2003
    ..This twin pair suggests a possibility that hypoxic brain damage associated with prenatal underdevelopment may be a causal factor for abnormalities in psychosocial development and subsequent schizophrenia...
  6. ncbi request reprint Combined DEX/CRH test among Japanese patients with major depression
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, 187 8502, Tokyo, Japan
    J Psychiatr Res 38:123-8. 2004
    ..In addition, a possible relationship between suicidal acts and enhanced HPA axis abnormalities was suggested...
  7. ncbi request reprint A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 129:44-6. 2004
    ..Our results suggest that the S205L polymorphism of the p75NTR gene is involved in the pathogenesis of depressive disorder and suicidal behavior...
  8. ncbi request reprint No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
    ....
  9. doi request reprint Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 64:447-59. 2010
    ..Based on these findings, an integrated schema of the pathological and recovery processes of depression is illustrated...
  10. ncbi request reprint Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a Multicenter Study
    Hiroshi Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neuropsychopharmacology 31:212-20. 2006
    ..Restoration from HPA axis abnormalities occurred with clinical responses to treatment, particularly in depressed patients who underwent ECT...
  11. ncbi request reprint Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Res 59:23-8. 2007
    ..Our results confirm impaired PPI in chronic schizophrenia patients compared with controls in Japanese...
  12. ncbi request reprint Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
    H Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 113:1569-73. 2006
    ..0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia...
  13. ncbi request reprint A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
    T Okada
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Psychiatry 11:695-703. 2006
    ..Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene...
  14. ncbi request reprint Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Med Genet 96:307-9. 2000
    ..There was no significant difference in genotype or allele distribution between either patient group and controls in our sample, suggesting that the 5-HTTLPR does not play a major role in the pathogenesis of AD in Japanese...
  15. ncbi request reprint C677T polymorphism in methylenetetrahydrofolate reductase gene and psychoses
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Mol Psychiatry 3:435-7. 1998
    ..Our results suggest that homozygosity for the T677 allele of the MTHFR gene is unlikely to play a major role in the pathogenesis of schizophrenia or affective disorders in our sample...
  16. ncbi request reprint No evidence for an association of polymorphisms of the tryptophan hydroxylase gene with affective disorders or attempted suicide among Japanese patients
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Psychiatry 156:774-6. 1999
    ..The authors examined whether polymorphisms A218C and A779C in intron 7 of the tryptophan hydroxylase gene are associated with a risk for affective disorders or suicidal behavior...
  17. ncbi request reprint Possible association of missense mutation (Gly[-63]Glu) of the neurotrophin-3 gene with Alzheimer's disease in Japanese
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neurosci Lett 241:65-7. 1998
    ..Our results suggest that the Glu(-63) allele of the NT-3 gene by itself or another mutation nearby which would be in linkage disequilibrium to the mutation is a risk factor for AD...
  18. ncbi request reprint No evidence for an association between the Glu298Asp polymorphism of the NOS3 gene and Alzheimer's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    J Neural Transm 107:1081-4. 2000
    ..However, the genotype and allelic distributions for the Glu298Asp polymorphism were similar for these three groups, suggesting that the Glu298Asp polymorphism of the NOS3 gene has no relevance to the development of AD in Japanese...
  19. ncbi request reprint Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 112:303-7. 2005
    ..We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample...
  20. ncbi request reprint Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 13:2699-708. 2004
    ..Genetic variants associated with impairments of these functions of dysbindin could play an important role in the pathogenesis of schizophrenia...
  21. ncbi request reprint High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Kaga, Itabashi ku, Tokyo, Japan
    Neurosci Lett 221:202-4. 1997
    ..017; odds ratio, 2.8, 95% CI 1.2-6.5), suggesting that homozygosity for the low activity allele may increase susceptibility to PD...
  22. ncbi request reprint Association study of C825T polymorphism of the G-protein b3 subunit gene with schizophrenia and mood disorders
    H Kunugi
    Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan
    J Neural Transm 109:213-8. 2002
    ..We obtained no evidence for an association of the polymorphism with any diagnostic group...
  23. ncbi request reprint Association of bipolar disorder with the 5178 polymorphism in mitochondrial DNA
    T Kato
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Med Genet 96:182-6. 2000
    ..These results suggest that the 5178 polymorphism in mitochondrial DNA may regulate vulnerability to bipolar disorder via alteration of brain energy metabolism. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:182-186, 2000...
  24. ncbi request reprint Novel polymorphism in the promoter region of the tumor necrosis factor alpha gene: No association with narcolepsy
    T Kato
    Department of Neuropsychiatry, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Am J Med Genet 88:301-4. 1999
    ..These results do not support our hypothesis that genetic abnormality of TNF alpha production is pathogenetic for narcolepsy...
  25. doi request reprint BDNF is not associated with schizophrenia: data from a Japanese population study and meta-analysis
    Kunihiro Kawashima
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Schizophr Res 112:72-9. 2009
    ..Further LD evaluation, as well as an association study in which BDNF-LCPR is genotyped directly, would be required for a more conclusive result...
  26. doi request reprint Pharmacotherapeutic determinants for QTc interval prolongation in Japanese patients with mood disorder
    H Okayasu
    Department of Psychiatry, Dokkyo Medical University School of Medicine, Mibu, Japan
    Pharmacopsychiatry 45:279-83. 2012
    ..The selective serotonin reuptake inhibitors investigated (fluvoxamine, paroxetine, sertraline) were not indicated as risk factors for QTc prolongation...
  27. doi request reprint SIRT1 gene, schizophrenia and bipolar disorder in the Japanese population: an association study
    T Kishi
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Genes Brain Behav 10:257-63. 2011
    ..89 × 10(-15)). Also, four tagging SNPs in the SIRT1 gene were not associated with BP. In conclusion, the SIRT1 gene may play an important role in the pathophysiology of schizophrenia in the Japanese population...
  28. ncbi request reprint Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder
    K Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology, and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Neuropsychobiology 50:206-10. 2004
    ..Although the polymorphic region may have an enhancer-like effect on transcriptional activity, we obtained no evidence for allele-dependent differential effects...
  29. ncbi request reprint Epigenetic aberration of the human REELIN gene in psychiatric disorders
    Y Tamura
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Mol Psychiatry 12:519, 593-600. 2007
    ..These data suggest the possibility that epigenetic aberration from the normal DNA methylation status of RELN may confer susceptibility to psychiatric disorders...
  30. ncbi request reprint Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 111:217-21. 2004
    ..We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-alpha gene...
  31. ncbi request reprint Glial cell line-derived neurotrophic factor (GDNF) gene and schizophrenia: polymorphism screening and association analysis
    K Lee
    Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chome, Itabashi ku, Tokyo 173 8605, Japan
    Psychiatry Res 104:11-7. 2001
    ....
  32. pmc 13C-phenylalanine breath test detects altered phenylalanine kinetics in schizophrenia patients
    T Teraishi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Transl Psychiatry 2:e119. 2012
    ..Animal experiments suggest that the observed changes are unlikely to be attributable to antipsychotic medication...
  33. ncbi request reprint A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Mol Psychiatry 6:83-6. 2001
    ..We obtained no evidence for the possible interactions between the BDNF and apolipoprotein E (APOE) genes, suggesting that the possible effect of the BDNF gene on the development of late-onset AD might be independent of the APOE genotype...
  34. ncbi request reprint A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:204-8. 2008
    ..We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings...
  35. doi request reprint Cortical neurons from intrauterine growth retardation rats exhibit lower response to neurotrophin BDNF
    Midori Ninomiya
    Laboratory of Physiology and Pharmacology, School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo, Japan
    Neurosci Lett 476:104-9. 2010
    ..Taken together, IUGR resulted in reductions in cell viability and in synaptic function following TrkB down-regulation, which may play a role in schizophrenia-like behaviors...
  36. ncbi request reprint Glucocorticoid prevents brain-derived neurotrophic factor-mediated maturation of synaptic function in developing hippocampal neurons through reduction in the activity of mitogen-activated protein kinase
    Emi Kumamaru
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Mol Endocrinol 22:546-58. 2008
    ..These results suggest that BDNF-mediated synaptic maturation is disturbed after neurons are exposed to high-level glucocorticoid in their development stage...
  37. ncbi request reprint The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology
    Kiyotaka Nemoto
    Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Neurosci Lett 397:25-9. 2006
    ..Furthermore, we suggest that genotype effects of the BDNF gene on brain morphology might differ in female from in male...
  38. doi request reprint Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions
    Aiko Izumi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropsychopharmacology 33:3237-45. 2008
    ..016) and verbal IQ (P<0.001). Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence...
  39. ncbi request reprint Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:873-7. 2007
    ..Furthermore, haplotype-based analyses did not provide evidence for an association. These results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample...
  40. ncbi request reprint Association analysis of polymorphic CGG repeat in 5' UTR of the reelin and VLDLR genes with schizophrenia
    Akihisa Akahane
    Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, 11 1, Kaga 2 Chome, Itabashi, Tokyo 173 8605, Japan
    Schizophr Res 58:37-41. 2002
    ..We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin or VLDLR genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease...
  41. ncbi request reprint Exon/intron boundaries, novel polymorphisms, and association analysis with schizophrenia of the human synaptic vesicle monoamine transporter (SVMT) gene
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine 11 1, Kaga 2 Chome, Itabashi ku, Tokyo, 173 8605, Japan
    Mol Psychiatry 6:456-60. 2001
    ..Furthermore, we obtained no evidence for the major effect of the novel polymorphisms on susceptibility to schizophrenia...
  42. doi request reprint Glucocorticoid attenuates brain-derived neurotrophic factor-dependent upregulation of glutamate receptors via the suppression of microRNA-132 expression
    H Kawashima
    Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo, Japan
    Neuroscience 165:1301-11. 2010
    ..We demonstrate that the exposure of neurons to an excess glucocorticoid results in a decrease in the BDNF-dependent neuronal function via suppressing miR-132 expression...
  43. doi request reprint SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression
    Tuerhong Tuerxun
    Department of Pathology, Tokyo Medical University, Tokyo, 160 8401, Japan
    Neurosci Lett 469:303-8. 2010
    ..Taking these findings together, it is possible that SA4503 blocks neuronal cell death via repressing activation of the MAPK/ERK pathway and, consequently, expression levels of glutamate receptors...
  44. ncbi request reprint MCI-186 prevents brain tissue from neuronal damage in cerebral infarction through the activation of intracellular signaling
    Madinyet Niyaz
    Department of Pathology, Tokyo Medical University, Tokyo, Japan
    J Neurosci Res 85:2933-42. 2007
    ..We therefore conclude that, in addition to its role as a free radical scavenger, MCI-186 functions as an antiapoptotic factor by enhancing intracellular survival signaling...
  45. ncbi request reprint Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
    Neurosci Lett 415:28-33. 2007
    ..48), either. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients...
  46. ncbi request reprint Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia
    Mineko Hattori
    Department of Psychiatry and Genome Research Center, Teikyo University School of Medicine, Tokyo, Japan
    Am J Med Genet 114:304-9. 2002
    ..Our results suggest that the G(- 3004)-A3 haplotype has a modest effect of giving susceptibility to schizophrenia...
  47. ncbi request reprint The Gem interacting protein (GMIP) gene is associated with major depressive disorder
    Kazuyuki Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Neurogenetics 6:127-33. 2005
    ..Further study needs to be undertaken to validate the association between the GMIP gene and MDD...
  48. doi request reprint Sexually dimorphic effect of the Val66Met polymorphism of BDNF on susceptibility to Alzheimer's disease: New data and meta-analysis
    Noriko Fukumoto
    Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 153:235-42. 2010
    ..14, 95% CI 1.05-1.24, P = 0.002), but not in men. Our results provide evidence that the Met66 allele of BDNF has a sexually dimorphic effect on susceptibility to AD...
  49. ncbi request reprint A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Neuropsychopharmacol 9:83-8. 2006
    ..The association between the -116C/G polymorphism and clinical efficacy of mood stabilizers should be further investigated in a prospective study with a larger sample...
  50. doi request reprint Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder
    D Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Pharmacogenomics J 13:354-8. 2013
    ..0000023 and 0.0000040, respectively. Our results provide the first evidence that polymorphisms of the CUX1 gene may be associated with response to antidepressant treatment in Japanese patients with MDD. ..
  51. doi request reprint Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation
    M Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Acta Psychiatr Scand 126:72-8. 2012
    ..This study was aimed to examine several brain chemical mediators, including Glx (glutamate + glutamine), using (1)H magnetic resonance spectroscopy (MRS) in medicated patients with schizophrenia, with and without psychotic exacerbation...
  52. ncbi request reprint Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Am J Med Genet 81:131-3. 1998
    ..Thus we obtained no evidence for the involvement of the two structural mutations of the TH gene in the pathogenesis of schizophrenia or PD...
  53. ncbi request reprint No changes in paired viral antibody titers during the course of acute schizophrenia
    R Fukuda
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Neuropsychobiology 40:57-62. 1999
    ..It is unlikely that the active infection or reactivation of these viruses has direct causal relationship to schizophrenia in these patients...
  54. ncbi request reprint Familial schizophrenia with pericentric inversion of chromosome 9: a case report
    K B Lee
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Schizophr Res 32:123-6. 1998
    ..9 may vary depending on the location of breakpoints. Thus our cases may be valuable material to localize breakpoints on chromosome 9, which may lead to cloning of a susceptibility gene for schizophrenia...
  55. ncbi request reprint Early parental loss and depressive disorder in Japan
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Eur Arch Psychiatry Clin Neurosci 245:109-13. 1995
    ..Separation from either parent also showed a trend towards an increased incidence in the depressive group. No significant difference in the incidence of early paternal death was found...
  56. doi request reprint Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population
    Misty Richards
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neural Transm 115:1347-54. 2008
    ..Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese...
  57. ncbi request reprint [Analysis of the fyn kinase gene in Alzheimer's disease and schizophrenia]
    Yuko Nakano
    Department of Psychiatry, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo 173 8606, Japan
    No To Shinkei 56:153-6. 2004
    ..Thus, it is unlikely that these polymorphisms play an important role in the pathogenesis of Alzheimer's disease or schizophrenia...
  58. pmc Glucocorticoid receptor interaction with TrkB promotes BDNF-triggered PLC-gamma signaling for glutamate release via a glutamate transporter
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 106:647-52. 2009
    ....
  59. ncbi request reprint Neuronal roles of the integrin-associated protein (IAP/CD47) in developing cortical neurons
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry of Japan, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 279:43245-53. 2004
    ..These observations suggest that the IAP plays important roles in dendritic outgrowth and synaptic transmission in developing cortical neurons through the activation of MAPK...
  60. ncbi request reprint Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurosci Lett 369:1-3. 2004
    ..Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder...
  61. doi request reprint No association between the Bcl2-interacting killer (BIK) gene and schizophrenia
    Kazutaka Ohi
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Lett 463:60-3. 2009
    ..105, rs2235316: corrected p=0.108). We conclude that BIK might not play a major role in the susceptibility of schizophrenia in Japanese population...
  62. ncbi request reprint BDNF function and intracellular signaling in neurons
    Tadahiro Numakawa
    Deparment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo, Japan
    Histol Histopathol 25:237-58. 2010
    ..Furthermore, understanding the secretion and intracellular dynamics of BDNF proteins is critical as the fate of secreted BDNF may contribute to differences in neuronal response...
  63. doi request reprint Gene expression and association analyses of the phosphodiesterase 4B (PDE4B) gene in major depressive disorder in the Japanese population
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:527-34. 2009
    ..Our results suggest that the PDE4B gene itself does not link to MDD but the elevated mRNA levels of PDE4B might be implicated in the pathophysiology of MDD...
  64. ncbi request reprint Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release
    Yuki Yagasaki
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo 187 8502, Japan
    J Biol Chem 281:12941-9. 2006
    ..These results suggest that antidepressant pretreatment selectively enhance the BDNF signaling on the PLC-gamma/IP3/Ca2+ pathway via Sig-1R, and that Sig-1R plays an important role in BDNF signaling leading to glutamate release...
  65. doi request reprint The dopamine D3 receptor (DRD3) gene and risk of schizophrenia: case-control studies and an updated meta-analysis
    Ayako Nunokawa
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 116:61-7. 2010
    ..Our updated meta-analysis also failed to confirm the existence of a protective haplotype. To draw a definitive conclusion, further studies using larger samples and sufficient markers should be carried out in various ethnic populations...
  66. ncbi request reprint The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder
    Ryota Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Biol Psychiatry 57:1097-102. 2005
    ..The BCR gene encodes a Rho GTPase activating protein, which is known to play important roles in neurite growth and axonal guidance...
  67. ncbi request reprint Vitamin E protected cultured cortical neurons from oxidative stress-induced cell death through the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    Yumiko Numakawa
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology AIST, Midorigaoka, Ikeda, Osaka, Japan
    J Neurochem 97:1191-202. 2006
    ..These observations suggest that vitamin E analogs play an essential role in neuronal maintenance and survival in the CNS...
  68. doi request reprint Brain-derived neurotrophic factor and glucocorticoids: Reciprocal influence on the central nervous system
    T Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, Tokyo 187 8502, Japan Core Research for Evolutional Science and Technology Program CREST, Japan Science and Technology Agency JST, Saitama 332 0012, Japan Electronic address
    Neuroscience 239:157-72. 2013
    ..In the present review, we provide an overview of recent evidence concerning the interaction between BDNF and glucocorticoids...
  69. doi request reprint Plasma levels of vascular endothelial growth factor and fibroblast growth factor 2 in patients with major depressive disorders
    M Takebayashi
    Department of Psychiatry, National Hospital Organization NHO Kure Medical Center, 3 1 Aoyama, Kure 737 0023, Japan
    J Neural Transm 117:1119-22. 2010
    ..Although this is a preliminary study, altered VEGF levels might be involved in the pathophysiology of MDD...
  70. ncbi request reprint Cytogenetic findings in 250 schizophrenics: evidence confirming an excess of the X chromosome aneuploidies and pericentric inversion of chromosome 9
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan
    Schizophr Res 40:43-7. 1999
    ....
  71. ncbi request reprint Obstetric complications and schizophrenia: prenatal underdevelopment and subsequent neurodevelopmental impairment
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine, 11 1, Kaga 2 Chrome, Itabashi ku, Tokyo 173 8605, Japan
    Br J Psychiatry Suppl 40:s25-9. 2001
    ..Many studies have shown an association between obstetric complications and schizophrenia...
  72. ncbi request reprint Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus
    S Chiba
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    J Neural Transm 113:1337-46. 2006
    ..Our results also suggest a potential role of DISC1 in the therapeutic mechanisms of certain atypical antipsychotics...
  73. doi request reprint Two-stage case-control association study of polymorphisms in rheumatoid arthritis susceptibility genes with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:62-5. 2009
    ..The results of this study suggest that these polymorphisms in RA susceptibility genes do not contribute to genetic susceptibility to schizophrenia...
  74. doi request reprint Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis
    Yasuhisa Fukuo
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan
    Neurosci Res 67:250-5. 2010
    ....
  75. ncbi request reprint TGFBR2 gene expression and genetic association with schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho Tokushima 770 8503, Japan
    J Psychiatr Res 42:425-32. 2008
    ..Our results suggest that the TGFBR2 gene itself does not link to schizophrenia but that the TGFBR2 mRNA levels in the peripheral leukocytes may be a potential state marker for schizophrenia...
  76. doi request reprint Failure to find an association between myosin heavy chain 9, non-muscle (MYH9) and schizophrenia: a three-stage case-control association study
    Hideki Amagane
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, 757 Asahimachidori ichibancho, Chuo Ku, Niigata 951 8510, Japan
    Schizophr Res 118:106-12. 2010
    ..Our results suggest that MYH9 does not confer increased susceptibility to schizophrenia in the Japanese population, although we could not exclude possible contributions of other genes on 22q to the pathogenesis of schizophrenia...
  77. ncbi request reprint Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 391:7-10. 2005
    ..Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments...
  78. doi request reprint Prednisolone causes anxiety- and depression-like behaviors and altered expression of apoptotic genes in mice hippocampus
    Yu Kajiyama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:159-65. 2010
    ..Our results demonstrated that PSL causes anxiety- and depression-like behaviors, and suggest that altered gene expressions related to hippocampal remodeling or damage are involved in the effect of PSL on such behaviors...
  79. doi request reprint A two-stage case-control association study of PADI2 with schizophrenia
    Yuichiro Watanabe
    Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Chuo Ku, Niigata, Japan
    J Hum Genet 54:430-2. 2009
    ..However, we could not replicate this association in a confirmatory population of 2126 patients and 2228 control individuals. The results of this study suggest that PADI2 does not contribute to genetic susceptibility to schizophrenia...
  80. doi request reprint Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Psychiatry Res 160:175-83. 2008
    ....
  81. ncbi request reprint The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia
    Takashi Ohnishi
    Department of Radiology, National Center Hospital of Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
    Brain 129:399-410. 2006
    ..Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia...
  82. doi request reprint Association study of ubiquitin-specific peptidase 46 (USP46) with bipolar disorder and schizophrenia in a Japanese population
    Itaru Kushima
    Department of Psychiatry, Graduate School of Medicine, Nagoya University, Aichi, Japan
    J Hum Genet 55:133-6. 2010
    ..No significant association was detected for bipolar disorder. In conclusion, our data argue against the presence of any strong genetic susceptibility factors for bipolar disorder or schizophrenia in the region USP46...
  83. ncbi request reprint Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi
    Satoko Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Behav Brain Res 180:69-76. 2007
    ..Our results suggest that EE, which enhanced the survival of newborn neurons, shows beneficial effects on behavioral despair and habituation to a novel environment...
  84. ncbi request reprint [Low serum cholesterol and suicidal behavior]
    H Kunugi
    Department of Psychiatry, Teikyo University School of Medicine
    Nippon Rinsho 59:1599-604. 2001
    ..Clinicians should be aware of potential effects of lowering cholesterol interventions on behavioral symptoms...
  85. ncbi request reprint p75NTR as a therapeutic target for neuropsychiatric diseases
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187 8502, Japan
    Curr Mol Pharmacol 2:70-6. 2009
    ..In this review, we focus on recent findings on p75NTR as a therapeutic target for neuropsychiatric diseases...
  86. doi request reprint Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test
    Akira Midorikawa
    Department of Psychology, Chuo University, Tokyo, Japan
    Psychiatry Res 159:281-9. 2008
    ..The present results suggest that impairment in motor dexterity is a major characteristic of schizophrenia, which might be independent of cognitive functions...
  87. ncbi request reprint Antipsychotic medication and cognitive function in schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Schizophr Res 86:138-46. 2006
    ..Alternatively, poorer cognitive function may be due in part to polypharmacy or excessive dosing. Further investigations are required to draw any conclusions...
  88. doi request reprint Cabergoline, a dopamine receptor agonist, has an antidepressant-like property and enhances brain-derived neurotrophic factor signaling
    Shuichi Chiba
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychopharmacology (Berl) 211:291-301. 2010
    ..Cabergoline is an ergot derivative with a high affinity to dopamine D(2)-like receptors; however, there have been few preclinical studies on its antidepressant-like effects...
  89. ncbi request reprint RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed
    Noriko Sago
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 319:50-7. 2004
    ..Altogether, the data presented here suggest that muscle cells retain the ability to induce RNAi, although Dicer and eIF2C1 approximately 4 appear to be barely expressed in them...
  90. doi request reprint QTc prolongation and antipsychotic medications in a sample of 1017 patients with schizophrenia
    Yuji Ozeki
    Department of Psychiatry, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, 321 0293, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:401-5. 2010
    ....
  91. doi request reprint Schizotypal traits and cognitive function in healthy adults
    Hiroko Noguchi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychiatry Res 161:162-9. 2008
    ....
  92. doi request reprint IQ decline and memory impairment in Japanese patients with chronic schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Psychiatry Res 158:251-5. 2008
    ..Our results suggest that schizophrenia patients experience marked IQ decline due to the development of illness and their wide-ranging memory impairments are even more severe than the IQ decline...
  93. doi request reprint Functional near-infrared spectroscopy reveals altered hemispheric laterality in relation to schizotypy during verbal fluency task
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1944-51. 2008
    ....
  94. ncbi request reprint Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
    Takeyuki Mori
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira City, Tokyo, 187 8551, Japan
    Psychiatry Res 154:133-45. 2007
    ..Our data confirmed decreased FA in schizophrenics, compared to controls in the widespread WM areas. Such decreased FA values in schizophrenia might be attributable, at least in part, to progressive changes after the onset of the illness...
  95. doi request reprint Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia
    Satoko Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 373:298-302. 2008
    ..These findings indicate that sdy mice display a number of behavioral abnormalities associated with schizophrenia and suggest that these abnormalities may be mediated by reductions in forebrain dopamine transmission...
  96. ncbi request reprint [Premorbid stress vulnerability and genetic polymorphism of brain-derived neurotrophic factor]
    Hiroshi Kunugi
    Seishin Shinkeigaku Zasshi 109:771-6. 2007
  97. ncbi request reprint Mitochondrial DNA sequence analysis of patients with 'atypical psychosis'
    An a Kazuno
    Laboratory for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Saitama, Japan
    Psychiatry Clin Neurosci 59:497-503. 2005
    ..However, the subhaplogroup F1b1a may be a good target for association study of 'atypical psychosis'...
  98. ncbi request reprint A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men
    Ryota Hashimoto
    Schizophr Res 73:383-5. 2005
  99. ncbi request reprint Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees
    Shinsuke Washizuka
    Laboratories for Molecular Dynamics of Mental Disorders, Brain Science Institute, RIKEN, Wako, Saitama, Japan
    Biol Psychiatry 56:483-9. 2004
    ..We previously reported that a polymorphism in the upstream region of NDUFV2, -602G> A, was associated with bipolar disorder in Japanese subjects; however, functional significance of -602G> A was not known...
  100. ncbi request reprint A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Lett 428:17-20. 2007
    ..These results suggest that the Val/Met polymorphism of the COMT gene may play a role in HA in Japanese population...
  101. doi request reprint A polymorphism of the metabotropic glutamate receptor mGluR7 (GRM7) gene is associated with schizophrenia
    Tsuyuka Ohtsuki
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8577, Japan
    Schizophr Res 101:9-16. 2008
    ..The GRM7 gene is located on human chromosome 3p26, which has been suggested by linkage analysis to contain a susceptibility locus for schizophrenia...