Affiliation: National Institute of Infectious Diseases
Kubota T, Yokosawa N, Yokota S, Fujii N, Tashiro M, Kato A. Mumps virus V protein antagonizes interferon without the complete degradation of STAT1. J Virol. 2005;79:4451-9 pubmed
Kubota T, Matsuoka M, Chang T, Tailor P, Sasaki T, Tashiro M, et al. Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression. J Biol Chem. 2008;283:25660-70 pubmed publisher
..Together, SUMO modification is an integral part of IRF3 and IRF7 activity that contributes to postactivation attenuation of IFN production. ..
Kubota T, Matsuoka M, Xu S, Otsuki N, Takeda M, Kato A, et al. PIASy inhibits virus-induced and interferon-stimulated transcription through distinct mechanisms. J Biol Chem. 2011;286:8165-75 pubmed publisher
..Our results demonstrate that PIASy negatively regulates both IFN transcription and IFN-stimulated gene expression through multiple mechanisms utilizing the function of different domains. ..