Research Topics
Genomes and Genes
| Yoshihiro KokuboSummaryAffiliation: National Cardiovascular Center Country: Japan Publications
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Detail Information
Publications
The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohortYoshihiro Kokubo
FACC, FAHA, FESC, Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
Stroke 44:1369-74. 2013..Few prospective studies have examined the impact of both green tea and coffee consumption on strokes. We investigated the association of the combination of those consumption with stroke incidence in a general population...- Traditional risk factor management for stroke: a never-ending challenge for health behaviors of diet and physical activityYoshihiro Kokubo
Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
Curr Opin Neurol 25:11-7. 2012..Recently, many guidelines have given new evidence on the risk factors for stroke. In this review, I refer to the most important guidelines for primary prevention of stroke and hypertension, especially focused on diet and physical activity... - Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita StudyYoshihiro Kokubo
Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
Stroke 40:2674-9. 2009..Few studies, however, have examined the relationship between blood pressure (BP) category and these diseases in subjects with and without CKD... - Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the suita studyYoshihiro Kokubo
Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita 565 8565, Japan
Hypertens Res 31:2027-35. 2008..Hypertens Res 2008; 31: 2027-2035)... - Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort: the Suita studyYoshihiro Kokubo
Department of Preventive Cardiology, National Cardiovascular Center, Suita, Osaka, 565 8565 Japan
Hypertension 52:652-9. 2008..2% and 35.3% in men and 7.1% and 23.4% in women, respectively. In conclusion, high-normal blood pressure is a risk factor for the incidence of stroke and myocardial infarction in a general urban population of Japanese men... 
Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general populationYoshihiro Kokubo
Division of Preventive Cardiology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
J Hum Genet 49:507-15. 2004..010, 95% confidence interval, 1.12-2.33). Association of TSC and WNK1 with hypertension was not observed. In conclusion, our study suggests the possible involvement of WNK4 in essential hypertension in a Japanese general population...- The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita StudyYoshihiro Kokubo
Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
Hypertens Res 33:1238-43. 2010..Further investigation of larger cohorts of DM subjects should be conducted to better understand this phenomenon... - High-normal blood pressure and the risk of cardiovascular diseaseYoshihiro Kokubo
Department of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
Circ J 73:1381-5. 2009.... - Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort IYoshihiro Kokubo
Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
Circulation 116:2553-62. 2007..We investigated the association of soy and isoflavone intake with risk of cerebral and myocardial infarctions (CI and MI)... - Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertensionYoshihiro Kokubo
Division of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
Hypertens Res 29:611-9. 2006..Thus, our study suggests that these five genes were susceptibility genes for essential hypertension in this Japanese population... - Dietary fiber intake and risk of cardiovascular disease in the Japanese population: the Japan Public Health Center-based study cohortY Kokubo
Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan
Eur J Clin Nutr 65:1233-41. 2011..We investigated the association between dietary fiber and the risk of cardiovascular disease (CVD), which we defined as stroke or CHD, in a Japanese population... - Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general populationYoshihiro Kokubo
Division of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
Hypertens Res 27:697-702. 2004..TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p =0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population... - Association of genetic polymorphisms of ACADSB and COMT with human hypertensionKei Kamide
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
J Hypertens 25:103-10. 2007..We examined the association of human homologues of these genes with human hypertension... - Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general populationJin Yang
Divisions of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
J Hypertens 23:1497-505. 2005..We studied whether genetic variations in RGS2 are implicated in hypertension or other phenotypes in Japanese hypertensive individuals and the general population... - A genome-wide association study of hypertension-related phenotypes in a Japanese populationYumiko Hiura
Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Japan
Circ J 74:2353-9. 2010..A GWAS of hypertension-related phenotypes in a Japanese population was conducted in the current study... - Effects of the Y chromosome on cardiovascular risk factors in Japanese menYumiko Hiura
Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Japan
Hypertens Res 31:1687-94. 2008..Studies using much larger sample sizes and/or additional independent samples will be required for definitive conclusions... - Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in JapaneseYumiko Hiura
Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
Circ J 74:518-22. 2010..The aim of this study was to examine the association between rs3846662 of HMGCR and the level of LDL-C in Japanese... - Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypesKei Kamide
Division of Hypertension and Nephrology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Am J Hypertens 17:446-9. 2004..The objective of this study was to test whether more subtle changes of WNK4 could be implicated in hypertension or renal failure... - Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese populationShin Takiuchi
Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
Atherosclerosis 173:301-7. 2004..This study provides the first evidence that HGF may be a candidate susceptibility loci that affects the progression of atherosclerosis in Japanese subjects... - Associations of hypertension and its complications with variations in the xanthine dehydrogenase geneJin Yang
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
Hypertens Res 31:931-40. 2008..0006). Our results suggest that genetic variations in XDH contribute partly to hypertension and its complications, including atherosclerosis and CKD... - Genetic variations of HSD11B2 in hypertensive patients and in the general population, six rare missense/frameshift mutationsKei Kamide
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
Hypertens Res 29:243-52. 2006..Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese... - Protein tyrosine kinase 2beta as a candidate gene for hypertensionKei Kamide
Divisions of Hypertension, National Cardiovascular Center, Suita, Osaka, Japan
Pharmacogenet Genomics 17:931-9. 2007..Thus, a haplotype in PTK2B may play a role in essential hypertension in Japanese... - Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohortYoshihiro Miyamoto
Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
Diabetes Res Clin Pract 85:132-8. 2009..Our findings indicate that polymorphisms and haplotypes in the 11beta-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population... - A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemiaKoji Harada
Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
J Atheroscler Thromb 17:131-40. 2010..Several researchers have identified mutations of ARH that cause autosomal recessive hypercholesterolemia; however, it remains unknown whether this gene is involved in common hypercholesterolemia... - Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and atherosclerosis in a Japanese general populationChihiro Tanaka
Research Institute, National Cardiovascular Center, Suita, Japan
Hypertens Res 28:35-41. 2005..Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese... - Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensivesMariko Banno
Research Institute, National Cardiovascular Center, Suita, Japan
Hypertens Res 30:513-20. 2007..Taken together, these findings reveal that the EDN-ECE pathway is an important system involved in essential hypertension in Japanese... - Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita StudyYoshihiro Kokubo
National Cardiovascular Center, Suita, Osaka, Japan
Circ J 69:138-42. 2005.... - Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general populationKei Kamide
Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
Hypertens Res 34:740-6. 2011..Taken together, these data suggest that genetic polymorphisms in RGS2 are associated with intima-media thickening of carotid artery in humans... - Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese populationKei Kamide
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
J Hypertens 23:955-60. 2005..Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2... - Genetic analysis of 22 candidate genes for hypertension in the Japanese populationNaoharu Iwai
National Cardiovascular Center, Suita, Osaka, Japan
J Hypertens 22:1119-26. 2004..We performed association studies between 118 single-nucleotide polymorphisms (SNPs) of 22 candidate genes (or gene family) and hypertension in a Japanese population... - Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort: the Suita studyTomonori Okamura
Department of Preventive Cardiology, National Cardiovascular Center, Suita, Osaka, Japan
Atherosclerosis 209:290-4. 2010.... - Risk of smoking and metabolic syndrome for incidence of cardiovascular disease--comparison of relative contribution in urban Japanese population: the Suita studyAya Higashiyama
Department of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
Circ J 73:2258-63. 2009..Smoking is also an important CVD risk factor with still a high prevalence. However, few previous studies have compared the risk for CVD or the population-attributable fraction (PAF) of smoking, MetS, and both... - Heterozygous disruption of CMA1 does not affect blood pressureKoh Ono
National Cardiovascular Center, Suita, Osaka, Japan
J Hypertens 22:103-9. 2004..It has been suspected that the mast cell chymase gene (CMA1) is important for the generation of angiotensin II and therefore might be associated with the pathogenesis of hypertension... - A high prevalence of Gitelman's syndrome mutations in JapaneseNaomi Tago
National Cardiovascular Center, Suita, Japan
Hypertens Res 27:327-31. 2004..In conclusion, GS could be one of the major causes of low blood pressure in Japanese... - Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese populationYumiko Hiura
Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
Circ J 72:1213-7. 2008..The effect of the CAD-associated SNPs on cardiovascular risk factors in the control group was also investigated... - High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: the JPHC studyRenzhe Cui
Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
Atherosclerosis 221:565-9. 2012..High serum total cholesterol levels represent a risk factor of ischemic stroke in Western countries. However, this association has not been thoroughly investigated in Asian populations where the incidence of stroke is high... - Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertensionRyosuke Oguro
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
Geriatr Gerontol Int 10:311-8. 2010..Here, we studied whether klotho single nucleotide polymorphisms (SNP) were associated with carotid atherosclerosis... - Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartanTong Yin
Research Institute, Department of Medicine, National Cardiovascular Center, Suita, Japan
Hypertens Res 31:1549-57. 2008..CYP2C9*30 might be associated with a diminished response to the antihypertensive effects of losartan... - Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita studyTomonori Okamura
Department of Preventive Cardiology, National Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
Atherosclerosis 203:587-92. 2009.... - Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita studyYumiko Hiura
Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita 565 8565, Japan
Circ J 73:1119-26. 2009.... - Validation of the association between the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a Japanese populationKazuaki Kajimoto
National Cardiovascular Center, Suita, Japan
Circ J 69:1029-34. 2005..The purpose of the present study was to validate those findings in a Japanese population... - Elevated serum creatine kinase predicts first-ever myocardial infarction: a 12-year population-based cohort study in Japan, the Suita studyMakoto Watanabe
Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan
Int J Epidemiol 38:1571-9. 2009..The present analysis examined whether elevated s-CK levels predicted first-ever MI or stroke... - No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient populationTong Yin
Research Institute, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan
Thromb Res 122:179-84. 2008 - Soft drink intake in relation to incident ischemic heart disease, stroke, and stroke subtypes in Japanese men and women: the Japan Public Health Centre-based study cohort IEhab S Eshak
Public Health Medicine, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita Shi, Osaka, Japan
Am J Clin Nutr 96:1390-7. 2012..Soft drink intake has been associated with obesity and diabetes, but its relation with risk of cardiovascular disease (CVD) is limited... - CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese populationHiroko Morisaki
Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
Hum Mutat 33:402-10. 2012.... - Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general populationNozomu Inamoto
Department of Geriatric Medicine, National Cardiovascular Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
Stroke 34:1628-33. 2003..This may be due to small sample size and inappropriate analysis. We investigated the association of C677T/MTHFR with blood pressure and carotid atherosclerosis in a Japanese general population... - A novel missense mutation, F826Y, in the mineralocorticoid receptor gene in Japanese hypertensives: its implications for clinical phenotypesKei Kamide
Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
Hypertens Res 28:703-9. 2005.... - Protein intakes and serum albumin levels in a Japanese general population: NIPPON DATA90Makoto Watanabe
Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan
J Epidemiol 20:S531-6. 2010..We cross-sectionally investigated in the representative Japanese the association between dietary protein intake and serum albumin levels... - Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in JapaneseNaoharu Iwai
Department of Epidemiology, National Cardiovascular Center, Suita, Japan
Circ J 70:805-9. 2006..The purpose of the present study was to investigate the possible involvement of CCL2 in the pathogenesis of atherosclerosis and MI in Japanese... - Validation of the association between the gene encoding proteasome subunit alpha type 6 and myocardial infarction in a Japanese populationNaoyuki Takashima
Department of Epidemiology, National Cardiovascular Center, Suita
Circ J 71:495-8. 2007..The frequency of the risk conferring genotype (GG) in cases was reported to be greater than that in controls (12.4% vs 8.9%). The purpose of the present study was to validate this observation in our study population... - A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese populationKeisuke Shioji
Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
J Hum Genet 49:141-7. 2004..These results indicate that ABCA1 G(-273)C has a significant effect on the HDL-C level in the general Japanese population, but not on the incidence of MI... - Association of platelet aggregation with lipid levels in the Japanese population: the Suita studySachika Kameda
Laboratory of Clinical Chemistry, National Cerebral and Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
J Atheroscler Thromb 18:560-7. 2011..Platelet aggregability induced by agonists has great interindividual variability; however, the factors influencing platelet aggregability variation have not been characterized in Asia... - Genetic variants in PCSK9 in the Japanese population: rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general populationYasuko Miyake
Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Atherosclerosis 196:29-36. 2008.... - Extensive genetic analysis of 10 candidate genes for hypertension in JapaneseNaoharu Iwai
Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Hypertension 48:901-7. 2006..Thus, ELN seems to contribute to blood pressure regulation by affecting arterial stiffness in Japanese... - Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita studyKeisuke Shioji
Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
Hypertens Res 27:31-7. 2004..Accordingly, it will be necessary to verify the association between these three genes and hypertension using a larger number of subjects from the Suita cohort or another population... - Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general populationRina Kimura
Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
Int J Hematol 84:387-97. 2006..Thus, polymorphisms in genes involved in the vitamin K-dependent gamma-carboxylation reaction influence interindividual variation in the activities of protein C and protein S in the general population... - An association analysis between ApoA1 polymorphisms and the high-density lipoprotein (HDL) cholesterol level and myocardial infarction (MI) in JapaneseKeisuke Shioji
Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
J Hum Genet 49:433-9. 2004..0145, OR=0.4955, 95% CI: 0.2746-0.8525). The ApoA1 T84C polymorphism is an important marker for the HDL-C level and may be a new risk marker for MI in Japanese... - A high prevalence of renal hypouricemia caused by inactive SLC22A12 in JapaneseNaoharu Iwai
National Cardiovascular Center, Suita, Osaka, Japan
Kidney Int 66:935-44. 2004..Recently, SLC22A12 has been identified as a urate-anion exchanger in the human kidney... - Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center studyRenzhe Cui
Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2 2 Yamadaoka, Suita Shi, Osaka, 565 0871 Japan
Stroke 42:2611-4. 2011..Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians... - Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita StudyTakako Sugisawa
The Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
Endocr J 57:727-33. 2010..In conclusion, plasma BNP was inversely associated with obesity related markers such as body fat mass, skinfold thickness and waist circumferences after adjusted for relevant covariates in a Japanese population... - Genetic variants in PCSK9 affect the cholesterol level in JapaneseKeisuke Shioji
Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai Suita, Osaka 565 8565, Japan
J Hum Genet 49:109-14. 2004..These results provide the first evidence that common variants intron 1/C(-161)T and exon 9/I474 V in PCSK9 significantly affect TC and LDL-C levels in the general population in Japan... - Epidemiological evidence of an association between SLC6A2 gene polymorphism and hypertensionKoh Ono
National Cardiovascular Center, Suita, Japan
Hypertens Res 26:685-9. 2003..08-1.69) over the AA genotype. SLC6A2 may be one of the genes that contribute to hypertension in Japanese. To our knowledge, this is the first report to detect associations between SLC6A2 genetic variants and blood pressure... - Genetic risk factors for deep vein thrombosis among Japanese: importance of protein S K196E mutationToshiyuki Miyata
Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
Int J Hematol 83:217-23. 2006.... - New diagnosis criteria for diabetes with hemoglobin A1c and risks of macro-vascular complications in an urban Japanese cohort: the Suita studyMakoto Watanabe
Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
Diabetes Res Clin Pract 88:e20-3. 2010..The present analysis suggested that this new criteria were applicable to macro-vascular complications in the Japanese... - Functional confirmation of Gitelman's syndrome mutations in JapaneseHiroaki Naraba
National Cardiovascular Center, Suita, Japan
Hypertens Res 28:805-9. 2005..This observation may have very important clinical implications, since the allele frequency of this variation is 0.0126... - Visceral fat is negatively associated with B-type natriuretic peptide levels in patients with advanced type 2 diabetesTakako Sugisawa
Department of Atherosclerosis and Diabetes, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
Diabetes Res Clin Pract 89:174-80. 2010..We examined the effects of obesity on BNP levels in patients with diabetes that are often associated with obesity and a higher risk for heart failure... - The relationship between waist circumference and the risk of stroke and myocardial infarction in a Japanese urban cohort: the suita studyYoko Furukawa
Department of Preventive Cardiology, National Cardiovascular Center, Fujishiro dai, Suita, Osaka, 565 8565 Japan
Stroke 41:550-3. 2010..No associations of body mass index with CVD or strokes were observed. CONCLUSIONS: WC may be a better predictor for CVD or stroke in Japanese women... - Association of Asn221Ser mutation in tissue factor pathway inhibitor-beta with plasma total tissue factor pathway inhibitor levelJunko Ishikawa
National Cardiovascular Center Research Institute, Osaka, Japan
Blood Coagul Fibrinolysis 20:22-6. 2009..The absence of the putative glycosylphosphatidylinositol anchor in TFPI-beta under pathological conditions remains to be studied... - Relationships between protein intake and renal function in a Japanese general population: NIPPON DATA90Aya Higashiyama
Lifestyle Related Disease Prevention Center, Shiga University of Medical Science, Otsu, Japan
J Epidemiol 20:S537-43. 2010..However, the relationship between protein intake and renal function is still uncertain, especially in relatively healthy general population... - FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assayKoichi Kokame
National Cardiovascular Centre Research Institute, Suita, Osaka, Japan
Br J Haematol 129:93-100. 2005..The FRETS-VWF73 assay will be useful for the characterization of thrombotic microangiopathies like TTP and may clarify the importance of ADAMTS13 activity as a predictive marker for various thrombotic diseases... - Update of Japanese common LDLR gene mutations and their phenotypes: Mild type mutation L547V might predominate in the Japanese populationYasuko Miyake
Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
Atherosclerosis 203:153-60. 2009..In conclusion, although there is a broad spectrum of LDLR gene mutations in the Japanese population, eight common mutations were observed. Among them, a mild phenotype mutation, L547V, might predominate in the Japanese population... - Sex hormone and gender difference--role of testosterone on male predominance in Brugada syndromeWataru Shimizu
Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
J Cardiovasc Electrophysiol 18:415-21. 2007..Brugada syndrome has been reported to be thinner than asymptomatic normal controls. We tested the hypothesis that higher testosterone level associated with lower visceral fat may relate to Brugada phenotype and male predominance... - Potential of free-form TFPI and PAI-1 to be useful markers of early atherosclerosis in a Japanese general population (the Suita Study): association with the intimal-medial thickness of carotid arteriesToshiyuki Sakata
Laboratory of Clinical Chemistry, National Cardiovascular Center, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
Atherosclerosis 176:355-60. 2004..These results indicate that measurement of the levels of free TFPI and PAI-1 is a potentially useful tool for the detection of early atherosclerosis in men... - Abnormal glucose tolerance contributes to the progression of chronic heart failure in patients with dilated cardiomyopathyJiyoong Kim
Cardiovascular Division, National Cardiovascular Center, Suita, Japan
Hypertens Res 29:775-82. 2006..In conclusion, abnormal glucose tolerance was more prevalent among patients with DCM-induced CHF than controls, and the correction of IGT improved the pathophysiology of CHF...