Yoshihiro Kokubo

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi request reprint Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Circulation 116:2553-62. 2007
  2. doi request reprint Traditional risk factor management for stroke: a never-ending challenge for health behaviors of diet and physical activity
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
    Curr Opin Neurol 25:11-7. 2012
  3. pmc Associations of impaired glucose metabolism and dyslipidemia with cardiovascular diseases: what have we learned from Japanese cohort studies for individualized prevention and treatment?
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka 565 8565 Japan
    EPMA J 2:75-81. 2011
  4. doi request reprint Carotid atherosclerosis in kidney disease
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Disease, Suita, Japan
    Contrib Nephrol 179:35-41. 2013
  5. doi request reprint The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Stroke 44:1369-74. 2013
  6. ncbi request reprint Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
    Yoshihiro Kokubo
    Division of Preventive Cardiology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    J Hum Genet 49:507-15. 2004
  7. doi request reprint Dietary fiber intake and risk of cardiovascular disease in the Japanese population: the Japan Public Health Center-based study cohort
    Y Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan
    Eur J Clin Nutr 65:1233-41. 2011
  8. ncbi request reprint Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population
    Yoshihiro Kokubo
    Division of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:697-702. 2004
  9. doi request reprint Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Stroke 40:2674-9. 2009
  10. doi request reprint The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 33:1238-43. 2010

Detail Information

Publications77

  1. ncbi request reprint Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Circulation 116:2553-62. 2007
    ..We investigated the association of soy and isoflavone intake with risk of cerebral and myocardial infarctions (CI and MI)...
  2. doi request reprint Traditional risk factor management for stroke: a never-ending challenge for health behaviors of diet and physical activity
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan
    Curr Opin Neurol 25:11-7. 2012
    ..Recently, many guidelines have given new evidence on the risk factors for stroke. In this review, I refer to the most important guidelines for primary prevention of stroke and hypertension, especially focused on diet and physical activity...
  3. pmc Associations of impaired glucose metabolism and dyslipidemia with cardiovascular diseases: what have we learned from Japanese cohort studies for individualized prevention and treatment?
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka 565 8565 Japan
    EPMA J 2:75-81. 2011
    ..Overall, the studies reviewed here show that impaired glucose metabolism and dyslipidemia are emerging risk factors for CVD in the Japanese population...
  4. doi request reprint Carotid atherosclerosis in kidney disease
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Disease, Suita, Japan
    Contrib Nephrol 179:35-41. 2013
    ..These findings pointed to the importance of early detection of subjects with decreased renal function and the strict management of blood pressure in general populations...
  5. doi request reprint The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Stroke 44:1369-74. 2013
    ..Few prospective studies have examined the impact of both green tea and coffee consumption on strokes. We investigated the association of the combination of those consumption with stroke incidence in a general population...
  6. ncbi request reprint Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population
    Yoshihiro Kokubo
    Division of Preventive Cardiology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    J Hum Genet 49:507-15. 2004
    ..010, 95% confidence interval, 1.12-2.33). Association of TSC and WNK1 with hypertension was not observed. In conclusion, our study suggests the possible involvement of WNK4 in essential hypertension in a Japanese general population...
  7. doi request reprint Dietary fiber intake and risk of cardiovascular disease in the Japanese population: the Japan Public Health Center-based study cohort
    Y Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Osaka, Japan
    Eur J Clin Nutr 65:1233-41. 2011
    ..We investigated the association between dietary fiber and the risk of cardiovascular disease (CVD), which we defined as stroke or CHD, in a Japanese population...
  8. ncbi request reprint Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population
    Yoshihiro Kokubo
    Division of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:697-702. 2004
    ..TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p =0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population...
  9. doi request reprint Relationship between blood pressure category and incidence of stroke and myocardial infarction in an urban Japanese population with and without chronic kidney disease: the Suita Study
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Stroke 40:2674-9. 2009
    ..Few studies, however, have examined the relationship between blood pressure (BP) category and these diseases in subjects with and without CKD...
  10. doi request reprint The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 33:1238-43. 2010
    ..Further investigation of larger cohorts of DM subjects should be conducted to better understand this phenomenon...
  11. doi request reprint Impact of high-normal blood pressure on the risk of cardiovascular disease in a Japanese urban cohort: the Suita study
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, Suita, Osaka, 565 8565 Japan
    Hypertension 52:652-9. 2008
    ..2% and 35.3% in men and 7.1% and 23.4% in women, respectively. In conclusion, high-normal blood pressure is a risk factor for the incidence of stroke and myocardial infarction in a general urban population of Japanese men...
  12. ncbi request reprint Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension
    Yoshihiro Kokubo
    Division of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 29:611-9. 2006
    ..Thus, our study suggests that these five genes were susceptibility genes for essential hypertension in this Japanese population...
  13. ncbi request reprint High-normal blood pressure and the risk of cardiovascular disease
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
    Circ J 73:1381-5. 2009
    ....
  14. doi request reprint Impact of metabolic syndrome components on the incidence of cardiovascular disease in a general urban Japanese population: the suita study
    Yoshihiro Kokubo
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita 565 8565, Japan
    Hypertens Res 31:2027-35. 2008
    ..Hypertens Res 2008; 31: 2027-2035)...
  15. ncbi request reprint Association of genetic polymorphisms of ACADSB and COMT with human hypertension
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 25:103-10. 2007
    ..We examined the association of human homologues of these genes with human hypertension...
  16. ncbi request reprint A genome-wide association study of hypertension-related phenotypes in a Japanese population
    Yumiko Hiura
    Department of Genomic Medicine, Research Institute, National Cerebral and Cardiovascular Center, Suita, Japan
    Circ J 74:2353-9. 2010
    ..A GWAS of hypertension-related phenotypes in a Japanese population was conducted in the current study...
  17. ncbi request reprint Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population
    Jin Yang
    Divisions of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 23:1497-505. 2005
    ..We studied whether genetic variations in RGS2 are implicated in hypertension or other phenotypes in Japanese hypertensive individuals and the general population...
  18. doi request reprint Effects of the Y chromosome on cardiovascular risk factors in Japanese men
    Yumiko Hiura
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Japan
    Hypertens Res 31:1687-94. 2008
    ..Studies using much larger sample sizes and/or additional independent samples will be required for definitive conclusions...
  19. ncbi request reprint Association of the functional variant in the 3-hydroxy-3-methylglutaryl-coenzyme a reductase gene with low-density lipoprotein-cholesterol in Japanese
    Yumiko Hiura
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Circ J 74:518-22. 2010
    ..The aim of this study was to examine the association between rs3846662 of HMGCR and the level of LDL-C in Japanese...
  20. ncbi request reprint Three novel missense mutations of WNK4, a kinase mutated in inherited hypertension, in Japanese hypertensives: implication of clinical phenotypes
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Am J Hypertens 17:446-9. 2004
    ..The objective of this study was to test whether more subtle changes of WNK4 could be implicated in hypertension or renal failure...
  21. ncbi request reprint Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population
    Shin Takiuchi
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 173:301-7. 2004
    ..This study provides the first evidence that HGF may be a candidate susceptibility loci that affects the progression of atherosclerosis in Japanese subjects...
  22. ncbi request reprint Genetic variations of HSD11B2 in hypertensive patients and in the general population, six rare missense/frameshift mutations
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 29:243-52. 2006
    ..Taken together, our results indicate that missense mutations in HSD11B2 do not substantially contribute to essential hypertension in Japanese...
  23. doi request reprint Associations of hypertension and its complications with variations in the xanthine dehydrogenase gene
    Jin Yang
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 31:931-40. 2008
    ..0006). Our results suggest that genetic variations in XDH contribute partly to hypertension and its complications, including atherosclerosis and CKD...
  24. ncbi request reprint Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and atherosclerosis in a Japanese general population
    Chihiro Tanaka
    Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:35-41. 2005
    ..Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese...
  25. ncbi request reprint Protein tyrosine kinase 2beta as a candidate gene for hypertension
    Kei Kamide
    Divisions of Hypertension, National Cardiovascular Center, Suita, Osaka, Japan
    Pharmacogenet Genomics 17:931-9. 2007
    ..Thus, a haplotype in PTK2B may play a role in essential hypertension in Japanese...
  26. ncbi request reprint A novel Thr56Met mutation of the autosomal recessive hypercholesterolemia gene associated with hypercholesterolemia
    Koji Harada
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
    J Atheroscler Thromb 17:131-40. 2010
    ..Several researchers have identified mutations of ARH that cause autosomal recessive hypercholesterolemia; however, it remains unknown whether this gene is involved in common hypercholesterolemia...
  27. doi request reprint Association study of 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in urban Japanese cohort
    Yoshihiro Miyamoto
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
    Diabetes Res Clin Pract 85:132-8. 2009
    ..Our findings indicate that polymorphisms and haplotypes in the 11beta-HSD1 gene are not significantly associated with metabolic syndrome in the Japanese population...
  28. doi request reprint Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population
    Kei Kamide
    Division of Hypertension and Nephrology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 34:740-6. 2011
    ..Taken together, these data suggest that genetic polymorphisms in RGS2 are associated with intima-media thickening of carotid artery in humans...
  29. ncbi request reprint Association of genetic polymorphisms of endothelin-converting enzyme-1 gene with hypertension in a Japanese population and rare missense mutation in preproendothelin-1 in Japanese hypertensives
    Mariko Banno
    Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 30:513-20. 2007
    ..Taken together, these findings reveal that the EDN-ECE pathway is an important system involved in essential hypertension in Japanese...
  30. ncbi request reprint Association analysis between hypertension and CYBA, CLCNKB, and KCNMB1 functional polymorphisms in the Japanese population--the Suita Study
    Yoshihiro Kokubo
    National Cardiovascular Center, Suita, Osaka, Japan
    Circ J 69:138-42. 2005
    ....
  31. ncbi request reprint A high prevalence of Gitelman's syndrome mutations in Japanese
    Naomi Tago
    National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:327-31. 2004
    ..In conclusion, GS could be one of the major causes of low blood pressure in Japanese...
  32. ncbi request reprint Hypertension susceptibility genes on chromosome 2p24-p25 in a general Japanese population
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 23:955-60. 2005
    ..Genome-wide scans from Italy and China suggest a hypertension-susceptible locus between D2S2278 (nucleotides 11,245,080 - 11,245,358) and D2S168 (nucleotides 11,467,214 - 11,467,422) on chromosome 2...
  33. ncbi request reprint Genetic analysis of 22 candidate genes for hypertension in the Japanese population
    Naoharu Iwai
    National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 22:1119-26. 2004
    ..We performed association studies between 118 single-nucleotide polymorphisms (SNPs) of 22 candidate genes (or gene family) and hypertension in a Japanese population...
  34. doi request reprint Triglycerides and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort: the Suita study
    Tomonori Okamura
    Department of Preventive Cardiology, National Cardiovascular Center, Suita, Osaka, Japan
    Atherosclerosis 209:290-4. 2010
    ....
  35. ncbi request reprint Risk of smoking and metabolic syndrome for incidence of cardiovascular disease--comparison of relative contribution in urban Japanese population: the Suita study
    Aya Higashiyama
    Department of Preventive Cardiology, National Cardiovascular Center, Suita, Japan
    Circ J 73:2258-63. 2009
    ..Smoking is also an important CVD risk factor with still a high prevalence. However, few previous studies have compared the risk for CVD or the population-attributable fraction (PAF) of smoking, MetS, and both...
  36. ncbi request reprint Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population
    Nozomu Inamoto
    Department of Geriatric Medicine, National Cardiovascular Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 34:1628-33. 2003
    ..This may be due to small sample size and inappropriate analysis. We investigated the association of C677T/MTHFR with blood pressure and carotid atherosclerosis in a Japanese general population...
  37. doi request reprint Genetic variations of CYP2C9 in 724 Japanese individuals and their impact on the antihypertensive effects of losartan
    Tong Yin
    Research Institute, Department of Medicine, National Cardiovascular Center, Suita, Japan
    Hypertens Res 31:1549-57. 2008
    ..CYP2C9*30 might be associated with a diminished response to the antihypertensive effects of losartan...
  38. ncbi request reprint Validation of the association between the gene encoding 5-lipoxygenase-activating protein and myocardial infarction in a Japanese population
    Kazuaki Kajimoto
    National Cardiovascular Center, Suita, Japan
    Circ J 69:1029-34. 2005
    ..The purpose of the present study was to validate those findings in a Japanese population...
  39. doi request reprint Low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol and the incidence of cardiovascular disease in an urban Japanese cohort study: The Suita study
    Tomonori Okamura
    Department of Preventive Cardiology, National Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
    Atherosclerosis 203:587-92. 2009
    ....
  40. ncbi request reprint Validation of the association of genetic variants on chromosome 9p21 and 1q41 with myocardial infarction in a Japanese population
    Yumiko Hiura
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Circ J 72:1213-7. 2008
    ..The effect of the CAD-associated SNPs on cardiovascular risk factors in the control group was also investigated...
  41. ncbi request reprint Heterozygous disruption of CMA1 does not affect blood pressure
    Koh Ono
    National Cardiovascular Center, Suita, Osaka, Japan
    J Hypertens 22:103-9. 2004
    ..It has been suspected that the mast cell chymase gene (CMA1) is important for the generation of angiotensin II and therefore might be associated with the pathogenesis of hypertension...
  42. doi request reprint High serum total cholesterol levels is a risk factor of ischemic stroke for general Japanese population: the JPHC study
    Renzhe Cui
    Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Atherosclerosis 221:565-9. 2012
    ..High serum total cholesterol levels represent a risk factor of ischemic stroke in Western countries. However, this association has not been thoroughly investigated in Asian populations where the incidence of stroke is high...
  43. doi request reprint Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension
    Ryosuke Oguro
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Geriatr Gerontol Int 10:311-8. 2010
    ..Here, we studied whether klotho single nucleotide polymorphisms (SNP) were associated with carotid atherosclerosis...
  44. doi request reprint Elevated serum creatine kinase predicts first-ever myocardial infarction: a 12-year population-based cohort study in Japan, the Suita study
    Makoto Watanabe
    Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan
    Int J Epidemiol 38:1571-9. 2009
    ..The present analysis examined whether elevated s-CK levels predicted first-ever MI or stroke...
  45. ncbi request reprint Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita study
    Yumiko Hiura
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita 565 8565, Japan
    Circ J 73:1119-26. 2009
    ....
  46. ncbi request reprint No association between vitamin K epoxide reductase complex subunit 1-like 1 (VKORC1L1) and the variability of warfarin dose requirement in a Japanese patient population
    Tong Yin
    Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Thromb Res 122:179-84. 2008
  47. doi request reprint Impact of chronic kidney disease on carotid atherosclerosis according to blood pressure category: the Suita study
    Tomoyuki Ohara
    From the Departments of Cerebrovascular Medicine T O, K T, K M, Preventive Cardiology Y K, M W, Y M, Stroke Care Unit M K, Hypertension and Nephrology S N, and Neurology K N, National Cerebral and Cardiovascular Center, Osaka, Japan and North Medical Center M N, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Stroke 44:3537-9. 2013
    ..We aimed to clarify the association of chronic kidney disease (CKD) with carotid atherosclerosis and the impact of CKD on carotid atherosclerosis according to blood pressure categories in an urban general population...
  48. doi request reprint Soft drink intake in relation to incident ischemic heart disease, stroke, and stroke subtypes in Japanese men and women: the Japan Public Health Centre-based study cohort I
    Ehab S Eshak
    Public Health Medicine, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita Shi, Osaka, Japan
    Am J Clin Nutr 96:1390-7. 2012
    ..Soft drink intake has been associated with obesity and diabetes, but its relation with risk of cardiovascular disease (CVD) is limited...
  49. doi request reprint CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population
    Hiroko Morisaki
    Department of Bioscience and Genetics, National Cerebral and Cardiovascular Center Research Institute, Osaka, Japan
    Hum Mutat 33:402-10. 2012
    ....
  50. ncbi request reprint Association of platelet aggregation with lipid levels in the Japanese population: the Suita study
    Sachika Kameda
    Laboratory of Clinical Chemistry, National Cerebral and Cardiovascular Center, Fujishiro dai, Suita, Osaka, Japan
    J Atheroscler Thromb 18:560-7. 2011
    ..Platelet aggregability induced by agonists has great interindividual variability; however, the factors influencing platelet aggregability variation have not been characterized in Asia...
  51. ncbi request reprint Protein intakes and serum albumin levels in a Japanese general population: NIPPON DATA90
    Makoto Watanabe
    Department of Preventive Cardiology, National Cardiovascular Center, Osaka, Japan
    J Epidemiol 20:S531-6. 2010
    ..We cross-sectionally investigated in the representative Japanese the association between dietary protein intake and serum albumin levels...
  52. ncbi request reprint A promoter variant of the ATP-binding cassette transporter A1 gene alters the HDL cholesterol level in the general Japanese population
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Hum Genet 49:141-7. 2004
    ..These results indicate that ABCA1 G(-273)C has a significant effect on the HDL-C level in the general Japanese population, but not on the incidence of MI...
  53. ncbi request reprint A novel missense mutation, F826Y, in the mineralocorticoid receptor gene in Japanese hypertensives: its implications for clinical phenotypes
    Kei Kamide
    Division of Hypertension and Nephrology, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:703-9. 2005
    ....
  54. ncbi request reprint Assessment of genetic effects of polymorphisms in the MCP-1 gene on serum MCP-1 levels and myocardial infarction in Japanese
    Naoharu Iwai
    Department of Epidemiology, National Cardiovascular Center, Suita, Japan
    Circ J 70:805-9. 2006
    ..The purpose of the present study was to investigate the possible involvement of CCL2 in the pathogenesis of atherosclerosis and MI in Japanese...
  55. ncbi request reprint Validation of the association between the gene encoding proteasome subunit alpha type 6 and myocardial infarction in a Japanese population
    Naoyuki Takashima
    Department of Epidemiology, National Cardiovascular Center, Suita
    Circ J 71:495-8. 2007
    ..The frequency of the risk conferring genotype (GG) in cases was reported to be greater than that in controls (12.4% vs 8.9%). The purpose of the present study was to validate this observation in our study population...
  56. ncbi request reprint Genetic variants in PCSK9 in the Japanese population: rare genetic variants in PCSK9 might collectively contribute to plasma LDL cholesterol levels in the general population
    Yasuko Miyake
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 196:29-36. 2008
    ....
  57. ncbi request reprint Extensive genetic analysis of 10 candidate genes for hypertension in Japanese
    Naoharu Iwai
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Hypertension 48:901-7. 2006
    ..Thus, ELN seems to contribute to blood pressure regulation by affecting arterial stiffness in Japanese...
  58. ncbi request reprint An association analysis between ApoA1 polymorphisms and the high-density lipoprotein (HDL) cholesterol level and myocardial infarction (MI) in Japanese
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    J Hum Genet 49:433-9. 2004
    ..0145, OR=0.4955, 95% CI: 0.2746-0.8525). The ApoA1 T84C polymorphism is an important marker for the HDL-C level and may be a new risk marker for MI in Japanese...
  59. ncbi request reprint A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese
    Naoharu Iwai
    National Cardiovascular Center, Suita, Osaka, Japan
    Kidney Int 66:935-44. 2004
    ..Recently, SLC22A12 has been identified as a urate-anion exchanger in the human kidney...
  60. ncbi request reprint Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 27:31-7. 2004
    ..Accordingly, it will be necessary to verify the association between these three genes and hypertension using a larger number of subjects from the Suita cohort or another population...
  61. ncbi request reprint Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
    Rina Kimura
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Int J Hematol 84:387-97. 2006
    ..Thus, polymorphisms in genes involved in the vitamin K-dependent gamma-carboxylation reaction influence interindividual variation in the activities of protein C and protein S in the general population...
  62. doi request reprint Diabetes mellitus and risk of stroke and its subtypes among Japanese: the Japan public health center study
    Renzhe Cui
    Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan, 2 2 Yamadaoka, Suita Shi, Osaka, 565 0871 Japan
    Stroke 42:2611-4. 2011
    ..Although diabetes mellitus has been recognized as a risk factor for ischemic stroke, evidence is limited for ischemic stroke subtypes among Asians...
  63. ncbi request reprint Genetic risk factors for deep vein thrombosis among Japanese: importance of protein S K196E mutation
    Toshiyuki Miyata
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Int J Hematol 83:217-23. 2006
    ....
  64. ncbi request reprint Association of plasma B-type natriuretic peptide levels with obesity in a general urban Japanese population: the Suita Study
    Takako Sugisawa
    The Department of Atherosclerosis and Diabetes, National Cardiovascular Center, Osaka, Japan
    Endocr J 57:727-33. 2010
    ..In conclusion, plasma BNP was inversely associated with obesity related markers such as body fat mass, skinfold thickness and waist circumferences after adjusted for relevant covariates in a Japanese population...
  65. ncbi request reprint Genetic variants in PCSK9 affect the cholesterol level in Japanese
    Keisuke Shioji
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai Suita, Osaka 565 8565, Japan
    J Hum Genet 49:109-14. 2004
    ..These results provide the first evidence that common variants intron 1/C(-161)T and exon 9/I474 V in PCSK9 significantly affect TC and LDL-C levels in the general population in Japan...
  66. ncbi request reprint Epidemiological evidence of an association between SLC6A2 gene polymorphism and hypertension
    Koh Ono
    National Cardiovascular Center, Suita, Japan
    Hypertens Res 26:685-9. 2003
    ..08-1.69) over the AA genotype. SLC6A2 may be one of the genes that contribute to hypertension in Japanese. To our knowledge, this is the first report to detect associations between SLC6A2 genetic variants and blood pressure...
  67. doi request reprint New diagnosis criteria for diabetes with hemoglobin A1c and risks of macro-vascular complications in an urban Japanese cohort: the Suita study
    Makoto Watanabe
    Department of Preventive Cardiology, National Cardiovascular Center, 5 7 1, Fujishiro dai, Suita, Osaka, 565 8565, Japan
    Diabetes Res Clin Pract 88:e20-3. 2010
    ..The present analysis suggested that this new criteria were applicable to macro-vascular complications in the Japanese...
  68. ncbi request reprint The relationship between waist circumference and the risk of stroke and myocardial infarction in a Japanese urban cohort: the suita study
    Yoko Furukawa
    Department of Preventive Cardiology, National Cardiovascular Center, Fujishiro dai, Suita, Osaka, 565 8565 Japan
    Stroke 41:550-3. 2010
    ..No associations of body mass index with CVD or strokes were observed. CONCLUSIONS: WC may be a better predictor for CVD or stroke in Japanese women...
  69. doi request reprint Visceral fat is negatively associated with B-type natriuretic peptide levels in patients with advanced type 2 diabetes
    Takako Sugisawa
    Department of Atherosclerosis and Diabetes, National Cardiovascular Center, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Diabetes Res Clin Pract 89:174-80. 2010
    ..We examined the effects of obesity on BNP levels in patients with diabetes that are often associated with obesity and a higher risk for heart failure...
  70. ncbi request reprint Functional confirmation of Gitelman's syndrome mutations in Japanese
    Hiroaki Naraba
    National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:805-9. 2005
    ..This observation may have very important clinical implications, since the allele frequency of this variation is 0.0126...
  71. doi request reprint Association of Asn221Ser mutation in tissue factor pathway inhibitor-beta with plasma total tissue factor pathway inhibitor level
    Junko Ishikawa
    National Cardiovascular Center Research Institute, Osaka, Japan
    Blood Coagul Fibrinolysis 20:22-6. 2009
    ..The absence of the putative glycosylphosphatidylinositol anchor in TFPI-beta under pathological conditions remains to be studied...
  72. ncbi request reprint Potential of free-form TFPI and PAI-1 to be useful markers of early atherosclerosis in a Japanese general population (the Suita Study): association with the intimal-medial thickness of carotid arteries
    Toshiyuki Sakata
    Laboratory of Clinical Chemistry, National Cardiovascular Center, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    Atherosclerosis 176:355-60. 2004
    ..These results indicate that measurement of the levels of free TFPI and PAI-1 is a potentially useful tool for the detection of early atherosclerosis in men...
  73. ncbi request reprint FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay
    Koichi Kokame
    National Cardiovascular Centre Research Institute, Suita, Osaka, Japan
    Br J Haematol 129:93-100. 2005
    ..The FRETS-VWF73 assay will be useful for the characterization of thrombotic microangiopathies like TTP and may clarify the importance of ADAMTS13 activity as a predictive marker for various thrombotic diseases...
  74. doi request reprint Update of Japanese common LDLR gene mutations and their phenotypes: Mild type mutation L547V might predominate in the Japanese population
    Yasuko Miyake
    Department of Etiology and Pathophysiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 203:153-60. 2009
    ..In conclusion, although there is a broad spectrum of LDLR gene mutations in the Japanese population, eight common mutations were observed. Among them, a mild phenotype mutation, L547V, might predominate in the Japanese population...
  75. ncbi request reprint Sex hormone and gender difference--role of testosterone on male predominance in Brugada syndrome
    Wataru Shimizu
    Division of Cardiology, Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka, Japan
    J Cardiovasc Electrophysiol 18:415-21. 2007
    ..Brugada syndrome has been reported to be thinner than asymptomatic normal controls. We tested the hypothesis that higher testosterone level associated with lower visceral fat may relate to Brugada phenotype and male predominance...
  76. ncbi request reprint Relationships between protein intake and renal function in a Japanese general population: NIPPON DATA90
    Aya Higashiyama
    Lifestyle Related Disease Prevention Center, Shiga University of Medical Science, Otsu, Japan
    J Epidemiol 20:S537-43. 2010
    ..However, the relationship between protein intake and renal function is still uncertain, especially in relatively healthy general population...
  77. ncbi request reprint Abnormal glucose tolerance contributes to the progression of chronic heart failure in patients with dilated cardiomyopathy
    Jiyoong Kim
    Cardiovascular Division, National Cardiovascular Center, Suita, Japan
    Hypertens Res 29:775-82. 2006
    ..In conclusion, abnormal glucose tolerance was more prevalent among patients with DCM-induced CHF than controls, and the correction of IGT improved the pathophysiology of CHF...