Genomes and Genes
Affiliation: National Cardiovascular Center
- Kokubo Y, Inamoto N, Tomoike H, Kamide K, Takiuchi S, Kawano Y, et al. Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population. Hypertens Res. 2004;27:697-702 pubmed..TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p =0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population. ..
- Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, et al. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Clin Nutr. 2017;: pubmed publisher..We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men. ..
- Kokubo Y, Kamide K, Inamoto N, Tanaka C, Banno M, Takiuchi S, et al. Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. J Hum Genet. 2004;49:507-15 pubmed..010, 95% confidence interval, 1.12-2.33). Association of TSC and WNK1 with hypertension was not observed. In conclusion, our study suggests the possible involvement of WNK4 in essential hypertension in a Japanese general population. ..
- Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, et al. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. Hypertens Res. 2006;29:611-9 pubmed..Thus, our study suggests that these five genes were susceptibility genes for essential hypertension in this Japanese population. ..