Yoshihiro Kokubo


Affiliation: National Cardiovascular Center
Country: Japan


  1. request reprint
    Kokubo Y, Iso H, Ishihara J, Okada K, Inoue M, Tsugane S. Association of dietary intake of soy, beans, and isoflavones with risk of cerebral and myocardial infarctions in Japanese populations: the Japan Public Health Center-based (JPHC) study cohort I. Circulation. 2007;116:2553-62 pubmed
    ..High isoflavone intake was associated with reduced risk of CI and MI in Japanese women. The risk reduction was pronounced for postmenopausal women. ..
  2. Kosaka T, Kokubo Y, Ono T, Sekine S, Kida M, Kikui M, et al. Salivary inflammatory cytokines may be novel markers of carotid atherosclerosis in a Japanese general population: the Suita study. Atherosclerosis. 2014;237:123-8 pubmed publisher
    ..Selected salivary inflammatory cytokines may be useful screening markers for periodontal disease and carotid atherosclerosis. ..
  3. Kokubo Y, Watanabe M, Higashiyama A, Nakao Y, Kobayashi T, Watanabe T, et al. Interaction of Blood Pressure and Body Mass Index With Risk of Incident Atrial Fibrillation in a Japanese Urban Cohort: The Suita Study. Am J Hypertens. 2015;28:1355-61 pubmed publisher
    ..10-2.50), and 2.31 (1.47-3.65), respectively (P for interaction = 0.04). Systolic prehypertension and overweight are associated with incident AF in Japanese population. The association between SBP and AF may be evident by overweight. ..
  4. Kokubo Y, Iso H, Saito I, Yamagishi K, Ishihara J, Inoue M, et al. Dietary fiber intake and risk of cardiovascular disease in the Japanese population: the Japan Public Health Center-based study cohort. Eur J Clin Nutr. 2011;65:1233-41 pubmed publisher
    ..001) and not in smokers (probability values for interaction between total fiber and smoking were 0.06 and 0.01 in men and women, respectively). Higher total dietary fiber was associated with reduced risk of CVD in Japanese non-smokers. ..
  5. Kokubo Y, Iso H, Saito I, Yamagishi K, Yatsuya H, Ishihara J, et al. The impact of green tea and coffee consumption on the reduced risk of stroke incidence in Japanese population: the Japan public health center-based study cohort. Stroke. 2013;44:1369-74 pubmed publisher
    ..04). None of the significant association was observed in coronary heart disease. Higher green tea and coffee consumption were inversely associated with risk of CVD and stroke in general population. ..
  6. Kokubo Y, Matsumoto C. Hypertension Is a Risk Factor for Several Types of Heart Disease: Review of Prospective Studies. Adv Exp Med Biol. 2017;956:419-426 pubmed publisher
    ..Those relations tended to be stronger in men. The prevention of hypertension and lowering one's blood pressure may help reduce the risk of developing heart disease. ..
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    Kokubo Y, Inamoto N, Tomoike H, Kamide K, Takiuchi S, Kawano Y, et al. Association of genetic polymorphisms of sodium-calcium exchanger 1 gene, NCX1, with hypertension in a Japanese general population. Hypertens Res. 2004;27:697-702 pubmed
    ..TC+TT: odds ratio=1.45; 95% confidence intervals: 1.04 to 2.02; p =0.03), respectively. Thus, our study suggests that NCX1 is one of the genes related to susceptibility to essential hypertension in the Japanese general population. ..
  8. Kokubo Y, Saito I, Iso H, Yamagishi K, Yatsuya H, Ishihara J, et al. Dietary magnesium intake and risk of incident coronary heart disease in men: A prospective cohort study. Clin Nutr. 2018;37:1602-1608 pubmed publisher
    ..We observed no decreased risks of incident stroke in men or women with higher dietary magnesium intakes. Higher dietary magnesium intake was associated with a reduced risk of CHD in Japanese men. ..
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    Kokubo Y, Kamide K, Inamoto N, Tanaka C, Banno M, Takiuchi S, et al. Identification of 108 SNPs in TSC, WNK1, and WNK4 and their association with hypertension in a Japanese general population. J Hum Genet. 2004;49:507-15 pubmed
    ..010, 95% confidence interval, 1.12-2.33). Association of TSC and WNK1 with hypertension was not observed. In conclusion, our study suggests the possible involvement of WNK4 in essential hypertension in a Japanese general population. ..

More Information


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    Kokubo Y, Tomoike H, Tanaka C, Banno M, Okuda T, Inamoto N, et al. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. Hypertens Res. 2006;29:611-9 pubmed
    ..Thus, our study suggests that these five genes were susceptibility genes for essential hypertension in this Japanese population. ..