Hiroki Kokubo

Summary

Affiliation: National Institute of Genetics
Country: Japan

Publications

  1. ncbi request reprint Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Mishima, Japan
    Circ Res 95:540-7. 2004
  2. ncbi request reprint Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima Shizuoka 411 8540, Japan
    Development 134:747-55. 2007
  3. ncbi request reprint Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Mishima, Shizuoka, Japan
    Dev Biol 278:301-9. 2005
  4. ncbi request reprint Hesr, a mediator of the Notch signaling, functions in heart and vessel development
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Trends Cardiovasc Med 15:190-4. 2005
  5. ncbi request reprint Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse
    Yusuke Watanabe
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:1625-34. 2006
  6. doi request reprint Hesr2 knockout mice develop aortic valve disease with advancing age
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Shizuoka, Japan
    Arterioscler Thromb Vasc Biol 33:e84-92. 2013
  7. doi request reprint Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway
    Masahide Sakabe
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata Mishima, Shizuoka 411 8540, Japan
    Development 139:385-95. 2012
  8. ncbi request reprint Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling
    Aki Ishikawa
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 121:1443-53. 2004
  9. ncbi request reprint Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning
    Kwang Won Seo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 290:200-10. 2006
  10. ncbi request reprint Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system
    Satoshi Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan
    J Neurosci Res 84:1555-63. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Mishima, Japan
    Circ Res 95:540-7. 2004
    ..Because of the unique spectrum of cardiac anomalies expressed by hesr2-null mice, they represent a useful model system for elucidating the genetic basis of heart dysfunction...
  2. ncbi request reprint Hesr1 and Hesr2 regulate atrioventricular boundary formation in the developing heart through the repression of Tbx2
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata, Mishima Shizuoka 411 8540, Japan
    Development 134:747-55. 2007
    ..Furthermore, we find that the expression of Hesr1 and Hesr2 is independent of Notch2 signaling. Taken together, our data demonstrate that Hesr1 and Hesr2 play crucial roles in AV boundary formation through the suppression of Tbx2...
  3. ncbi request reprint Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Mishima, Shizuoka, Japan
    Dev Biol 278:301-9. 2005
    ..Taken together, our results demonstrate a requirement for hesr1 and hesr2 in mediating Notch signaling in the developing cardiac and vascular systems...
  4. ncbi request reprint Hesr, a mediator of the Notch signaling, functions in heart and vessel development
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Trends Cardiovasc Med 15:190-4. 2005
    ..This review highlights the many functions of the hesr gene family in heart and vessel development...
  5. ncbi request reprint Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse
    Yusuke Watanabe
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Development 133:1625-34. 2006
    ..Our present study thus indicates that the Notch1 signaling pathway plays a suppressive role both in AV myocardial differentiation and the maturation of the ventricular myocardium...
  6. doi request reprint Hesr2 knockout mice develop aortic valve disease with advancing age
    Hiroki Kokubo
    Division of Mammalian Development, National Institute of Genetics, Shizuoka, Japan
    Arterioscler Thromb Vasc Biol 33:e84-92. 2013
    ..However, the pathological mechanisms underlying these diseases are largely unknown. Our aim is to identify the role of the hairy and enhancer of split-related (Hesr)-2 gene in the adult heart...
  7. doi request reprint Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway
    Masahide Sakabe
    Division of Mammalian Development, National Institute of Genetics, 1111 Yata Mishima, Shizuoka 411 8540, Japan
    Development 139:385-95. 2012
    ..These data suggest that RA signaling participates in the Tbx2 transcriptional mechanism during OFT development and that the Tbx2-Tgfβ2 cascade is one of the key pathways involved in inducing the TGA phenotype...
  8. ncbi request reprint Mouse Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under the control of Notch signaling
    Aki Ishikawa
    Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411 8540, Japan
    Mech Dev 121:1443-53. 2004
    ..Collectively, our data suggest that the reciprocal interaction of Notch and Wnt signals, and of their respective negative feedback loops, function to organize the segmentation clock required for somitogenesis...
  9. ncbi request reprint Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning
    Kwang Won Seo
    Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, 77030, USA
    Dev Biol 290:200-10. 2006
    ....
  10. ncbi request reprint Hesr1 knockout mice exhibit behavioral alterations through the dopaminergic nervous system
    Satoshi Fuke
    Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, Japan
    J Neurosci Res 84:1555-63. 2006
    ..These results indicate that the HESR1 gene is related to neuropsychiatric disorders and behavioral traits through the dopaminergic nervous system...
  11. pmc Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea
    Toshinori Hayashi
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology HNS, Box 357923, USA
    Dev Biol 316:87-99. 2008
    ..This treatment also reduces Hesr1 and Hesr2 expression by as much as 80%. These results support the hypothesis that Hesr1 and Hesr2 are the downstream mediators of the prosensory function of Notch in early cochlear development...
  12. ncbi request reprint HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes
    Matthew T Holderfield
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA
    Biochem Biophys Res Commun 346:637-48. 2006
    ..Thus, HESR1 represses VEGFR2 through interactions with SP-1-like factors and requires an Inr element in the absence of a TATA box. Our findings illuminate an important mechanism for notch/HESR1 regulation of VEGF-induced angiogenesis...