Koichi Kokame

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. pmc Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
    Yuka Eura
    Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    PLoS ONE 7:e34298. 2012
  2. pmc Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) on hemodialysis for 19 years: a case report
    Koki Mise
    Nephrology Center, Toranomon Hospital, Tokyo, Japan
    BMC Nephrol 14:156. 2013
  3. ncbi request reprint Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes
    K Kokame
    National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565, Japan
    J Biol Chem 271:29659-65. 1996
  4. ncbi request reprint VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13
    Koichi Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 103:607-12. 2004
  5. ncbi request reprint Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response
    K Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Biol Chem 276:9199-205. 2001
  6. ncbi request reprint Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress
    K Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Biol Chem 275:32846-53. 2000
  7. ncbi request reprint FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay
    Koichi Kokame
    National Cardiovascular Centre Research Institute, Suita, Osaka, Japan
    Br J Haematol 129:93-100. 2005
  8. pmc Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells
    Yumiko Abe
    Department of Gynecology and Reproductive Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Reprod Biol Endocrinol 4:27. 2006
  9. ncbi request reprint Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease
    Fumiaki Banno
    National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Biol Chem 279:30896-903. 2004
  10. ncbi request reprint Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura
    Fumiaki Banno
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 107:3161-6. 2006

Collaborators

Detail Information

Publications34

  1. pmc Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice
    Yuka Eura
    Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan
    PLoS ONE 7:e34298. 2012
    ..Derlin-3- and Herp-deficient mice may become useful model animals for investigations of the physiological contribution of ERAD under stressful or pathological conditions...
  2. pmc Long term follow up of congenital thrombotic thrombocytopenic purpura (Upshaw-Schulman syndrome) on hemodialysis for 19 years: a case report
    Koki Mise
    Nephrology Center, Toranomon Hospital, Tokyo, Japan
    BMC Nephrol 14:156. 2013
    ..In particular, little is known about the long-term prognosis of patients with childhood-onset congenital TTP...
  3. ncbi request reprint Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes
    K Kokame
    National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565, Japan
    J Biol Chem 271:29659-65. 1996
    ..These observations indicate that homocysteine can alter the expressivity of multiple genes, including a stress protein and several novel genes. These responses may contribute to atherogenesis...
  4. ncbi request reprint VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13
    Koichi Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 103:607-12. 2004
    ..Thus, VWF73 will be a useful seed to develop a new rapid assay to determine ADAMTS-13 activity...
  5. ncbi request reprint Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response
    K Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Biol Chem 276:9199-205. 2001
    ..Interestingly, ERSE-II was also dependent on p50ATF6, in a manner similar to that of ERSE, despite the disparate structure. The strong induction of Herp mRNA by ER stress would be achieved by the cooperation of ERSE and ERSE-II...
  6. ncbi request reprint Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress
    K Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Biol Chem 275:32846-53. 2000
    ..Herp may, therefore, play an unknown role in the cellular survival response to stress...
  7. ncbi request reprint FRETS-VWF73, a first fluorogenic substrate for ADAMTS13 assay
    Koichi Kokame
    National Cardiovascular Centre Research Institute, Suita, Osaka, Japan
    Br J Haematol 129:93-100. 2005
    ..The FRETS-VWF73 assay will be useful for the characterization of thrombotic microangiopathies like TTP and may clarify the importance of ADAMTS13 activity as a predictive marker for various thrombotic diseases...
  8. pmc Identification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-inducible genes in human amniotic epithelial cells
    Yumiko Abe
    Department of Gynecology and Reproductive Medicine, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    Reprod Biol Endocrinol 4:27. 2006
    ..In order to evaluate the effects of dioxins on the feto-placental tissues, we analyzed the gene expression in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) treated primary cultures of human amniotic epithelial cells...
  9. ncbi request reprint Identification of strain-specific variants of mouse Adamts13 gene encoding von Willebrand factor-cleaving protease
    Fumiaki Banno
    National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Biol Chem 279:30896-903. 2004
    ..The natural variation in mouse ADAMTS13 should allow for the determination of hitherto unknown functions of its C-terminal domains in vivo...
  10. ncbi request reprint Complete deficiency in ADAMTS13 is prothrombotic, but it alone is not sufficient to cause thrombotic thrombocytopenic purpura
    Fumiaki Banno
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Blood 107:3161-6. 2006
    ..Alternatively, factors in addition to ADAMTS13 deficiency may be necessary for development of TTP...
  11. pmc The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formation
    Fumiaki Banno
    Research Institute, National Cardiovascular Center, Suita, Japan
    Blood 113:5323-9. 2009
    ..These results suggested that the C-terminally truncated ADAMTS13 exhibited decreased activity in the cleavage of VWF under high shear rate. Role of the C-terminal domains may become increasingly important under prothrombotic conditions...
  12. doi request reprint Binding of von Willebrand factor cleaving protease ADAMTS13 to Lys-plasmin(ogen)
    Yongchol Shin
    Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, 5 7 1 Fujishirodai, Suita, Osaka 5658565, Japan
    J Biochem 152:251-8. 2012
    ..The binding of ADAMTS13 to Lys-plasminogen may play an important role to localize these two proteases at sites of thrombus formation or vascular injury where the fibrinolytic system is activated...
  13. pmc Differential expression patterns of NDRG family proteins in the central nervous system
    Tomohiko Okuda
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Histochem Cytochem 56:175-82. 2008
    ..These expression patterns demonstrated the cell type-specific and ubiquitous localization of the NDRG family proteins. Each NDRG may play a partially redundant role in specific cells in the brain...
  14. pmc NDRG4 protein-deficient mice exhibit spatial learning deficits and vulnerabilities to cerebral ischemia
    Hitomi Yamamoto
    Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Biol Chem 286:26158-65. 2011
    ....
  15. ncbi request reprint The role of a common TNNT2 polymorphism in cardiac hypertrophy
    Kazuo Komamura
    Department of Cardiovascular Dynamics, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita 565 8565, Japan
    J Hum Genet 49:129-33. 2004
    ..In conclusion, TNNT2 deletion allele could be associated with a predisposition to prominent left ventricular hypertrophy...
  16. pmc Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity
    Koichi Kokame
    Research Institute, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    Proc Natl Acad Sci U S A 99:11902-7. 2002
    ..We report on a single-nucleotide polymorphism associated with alterations in VWF-CP activity; it will be important to assess this single-nucleotide polymorphism as a risk factor for thrombotic disorders...
  17. pmc Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
    Masashi Akiyama
    aNational Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Proc Natl Acad Sci U S A 106:19274-9. 2009
    ....
  18. pmc The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice
    Takafumi Yokota
    Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Japan
    Blood 113:2914-23. 2009
    ..Interestingly, ESAM expression in the HSC-enriched fraction was up-regulated in aged mice. We conclude that ESAM marks HSC in murine fetal liver and will facilitate studies of hematopoiesis throughout life...
  19. ncbi request reprint ADAMTS13 assays and ADAMTS13-deficient mice
    Toshiyuki Miyata
    National Cardiovascular Center Research Institute, Fujishirodai, Suita, Osaka, Japan
    Curr Opin Hematol 14:277-83. 2007
    ..Phenotypic analysis of mice lacking the Adamts13 gene is valuable for understanding the pathogenesis of microangiopathies...
  20. ncbi request reprint [Functional analyses of NDRG1, a stress-responsive gene]
    Tomohiko Okuda
    National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Seikagaku 77:630-4. 2005
  21. doi request reprint Prevalence of genetic mutations in protein S, protein C and antithrombin genes in Japanese patients with deep vein thrombosis
    Toshiyuki Miyata
    National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Thromb Res 124:14-8. 2009
    ..This study was undertaken to reveal the frequency of nonsynonymous mutations of these three genes in Japanese DVT patients...
  22. doi request reprint NDRG1 deficiency attenuates fetal growth and the intrauterine response to hypoxic injury
    Jacob Larkin
    Magee Womens Research Institute J L, X H S, T M, Y B, Y S, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15213 Department of Obstetrics and Gynecology B C, Washington University, St Louis, Missouri 63110 Department of Molecular Pathogenesis K K, National Cerebral and Cardiovascular Center, Osaka, Japan 565 8565 and Department of Microbiology and Molecular Genetics Y B, Y S, University of Pittsburgh, Pittsburgh, Pennsylvania 15213
    Endocrinology 155:1099-106. 2014
    ..Collectively, our findings indicate that NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner. ..
  23. doi request reprint Genetic analysis of patients with deep vein thrombosis during pregnancy and postpartum
    Reiko Neki
    Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Int J Hematol 94:150-5. 2011
    ..Considering the rapid decrease in protein S activity during pregnancy, we may need to assess thrombophilia in women before pregnancy...
  24. pmc Ndrg1-deficient mice exhibit a progressive demyelinating disorder of peripheral nerves
    Tomohiko Okuda
    National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Mol Cell Biol 24:3949-56. 2004
    ..These mice will be used for future analyses of the mechanisms of myelin maintenance...
  25. doi request reprint Gene expression associated with an enriched environment after transient focal ischemia
    Yuji Shono
    Department of Cerebrovascular Medicine, National Cerebral and Cardiovascular Center, Japan
    Brain Res 1376:60-5. 2011
    ....
  26. pmc The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages
    Yusuke Satoh
    Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Immunity 38:1105-15. 2013
    ..Thus, Satb1 governs the initiating process central to the replenishing of lymphoid lineages. Such activity in lymphoid cell generation may be of clinical importance and useful to overcome immunosenescence. ..
  27. ncbi request reprint [ADAMTS-13 is a metalloprotease that regulates platelet aggregation in hemostasis]
    Fumiaki Banno
    National Cardiovascular Center Research Institute, 5 7 1 Fuji shirodai, Suita, Osaka 565 8565, Japan
    Seikagaku 78:528-32. 2006
  28. ncbi request reprint Genetic defects leading to hereditary thrombotic thrombocytopenic purpura
    Koichi Kokame
    National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Semin Hematol 41:34-40. 2004
    ..Further analysis may reveal the genetic background associated with acquired TTP and other thrombotic diseases...
  29. doi request reprint Nonsynonymous mutations in three anticoagulant genes in Japanese patients with adverse pregnancy outcomes
    Reiko Neki
    Department of Perinatology and Gynecology, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan Electronic address
    Thromb Res 133:914-8. 2014
    ....
  30. ncbi request reprint Measurement of ADAMTS13 activity and inhibitors
    Toshiyuki Miyata
    National Cardiovascular Center Research Institute, Osaka, Japan
    Curr Opin Hematol 12:384-9. 2005
    ..This review introduces both established and emerging assays for ADAMTS13 activity, focusing on their impact on clinical practice...
  31. pmc Production, crystallization and preliminary crystallographic analysis of an exosite-containing fragment of human von Willebrand factor-cleaving proteinase ADAMTS13
    Masashi Akiyama
    National Cardiovascular Center Research Institute, Suita, Osaka 565 8565, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 65:739-42. 2009
    ..Diffraction data sets were collected using the SPring-8 beamline. Two ADAMTS13-DTCS crystals with distinct unit-cell parameters generated data sets to 2.6 and 2.8 A resolution, respectively...
  32. ncbi request reprint Tissue factor pathway inhibitor induces expression of JUNB and GADD45B mRNAs
    Hiroko Shirotani-Ikejima
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Biochem Biophys Res Commun 299:847-52. 2002
    ..In conclusion, this is the first report to show an effect of TFPI on mRNA expression, and suggests that TFPI modulates cellular functions by inducing JUNB and GADD45B expression through binding to VLDL-R...
  33. ncbi request reprint [Genetic polymorphism of von Willebrand factor (VWF)-cleaving protease, ADAMTS13]
    Koichi Kokame
    National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita Shi, Osaka 565 8565, Japan
    Brain Nerve 60:1325-32. 2008
    ....
  34. ncbi request reprint Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension
    Naoharu Iwai
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 105:41-7. 2002
    ..Recently, the SA protein has been reported to be highly homologous to bovine xenobiotic-metabolizing medium-chain fatty acid:CoA ligase...