M Kojima

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi [Ghrelin: a novel growth-hormone releasing peptide]
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute
    Nippon Rinsho 59:1400-7. 2001
  2. ncbi Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
    M Kojima
    Dept of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Trends Endocrinol Metab 12:118-22. 2001
  3. ncbi Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
    Circulation 104:1430-5. 2001
  4. ncbi Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nature 402:656-60. 1999
  5. ncbi Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity
    H Kaiya
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Endocrinol 176:415-23. 2003
  6. ncbi Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue
    H Kaiya
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan
    J Biol Chem 276:40441-8. 2001
  7. ncbi Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor
    H Hosoda
    Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    J Biol Chem 275:21995-2000. 2000
  8. ncbi Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3)
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka, 565 8565, Japan
    Biochem Biophys Res Commun 276:435-8. 2000
  9. ncbi Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue
    H Hosoda
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Biochem Biophys Res Commun 279:909-13. 2000
  10. ncbi Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 86:5854-9. 2001

Detail Information

Publications58

  1. ncbi [Ghrelin: a novel growth-hormone releasing peptide]
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute
    Nippon Rinsho 59:1400-7. 2001
    ..Moreover, ghrelin induces appetite-stimulating effect and adiposity in rat. These facts indicate that ghrelin is a natural leptin antagonist...
  2. ncbi Ghrelin: discovery of the natural endogenous ligand for the growth hormone secretagogue receptor
    M Kojima
    Dept of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Trends Endocrinol Metab 12:118-22. 2001
    ..The discovery of ghrelin indicates that the release of GH from the pituitary might be regulated not only by hypothalamic GH-releasing hormone, but also by ghrelin derived from the stomach and hypothalamus...
  3. ncbi Chronic administration of ghrelin improves left ventricular dysfunction and attenuates development of cardiac cachexia in rats with heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Fujishirodai, Suita, Osaka, Japan
    Circulation 104:1430-5. 2001
    ..We investigated whether ghrelin improves left ventricular (LV) dysfunction and attenuates cardiac cachexia in rats with chronic heart failure (CHF)...
  4. ncbi Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Nature 402:656-60. 1999
    ..Human ghrelin is homologous to rat ghrelin apart from two amino acids. The occurrence of ghrelin in both rat and human indicates that GH release from the pituitary may be regulated not only by hypothalamic GHRH, but also by ghrelin...
  5. ncbi Amidated fish ghrelin: purification, cDNA cloning in the Japanese eel and its biological activity
    H Kaiya
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    J Endocrinol 176:415-23. 2003
    ..A novel regulatory pathway of GH secretion by gastric ghrelin seems to be conserved from fish to human...
  6. ncbi Bullfrog ghrelin is modified by n-octanoic acid at its third threonine residue
    H Kaiya
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan
    J Biol Chem 276:40441-8. 2001
    ..These results indicate that although the regulatory mechanism of ghrelin to induce GH secretion is evolutionary conserved, the structural changes in the different ghrelins result in species-specific receptor binding...
  7. ncbi Purification and characterization of rat des-Gln14-Ghrelin, a second endogenous ligand for the growth hormone secretagogue receptor
    H Hosoda
    Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka 565 8565, Japan
    J Biol Chem 275:21995-2000. 2000
    ..Des-Gln(14)-ghrelin-stimulated growth hormone releases when injected into rats. Thus, growth hormone release is regulated by two gastric peptides, ghrelin and des-Gln(14)-ghrelin...
  8. ncbi Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3)
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Fujishirodai 5 7 1, Suita, Osaka, 565 8565, Japan
    Biochem Biophys Res Commun 276:435-8. 2000
    ..In contrast, ICV injection of NMU-antibody increased food intake. These results suggest that NMU is a potent endogenous anorexic peptide...
  9. ncbi Ghrelin and des-acyl ghrelin: two major forms of rat ghrelin peptide in gastrointestinal tissue
    H Hosoda
    Department of Biochemistry, National Cardiovascular Center Research Institute, 5 7 1 Fujishirodai, Suita, Osaka, 565 8565, Japan
    Biochem Biophys Res Commun 279:909-13. 2000
    ..In addition to these findings, our radioimmunoassay systems also revealed high concentrations of ghrelin in the stomach and small intestine...
  10. ncbi Hemodynamic, renal, and hormonal effects of ghrelin infusion in patients with chronic heart failure
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Suita, Osaka 565 8565, Japan
    J Clin Endocrinol Metab 86:5854-9. 2001
    ..In summary, iv infusion of ghrelin, a potent GH-releasing peptide, had beneficial hemodynamic effects in patients with CHF in the absence of renal effects...
  11. ncbi cDNA cloning of canine adrenomedullin and its gene expression in the heart and blood vessels in endotoxin shock
    Y Ono
    Department of Biochemistry, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Shock 10:243-7. 1998
    ..In addition, the plasma concentrations of the AM were high enough to allow for AM to act as a vasodilating hormone. Consequently, AM may be one of the factors facilitating severe hypotension complicated with endotoxin shock...
  12. ncbi A new type soluble guanylyl cyclase, which contains a kinase-like domain: its structure and expression
    M Kojima
    Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 217:993-1000. 1995
    ..The ksGC contains in its N-terminal region a protein kinase-like domain, which is usually a characteristic feature only of particulate type guanylyl cyclases. This unique feature of ksGC suggests a novel pathway of cGMP synthesis...
  13. ncbi Brain-derived neurotrophic factor triggers a rapid glutamate release through increase of intracellular Ca(2+) and Na(+) in cultured cerebellar neurons
    T Numakawa
    Division of Protein Biosynthesis, Institute for Protein Research, Osaka University, Suita, Osaka, Japan
    J Neurosci Res 66:96-108. 2001
    ..All the results therefore suggest that Na(+)-dependent reverse transport contributes to BDNF-mediated transmitter release through the PLC-gamma/IP(3)-mediated Ca(2+) signaling...
  14. ncbi Genomic structure of human adrenomedullin gene
    T Ishimitsu
    Department of Biochemistry, National Cardiovascular Center Research Institute, Osaka, Japan
    Biochem Biophys Res Commun 203:631-9. 1994
    ..These indicate that the human AM gene has components for its functional expression and that the expression may be subject to the activity of protein kinase C and the feedback from cAMP level...
  15. doi Alleviation of Abeta-induced cognitive impairment by ultrasound-mediated gene transfer of HGF in a mouse model
    D Takeuchi
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Yamadaoka, Suita, Japan
    Gene Ther 15:561-71. 2008
    ..A pharmacological approach including gene therapy to increase the HGF level in combination with anti-Abeta therapy might be a new therapeutic option for the treatment of AD...
  16. ncbi Hemodynamic and hormonal effects of human ghrelin in healthy volunteers
    N Nagaya
    Department of Internal Medicine, National Cardiovascular Center, Osaka 565 - 8565, Japan
    Am J Physiol Regul Integr Comp Physiol 280:R1483-7. 2001
    ..In summary, human ghrelin elicited a potent, long-lasting GH release and had beneficial hemodynamic effects via reducing cardiac afterload and increasing cardiac output without an increase in heart rate...
  17. ncbi Upregulation of Ghrelin expression in the stomach upon fasting, insulin-induced hypoglycemia, and leptin administration
    K Toshinai
    Third Department of Internal Medicine, Miyazaki Medical College, Miyazaki, 889 1692, Japan
    Biochem Biophys Res Commun 281:1220-5. 2001
    ..Conversely, db/db mice, which are deficient in the leptin receptor, had lower ghrelin mRNA levels than control mice. These findings suggest that this novel gastrointestinal hormone plays a role in the regulation of energy balance...
  18. ncbi A role for ghrelin in the central regulation of feeding
    M Nakazato
    Third Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    Nature 409:194-8. 2001
    ..We conclude that ghrelin is a physiological mediator of feeding, and probably has a function in growth regulation by stimulating feeding and release of growth hormone...
  19. ncbi Gender and gonadal influences on ghrelin mRNA levels in rat stomach
    O Gualillo
    Department of Medicine, Molecular Endocrinology Section, School of Medicine, University of Santiago de Compostela, Spain
    Eur J Endocrinol 144:687-90. 2001
    ..Gonadal hormones did not alter ghrelin mRNA levels. Taken together, these data showed that ghrelin mRNA levels in young rats are age but not gender dependent, and are not influenced by gonadal steroids...
  20. ncbi Ghrelin in domestic animals: distribution in stomach and its possible role
    T Hayashida
    Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2155, Japan
    Domest Anim Endocrinol 21:17-24. 2001
    ..These results suggest that ghrelin plays an important role in GH secretion and feeding regulation in domestic animals...
  21. ncbi Structure-activity relationship of ghrelin: pharmacological study of ghrelin peptides
    M Matsumoto
    Suntory Institute for Medicinal Research and Development, Kurakake 2716 1, Akaiwa, Chiyoda Machi, Ohra Gun, Gunma 370 0503, Japan
    Biochem Biophys Res Commun 287:142-6. 2001
    ..In addition, more stable ether or thioether bonds are capable of replacing the octanoyl ester bond in ghrelin, advantageous for the generation of pharmaceuticals with longer stability...
  22. ncbi A low dose of ghrelin stimulates growth hormone (GH) release synergistically with GH-releasing hormone in humans
    Y Hataya
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan
    J Clin Endocrinol Metab 86:4552. 2001
    ..No synergistic effects with respect to ACTH or prolactin secretion were observed. In conclusion, the synergistic interaction between ghrelin and GHRH was clearly shown and might be useful for a provocation test to diagnose GH deficiency...
  23. ncbi Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression
    T Sekiguchi
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, 910-1193, Fukui, Japan
    Gene 273:251-7. 2001
    ..This clearly indicates that the bullfrog receptor is a counterpart of mammalian NPR-A, and is specific for ANP or BNP but not for CNP...
  24. ncbi Ghrelin in neonatal rats: distribution in stomach and its possible role
    T Hayashida
    Department of Veterinary Physiology, Faculty of Agriculture, University of Miyazaki, Miyazaki 889 2155, Japan
    J Endocrinol 173:239-45. 2002
    ..7+/-0.94 to day 27.9+/-0.05. These results suggest that ghrelin may be involved in neonatal development...
  25. ncbi A transient ghrelin surge occurs just before feeding in a scheduled meal-fed sheep
    T Sugino
    High tech Research Center and Laboratory of Animal Nutrition, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada shi, Aomori 034 8628, Japan
    Biochem Biophys Res Commun 295:255-60. 2002
    ....
  26. ncbi Changes in expression of the genes for the leptin receptor and the growth hormone-releasing peptide/ghrelin receptor in the hypothalamic arcuate nucleus with long-term manipulation of adiposity by dietary means
    Y Kurose
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    J Neuroendocrinol 17:331-40. 2005
    ..This may be an adaptive mechanism to increase responsivity to both leptin and ghrelin...
  27. ncbi Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans
    H Ariyasu
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan
    J Clin Endocrinol Metab 86:4753-8. 2001
    ..We conclude that the stomach is a major source of circulating ghrelin and that plasma ghrelin-like immunoreactivity levels reflect acute and chronic feeding states in humans...
  28. ncbi Ghrelin, a novel placental-derived hormone
    O Gualillo
    Department of Medicine, Molecular Endocrinology Section and Complejo Hospitalario Universitario de Santiago
    Endocrinology 142:788-94. 2001
    ..Whether placenta-derived ghrelin is involved in the modulation of GH release, or placental cell growth and differentiation remains to be established...
  29. ncbi Cloning and characterization of a cDNA encoding a precursor for human uroguanylin
    M Miyazato
    Third Department of Medicine, Miyazaki Medical College, Kiyotake, Japan
    Biochem Biophys Res Commun 219:644-8. 1996
    ..Uroguanylin, as well as guanylin, may be a potent physiological regulator of intestinal fluid and electrolyte transport...
  30. ncbi Decreased gene expression of adrenomedullin receptor in mouse lungs during sepsis
    Y Ono
    Department of Anesthesiology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi ku, Tokyo, 173 8605, Japan
    Biochem Biophys Res Commun 271:197-202. 2000
    ..It is revealed that the distributions of receptor or binding sites of AM are changed in sepsis, and it is suggested that AM plays distinct roles in the clinical course of this syndrome...
  31. ncbi Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans
    Y Date
    Department of Internal Medicine, Miyazaki Medical College, Kiyotake, Japan
    Endocrinology 141:4255-61. 2000
    ..Our findings provide clues to additional, as yet undefined, physiological functions of this novel gastrointestinal hormone...
  32. ncbi The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors
    M Korbonits
    Department of Endocrinology, St Bartholomew s and the Royal London School of Medicine and Dentistry, London, United Kingdom EC1A 7BE
    J Clin Endocrinol Metab 86:881-7. 2001
    ..We suggest that the presence of ghrelin mRNA and peptide in the pituitary implies that the locally synthesized hormone may have an autocrine/paracrine modulatory effect on pituitary hormone release...
  33. ncbi Circadian waves of expression of the APRR1/TOC1 family of pseudo-response regulators in Arabidopsis thaliana: insight into the plant circadian clock
    A Matsushika
    Laboratory of Molecular Microbiology, School of Agriculture, Nagoya University, Japan
    Plant Cell Physiol 41:1002-12. 2000
    ..Here we propose that the circadian waves of the APRR1/TOC1 family members are most likely a molecular basis of such a biological clock in higher plants...
  34. ncbi Cloning and characterization of cDNA encoding a precursor for human adrenomedullin
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 194:720-5. 1993
    ..By RNA blot analysis, human adrenomedullin mRNA was found to be highly expressed in several tissues including adrenal medulla, ventricle, lung and kidney as well as pheochromocytoma...
  35. ncbi Immunocytochemical observation of ghrelin-containing neurons in the rat arcuate nucleus
    S Lu
    Department of Anatomy, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo, Japan
    Neurosci Lett 321:157-60. 2002
    ..Ghrelin-LI presynaptic axon terminals often made synapses with unknown immunonegative neurons. These results suggest that ghrelin acts to regulate food intake through synaptic connections in hypothalamic neuronal networks...
  36. ncbi Primary structure of the receptor for calcium channel blockers from skeletal muscle
    T Tanabe
    Nature 328:313-8. 1987
    ....
  37. ncbi Cloning and sequence analysis of cDNA encoding a precursor for human brain natriuretic peptide
    T Sudoh
    Daiichi Pure Chemicals Co Ltd, Tokyo, Japan
    Biochem Biophys Res Commun 159:1427-34. 1989
    ....
  38. ncbi A basic transthyretin variant (Glu61-->Lys) causes familial amyloidotic polyneuropathy: protein and DNA sequencing and PCR-induced mutation restriction analysis
    K Shiomi
    Third Department of Medicine, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 194:1090-6. 1993
    ..TTR-Lys61 is the first variant TTR with a replacement of the acidic with basic amino acid to be found in the amyloid precursor proteins of FAP...
  39. ncbi Effects of Ghrelin on growth hormone secretion from cultured adenohypophysial cells in pigs
    T Hashizume
    Faculty of Agriculture, Iwate University, Ueda 3, Morioka 020 8550, Japan
    Domest Anim Endocrinol 24:209-18. 2003
    ..The present results also show that Ghrelin interacts with GHRH and SS to in the release of GH from porcine adenohypophysial cells...
  40. ncbi Changes in plasma ghrelin and growth hormone concentrations in mature Holstein cows and three-month-old calves
    H Miura
    Laboratory of Veterinary Theriogenology, School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada shi, Aomori 034 8628, Japan
    J Anim Sci 82:1329-33. 2004
    ..Further studies are required to define the relationship between plasma ghrelin and GH concentrations...
  41. ncbi Effects of ghrelin on food intake and neuroendocrine function in sheep
    T Sugino
    Graduate School of Biosphere Science, Hiroshima University, Higashi Hiroshima Shi, Hiroshima 739 8528, Japan
    Anim Reprod Sci 82:183-94. 2004
    ..This mini review describes mechanisms regulating ghrelin secretion at feeding time, and also focuses on the neuroendocrine functions of ghrelin...
  42. ncbi GH secretory responses to ghrelin and GHRH in growing and lactating dairy cattle
    F Itoh
    Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science, Tsukuba Norindanchi, PO Box 5, Ibaraki 305 0901, Japan
    Domest Anim Endocrinol 28:34-45. 2005
    ..These results suggest that GHRH is an effective inducer of GH release in growing calves, and that the relative importance of ghrelin in contributing to the rise in plasma GH increases in early lactating cows...
  43. ncbi Cloning and sequence analysis of cDNA encoding a precursor for rat brain natriuretic peptide
    M Kojima
    Department of Biochemistry, Miyazaki Medical College, Japan
    Biochem Biophys Res Commun 159:1420-6. 1989
    ..Comparing sequences of precursors of ANP and BNP thus far identified, structural and processing features characteristic of the BNP family were discussed...
  44. ncbi Ghrelin enhances glucose-induced insulin secretion in scheduled meal-fed sheep
    H Takahashi
    School of Veterinary Medicine and Animal Science, Kitasato University, Towada shi, Aomori 034 8628, Japan
    J Endocrinol 189:67-75. 2006
    ..In conclusion, the present study has demonstrated for the first time that ghrelin enhances glucose-induced insulin secretion in the ruminant animal...
  45. ncbi The tree squirrel HP-25 gene is a pseudogene
    M Kojima
    Department of Biosciences, School of Science, Kitasato University, Kanagawa Japan
    Eur J Biochem 268:5997-6002. 2001
    ..Thus, the point mutation in the HNF-4-binding site is likely to be involved in the lack of HP-25 gene expression in the tree squirrel...
  46. ncbi Substantial production of ghrelin by a human medullary thyroid carcinoma cell line
    N Kanamoto
    Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan
    J Clin Endocrinol Metab 86:4984-90. 2001
    ..These findings suggest that ghrelin is produced in the thyroid C cells as well as in medullary thyroid carcinoma and may provide opportunities to investigate its physiological role in the thyroid gland...
  47. ncbi Expression of adrenomedullin in the human corpus luteum
    K Abe
    School of Medicine, Gunma University, Maebashi, Japan
    Fertil Steril 74:141-5. 2000
    ..Adrenomedullin (AM) is a potent hypotensive peptide found in human pheochromocytoma tissue. In the present study, the expression of AM mRNA in the human ovary was examined...
  48. ncbi Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues
    M Matsumoto
    Suntory Institute for Medicinal Research and Development, 2716-1 Kurakake, Akaiwa, Chiyoda-machi, Ohra-gun, Gunma 370-0503, Japan
    Biochem Biophys Res Commun 284:655-9. 2001
    ..Replacement of 3rd and 4th amino acid residues to D-isomer suggested that the N-terminal dipeptide contributes to shape the biologically active geometry by effecting conformation of residues in positions 3 and 4...
  49. ncbi Effects of dopamine d2 receptor agonists in a pituitary transplantation-induced hyperprolactinaemia/anovulation model in rats
    M Moro
    Pharmacological Laboratories, Kissei Pharmaceutical Co. Ltd, 4365-1 Kashiwabara, Hotaka-machi, Minamiazumi-gun, Nagano 399-8304, Japan
    Clin Exp Pharmacol Physiol 28:651-8. 2001
    ....
  50. pmc Primary structure and expression of a 24-kD vacuolar protein (VP24) precursor in anthocyanin-producing cells of sweet potato in suspension culture
    W Xu
    Graduate School of Science and Technology, Faculty of Textile Science and Technology, Shinshu University, 3-15-1 Tokida, Ueda, Nagano 386-8567, Japan
    Plant Physiol 125:447-55. 2001
    ..These results suggested that proteins derived from the VP24 precursor protein may be involved in vacuolar transport and/or accumulation of anthocyanin synthesized in the cytosol...
  51. ncbi Expression of adrenomedullin in the endometrium of the human uterus
    M Michishita
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan
    Obstet Gynecol 93:66-70. 1999
    ..Our purpose was to determine whether adrenomedullin is present in the human uterus...
  52. ncbi Rainbow trout Sox24, a novel member of the Sox family, is a transcriptional regulator during oogenesis
    H Kanda
    Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228, Japan
    Gene 211:251-7. 1998
    ..These results suggest that Sox24 plays a role as a transcriptional regulator during oogenesis...
  53. ncbi Aspergillus niger acid proteinase A. Structure and function
    K Takahashi
    School of Life Science, Tokyo University of Pharmacy and Life Science, Japan
    Adv Exp Med Biol 436:275-82. 1998
  54. ncbi cDNA cloning of a novel rainbow trout SRY-type HMG box protein, rtSox23, and its functional analysis
    A Yamashita
    Department of Biosciences, School of Science, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228, Japan
    Gene 209:193-200. 1998
    ..The rainbow trout p62 mRNA was also prominent in ovary and brain. Taken together, these results suggest that the rainbow trout p62 associates with rtSox23 in vivo and modulates the function of rtSox23...
  55. ncbi Organogenesis of the liver, thymus and spleen is affected in jumonji mutant mice
    J Motoyama
    Mitsubishi Kasei Institute of Life Sciences, Machida, Tokyo, Japan
    Mech Dev 66:27-37. 1997
    ..These phenotypes were also observed with C57BL/6J and DBA/2J backgrounds, suggesting that the jmj gene plays an essential role in the organogenesis of these tissues...
  56. pmc Post-translational processing of the phosphatidylserine decarboxylase gene product in Chinese hamster ovary cells
    O Kuge
    Department of Biochemistry and Cell Biology, National Institute of Health, Tokyo, Japan
    Biochem J 319:33-8. 1996
    ..Thus, the pssC gene product is converted into mature phosphatidylserine decarboxylase through multiple steps of post-translational processing...
  57. ncbi Complete amino acid sequence of porcine adrenomedullin and cloning of cDNA encoding its precursor
    K Kitamura
    First Department of Internal Medicine, Miyazaki Medical College, Japan
    FEBS Lett 338:306-10. 1994
    ..By RNA blot analysis, porcine adrenomedullin mRNA was found to be highly expressed in several porcine tissues including lung and kidney as well as adrenal medulla...
  58. ncbi Cloning and sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP)
    M Kojima
    Department of Biochemistry, Miyazaki Medical College, Japan
    FEBS Lett 276:209-13. 1990
    ..By RNA blot analysis, rat CNP mRNA was found to be expressed exclusively in the brain, implying that CNP may function in the central nervous system as a neuropeptide...