Takehiko Kobayashi

Summary

Affiliation: National Institute for Basic Biology
Country: Japan

Publications

  1. pmc Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae
    Koji Kasahara
    Division of Molecular and Cellular Biology, Science of Supramolecular Biology, International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa, Japan
    Mol Cell Biol 27:6686-705. 2007
  2. ncbi request reprint Phylogenetic footprinting to find functional DNA elements
    Austen R D Ganley
    Division of Cytogenetics, National Institutes of Genetics
    Methods Mol Biol 395:367-80. 2007
  3. doi request reprint A new role of the rDNA and nucleolus in the nucleus--rDNA instability maintains genome integrity
    Takehiko Kobayashi
    National Institute of Genetics and The Graduate University for Advanced Studies, SOKENDAI, 1111 Yata, Mishima 411 8540 Japan
    Bioessays 30:267-72. 2008
  4. pmc Identification of DNA cis elements essential for expansion of ribosomal DNA repeats in Saccharomyces cerevisiae
    T Kobayashi
    National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Cell Biol 21:136-47. 2001
  5. ncbi request reprint [Recombination regulation by noncoding transcription in yeast rDNA repeats]
    Takehiko Kobayashi
    Tanpakushitsu Kakusan Koso 51:2141-3. 2006
  6. pmc The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork
    Takehiko Kobayashi
    National Institute for Basic Biology, 38 Nishigonaka, Myodaijicho, Okazaki 444 8585, Japan
    Mol Cell Biol 23:9178-88. 2003
  7. ncbi request reprint SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast
    Takehiko Kobayashi
    National Institute for Basic Biology, Okazaki, Japan
    Cell 117:441-53. 2004
  8. ncbi request reprint Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats
    Takehiko Kobayashi
    National Institute for Basic Biology, SOKENDAI, School of Life Science, 38 Nishigonaka, Myodaijicho, Okazaki, 444 8585 Japan
    Science 309:1581-4. 2005
  9. ncbi request reprint Strategies to maintain the stability of the ribosomal RNA gene repeats--collaboration of recombination, cohesion, and condensation
    Takehiko Kobayashi
    National Institute for Basic Biology and The Graduate University for Advanced Studies SOKENDAI, School of Life Science, Okazaki, Japan
    Genes Genet Syst 81:155-61. 2006
  10. pmc Transcription-dependent recombination and the role of fork collision in yeast rDNA
    Yasushi Takeuchi
    National Institute for Basic Biology, Myodaijicho, Okazaki 444 8585, Japan
    Genes Dev 17:1497-506. 2003

Collaborators

  • Taku Oshima
  • Hironori Niki
  • Hirotada Mori
  • Prasad Tongaonkar
  • Austen R D Ganley
  • Satoru Ide
  • Takashi Horiuchi
  • Kimiko Saka
  • Katsuyuki Tozawa
  • Koji Kasahara
  • Katsuhiko Shirahige
  • Naomi Serizawa
  • Yasushi Takeuchi
  • Ken ichi Kodama
  • Takayuki Matsumoto
  • Noriyasu Yamamoto
  • Chizuko Hayashi
  • Hiroto Miwa
  • Keiichi Watanabe
  • Hiromitsu Watanabe
  • Sewon Ki
  • Hiroyuki Takahashi
  • Tetsuro Kokubo
  • Kazushige Ohtsuki
  • Kayo Aoyama
  • Hisaji Maki
  • Kouji Hayashi
  • Sota Hiraga

Detail Information

Publications19

  1. pmc Assembly of regulatory factors on rRNA and ribosomal protein genes in Saccharomyces cerevisiae
    Koji Kasahara
    Division of Molecular and Cellular Biology, Science of Supramolecular Biology, International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa, Japan
    Mol Cell Biol 27:6686-705. 2007
    ..Reporter gene assays indicate that these functional properties are determined by the promoter sequence...
  2. ncbi request reprint Phylogenetic footprinting to find functional DNA elements
    Austen R D Ganley
    Division of Cytogenetics, National Institutes of Genetics
    Methods Mol Biol 395:367-80. 2007
    ..Our methods are broadly applicable and should appeal to molecular biologists with little experience in bioinformatics...
  3. doi request reprint A new role of the rDNA and nucleolus in the nucleus--rDNA instability maintains genome integrity
    Takehiko Kobayashi
    National Institute of Genetics and The Graduate University for Advanced Studies, SOKENDAI, 1111 Yata, Mishima 411 8540 Japan
    Bioessays 30:267-72. 2008
    ..Here I would like to propose a new model regarding the roles of the rDNA and nucleolus. The key point of this model is that they act to preserve genome stability and trigger aging...
  4. pmc Identification of DNA cis elements essential for expansion of ribosomal DNA repeats in Saccharomyces cerevisiae
    T Kobayashi
    National Institute for Basic Biology, Okazaki 444 8585, Japan
    Mol Cell Biol 21:136-47. 2001
    ..This approximately 400-bp DNA element is not required for the RFB activity or the HOT1 activity and therefore defines a function unique to rDNA repeat expansion (and presumably contraction) separate from HOT1 and RFB activities...
  5. ncbi request reprint [Recombination regulation by noncoding transcription in yeast rDNA repeats]
    Takehiko Kobayashi
    Tanpakushitsu Kakusan Koso 51:2141-3. 2006
  6. pmc The replication fork barrier site forms a unique structure with Fob1p and inhibits the replication fork
    Takehiko Kobayashi
    National Institute for Basic Biology, 38 Nishigonaka, Myodaijicho, Okazaki 444 8585, Japan
    Mol Cell Biol 23:9178-88. 2003
    ..The RFB seems to wrap around Fob1p, and this wrapping structure may be important for function in the rDNA repeats...
  7. ncbi request reprint SIR2 regulates recombination between different rDNA repeats, but not recombination within individual rRNA genes in yeast
    Takehiko Kobayashi
    National Institute for Basic Biology, Okazaki, Japan
    Cell 117:441-53. 2004
    ..From these and other experiments, we conclude that SIR2 prevents unequal sister-chromatid recombination, probably by forming special cohesin structures, without significant effects on recombinational events within individual rRNA genes...
  8. ncbi request reprint Recombination regulation by transcription-induced cohesin dissociation in rDNA repeats
    Takehiko Kobayashi
    National Institute for Basic Biology, SOKENDAI, School of Life Science, 38 Nishigonaka, Myodaijicho, Okazaki, 444 8585 Japan
    Science 309:1581-4. 2005
    ..This transcription is regulated by the silencing gene, SIR2, and by copy number. Transcription-induced cohesin dissociation may be a general mechanism of recombination regulation...
  9. ncbi request reprint Strategies to maintain the stability of the ribosomal RNA gene repeats--collaboration of recombination, cohesion, and condensation
    Takehiko Kobayashi
    National Institute for Basic Biology and The Graduate University for Advanced Studies SOKENDAI, School of Life Science, Okazaki, Japan
    Genes Genet Syst 81:155-61. 2006
    ....
  10. pmc Transcription-dependent recombination and the role of fork collision in yeast rDNA
    Yasushi Takeuchi
    National Institute for Basic Biology, Myodaijicho, Okazaki 444 8585, Japan
    Genes Dev 17:1497-506. 2003
    ..These results suggest that such a transcription-dependent fork collision induces recombination, and may function as a general recombination trigger for multiplication of highly transcribed single-copy genes...
  11. ncbi request reprint Transcription-mediated hyper-recombination in HOT1
    Naomi Serizawa
    National Institute for Basic Biology, School of Life Science, 38 Nishigonaka, Myodaijicho, Okazaki, 444 8585, Japan
    Genes Cells 9:305-15. 2004
    ..This suggests that Fob1p is functioning as a PolI transcriptional activator in the wild-type strain...
  12. ncbi request reprint Cellular senescence in yeast is regulated by rDNA noncoding transcription
    Kimiko Saka
    Division of Cytogenetics, National Institute of Genetics, The Graduate University for Advanced Studies, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Curr Biol 23:1794-8. 2013
    ..The observation of rDNA instability in other organisms, including humans, suggests that this may be a conserved aging pathway...
  13. pmc Highly efficient concerted evolution in the ribosomal DNA repeats: total rDNA repeat variation revealed by whole-genome shotgun sequence data
    Austen R D Ganley
    National Institute for Basic Biology, Okazaki, 444 8585, Japan
    Genome Res 17:184-91. 2007
    ..These low levels of intra-genomic variation are consistent with a model of concerted evolution in which homogenization is very rapid and efficiently maintains highly similar repeat arrays...
  14. pmc Identifying gene-independent noncoding functional elements in the yeast ribosomal DNA by phylogenetic footprinting
    Austen R D Ganley
    National Institute for Basic Biology, Graduate University for Advanced Studies, SOKENDAI, 38 Nishigonaka, Myodaijicho, Okazaki 444 8585, Japan
    Proc Natl Acad Sci U S A 102:11787-92. 2005
    ....
  15. ncbi request reprint Amplification of Hot DNA segments in Escherichia coli
    Ken ichi Kodama
    National Institute for Basic Biology, Myodaiji, Okazaki, Aichi, Japan
    Mol Microbiol 45:1575-88. 2002
    ....
  16. pmc Regulation of ribosomal RNA gene copy number and its role in modulating genome integrity and evolutionary adaptability in yeast
    Takehiko Kobayashi
    Division of Cytogenetics, National Institute of Genetics The Graduate University for Advanced Studies, SOKENDAI, 1111 Yata, Mishima, Shizuoka, Japan
    Cell Mol Life Sci 68:1395-403. 2011
    ..In this review, I would like to introduce a new aspect of the rRNA gene repeat (called rDNA) as a center of maintenance of genome integrity and discuss its contribution to evolution...
  17. pmc How does genome instability affect lifespan?: roles of rDNA and telomeres
    Takehiko Kobayashi
    Division of Cytogenetics, National Institute of Genetics The Graduate University for Advanced Studies, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Genes Cells 16:617-24. 2011
    ..However, rDNA may also act as a NOC with respect to cellular senescence by limiting the number of times a cell can divide. Here, I discuss how rDNA might function as a NOC to influence life span in a manner analogous to telomeres...
  18. pmc Abnormality in initiation program of DNA replication is monitored by the highly repetitive rRNA gene array on chromosome XII in budding yeast
    Satoru Ide
    Department of Molecular Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama cho 8916 5, Ikoma, Nara 630 0192, Japan
    Mol Cell Biol 27:568-78. 2007
    ..These results suggest that the rDNA locus primarily signals abnormalities in the initiation program to the DNA damage checkpoint and that the rDNA copy number modulates the sensitivity of this monitoring function...
  19. ncbi request reprint Oxaliplatin in treatment of the cisplatin-resistant MKN45 cell line of gastric cancer
    Katsuyuki Tozawa
    Division of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Anticancer Res 28:2087-92. 2008
    ..Here, we studied oxaliplatin in vitro to reveal the mechanism of acquiring drug resistance and whether a cisplatin-resistant gastric cancer cell line has susceptibility to oxaliplatin...