Mariko Kobayashi

Summary

Affiliation: National Institute for Longevity Sciences
Country: Japan

Publications

  1. ncbi request reprint A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release
    M Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
    J Neurosci 21:7226-35. 2001
  2. ncbi request reprint Role of cholesterol in amyloid cascade: cholesterol-dependent modulation of tau phosphorylation and mitochondrial function
    M Michikawa
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Institute for Geriatrics and Gerontology, Aichi, Japan
    Acta Neurol Scand Suppl 185:21-6. 2006
  3. ncbi request reprint The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol
    Makoto Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    Mol Neurobiol 27:1-12. 2003
  4. pmc Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
    Toshiyuki Nakamura
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Mol Neurodegener 4:35. 2009
  5. ncbi request reprint Cholesterol paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease?
    Makoto Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    J Neurosci Res 72:141-6. 2003
  6. ncbi request reprint Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
    M Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Neurochem 74:1008-16. 2000
  7. ncbi request reprint Neurodegenerative disorders and cholesterol
    Makoto Michikawa
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3 Gengo, Obu, Aichi 474 8522, Japan
    Curr Alzheimer Res 1:271-5. 2004
  8. ncbi request reprint Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice
    Jian Sheng Gong
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 277:29919-26. 2002
  9. ncbi request reprint Cholesterol-dependent modulation of tau phosphorylation in cultured neurons
    Q W Fan
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Neurochem 76:391-400. 2001
  10. ncbi request reprint Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice
    N Sawamura
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 276:10314-9. 2001

Collaborators

Detail Information

Publications39

  1. ncbi request reprint A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release
    M Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
    J Neurosci 21:7226-35. 2001
    ..Our findings indicate that oligomeric Abeta promotes lipid release from neuronal membrane, which may lead to the disruption of neuronal lipid homeostasis and the loss of neuronal function...
  2. ncbi request reprint Role of cholesterol in amyloid cascade: cholesterol-dependent modulation of tau phosphorylation and mitochondrial function
    M Michikawa
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Institute for Geriatrics and Gerontology, Aichi, Japan
    Acta Neurol Scand Suppl 185:21-6. 2006
    ..The isoform-specific involvement of apoE in this cascade, in which high-density lipoprotein-like particles are generated and supplied to neurons to maintain cholesterol homeostasis, is also discussed...
  3. ncbi request reprint The role of cholesterol in pathogenesis of Alzheimer's disease: dual metabolic interaction between amyloid beta-protein and cholesterol
    Makoto Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    Mol Neurobiol 27:1-12. 2003
    ....
  4. pmc Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells
    Toshiyuki Nakamura
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Mol Neurodegener 4:35. 2009
    ..abstract:..
  5. ncbi request reprint Cholesterol paradox: is high total or low HDL cholesterol level a risk for Alzheimer's disease?
    Makoto Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    J Neurosci Res 72:141-6. 2003
    ..The mechanism(s), if this is the case, of how cholesterol in the central nervous system (CNS) is involved in the induction of pathologies of AD including Abeta generation and tauopathy, and how statins prevent it are also discussed...
  6. ncbi request reprint Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture
    M Michikawa
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Neurochem 74:1008-16. 2000
    ..This study suggests that apoE promotes lipid efflux from astrocytes and neurons in an isoform-specific manner and that cell surface HSPGs and/or HSPG-LRP pathway may mediate this apoE-promoted lipid efflux...
  7. ncbi request reprint Neurodegenerative disorders and cholesterol
    Makoto Michikawa
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3 Gengo, Obu, Aichi 474 8522, Japan
    Curr Alzheimer Res 1:271-5. 2004
    ..In this review, the association between cholesterol and AD pathogenesis is discussed from different viewpoints and several basic issues are delineated and addressed to fully understand the mechanisms underlying this relationship...
  8. ncbi request reprint Apolipoprotein E (ApoE) isoform-dependent lipid release from astrocytes prepared from human ApoE3 and ApoE4 knock-in mice
    Jian Sheng Gong
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 277:29919-26. 2002
    ..These findings provide a new insight into the issue concerning the putative alteration of apoE-related cholesterol metabolism in Alzheimer's disease...
  9. ncbi request reprint Cholesterol-dependent modulation of tau phosphorylation in cultured neurons
    Q W Fan
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    J Neurochem 76:391-400. 2001
    ..We propose that intracellular cholesterol plays an essential role in the modulation of tau phosphorylation and the maintenance of microtubule stability...
  10. ncbi request reprint Site-specific phosphorylation of tau accompanied by activation of mitogen-activated protein kinase (MAPK) in brains of Niemann-Pick type C mice
    N Sawamura
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 276:10314-9. 2001
    ....
  11. ncbi request reprint Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain
    Naoki Yamamoto
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, 36 3 Gengo, Morioka, Obu 474 8522, Japan
    FEBS Lett 569:135-9. 2004
    ..These observations suggest that aging and apoE4 expression cooperatively accelerate Abeta aggregation in the brain through an increase in the level of GM1 in neuronal membranes...
  12. ncbi request reprint Amyloid beta-protein (A beta) associated with lipid molecules: immunoreactivity distinct from that of soluble A beta
    K Yanagisawa
    Department of Dementia Research, National Institute for Longevity Sciences, Morioka, Obu, Japan
    FEBS Lett 420:43-6. 1997
    ..In contrast, a control anti-A beta monoclonal antibody does not recognize the A beta bound to these lipid vesicles. These results indicate that A beta associated with lipids has an immunoreactivity distinct from that of soluble A...
  13. pmc Novel action of apolipoprotein E (ApoE): ApoE isoform specifically inhibits lipid-particle-mediated cholesterol release from neurons
    Jian Sheng Gong
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3, Morioka, Obu, Aichi 474 8522, Japan
    Mol Neurodegener 2:9. 2007
    ..However, the apoE-isoform-specific effect of apoE-HDL on cholesterol transport remains unclarified...
  14. ncbi request reprint 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) causes Akt phosphorylation and morphological changes in intracellular organellae in cultured rat astrocytes
    I Isobe
    Department of Dementia Research, National Institute for Longevity Sciences, Nagoya City University Medical School, Japan
    J Neurochem 77:274-80. 2001
    ..Moreover, MTT or other tetrazolium salts could be used as interesting activators of Akt to investigate the mechanism by which Akt or PI(3)K is activated...
  15. ncbi request reprint Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat protein/delta-catenin in rodent neurons and glial cells
    Y Kawamura
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi, Japan
    Neurosci Lett 277:185-8. 1999
    ..These data suggest that the two NPRAP isoforms function not only in neurons and glial cells in the brain, but also play a role in the differentiation of precursor cells into neurons and glial cells...
  16. ncbi request reprint [Alzheimer's disease and cholesterol metabolism]
    Makoto Michikawa
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences National Institute for Geriatrics and Gerontology 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    Seikagaku 78:831-9. 2006
  17. ncbi request reprint Amyloid beta-protein affects cholesterol metabolism in cultured neurons: implications for pivotal role of cholesterol in the amyloid cascade
    Jian Sheng Gong
    Department of Dementia Research, National Institute for Longevity Sciences, Morioka, Obu, Japan
    J Neurosci Res 70:438-46. 2002
    ..Since alterations in cholesterol metabolism induce tau phosphorylation, our findings that oligomeric A beta alters cellular cholesterol homeostasis may provide new insight into the mechanism underlying the amyloid cascade hypothesis...
  18. ncbi request reprint Promotion of tau phosphorylation by MAP kinase Erk1/2 is accompanied by reduced cholesterol level in detergent-insoluble membrane fraction in Niemann-Pick C1-deficient cells
    Naoya Sawamura
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Neurochem 84:1086-96. 2003
    ....
  19. ncbi request reprint Neurodegeneration in heterozygous Niemann-Pick type C1 (NPC1) mouse: implication of heterozygous NPC1 mutations being a risk for tauopathy
    Wenxin Yu
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 280:27296-302. 2005
    ....
  20. ncbi request reprint Cholesterol is increased in the exofacial leaflet of synaptic plasma membranes of human apolipoprotein E4 knock-in mice
    Hideki Hayashi
    Department of Dementia Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu 474 8522, Japan
    Neuroreport 13:383-6. 2002
    ..The results of this study suggest that pathogenic effects of apoE4 on AD development could be closely linked to alteration of cholesterol distribution in SPM...
  21. ncbi request reprint A seed for Alzheimer amyloid in the brain
    Hideki Hayashi
    Department of Dementia Research, National Institute for Longevity Sciences, Obu 474 8522, Japan
    J Neurosci 24:4894-902. 2004
    ..These results imply a mechanism underlying the onset of AD and suggest that an endogenous seed can be a target of therapeutic strategy...
  22. ncbi request reprint Amyloid beta-protein (Abeta)1-40 protects neurons from damage induced by Abeta1-42 in culture and in rat brain
    Kun Zou
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    J Neurochem 87:609-19. 2003
    ..Our data suggest a mechanism by which elevated Abeta1-42/Abeta1-40 ratio accelerates the development of Alzheimer's disease (AD) in familial AD...
  23. ncbi request reprint A ganglioside-induced toxic soluble Abeta assembly. Its enhanced formation from Abeta bearing the Arctic mutation
    Naoki Yamamoto
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu 474 8522, Japan
    J Biol Chem 282:2646-55. 2007
    ..Our results suggest that soluble Abeta assemblies, such as TAbeta, can cause plaque-independent neuronal death that favorably occurs in nerve growth factor-dependent neurons in the cholinergic basal forebrain in AD...
  24. ncbi request reprint Cholesterol-dependent modulation of dendrite outgrowth and microtubule stability in cultured neurons
    Qi Wen Fan
    Department of Dementia Research, National Institute for Longevity Sciences, Aichi, Japan
    J Neurochem 80:178-90. 2002
    ..Taken together, we propose that cholesterol-deficiency causes a selective inhibition of dendrite outgrowth due to the decreased stability of microtubules as a result of inhibition of MAP2 phosphorylation...
  25. ncbi request reprint Oligomerization of amyloid beta-protein occurs during the isolation of lipid rafts
    Wenxin Yu
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, Aichi, Japan
    J Neurosci Res 80:114-9. 2005
    ..Thus, one should be careful when one discusses the role of lipid rafts in amyloid precursor protein processing and in the generation, aggregation, and degradation of Abeta...
  26. ncbi request reprint Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function
    Wenxin Yu
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 280:11731-9. 2005
    ..These results suggest that mitochondrial dysfunctions and subsequent ATP deficiency, which are induced by altered cholesterol metabolism in mitochondria, may be responsible for neuronal impairment in NPC1 disease...
  27. doi request reprint An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein
    Tomoji Maeda
    Department of Neuroscience, School of Pharmacy, Iwate Medical University, Morioka, Japan
    FEBS J 276:5832-40. 2009
    ....
  28. pmc Mechanism underlying apolipoprotein E (ApoE) isoform-dependent lipid efflux from neural cells in culture
    Hirohisa Minagawa
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan
    J Neurosci Res 87:2498-508. 2009
    ..In conclusion, there are two major factors, intramolecular domain interaction and intermolecular dimerization, that cause ApoE-isoform-dependent lipid efflux from neural cells in culture...
  29. ncbi request reprint Angiotensin-converting enzyme converts amyloid beta-protein 1-42 (Abeta(1-42)) to Abeta(1-40), and its inhibition enhances brain Abeta deposition
    Kun Zou
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology, Obu, Aichi 474 8522, Japan
    J Neurosci 27:8628-35. 2007
    ..The upregulation of ACE activity can be a novel therapeutic strategy for AD...
  30. ncbi request reprint A novel function of monomeric amyloid beta-protein serving as an antioxidant molecule against metal-induced oxidative damage
    Kun Zou
    Department of Dementia Research, National Institute for Longevity Sciences, Obu, Aichi 474 8522, Japan
    J Neurosci 22:4833-41. 2002
    ..Because aggregated Abeta is known to be an oxygen radical generator, our results provide a novel concept that the aggregation-dependent biological effects of Abeta are dualistic, being either an oxygen radical generator or its inhibitor...
  31. pmc Homocysteine, another risk factor for Alzheimer disease, impairs apolipoprotein E3 function
    Hirohisa Minagawa
    Department of Alzheimer Disease Research, National Center for Geriatrics and Gerontology, 35 Gengo, Morioka, Obu, Aichi 474 8511, Japan
    J Biol Chem 285:38382-8. 2010
    ....
  32. ncbi request reprint Cholesterol-mediated neurite outgrowth is differently regulated between cortical and hippocampal neurons
    Mihee Ko
    Department of Alzheimer s Disease Research, National Institute for Longevity Sciences, 36 3 Gengo, Morioka, Obu, Aichi 474 8522, Japan
    J Biol Chem 280:42759-65. 2005
    ....
  33. pmc Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice
    Masahisa Watarai
    Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine, Obihiro shi, Hokkaido 080 8555, Japan
    Infect Immun 70:4818-25. 2002
    ..abortus. Thus, trafficking of cholesterol-associated microdomains controlled by NPC1 is critical for the establishment of B. abortus infection...
  34. ncbi request reprint Alteration of the glutamate and GABA transporters in the hippocampus of the Niemann-Pick disease, type C mouse using proteomic analysis
    Kyunghee Byun
    Department of Anatomy and Neurobiology, College of Medicine, Institute of Medical Science, Cheju National University, Jeju City, Jeju, South Korea
    Proteomics 6:1230-6. 2006
    ..In conclusion, our data may provide insight into the understanding of the basic mechanism through perturbation of protein networks and neurotransporter systems in a single gene knockout model of NPC disease...
  35. ncbi request reprint Niemann-Pick C1 protein regulates cholesterol transport to the trans-Golgi network and plasma membrane caveolae
    William S Garver
    Department of Pediatrics, Arizona Health Sciences Center, The University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Lipid Res 43:579-89. 2002
    ..These studies demonstrate that NPC1 regulates cholesterol transport to caveolin-1 and caveolin-2 containing compartments such as the TGN and plasma membrane caveolae...
  36. ncbi request reprint [Etiology and physiopathology of Alzheimer disease]
    Makoto Michikawa
    Nihon Naika Gakkai Zasshi 94:1473-81. 2005
  37. ncbi request reprint Tissue culture methods to study neurological disorders: establishment of immortalized Schwann cells from murine disease models
    Kazuhiko Watabe
    Department of Molecular Neuropathology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan
    Neuropathology 23:68-78. 2003
    ..These immortalized Schwann cell lines can be useful in studies of nervous system lesions in these mutant mice and relevant human disorders...
  38. ncbi request reprint Substance P immunoreactive cell reductions in cerebral cortex of Niemann-Pick disease type C mouse
    Myeung Ju Kim
    Department of Anatomy, Dankook University College of Medicine, Anseo Dong, Cheonan si, Chungnam, South Korea
    Brain Res 1043:218-24. 2005
    ..This study demonstrates for the first time, reduced number of SP-ir cells in the NPC mouse cortex...
  39. ncbi request reprint Ethnicity-dependent genetic association of ABCA2 with sporadic Alzheimer's disease
    M Axel Wollmer
    Division of Psychiatry Research, University of Zurich, Switzerland
    Am J Med Genet B Neuropsychiatr Genet 141:534-6. 2006
    ..These data suggest that ABCA2 may exert population-dependent effects on the genetic risk for sporadic AD and support a role of ABC lipid transporters in the pathogenesis of this disease...