K Kobayashi

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. ncbi request reprint The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice
    K Kobayashi
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo, 189 0002, Japan
    Clin Immunol Immunopathol 88:226-31. 1998
  2. pmc Expression of vascular endothelial growth factor by synovial fluid neutrophils in rheumatoid arthritis (RA)
    T Kasama
    The First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Immunol 121:533-8. 2000
  3. pmc Multidrug resistant Mycobacterium leprae from patients with leprosy
    S Maeda
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan
    Antimicrob Agents Chemother 45:3635-9. 2001
  4. ncbi request reprint Role of human CYP2B6 in S-mephobarbital N-demethylation
    K Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Drug Metab Dispos 27:1429-33. 1999
  5. ncbi request reprint Decreased expression of cytokines that induce type 1 helper T cell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium
    K Kobayashi
    Department of Host Defenses, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Clin Immunol Immunopathol 85:112-6. 1997
  6. ncbi request reprint Early axonal and glial pathology in fetal sheep brains with leukomalacia induced by repeated umbilical cord occlusion
    J Ohyu
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Brain Dev 21:248-52. 1999
  7. ncbi request reprint Motor cortex stimulation for post-stroke pain: comparison of spinal cord and thalamic stimulation
    Y Katayama
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Stereotact Funct Neurosurg 77:183-6. 2001
  8. ncbi request reprint New method of deep brain stimulation therapy with two electrodes implanted in parallel and side by side
    T Yamamoto
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurosurg 95:1075-8. 2001
  9. ncbi request reprint Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 267:124-8. 2000
  10. ncbi request reprint [Order-made therapy for early lung cancer patients]
    M Kawamura
    Division of General Thoracic Surgery, Keio University, Tokyo, Japan
    Kyobu Geka 54:962-7. 2001

Collaborators

Detail Information

Publications95

  1. ncbi request reprint The possible role of interleukin (IL)-12 and interferon-gamma-inducing factor/IL-18 in protection against experimental Mycobacterium leprae infection in mice
    K Kobayashi
    Leprosy Research Center, National Institute of Infectious Diseases, 4 2 1 Aoba cho, Higashimurayama shi, Tokyo, 189 0002, Japan
    Clin Immunol Immunopathol 88:226-31. 1998
    ..IL-12 therapy may be a possible rationale for treatment of M. leprae infection...
  2. pmc Expression of vascular endothelial growth factor by synovial fluid neutrophils in rheumatoid arthritis (RA)
    T Kasama
    The First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Clin Exp Immunol 121:533-8. 2000
    ..Thus, SF neutrophil-associated VEGF may be considered an indicator of both local and systemic inflammation of RA, contributing to the neovascularization seen during RA synovitis...
  3. pmc Multidrug resistant Mycobacterium leprae from patients with leprosy
    S Maeda
    Leprosy Research Center, National Institute of Infectious Diseases, Higashimurayama-shi, Tokyo 189-0002, Japan
    Antimicrob Agents Chemother 45:3635-9. 2001
    ..Thirteen isolates (14.8%) showed representative mutations in more than two genes, suggesting the emergence of multidrug-resistant M. leprae...
  4. ncbi request reprint Role of human CYP2B6 in S-mephobarbital N-demethylation
    K Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Drug Metab Dispos 27:1429-33. 1999
    ..Therefore, it appears that CYP2B6 mainly catalyzes S-mephobarbital N-demethylation in human liver microsomes...
  5. ncbi request reprint Decreased expression of cytokines that induce type 1 helper T cell/interferon-gamma responses in genetically susceptible mice infected with Mycobacterium avium
    K Kobayashi
    Department of Host Defenses, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    Clin Immunol Immunopathol 85:112-6. 1997
    ..These results suggest that decreased expression of IL-12 and IGIF leads to a diminished Th1 response without reciprocal enhanced Th2 responses in susceptible mice...
  6. ncbi request reprint Early axonal and glial pathology in fetal sheep brains with leukomalacia induced by repeated umbilical cord occlusion
    J Ohyu
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Brain Dev 21:248-52. 1999
    ..These findings suggest the glial reaction of cytokines and free radicals induced by fetal hypoxia may contribute to the occurrence of brain injury...
  7. ncbi request reprint Motor cortex stimulation for post-stroke pain: comparison of spinal cord and thalamic stimulation
    Y Katayama
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Stereotact Funct Neurosurg 77:183-6. 2001
    ..This may be one of the reasons why satisfactory pain control was obtained more frequently as the stimulation site was moved to higher levels...
  8. ncbi request reprint New method of deep brain stimulation therapy with two electrodes implanted in parallel and side by side
    T Yamamoto
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    J Neurosurg 95:1075-8. 2001
    ..With the aid of this method, one can use two electrodes, implanted in parallel and side by side, to achieve maximum efficacy and to reduce adverse effects in some instances of DBS therapy...
  9. ncbi request reprint Erythromycin suppresses nuclear factor-kappaB and activator protein-1 activation in human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Biochem Biophys Res Commun 267:124-8. 2000
    ..Our findings support the concept that the recruitment of neutrophils in airway diseases may be regulated by NF-kappaB and AP-1...
  10. ncbi request reprint [Order-made therapy for early lung cancer patients]
    M Kawamura
    Division of General Thoracic Surgery, Keio University, Tokyo, Japan
    Kyobu Geka 54:962-7. 2001
    ..8 months and MST of those (n = 16) who did not have any sensitive agents according to CDDST was 5.6 months. There was significant difference between these two groups (p = 0.0048; logrank)...
  11. doi request reprint Dynamic changes in amniotic tight junctions during pregnancy
    K Kobayashi
    Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
    Placenta 30:840-7. 2009
    ..The above findings suggest that TJs in the amniotic epithelium maintain amniotic fluid volume during pregnancy, while apoptosis of amniotic epithelial cells between E16 and E17 causes disruption of the TJs...
  12. ncbi request reprint Diaminodiphenylsulfone resistance of Mycobacterium leprae due to mutations in the dihydropteroate synthase gene
    M Kai
    Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, Japan
    FEMS Microbiol Lett 177:231-5. 1999
    ..This is the first paper which links the mutations in DHPS and sulfonamide resistance in M. leprae. This finding is medically and socially relevant, since leprosy is still a big problem in certain regions...
  13. doi request reprint Expression and distribution of tight junction proteins in human amnion during late pregnancy
    K Kobayashi
    Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan
    Placenta 31:158-62. 2010
    ..These findings suggest that the human amniotic epithelium has TJs that disrupt during late pregnancy. The disruption may be induced by several factors such as glucocorticoids present in the amniotic fluid during late pregnancy...
  14. ncbi request reprint Experimental lung transplantation using non-penetrating vascular clips for anastomosis of the pulmonary artery
    M Watanabe
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Thorac Cardiovasc Surg 48:120-2. 2000
    ..Reliable and rapid anastomosis is critical in lung transplantation. The purpose of this study is to show the appropriateness of sutureless anastomosis of the pulmonary artery using a nonpenetrating vascular clipping device...
  15. doi request reprint Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice
    M Kohno
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    Thorac Cardiovasc Surg 60:124-30. 2012
    ..The systemic and pulmonary inflammatory response associated with pneumonectomy performed via minithoracotomy versus that after open posterolateral thoracotomy is uncertain...
  16. doi request reprint Brain localization of leucine-rich α2-glycoprotein and its role
    Madoka Nakajima
    Department of Neurosurgery, Juntendo University School of Medicine, Tokyo, Japan
    Acta Neurochir Suppl 113:97-101. 2012
    ..The objective of this study is to examine the localization of LRG - the cerebral areas where it is expressed...
  17. ncbi request reprint Entire hemithorax irradiation following complete resection in patients with stage II-III invasive thymoma
    M Uematsu
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan
    Int J Radiat Oncol Biol Phys 35:357-60. 1996
    ..To evaluate the feasibility and efficacy of prophylactic entire hemithorax irradiation (EH) in addition to mediastinal irradiation (MRT) following a complete resection in Stage II-III invasive thymoma...
  18. ncbi request reprint Nuclear factor-kappa b activation in silica-induced interleukin 8 production by human bronchial epithelial cells
    M Desaki
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cytokine 12:1257-60. 2000
    ..These data suggest that reactive oxygen species may be involved in the activation of NF-kappaB induced by silica...
  19. doi request reprint Simultaneous occurrence of anti-BP180 mucous membrane pemphigoid and mucosal-dominant pemphigus vulgaris
    K Kobayashi
    Department of Dermatology, Tokyo Women s Medical University Medical Center East, Tokyo, Japan
    Clin Exp Dermatol 34:e785-8. 2009
    ..To our knowledge, the simultaneous initial occurrence of MMP and PV has never been reported previously. We present a rare case of concurrent PV and anti-BP180 MMP, the diagnosis of which was confirmed by ELISA and immunoblotting assays...
  20. ncbi request reprint Staple-line reinforcement with a new type of polyglycolic acid felt
    M Kawamura
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Surg Laparosc Endosc Percutan Tech 11:43-6. 2001
    ..In one patient, the air leak was found to originate from an untouched lobe during reoperation. No infection or allergic reaction developed in a patient during a mean follow-up of 12 months (range, 1 to 24 months)...
  21. ncbi request reprint Vascular endothelial growth factor expression by activated synovial leukocytes in rheumatoid arthritis: critical involvement of the interaction with synovial fibroblasts
    T Kasama
    First Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan
    Arthritis Rheum 44:2512-24. 2001
    ....
  22. ncbi request reprint Generation of periventricular leukomalacia by repeated umbilical cord occlusion in near-term fetal sheep and its possible pathogenetical mechanisms
    G Marumo
    Department of Obstetrics and Gynecology, University of Tokyo, Tokyo, Japan
    Biol Neonate 79:39-45. 2001
    ..It is speculated that PVL might be produced by an association of preexisting chronic circulatory instability with an acute episode of severe repetitive cord occlusion...
  23. ncbi request reprint [Surgical indications for lung cancer: influence of the M factor]
    H Horinouchi
    Department of Surgery, School of Medicine, Keio University, Tokyo, Japan
    Nippon Geka Gakkai Zasshi 102:517-20. 2001
    ..The TNM classification had better be revised so that patients who benefit from simultaneous lung and metastatic resection are classified in earlier-stage groups...
  24. doi request reprint Interstitial lung disease induced by gefitinib and toll-like receptor ligands is mediated by Fra-1
    Y Takada
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
    Oncogene 30:3821-32. 2011
    ..These results indicate that Fra-1 is an important mediator of interstitial lung disease following gefitinib treatment...
  25. ncbi request reprint Genetic strain-dependent protein metabolism and muscle hypertrophy under chronic isometric training in rat gastrocnemius muscle
    K Kobayashi
    Graduate School of Health and Sport Sciences, Nippon Sport Science University, Tokyo, Japan
    Physiol Res 61:527-35. 2012
    ..05). However, in Wistar rats, there was no significant difference. These results suggest a genetic strain difference in protein metabolism. This phenomenon may be useful for studying individual differences in response to RT...
  26. doi request reprint Association of TLR polymorphisms with development of tuberculosis in Indonesian females
    K Kobayashi
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Tissue Antigens 79:190-7. 2012
    ..This finding indicated that a TLR9 polymorphism might have an important role in the susceptibility to M. tuberculosis in Asian populations...
  27. ncbi request reprint Enzymatic corrections for cells derived from Fabry disease patients by a recombinant adenovirus vector
    K Ohsugi
    Department of Inherited Metabolic Disease, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 45:1-5. 2000
    ..The infected cells continued to express alpha-gal for more than 10 days. These results suggest that AxCAG alpha-gal could be used as enzyme replacement gene therapy for Fabry disease...
  28. ncbi request reprint Prevention of irinotecan (CPT-11)-induced diarrhea by oral alkalization combined with control of defecation in cancer patients
    Y Takeda
    Department of Respiratory Medicine, International Medical Center of Japan, Tokyo, Japan
    Int J Cancer 92:269-75. 2001
    ..Risk factors statistically associated with delayed diarrhea include advanced age and the use of CPT-11 without OA and CD...
  29. ncbi request reprint Role of CYP2C19 in stereoselective hydroxylation of mephobarbital by human liver microsomes
    K Kobayashi
    Department of Clinical Pharmacy, Showa University, Tokyo, Japan
    Drug Metab Dispos 29:36-40. 2001
    ..These findings suggest that the 4-hydroxylation of mephobarbital catalyzed by CYP2C19 is preferential for R-enantiomer in human liver microsomes...
  30. ncbi request reprint Prediction of organ-confined disease by prostate-specific antigen nadir after neoadjuvant therapy
    T Hachiya
    Department of Urology, Nihon University, School of Medicine, Tokyo, Japan
    Int J Urol 7:393-401; discussion 402-3. 2000
    ..It is not clear whether or not serum prostate-specific antigen (PSA) levels after androgen deprivation prior to radical prostatectomy (neoadjuvant therapy) have any value in the prediction of the final pathologic stage...
  31. ncbi request reprint Effects of dobutamine on critical capillary PO(2) and lactic acidosis threshold in patients with cardiovascular disease
    A Koike
    Cardiovascular Institute, Minato ku, Tokyo, Japan
    Chest 120:1218-25. 2001
    ....
  32. ncbi request reprint [Studies on cell-mediated immunity (CMI) in the glomeruli: immunization with GBM antigen from Masugi nephritis in Wistar-Kyoto rats]
    Y Tsuji
    Department of Pediatrics, Showa University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 36:95-102. 1994
    ..Group II and Group III rats demonstrated no proteinuria and no histological changes. These findings indicated that the altered GBM obtained antigenicity and induced cell-mediated immunity in the glomeruli...
  33. ncbi request reprint Combinatorial synthesis of omega-conotoxin MVIIC analogues and their binding with N- and P/Q-type calcium channels
    T Sasaki
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida shi, Tokyo, Japan
    FEBS Lett 466:125-9. 2000
    ..Forty-seven analogues were prepared in six runs and some of them exhibited higher selectivity for P/Q-type calcium channels than MVIIC in binding assays...
  34. ncbi request reprint Prediction of anti-tumour effect of thermochemotherapy with in vitro thermochemosensitivity testing for non-small cell lung cancer
    T Abiko
    Department of Surgery, Keio University, Tokyo, Japan
    Int J Hyperthermia 23:267-75. 2007
    ..We investigated whether it is possible to predict the antitumour effects of thermochemotherapy from the results of anticancer agent sensitivity testing...
  35. ncbi request reprint Motor cortex stimulation for phantom limb pain: comprehensive therapy with spinal cord and thalamic stimulation
    Y Katayama
    Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan
    Stereotact Funct Neurosurg 77:159-62. 2001
    ..One patient of them reported better pain control by MCS than by DBS, whereas two reported the opposite results. There is no evidence at present for an advantage of MCS over SCS and DBS of the VC in controlling phantom limb pain...
  36. ncbi request reprint Ontogeny of the murine Ig joining chain gene and protein
    M Kimura
    Nihon University School of Dentistry, Department of Pathology, Tokyo, Japan
    Scand J Immunol 54:613-8. 2001
    ..These results suggest that the expression of J chain is a later event than the mu chain in the mouse, which thus differs in embryogenesis from humans...
  37. ncbi request reprint [Towards new strategies to combat mycobacterial diseases]
    K Kobayashi
    Department of Host Defenses, National Institute of Infectious Diseases, Tokyo, Japan
    Nihon Hansenbyo Gakkai Zasshi 66:191-8. 1997
    ..We believe that the immune-based strategies will contribute to elimination of mycobacterial diseases...
  38. pmc Outbreak of Legionnaires' disease on a cruise ship linked to spa-bath filter stones contaminated with Legionella pneumophila serogroup 5
    F Kura
    Department of Bacteriology, National Institute of Infectious Diseases, Tokyo, Japan
    Epidemiol Infect 134:385-91. 2006
    ..pneumophila, a phenomenon which has not been reported except in Japan. This is the first documented evidence of L. pneumophila sg 5 infection on a ship and of porous stones as a source of Legionella infection...
  39. ncbi request reprint Cloning, sequencing and expression of the gene for alpha antigen from Mycobacterium intracellulare and use of PCR for the rapid identification of Mycobacterium intracellulare
    H Kitaura
    School of Dentistry, Nagasaki University, Japan
    Biochem Biophys Res Commun 196:1466-73. 1993
    ..The cloned gene was expressed in Escherichia coli by using an E. coli expression vector. Based on these results, the feasibility of rapid identification of M. intracellulare by two step polymerase chain reaction (PCR) was demonstrated...
  40. ncbi request reprint Enhanced anti-tumor effects of herpes simplex virus thymidine kinase/ganciclovir system by codelivering monocyte chemoattractant protein-1 in hepatocellular carcinoma
    Y Sakai
    First Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
    Cancer Gene Ther 8:695-704. 2001
    ....
  41. ncbi request reprint Serial analysis of gene expression in chronic hepatitis C and hepatocellular carcinoma
    T Yamashita
    First Department of Internal Medicine and CREST, Kanazawa University School of Medicine, Kanazawa, 920-8641, Japan
    Biochem Biophys Res Commun 282:647-54. 2001
    ..This genome-wide scanning study discloses the molecular portraits of CH-C and HCC, and provides novel candidate genes that should help clarify the mechanism of hepatocarcinogenesis in the chronically HCV-infected liver...
  42. ncbi request reprint Interleukin-10 expression is correlated with growth fraction in human non-small cell lung cancer xenografts
    M Naruke
    Department of Surgery, School of Medicine, Keio University, Tokyo 160-8582, Japan
    Int J Oncol 18:1213-7. 2001
    ..4 +/- 96.3) (p=0.009, Mann-Whitney U test), and showed significantly increased vascular number (p=0.008, Mann-Whitney U test). These results suggested that IL-10 expression is correlated with growth features in human NSCLC...
  43. ncbi request reprint Benzene-extracted components are important for the major activity of diesel exhaust particles: effect on interleukin-8 gene expression in human bronchial epithelial cells
    S Kawasaki
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Respir Cell Mol Biol 24:419-26. 2001
    ..Finally, benzo[a]pyrene, one of the important compounds included in the benzene component, replicated the activities shown by DEPs...
  44. ncbi request reprint A novel mutation of CHRNA4 responsible for autosomal dominant nocturnal frontal lobe epilepsy
    S Hirose
    Department of Pediatrics, School of Medicine, Fukuoka University, Japan
    Neurology 53:1749-53. 1999
    ..To identify the mutation responsible for autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) in a nonwhite family...
  45. ncbi request reprint HVJ-liposome-mediated transfection of HSVtk gene driven by AFP promoter inhibits hepatic tumor growth of hepatocellular carcinoma in SCID mice
    T Hirano
    First Department of Surgery, Hyogo College of Medicine, Nishinomiya, Japan
    Gene Ther 8:80-3. 2001
    ..Three injections of the AFPTK1 plasmid vector completely inhibited tumor growth. This procedure seems to have great potential for the treatment of multiple hepatic tumors...
  46. pmc Influence of the CYP2D6*10 allele on the metabolism of mexiletine by human liver microsomes
    C Senda
    Department of Drug Metabolism and Pharmacokinetics, Kawanishi Pharma Research Institute, Nippon Boehringer Ingelheim Co, Hyogo
    Br J Clin Pharmacol 52:100-3. 2001
    ..CONCLUSIONS: The metabolism of mexiletine to form PHM and HMM appears to be impaired to a significant extent in human liver microsomes from hetero- and homozygotes of CYP2D6*10...
  47. ncbi request reprint Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1
    A Yoshida
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Kanazawa Ku, 236 0004, Yokohama, Japan
    Dev Cell 1:717-24. 2001
    ..These findings suggest that interference in O-mannosyl glycosylation is a new pathomechanism for muscular dystrophy as well as neuronal migration disorder...
  48. ncbi request reprint Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system
    V C Russo
    Centre for Hormone Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville 3052, Victoria, Australia
    Brain Res 1009:40-53. 2004
    ..These studies also point to the potential use of IGF-I therapy in prevention or amelioration of hypoglycaemic brain injury...
  49. ncbi request reprint Characterization of hair follicles induced in implanted, cultured rat keratinocyte sheets
    H Miyashita
    Graduate School of Science and Technology, Chiba University, Chiba, Japan
    Exp Dermatol 13:491-8. 2004
    ..This and the presence of label-retaining cells suggest that there are stem cells in the induced follicles, which seem to have a hair-growth cycle...
  50. ncbi request reprint MiniX-STR multiplex system population study in Japan and application to degraded DNA analysis
    H Asamura
    Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Int J Legal Med 120:174-81. 2006
    ..We conclude that analysis by the current miniX-STR multiplex systems offers high effectiveness for personal identification from degraded DNA samples...
  51. ncbi request reprint Healing of full-thickness tears of avian supracoracoid tendons: in situ hybridization of alpha1(I) and alpha1(III) procollagen mRNA
    K Kobayashi
    Department of Orthopaedics, Tokai University School of Medicine, Isehara, Kanagawa, Japan
    J Orthop Res 19:862-8. 2001
    ..This mode of repair is different from that of the digital flexor tendon...
  52. ncbi request reprint Horizontal and vertical transmission of mouse class I MHC sequence in Schistosoma mansoni
    A Imase
    Center for Arts and Humanities, Faculty of Medical Health, Ibaraki Prefectural University of Health Sciences, Inashiki, Japan
    Parasitology 123:163-8. 2001
    ..From the data we assumed that S. mansoni may have retained their own mouse class I MHC sequence in their genome throughout their life-cycle...
  53. ncbi request reprint Ability of transplanted cultured epithelium to respond to dermal papillae
    L Xing
    Department of Biology, Faculty of Science, Chiba University, Chiba-shi, Japan
    Tissue Eng 7:535-44. 2001
    ..We concluded that transplanted cultured epithelium of adult rat sole keratinocytes can respond to growth signals from adult dermal papillae...
  54. ncbi request reprint Cytokine production profile of splenocytes derived from zymosan A-treated SKG mice developing arthritis
    K Kobayashi
    Department of Allergy, Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, 1188 Shimotogari, Shizuoka ken, 411 8731, Japan
    Inflamm Res 55:335-41. 2006
    ..The purpose of this study was to investigate the cytokine production from splenocytes in SKG mice developing arthritis under the SPF condition...
  55. ncbi request reprint Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene
    H Ishiguro
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake Aichi 470 1192, Japan
    J Neurosci Res 65:289-97. 2001
    ..The HD model mouse may therefore have advantages for investigations of molecular mechanisms underlying instability of CAG repeats...
  56. ncbi request reprint Colonisation and transmission of Clostridium difficile in healthy individuals examined by PCR ribotyping and pulsed-field gel electrophoresis
    H Kato
    Department of Bacteriology, School of Medicine, Kanazawa University, Japan
    J Med Microbiol 50:720-7. 2001
    ..difficile-associated diarrhoea, but that cross-transmission of C. difficile does not occur frequently among family members at home...
  57. pmc Visualization, direct isolation, and transplantation of midbrain dopaminergic neurons
    K Sawamoto
    Division of Neuroanatomy (D12, Department of Neuroscience, Biomedical Research Center, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
    Proc Natl Acad Sci U S A 98:6423-8. 2001
    ..This strategy for isolating an enriched population of DA neurons should be useful for cellular and molecular studies of these neurons and for clinical applications in the treatment of Parkinson's disease...
  58. ncbi request reprint A novel homologue of the TIAP/m-survivin gene
    T Ogasawara
    Department of Developmental Genetics, Chiba University Graduate School of Medicine, Chiba, Japan
    Biochem Biophys Res Commun 282:207-11. 2001
    ....
  59. ncbi request reprint Molecular cloning of a canine metallothionein cDNA
    K Kobayashi
    Department of Veterinary Pathology, Tottori University, Japan
    J Vet Med Sci 59:819-23. 1997
    ..Thus, the canine metallothionein cDNA obtained in the present study should provide an useful tool for the molecular investigation of metallothionein in dog...
  60. ncbi request reprint Molecular basis and promise of genetic therapy for diabetic dyslipidaemia: studies in an animal model of diabetes
    L Chan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Diabetologia 40:S155-6. 1997
  61. ncbi request reprint A novel gene suppressed in the ventricle of carnitine-deficient juvenile visceral steatosis mice
    M Masuda
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    FEBS Lett 408:221-4. 1997
    ..The CDV-1 cDNA contained an open reading frame predicting a peptide of 107 amino acids, which composed the C-terminal portion of CDV-1R peptide consisting of 414 amino acids...
  62. ncbi request reprint Expression of 47 kDa heat shock protein (HSP47) during development of mouse cornea
    Y Tanaka
    Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan
    Exp Eye Res 63:383-93. 1996
    ..HSP47 expression is regulated developmentally toward completion and plays an important role during ocular development especially in corneal morphogenesis. We discuss here the relation between expression of HSP47 and alpha 1(I) collagen...
  63. ncbi request reprint Cloning, tissue expression, and mapping of a human photolyase homolog with similarity to plant blue-light receptors
    P J van der Spek
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
    Genomics 37:177-82. 1996
    ..In situ hybridization with a cDNA-derived probe localized this human gene to chromosome 12q23-q24.1. Southern analysis of the cloned human gene suggests a wide distribution of the gene family in various species...
  64. ncbi request reprint [Serological assay for diagnosis of verotoxin-producing Escherichia coli (VTEC) infection in the patients with diarrhea]
    K Kobayashi
    Osaka Prefectural Institute of Public Health
    Kansenshogaku Zasshi 70:80-6. 1996
    ....
  65. ncbi request reprint Characterization of human wild-type and mutant argininosuccinate synthetase proteins expressed in bacterial cells
    N Shaheen
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    Enzyme Protein 48:251-64. 1994
    ..190 mmol/l) than in wild-type ASS (0.056 mmol/l). The results confirm that these mutations are responsible for ASS deficiency and also indicate that these amino acid residues are important for the function and structure of ASS protein...
  66. ncbi request reprint Genomic structure and tissue distribution of the mouse dopamine D4 receptor
    T Suzuki
    Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Toyoake, Japan
    Neurosci Lett 199:69-72. 1995
    ..We observed several differences in tissue distribution of the D4 mRNA in mice from that reported in other mammalian species...
  67. ncbi request reprint [Differentiation of cholera-enterotoxin producing Vibrio strains by polymerase chain reaction]
    K Kobayashi
    Division of Public Health, Osaka Prefectural Institute of Public Health
    Kansenshogaku Zasshi 67:1045-51. 1993
    ..cholerae. These results indicates that the CT-producing V. cholerae strains are regulated by the toxR gene, but the ctx gene of V. mimicus is controlled by another different genome from toxR of V. cholerae...
  68. ncbi request reprint [Polymerase chain reaction (PCR) method for the detection of Salmonella by using Chelex resin after enrichment culture]
    K Kobayashi
    Laboratory of Microbiology, Osaka Prefectural Institute of Public Health
    Kansenshogaku Zasshi 68:1203-10. 1994
    ....
  69. ncbi request reprint Cholesteryl ester transfer protein gene: two common mutations and their effect on plasma high-density lipoprotein cholesterol content
    H Akita
    Department of Laboratory Medicine, Hokkaido University School of Medicine, Sapporo, Japan
    J Clin Endocrinol Metab 79:1615-8. 1994
    ..81% and 4.62%, respectively. These data suggest that D442G is a common mutation and that, although I14A is responsible for the most severe HALP, D442G leads to a relatively smaller increase in HDL-C...
  70. ncbi request reprint Establishment of a T cell-dependent nude mouse liver injury model induced by Propionibacterium acnes and LPS
    Y Tanaka
    Department of Immunology, Tokai University School of Medicine, Isehara, Japan
    J Immunol Methods 182:21-8. 1995
    ..acnes and LPS-induced liver injury in nude mice following T cell transfer. Thus, this model will provide a new strategy to investigate T cell-dependent cell-cell interaction during the induction of liver damage...
  71. ncbi request reprint Nature and frequency of mutations in the argininosuccinate synthetase gene that cause classical citrullinemia
    K Kobayashi
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Japan
    Hum Genet 96:454-63. 1995
    ..The deletion had a short direct repeat (CTCAGG) at the breakpoint junction and presumably resulted from slipped mispairing...
  72. ncbi request reprint Heterogeneity of mutations in argininosuccinate synthetase causing human citrullinemia
    K Kobayashi
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030
    J Biol Chem 265:11361-7. 1990
    ..There is extreme heterogeneity of mutations causing citrulinemia. This heterogeneity may prove typical for less common autosomal recessive human genetic diseases...
  73. ncbi request reprint [Detection of toxigenic Vibrio cholerae O1 using polymerase chain reaction for amplifying the cholera enterotoxin gene]
    K Kobayashi
    Division of Public Health, Osaka Prefectural Institute of Public Health
    Kansenshogaku Zasshi 64:1323-9. 1990
    ..A few isolates of CT producing V. mimicus and V. cholerae non-O1 were identified...
  74. ncbi request reprint Plasminogen with type-I mutation is polymorphic in the Japanese population
    S Kikuchi
    Department of Medical Genetics, University of Tsukuba, Japan
    Hum Genet 90:7-11. 1992
    ..2% of 360 unrelated healthy subjects. These data indicate that the type-I mutation of PLG is present in PLG M5 and polymorphic in the Japanese population. The data also suggest that the PLG M5 is identical with PLG Tochigi and Kagoshima...
  75. ncbi request reprint Structure of the mouse tyrosine hydroxylase gene
    N Iwata
    Department of Pharmacology, Nagoya University School of Medicine, Japan
    Biochem Biophys Res Commun 182:348-54. 1992
    ..There were the canonical TATA and GC boxes, cyclic AMP responsive element (CRE), and AP1 binding site in the 5'-flanking region of the mouse TH gene...
  76. ncbi request reprint Caldecrin is a novel-type serine protease expressed in pancreas, but its homologue, elastase IV, is an artifact during cloning derived from caldecrin gene
    I Yoshino-Yasuda
    Department of Biochemistry, Faculty of Medicine, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    J Biochem 123:546-54. 1998
    ..Although both caldecrins were found to be chymotrypsin-type proteases, on the basis of their substrate and inhibitor specificities, they were not inhibited by TPCK, suggesting that caldecrin is a novel type of serine protease...
  77. ncbi request reprint Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain
    F Oyama
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan
    J Neurochem 71:313-22. 1998
    ..These data show a definite effect of the PS2 mutation on an age-dependent increase of Abeta42 content in the brain...
  78. ncbi request reprint Reduced immunogenicity of beta-lactoglobulin by conjugation with carboxymethyl dextran differing in molecular weight
    K Kobayashi
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan
    J Agric Food Chem 49:823-31. 2001
    ..162. It was concluded that conjugation with CMD of higher molecular weight is effective in reducing the immunogenicity of beta-LG and that masking of epitopes by CMD is responsible for the reduced immunogenicity...
  79. ncbi request reprint Structural organization, complete genomic sequences and mutational analyses of the Fukuyama-type congenital muscular dystrophy gene, fukutin
    K Kobayashi
    Laboratory of Genome Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Japan
    FEBS Lett 489:192-6. 2001
    ..Analysis of expressed sequence tag clusters within the region revealed two novel genes upstream of the fukutin gene. These data provide fundamental information to support detailed genetic and functional analyses of the fukutin gene...
  80. ncbi request reprint Gene therapy for hepatocellular carcinoma using two recombinant adenovirus vectors with alpha-fetoprotein promoter and Cre/lox P system
    Y Sakai
    First Department of Internal Medicine, School of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan
    J Virol Methods 92:5-17. 2001
    ..Some strategies to overcome this dose limitation are needed, at least in the case of hepatocellular carcinoma...
  81. ncbi request reprint Neuronal expression of the fukutin gene
    J Sasaki
    Division of Clinical Genetics, Department of Medical Genetics, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 B9 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Mol Genet 9:3083-90. 2000
    ..Furthermore, differences in mRNA levels among neurons in early developmental stages may partially differentiate normal and abnormal regions...
  82. ncbi request reprint Mouse dopamine beta-hydroxylase: primary structure deduced from the cDNA sequence and exon/intron organization of the gene
    T Nakano
    Department of Oral Biochemistry, Kanagawa Dental College, Yokosuka, Japan
    Biochem Biophys Res Commun 189:590-9. 1992
    ..Typical TATA and CCAAT boxes were observed in the 5'-upstream region of the gene. Northern blot analysis of adrenal gland RNA detected a single size species of the mouse DBH mRNA...
  83. ncbi request reprint Mutant presenilin 2 transgenic mice. A large increase in the levels of Abeta 42 is presumably associated with the low density membrane domain that contains decreased levels of glycerophospholipids and sphingomyelin
    N Sawamura
    Department of Neuropathology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biol Chem 275:27901-8. 2000
    ..This unexpected finding suggests that a large increase in the levels of Abeta42 in mutant PS2 mice is presumably induced through alterations of the lipid composition in the low density membrane domain in the brain...
  84. ncbi request reprint Cloning of a novel murine gene Sfmbt, Scm-related gene containing four mbt domains, structurally belonging to the Polycomb group of genes
    H Usui
    Department of Molecular Neuropathology, Brain Research Institute, Niigata University, 1 757 Asahimachi, Niigata, Japan
    Gene 248:127-35. 2000
    ..Northern blot analysis showed that the Sfmbt mRNAs were expressed most abundantly in the adult testis, and less intensively in all other tissues examined...
  85. ncbi request reprint Modest neuropsychological deficits caused by reduced noradrenaline metabolism in mice heterozygous for a mutated tyrosine hydroxylase gene
    K Kobayashi
    Department of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical University School of Medicine, Fukushima 960 1295, Japan
    J Neurosci 20:2418-26. 2000
    ..These results provide genetic evidence that the central noradrenaline system plays an important role in memory formation, particularly in the long-term memory of conditioned learning...
  86. ncbi request reprint The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding
    K Kobayashi
    Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA
    Metabolism 49:22-31. 2000
    ....
  87. ncbi request reprint Doc2alpha is an activity-dependent modulator of excitatory synaptic transmission
    G Sakaguchi
    Shionogi Institute for Medical Science, Settsu, Japan
    Eur J Neurosci 11:4262-8. 1999
    ..Furthermore, the mutant mice showed impairment in long-term potentiation and passive avoidance task. Thus, Doc2alpha may regulate transmitter release during repetitive synaptic activation, thereby contributing to memory formation...
  88. ncbi request reprint Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
    G T van der Horst
    MGC, Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 398:627-30. 1999
    ..This suggests that, in addition to a possible photoreceptor and antagonistic clock-adjusting function, both proteins are essential for the maintenance of circadian rhythmicity...
  89. pmc Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
    K Kobayashi
    Department of Developmental Genetics, Chiba University Graduate School of Medicine, Inohana 1 8 1, Chuo Ku, Chiba 260 8670, Japan
    Proc Natl Acad Sci U S A 96:1457-62. 1999
    ..We propose that during cell proliferation, cellular protective activity may be augmented with inducible IAPs such as TIAP...
  90. ncbi request reprint Alleviation of lipopolysaccharide-induced acute liver injury in Propionibacterium acnes-primed IFN-gamma-deficient mice by a concomitant reduction of TNF-alpha, IL-12, and IL-18 production
    H Tsuji
    First Department of Internal Medicine, School of Medicine, Kanazawa University, Ishikawa, Japan
    J Immunol 162:1049-55. 1999
    ..Thus, endogenously produced IFN-gamma is involved in the pathogenesis of this liver injury model by regulating Mphi infiltration and granuloma formation in the priming phase as well as cytokine production in the eliciting phase...
  91. pmc Organic solvent tolerance of Escherichia coli is independent of OmpF levels in the membrane
    H Asako
    Department of Bioengineering, Faculty of Bioscience and Biotechnology, Tokyo Institute of Technology, Nagatsuta 4259, Midori ku, Yokohama 226 8501, Japan
    Appl Environ Microbiol 65:294-6. 1999
    ..It was shown that solvent tolerance of E. coli did not depend upon OmpF levels in the membrane...
  92. ncbi request reprint Motor and learning dysfunction during postnatal development in mice defective in dopamine neuronal transmission
    K Nishii
    Institute for Comprehensive Medical Science, School of Medicine, Fujita Health University, Toyoake, Aichi, Japan
    J Neurosci Res 54:450-64. 1998
    ..These results demonstrate that dopamine neurotransmission is essential for controlling spontaneous and voluntary movement and associative learning during postnatal development through the nigrostriatal and mesocorticolimbic pathways...
  93. ncbi request reprint Ablation of cerebellar Golgi cells disrupts synaptic integration involving GABA inhibition and NMDA receptor activation in motor coordination
    D Watanabe
    Department of Biological Sciences, Kyoto University Faculty of Medicine, Japan
    Cell 95:17-27. 1998
    ..Furthermore, this integration can adapt after Golgi cell elimination so as not to evoke overexcitation by the reduction of NMDA receptors...
  94. ncbi request reprint Molecular cloning of the transglutaminase gene from Bacillus subtilis and its expression in Escherichia coli
    K Kobayashi
    Central Research Laboratories, Ajinomoto Co, Inc, Kanagawa, Japan
    Biosci Biotechnol Biochem 62:1109-14. 1998
    ..Transglutaminase activity was detected in Escherichia coli cells transformed with a plasmid for expression of the tgl gene...
  95. ncbi request reprint [Detection of verotoxin-producing Escherichia coli using polymerase chain reaction from dairy cattle]
    H Tada
    Tokushima Prefectural Institute of Public Health and Environmental Sciences
    Kansenshogaku Zasshi 66:1383-9. 1992
    ..These results suggests that cattle may play an important role in human VTEC infections. The BGL B-PCR technique is usefull in ecological studies for VT-producing pathogens...