Hideo Kimura

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor
    H Kimura
    Salk Institute for Biological Studies, San Diego, California, 92138, USA
    Biochem Biophys Res Commun 267:129-33. 2000
  2. doi request reprint Hydrogen sulfide: from brain to gut
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 12:1111-23. 2010
  3. pmc A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide
    Yoshinori Mikami
    Department of Molecular Pharmacology National Institute of Neuroscience National Center of Neurology and Psychiatry Kodaira, Japan
    Commun Integr Biol 5:169-71. 2012
  4. ncbi request reprint Physiological role of hydrogen sulfide and polysulfide in the central nervous system
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan Electronic address
    Neurochem Int 63:492-7. 2013
  5. pmc Hydrogen sulfide is a signaling molecule and a cytoprotectant
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 17:45-57. 2012
  6. ncbi request reprint Hydrogen sulfide as a neuromodulator
    Hideo Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Mol Neurobiol 26:13-9. 2002
  7. doi request reprint Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria
    Yuka Kimura
    Department of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 12:1-13. 2010
  8. doi request reprint Hydrogen sulfide: its production, release and functions
    Hideo Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Amino Acids 41:113-21. 2011
  9. doi request reprint Hydrogen sulfide: its production and functions
    Hideo Kimura
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Exp Physiol 96:833-5. 2011
  10. ncbi request reprint Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS
    Yasushi Enokido
    Department of Molecular Geneticsy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    FASEB J 19:1854-6. 2005

Detail Information

Publications60

  1. ncbi request reprint Hydrogen sulfide induces cyclic AMP and modulates the NMDA receptor
    H Kimura
    Salk Institute for Biological Studies, San Diego, California, 92138, USA
    Biochem Biophys Res Commun 267:129-33. 2000
    ..The present findings provide a mechanism for the previous observation that H(2)S modulates NMDA receptors and enhances the induction of LTP...
  2. doi request reprint Hydrogen sulfide: from brain to gut
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 12:1111-23. 2010
    ..Recent progress in the studies of physiological functions of H(2)S in neurons and smooth muscle was described...
  3. pmc A mechanism of retinal protection from light-induced degeneration by hydrogen sulfide
    Yoshinori Mikami
    Department of Molecular Pharmacology National Institute of Neuroscience National Center of Neurology and Psychiatry Kodaira, Japan
    Commun Integr Biol 5:169-71. 2012
    ..The present study shows that H(2)S production by 3MST/CAT pathway is regulated by Ca(2+) and that H(2)S protects retinal photoreceptor cells from light induced degeneration by suppressing excessive Ca(2+) influx caused by intense light...
  4. ncbi request reprint Physiological role of hydrogen sulfide and polysulfide in the central nervous system
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan Electronic address
    Neurochem Int 63:492-7. 2013
    ..In addition, this review shows the recent findings that indicate that the H2S-derived polysulfides found in the brain activate TRPA1 channels more potently than parental H2S...
  5. pmc Hydrogen sulfide is a signaling molecule and a cytoprotectant
    Hideo Kimura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 17:45-57. 2012
    ..It also has a cytoprotective effect, since it can protect neurons and cardiac muscle from oxidative stress and ischemia-reperfusion injury, respectively. Hydrogen sulfide can also modulate inflammation, insulin release, and angiogenesis...
  6. ncbi request reprint Hydrogen sulfide as a neuromodulator
    Hideo Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Mol Neurobiol 26:13-9. 2002
    ..Recent progress in the study of H2S as a novel neuromodulator/transmitter in the brain is briefly reviewed...
  7. doi request reprint Hydrogen sulfide increases glutathione production and suppresses oxidative stress in mitochondria
    Yuka Kimura
    Department of Molecular Genetics, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 12:1-13. 2010
    ..H(2)S produced in mitochondria also may directly suppress oxidative stress. It provides a new mechanism of neuroprotection from oxidative stress by H(2)S...
  8. doi request reprint Hydrogen sulfide: its production, release and functions
    Hideo Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Amino Acids 41:113-21. 2011
    ..In this review, enzymatic production, release mechanism and functions of H(2)S are focused on...
  9. doi request reprint Hydrogen sulfide: its production and functions
    Hideo Kimura
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Exp Physiol 96:833-5. 2011
    ..In addition to reinstating glutathione levels, H(2)S produced by 3MST, which is mainly localized to mitochondria, reduces reactive oxygen species generated in these organelles...
  10. ncbi request reprint Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia/astrocyte lineage of developing mouse CNS
    Yasushi Enokido
    Department of Molecular Geneticsy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    FASEB J 19:1854-6. 2005
    ....
  11. doi request reprint A novel pathway for the production of hydrogen sulfide from D-cysteine in mammalian cells
    Norihiro Shibuya
    Department of Molecular Pharmacology, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Nat Commun 4:1366. 2013
    ..This study presents a novel pathway of hydrogen sulphide production and provides a new therapeutic approach to deliver hydrogen sulphide to specific tissues...
  12. ncbi request reprint Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population
    Akiko Soyama
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Drug Metab Pharmacokinet 20:24-33. 2005
    ..Our findings provide fundamental and useful information for genotyping CYP1A2 in the Japanese, and probably Asian populations...
  13. ncbi request reprint CYP2C8 haplotype structures and their influence on pharmacokinetics of paclitaxel in a Japanese population
    Yoshiro Saito
    Division of Biochemistry and Immunochemistry, National Institute of Health Sciences, Tokyo, Japan
    Pharmacogenet Genomics 17:461-71. 2007
    ..Although large interindividual differences in CYP2C8 enzymatic activity and several nonsynonymous variations were reported, neither haplotype structures nor their associations with pharmacokinetic parameters of paclitaxel were reported...
  14. doi request reprint Polysulfides are possible H2S-derived signaling molecules in rat brain
    Yuka Kimura
    Department of Molecular Pharmacology, National Institute of Neuroscience, Tokyo, Japan
    FASEB J 27:2451-7. 2013
    ..The present study suggests that polysulfides are possible H2S-derived signaling molecules that stimulate TRP channels in the brain...
  15. ncbi request reprint Hydrogen sulfide enhances reducing activity in neurons: neurotrophic role of H2S in the brain?
    Ken Umemura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 9:2035-41. 2007
    ..The H2S-specific enhancement of the reducing activity in neurons may lead to a neurotrophic role in the brain...
  16. ncbi request reprint Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population
    Yoshiko Tamura
    National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 379:149-51. 2005
    ..Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population...
  17. ncbi request reprint Differentiated astrocytes acquire sensitivity to hydrogen sulfide that is diminished by the transformation into reactive astrocytes
    Mamiko Tsugane
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 9:257-69. 2007
    ..This suppressive effect of EGF on the sensitivity to NaHS was inhibited by cycloheximide, indicating that de novo protein synthesis was required for the suppression of H2S sensitivity...
  18. ncbi request reprint Functional characterization of five novel CYP2C8 variants, G171S, R186X, R186G, K247R, and K383N, found in a Japanese population
    Hiroyuki Hichiya
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Drug Metab Dispos 33:630-6. 2005
    ..These results indicate that the novel CYP2C8 SNPs, 556C>T (R186X) and 556C>G (R186G), could influence the metabolism of CYP2C8 substrates such as paclitaxel and cerivastatin...
  19. ncbi request reprint Abnormal lipid metabolism in cystathionine beta-synthase-deficient mice, an animal model for hyperhomocysteinemia
    Kazuhiko Namekata
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi 4 1 1, Kodaira, Tokyo 187 8551, Japan
    J Biol Chem 279:52961-9. 2004
    ..Moreover, serum cholesterol/triglyceride distribution in lipoprotein fractions was altered in CBS(-/-) mice. These results suggest that hepatic steatosis in CBS(-/-) mice is caused by or associated with abnormal lipid metabolism...
  20. doi request reprint Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biochem 146:623-6. 2009
    ..Lysates of vascular endothelial cells produced H(2)S from cysteine and alpha-ketoglutarate. The present study provides a new insight into the production and release of H(2)S as a smooth muscle relaxant from vascular endothelium...
  21. ncbi request reprint Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients
    Ken Umemura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Neurosci Lett 400:97-100. 2006
    ..These observations suggest that expression of the autotaxin gene and cell signaling by lysophosphatidic acid may be involved in the pathology of ATD, and that this cell signaling pathway may be a potential target of treatments for ATD...
  22. ncbi request reprint A novel enhancing mechanism for hydrogen sulfide-producing activity of cystathionine beta-synthase
    Ko Eto
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    J Biol Chem 277:42680-5. 2002
    ..The present study demonstrates a novel mechanism for the regulation of CBS activity and provides a possible therapeutic application of SNP for the diseases in which CBS activity is deficient...
  23. ncbi request reprint Hydrogen sulfide is produced in response to neuronal excitation
    Ko Eto
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8551, Japan
    J Neurosci 22:3386-91. 2002
    ..In addition, LTP is altered in CBS knock-out mice. These observations suggest that H2S is produced by CBS in response to neuronal excitation and that it may regulate some aspects of synaptic activity...
  24. pmc Murine cystathionine gamma-lyase: complete cDNA and genomic sequences, promoter activity, tissue distribution and developmental expression
    Isao Ishii
    Department of Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi 4 1 1, Kodaira, Tokyo 187 8502, Japan
    Biochem J 381:113-23. 2004
    ..Immunohistochemical analyses revealed predominant CSE expression in hepatocytes and kidney cortical tubuli. These results suggest important physiological roles for CSE in mice...
  25. doi request reprint 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain
    Norihiro Shibuya
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Kiyose, Tokyo, Japan
    Antioxid Redox Signal 11:703-14. 2009
    ..These data present a new perspective on H(2)S production and storage in the brain...
  26. ncbi request reprint Physiological roles of hydrogen sulfide: synaptic modulation, neuroprotection, and smooth muscle relaxation
    Hideo Kimura
    National Institute of Neuroscience, Tokyo, Japan
    Antioxid Redox Signal 7:795-803. 2005
    ..H(2)S, the toxic gas, may therefore be used as a multifunctional signaling mechanism under normal physiological conditions...
  27. doi request reprint Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide
    Yoshinori Mikami
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawa Higashi, Kodaira, Tokyo, Japan
    Biochem J 439:479-85. 2011
    ..We also show that 3MST produces H2S from thiosulfate. The present study provides a new insight into a mechanism for the production of H2S by 3MST...
  28. pmc Hydrogen sulfide protects the retina from light-induced degeneration by the modulation of Ca2+ influx
    Yoshinori Mikami
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 286:39379-86. 2011
    ..It also shows a cytoprotective effect of H(2)S on retinal neurons and provides a basis for the therapeutic target for retinal degeneration...
  29. ncbi request reprint Hydrogen sulfide protects neurons from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Kodaira, Tokyo, Japan
    FASEB J 18:1165-7. 2004
    ..Cystine (cysteine) is the rate-limiting substrate of glutathione synthesis. These observations reveal that H2S protects neurons from oxytosis by increasing the production of the antioxidant glutathione...
  30. ncbi request reprint Haplotype structures of EPHX1 and their effects on the metabolism of carbamazepine-10,11-epoxide in Japanese epileptic patients
    Yukiko Nakajima
    Project Team for Pharmacogenetics, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, 158 8501, Japan
    Eur J Clin Pharmacol 61:25-34. 2005
    ..Utilizing single nucleotide polymorphisms (SNPs) of the EPHX1 gene encoding mEH, we identified the haplotypes of EPHX1 blocks and investigated the association between the block haplotypes and CBZ-epoxide metabolism...
  31. doi request reprint Hydrogen sulfide is produced by cystathionine γ-lyase at the steady-state low intracellular Ca(2+) concentrations
    Yoshinori Mikami
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 431:131-5. 2013
    ..These observations suggest that CSE produces H(2)S at the steady-state in cells and that the production is suppressed when the intracellular Ca(2+) concentrations are increased...
  32. ncbi request reprint Hydrogen sulfide protects HT22 neuronal cells from oxidative stress
    Yuka Kimura
    National Institute of Neuroscience, Tokyo, Japan
    Antioxid Redox Signal 8:661-70. 2006
    ..The present study therefore identifies a novel pathway for H2S protection from oxidative stress...
  33. ncbi request reprint Hydrogen sulfide induces calcium waves in astrocytes
    Yasuo Nagai
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    FASEB J 18:557-9. 2004
    ..These observations suggest that H2S induces Ca2+ waves that propagate to neighboring astrocytes...
  34. ncbi request reprint MOCA induces membrane spreading by activating Rac1
    Kazuhiko Namekata
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8551, Japan
    J Biol Chem 279:14331-7. 2004
    ..MOCA is also concentrated with actin on the growth cone in primary cultures of cortical neurons. These observations suggest that MOCA may induce cytoskeletal reorganization and changes in cell adhesion by regulating the activity of Rac1...
  35. ncbi request reprint Cadmium exposure alters metabolomics of sulfur-containing amino acids in rat testes
    Yasoo Sugiura
    Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
    Antioxid Redox Signal 7:781-7. 2005
    ..Although detailed mechanisms for such a remodeling event remain unknown, our study suggests that metabolomic analyses serve as a powerful tool to pinpoint a critical enzymatic reaction that regulates metabolic systems as a whole...
  36. ncbi request reprint Lack of association between TrkA single nucleotide polymorphisms and sporadic Alzheimer's disease in a Japanese population
    Yuji Sakasegawa
    Department of Cortical Function Disorders, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 353:49-52. 2003
    ..Thus, the TrkA genotype does not appear to influence the risk of developing sporadic AD in a Japanese population...
  37. doi request reprint Genetic association study on in and around the APOE in late-onset Alzheimer disease in Japanese
    Norihiro Takei
    Department of Molecular Genetics, Bioresource Science Branch, Center for Bioresources, Brain Research Institute, Niigata University, Niigata 951 8585, Japan
    Genomics 93:441-8. 2009
    ..Strong LD between these SNPs was observed (mean |D'|=0.914). These data suggest that the three genes other than APOE, i.e. PVRL2, TOMM40 and APOC1, could also yield a predisposition to LOAD...
  38. doi request reprint A source of hydrogen sulfide and a mechanism of its release in the brain
    Mari Ishigami
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Antioxid Redox Signal 11:205-14. 2009
    ..These data present a new perspective on the regulation of H2S in the brain...
  39. ncbi request reprint Haplotypes of CYP3A4 and their close linkage with CYP3A5 haplotypes in a Japanese population
    Hiromi Fukushima-Uesaka
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    Hum Mutat 23:100. 2004
    ..Our findings provide fundamental and useful information for genotyping CYP3A4 (and CYP3A5) in the Japanese, and probably Asian populations...
  40. ncbi request reprint The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain
    Ko Eto
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    J Neurochem 83:80-6. 2002
    ..Administration of SAM once a day for 3 days increases the brain H2S without significantly changing the testosterone level. These observations suggest that testosterone can regulate the brain H2S level via changing the level of SAM...
  41. ncbi request reprint Six novel nonsynonymous CYP1A2 gene polymorphisms: catalytic activities of the naturally occurring variant enzymes
    Norie Murayama
    Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
    J Pharmacol Exp Ther 308:300-6. 2004
    ..Thus, for the first time, phenylalanine at residue 186 is suggested to be a critical amino acid for catalytic activity...
  42. ncbi request reprint Cystathionine beta-synthase is enriched in the brains of Down's patients
    Akiko Ichinohe
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Biochem Biophys Res Commun 338:1547-50. 2005
    ..The over-expression of CBS may cause the developmental abnormality in cognition in DS children and that may lead to AD in DS adults...
  43. ncbi request reprint Brain hydrogen sulfide is severely decreased in Alzheimer's disease
    Ko Eto
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Biochem Biophys Res Commun 293:1485-8. 2002
    ..These observations suggest that CBS activity is reduced in AD brains and the decrease in H2S may be involved in some aspects of the cognitive decline in AD...
  44. ncbi request reprint Presenilin-binding protein forms aggresomes in monkey kidney COS-7 cells
    Kazuhiko Namekata
    National Institute of Neuroscience, NCNP, Tokyo, Japan
    J Neurochem 82:819-27. 2002
    ..These observations suggest that the malfunctioning of the proteasome can cause the formation of PBP aggresomes, which may lead to AD...
  45. ncbi request reprint Determination of oxidized and reduced nicotinamide adenine dinucleotide in cell monolayers using a single extraction procedure and a spectrophotometric assay
    Ken Umemura
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8551, Japan
    Anal Biochem 338:131-5. 2005
    ..The procedure presented here provides a simple and inexpensive measurement of NAD+ and NADH in cell monolayers...
  46. ncbi request reprint Effects of nitric oxide donors on vascular endothelial growth factor gene induction
    Hideo Kimura
    Division of Vascular Surgery, Department of Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 296:976-82. 2002
    ..SNAP, GSNO, and NOC18 induced the accumulation of HIF-1alpha protein, while others did not. These results suggest that SNAP, GSNO, and NOC compounds are suitable for pharmacological studies in HIF-1-mediated VEGF gene activation by NO...
  47. ncbi request reprint Structure, expression and function of a schwannoma-derived growth factor
    H Kimura
    Salk Institute for Biological Studies, San Diego, California 92186 5800
    Nature 348:257-60. 1990
    ..SDGF belongs to the epidermal growth factor family, and is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts...
  48. ncbi request reprint Phenotype and functional identity of GM-CSF-independent dendritic cells generated by long-term propagation of DC progenitor cells in bone marrow cells and skin Langerhans cells
    H Katayama
    Department of Research Surgery, National Research Center for Child Health and Development, Tokyo, Japan
    Transplant Proc 37:17-9. 2005
    ..A large population of DC generated by Flt3L/IL-6 from GM-CSF receptor-deficient mice by do not express NK1.1 (NKR-P1B and NKR-P1C). The profiles for BMC-derived DC were the same as for skin Langerhans cells...
  49. ncbi request reprint Two novel Xenopus homologs of mammalian LP(A1)/EDG-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells
    Y Kimura
    Department of Pharmacology, School of Medicine, University of California, San Diego, La Jolla, California 92093 0636, USA
    J Biol Chem 276:15208-15. 2001
    ..These results indicate that XLP(A1)-1 and XLP(A1)-2 are functional Xenopus LPA receptors and demonstrate the evolutionary conservation of LPA signaling over a range of vertebrate phylogeny...
  50. ncbi request reprint DNA methylation regulates placental lactogen I gene expression
    J H Cho
    Laboratory of Cellular Biochemistry, Animal Resource Sciences/Veterinary Medical Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, 113-8657, Japan
    Endocrinology 142:3389-96. 2001
    ..These results provide evidence that change in DNA methylation is the fundamental mechanism regulating the tissue-specific expression of the rat placental lactogen I gene...
  51. ncbi request reprint Hydrogen sulfide is a novel prosecretory neuromodulator in the Guinea-pig and human colon
    Rudolf Schicho
    Department of Human Biology, Technical University Munich, Munich, Germany
    Gastroenterology 131:1542-52. 2006
    ..Hydrogen sulfide (H(2)S) has been suggested as a novel gasomediator. We explored its unknown neuromodulatory role in human and guinea-pig colon...
  52. ncbi request reprint L-cysteine inhibits insulin release from the pancreatic beta-cell: possible involvement of metabolic production of hydrogen sulfide, a novel gasotransmitter
    Yukiko Kaneko
    Department of Pharmacology, Oita University Faculty of Medicine, 1 1 Idaigaoka, Hasama, Oita 879 5593, Japan
    Diabetes 55:1391-7. 2006
    ..Because the activities of H(2)S-producing enzymes and the tissue H(2)S contents are known to increase under diabetic conditions, the inhibition may participate in the deterioration of insulin release in this disease...
  53. ncbi request reprint Reciprocal regulation between nitric oxide and vascular endothelial growth factor in angiogenesis
    Hideo Kimura
    Investigative Treatment Division, National Cancer Center Research Institute East, Chiba, Japan
    Acta Biochim Pol 50:49-59. 2003
    ..These reciprocal relations between NO and VEGF may contribute to regulated angiogenesis in normal tissues...
  54. doi request reprint Atrial fibrillation in patients with Brugada syndrome relationships of gene mutation, electrophysiology, and clinical backgrounds
    Kengo F Kusano
    Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Am Coll Cardiol 51:1169-75. 2008
    ..The goal of our work was to examine the relationships of atrial fibrillation (AF) with genetic, clinical, and electrophysiological backgrounds in Brugada syndrome (BrS)...
  55. pmc Hydrogen sulfide attenuates myocardial ischemia-reperfusion injury by preservation of mitochondrial function
    John W Elrod
    Department of Medicine, Division of Cardiology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 104:15560-5. 2007
    ....
  56. ncbi request reprint Hydrogen sulfide as a biological mediator
    Hideo Kimura
    Antioxid Redox Signal 7:778-80. 2005
  57. ncbi request reprint Spontaneous transformation of cultured mouse bone marrow-derived stromal cells
    Yi Fu Zhou
    Vascular Biology and Immunobiology Programs, Institute for Cell Engineering, Departments of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Cancer Res 66:10849-54. 2006
    ..The remarkably rapid malignant transformation of cultured mouse bone marrow cells may have important implications for ongoing clinical trials of cell therapy and for models of oncogenesis...
  58. pmc A novel mechanism for the regulation of amyloid precursor protein metabolism
    Qi Chen
    Cellular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Cell Biol 158:79-89. 2002
    ..This is a new mechanism by which the expression of APP is regulated...