Makoto Kikuchi

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. ncbi request reprint Biomedical engineering's contribution to defending the homeland
    Makoto Kikuchi
    National Defense Medical College Research Institute NDMCRI, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    IEEE Eng Med Biol Mag 23:175-86. 2004
  2. ncbi request reprint Chitosan hydrogel as a drug delivery carrier to control angiogenesis
    Masayuki Ishihara
    Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    J Artif Organs 9:8-16. 2006
  3. ncbi request reprint Controlled releases of FGF-2 and paclitaxel from chitosan hydrogels and their subsequent effects on wound repair, angiogenesis, and tumor growth
    Masayuki Ishihara
    Research Institute, National Defense Medical Collage, Tokorozawa, Saitama 359 8513, Japan
    Curr Drug Deliv 3:351-8. 2006
  4. ncbi request reprint Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarction
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    J Surg Res 126:27-33. 2005
  5. ncbi request reprint Controlled release of paclitaxel from photocrosslinked chitosan hydrogels and its subsequent effect on subcutaneous tumor growth in mice
    Kiyohaya Obara
    Department of Surgery II, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Control Release 110:79-89. 2005
  6. ncbi request reprint The effect of chitosan hydrogel containing DMEM/F12 medium on full-thickness skin defects after deep dermal burn
    Tetsuro Kiyozumi
    Department of Traumatology and Critical Care Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Burns 33:642-8. 2007
  7. ncbi request reprint Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice
    Kiyohaya Obara
    Department of Surgery II, National Defence Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Biomaterials 24:3437-44. 2003
  8. ncbi request reprint Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold)
    Kazunori Masuoka
    Department of Orthopaedic Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res B Appl Biomater 75:177-84. 2005
  9. doi request reprint Amelioration of airway stenosis in rabbit models by photodynamic therapy with talaporfin sodium (NPe6)
    Yoshinori Nakagishi
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
    Photochem Photobiol 85:714-8. 2009
  10. ncbi request reprint Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel
    Masanori Fujita
    Department of Surgery II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Biomaterials 25:699-706. 2004

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Biomedical engineering's contribution to defending the homeland
    Makoto Kikuchi
    National Defense Medical College Research Institute NDMCRI, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    IEEE Eng Med Biol Mag 23:175-86. 2004
  2. ncbi request reprint Chitosan hydrogel as a drug delivery carrier to control angiogenesis
    Masayuki Ishihara
    Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
    J Artif Organs 9:8-16. 2006
    ..g., FGF-2 and paclitaxel) to control angiogenesis. It is thus proposed that chitosan hydrogel may be a promising new local carrier for drugs such as FGF-2 and paclitaxel to control vascularization...
  3. ncbi request reprint Controlled releases of FGF-2 and paclitaxel from chitosan hydrogels and their subsequent effects on wound repair, angiogenesis, and tumor growth
    Masayuki Ishihara
    Research Institute, National Defense Medical Collage, Tokorozawa, Saitama 359 8513, Japan
    Curr Drug Deliv 3:351-8. 2006
    ..It is thus proposed that the chitosan hydrogels may be a promising new local carrier for drugs such as FGF-2 and paclitaxel...
  4. ncbi request reprint Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarction
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    J Surg Res 126:27-33. 2005
    ..However, no effective delivery system for growth factor administration is yet known to induce important therapeutic angiogenic responses in ischemic myocardium...
  5. ncbi request reprint Controlled release of paclitaxel from photocrosslinked chitosan hydrogels and its subsequent effect on subcutaneous tumor growth in mice
    Kiyohaya Obara
    Department of Surgery II, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Control Release 110:79-89. 2005
    ..These results suggested that application of paclitaxel-incorporated Az-CH-LA hydrogel has an inhibitory activity on angiogenesis and tumor growth...
  6. ncbi request reprint The effect of chitosan hydrogel containing DMEM/F12 medium on full-thickness skin defects after deep dermal burn
    Tetsuro Kiyozumi
    Department of Traumatology and Critical Care Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Burns 33:642-8. 2007
    ..These findings suggest that early degradative and angiogenic activities of medium-Az-CH-LA may be beneficial for granulation tissue formation in deep dermal burn wounds...
  7. ncbi request reprint Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice
    Kiyohaya Obara
    Department of Surgery II, National Defence Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Biomaterials 24:3437-44. 2003
    ..Histological examination also has demonstrated an advanced granulation tissue formation, capillary formation and epithelialization in wounds treated with FGF-2-incorporated chitosan hydrogels in db/db mice...
  8. ncbi request reprint Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold)
    Kazunori Masuoka
    Department of Orthopaedic Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res B Appl Biomater 75:177-84. 2005
    ..These results indicate that implantation of allogenic chondrocytes cultured in ACHMS scaffolds may be effective in repairing articular cartilage defects...
  9. doi request reprint Amelioration of airway stenosis in rabbit models by photodynamic therapy with talaporfin sodium (NPe6)
    Yoshinori Nakagishi
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
    Photochem Photobiol 85:714-8. 2009
    ..025) and 44% of the treated animals achieved long-term survival (>60 days). In conclusion, PDT using NPe6 is effective for improvement in airway stenosis...
  10. ncbi request reprint Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogel
    Masanori Fujita
    Department of Surgery II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Biomaterials 25:699-706. 2004
    ..These results indicate that the controlled release of biologically active FGF-2 molecules is caused by biodegradation of the hydrogel, and that subsequent induction of the vascularization occurs...
  11. doi request reprint Intraosseous transfusion with liposome-encapsulated hemoglobin improves mouse survival after hypohemoglobinemic shock without scavenging nitric oxide
    Satoshi Shono
    Department of Defense Medicine, National Defense Medical College, Tokorozawa, Japan
    Shock 35:45-52. 2011
    ..Thus, intraosseous transfusion with LEH may be a candidate strategy for efficient prehospital resuscitation from hemorrhagic shock...
  12. ncbi request reprint Development of a diagnostic system for osteoarthritis using a photoacoustic measurement method
    Miya Ishihara
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Lasers Surg Med 38:249-55. 2006
    ..The purpose of this study was to develop a practical photoacoustic measurement system for diagnosis of osteoarthritis (OA) by viscoelastic characterization of articular cartilage...
  13. doi request reprint Efficacy of peritoneal oxygenation using a novel artificial oxygen carrier (TRM-645) in a rat respiratory insufficiency model
    Noriyuki Matsutani
    Department of Surgery II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Surg Today 40:451-5. 2010
    ....
  14. ncbi request reprint Inhibition of vascular prosthetic graft infection using a photocrosslinkable chitosan hydrogel
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
    J Surg Res 121:135-40. 2004
    ..coli). The antibacterial activity by adhering a photocrosslinkable chitosan hydrogel to Dacron grafts was investigated in vitro and in vivo using a rabbit model...
  15. doi request reprint Light scattering change precedes loss of cerebral adenosine triphosphate in a rat global ischemic brain model
    Satoko Kawauchi
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Neurosci Lett 459:152-6. 2009
    ..DC potential measurement showed that the triphasic scattering change was associated with anoxic depolarization. These findings suggest that light scattering signal can be used as an indicator of loss of tissue viability in brains...
  16. ncbi request reprint An experimental study of the regeneration of the intervertebral disc with an allograft of cultured annulus fibrosus cells using a tissue-engineering method
    Masato Sato
    Department of Orthopaedic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Spine (Phila Pa 1976) 28:548-53. 2003
    ..Regeneration of the intervertebral disc was assessed based on the viability and histologic status of the allografted annulus fibrosus cells, as well as the prevention of narrowing disc space...
  17. ncbi request reprint Usefulness of photoacoustic measurements for evaluation of biomechanical properties of tissue-engineered cartilage
    Miya Ishihara
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
    Tissue Eng 11:1234-43. 2005
    ..To our knowledge, this is the first report on noninvasive and time-dependent viscoelastic evaluation of engineered tissue for determining functions of engineered tissues...
  18. ncbi request reprint A real time non-invasive monitoring system for detection of hypovolemic state using RR interval variability in very low frequency ranges
    Takemi Matsui
    National Defense Medical College, 3 2 Namiki, 359 8513 Tokorozawa, Japan
    Biomed Pharmacother 58:S28-30. 2004
    ..5 +/- 1.2 degrees centigrade (p < 0.05) within 1 hour after blood withdrawal. Our monitoring system appears promising for the detection of hypovolemic state resulting from massive hemorrhage using a one-channel ECG monitor...
  19. ncbi request reprint Bone formation using human adipose tissue-derived stromal cells and a biodegradable scaffold
    Hidemi Hattori
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res B Appl Biomater 76:230-9. 2006
    ..The present results show that ATSCs have a similar ability to differentiate into osteoblasts and to synthesize bone in beta-TCP disk as have BMSCs...
  20. ncbi request reprint A new rabbit model of myocardial infarction without endotracheal intubation
    Masanori Fujita
    Department of Medical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Surg Res 116:124-8. 2004
    ..However, it is difficult to carry out endotracheal intubation due to the rabbit anatomy. We therefore attempted to develop a myocardial infarction model in rabbits without endotracheal intubation...
  21. doi request reprint Liposome-encapsulated hemoglobin transfusion rescues rats undergoing progressive hemodilution from lethal organ hypoxia without scavenging nitric oxide
    Yashiro Nogami
    Department of Surgery, National Defense Medical College Research Institute, Tokorozawa, Japan
    Ann Surg 248:310-9. 2008
    ..To investigate the efficacy of liposome-encapsulated hemoglobin (LHb) transfusion in rats undergoing lethal progressive hemodilution...
  22. ncbi request reprint Medium (DMEM/F12)-containing chitosan hydrogel as adhesive and dressing in autologous skin grafts and accelerator in the healing process
    Tetsuro Kiyozumi
    Department of Traumatology and Critical Care Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res B Appl Biomater 79:129-36. 2006
    ..Therefore, the medium (DMEM/F12)-containing chitosan hydrogel may become commonly accepted as a beneficial wound dressing and tissue adhesive in extensive wound management and skin grafts...
  23. ncbi request reprint Targeted increase in cerebral blood flow by transcranial near-infrared laser irradiation
    Yoichi Uozumi
    Department of Neurosurgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Lasers Surg Med 42:566-76. 2010
    ..The precise mechanisms by which blood flow is controlled by NIR laser irradiation on the central nervous system (CNS) have not been elucidated. In this study, we examined the effect of 808 nm laser diode irradiation on CBF in mice...
  24. ncbi request reprint Usefulness of photocrosslinkable chitosan for endoscopic cancer treatment in alimentary tract
    Takuya Hayashi
    Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan
    J Biomed Mater Res B Appl Biomater 71:367-72. 2004
    ..Thus, the photocrosslinkable chitosan developed holds promise for use in EMR as a submucosal injection agent that avoids complications...
  25. ncbi request reprint Inhibition of neointimal proliferation in balloon-injured arteries using non-anticoagulant heparin-carrying polystyrene
    Masanori Fujita
    Department of Medical Engineering, Morimoto, National Defense Medical College, Tokorozawa, Saitazma, Japan
    J Cardiovasc Pharmacol 43:31-8. 2004
    ....
  26. ncbi request reprint Photodynamic therapy for airway stenosis in rabbit models
    Yoshinori Nakagishi
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Chest 133:123-30. 2008
    ..We examined whether endoscope-assisted photodynamic therapy (PDT) is effective for airway stenosis in animal models of which the pathophysiologic progressions are similar to those of clinical cases showing rapid deterioration...
  27. doi request reprint Detection of skin perforators by indocyanine green fluorescence nearly infrared angiography
    Ryuichi Azuma
    Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
    Plast Reconstr Surg 122:1062-7. 2008
  28. ncbi request reprint A novel method to prevent secondary exposure of medical and rescue personnel to toxic materials under biochemical hazard conditions using microwave radar and infrared thermography
    Takemi Matsui
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, Japan
    IEEE Trans Biomed Eng 51:2184-8. 2004
    ..A toxic condition was induced by intravenous administration of lipopolysaccharide (LPS) in rabbits. The exposure to LPS was determined by linear discriminant analysis using non-contact derived variables...
  29. ncbi request reprint Accumulation of photofrin in lesions of airway stenosis rabbit models
    Yoshinori Nakagishi
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
    Photochem Photobiol 83:1220-5. 2007
    ..Photofrin preferentially accumulated in the lesion of airway stenosis. A preliminary experiment on PDT using transtracheal illumination showed an amelioration of airway stenosis, resulting in reduction in respiratory stridor...
  30. doi request reprint Light-scattering signal may indicate critical time zone to rescue brain tissue after hypoxia
    Satoko Kawauchi
    National Defense Medical College, Department of Medical Engineering, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Opt 16:027002. 2011
    ..The results demonstrate that light scattering signal can be an indicator of brain tissue reversibility...
  31. ncbi request reprint Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularization
    Masayuki Ishihara
    National Defense Medical College, Research Institute, Division of Biomedical Engineering, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res A 64:551-9. 2003
    ..These results indicate that the controlled release of biologically active FGF-1 and FGF-2 with heparin is caused by biodegradation of the chitosan hydrogel, and subsequent induction of vascularization...
  32. ncbi request reprint Simultaneous measurement of changes in light absorption due to the reduction of cytochrome c oxidase and light scattering in rat brains during loss of tissue viability
    Satoko Kawauchi
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Appl Opt 47:4164-76. 2008
    ..These findings suggest that the simultaneous measurement of absorption signals related to the redox changes in the CcO and the scattering signal is useful for monitoring tissue viability in the brain...
  33. doi request reprint Enhancement of ultrasonic thrombus imaging using novel liposomal bubbles targeting activated platelet glycoprotein IIb/IIIa complex--in vitro and in vivo study
    Kohsuke Hagisawa
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Int J Cardiol 152:202-6. 2011
    ..The aim of this study was to examine the enhancing effects in ultrasonic thrombus imaging using these targeted BL in vitro and in vivo...
  34. ncbi request reprint Correlation between oxygen consumption and photobleaching during in vitro photodynamic treatment with ATX-S10.Na(II) using pulsed light excitation: dependence of pulse repetition rate and irradiation time
    Satoko Kawauchi
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8913, Japan
    Photochem Photobiol 80:216-23. 2004
    ..We presumed that the change in the reaction mechanism was associated with the local concentrations of the photosensitizer and oxygen in cells during irradiation...
  35. doi request reprint Deficiency of interleukin-1 receptor antagonist promotes spontaneous femoral artery aneurysm formation in mice
    Kikuo Isoda
    Department of Internal Medicine 1, National Defense Medical College, Tokorozawa, Japan
    Am J Pathol 180:1254-63. 2012
    ..We believe that these mice will provide much information about the natural history and management of FAAs...
  36. ncbi request reprint An atelocollagen honeycomb-shaped scaffold with a membrane seal (ACHMS-scaffold) for the culture of annulus fibrosus cells from an intervertebral disc
    Masato Sato
    Department of Orthopaedic Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Biomed Mater Res A 64:248-56. 2003
    ..These results indicate that the AF cells are able to grow and remain phenotypically stable in the scaffold...
  37. ncbi request reprint Novel lymphography using indocyanine green dye for near-infrared fluorescence labeling
    Fusa Ogata
    Department of Medical Engineering, National Defense Medical College, Tokorozawa, Japan
    Ann Plast Surg 58:652-5. 2007
    ..These results suggest that this imaging technique is acceptable as an evaluation method for the lymphatic system...
  38. ncbi request reprint A novel ferromagnetic thermo-stent for plaque stabilization that self-regulates the temperature
    Takemi Matsui
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Japan
    IEEE Trans Biomed Eng 49:621-3. 2002
    ..Stent implants of this type in human blood vessels could potentially enable thermotherapy and temperature determination without catheterization...
  39. ncbi request reprint Long-term effects of UV light on contractility of rat arteries in vivo
    Yuji Morimoto
    Department of Medical Engineering, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
    Photochem Photobiol 78:372-6. 2003
    ..Acetylcholine-induced relaxations were not altered by UV treatment. These results suggest that the long-term effect of UV light is an attenuation of smooth muscle contractility without impairment of endothelial function...
  40. ncbi request reprint Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopy
    Naoko Fujioka
    Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Cancer Detect Prev 28:32-6. 2004
    ..6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer...
  41. ncbi request reprint Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury model
    Shinya Kohyama
    Department of Radiology, National Defense Medical College, Saitama, Japan 359 8513
    Lasers Surg Med 39:659-66. 2007
    ..We assessed the effects of NBUVB irradiation for prevention of intimal hyperplasia...
  42. ncbi request reprint Preliminary study of laser welding for aortic dissection in a porcine model using a diode laser with indocyanine green
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Japan
    Lasers Surg Med 32:341-5. 2003
    ..The objective of this study was to determine whether a dissected aorta could be welded by a diode laser with a solder using an in vitro porcine aortic dissection model...
  43. ncbi request reprint Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing process
    Masayuki Ishihara
    Research Institute, National Defense Medical College, Saitama, Japan
    Biomaterials 23:833-40. 2002
    ..The chitosan hydrogel due to its accelerating healing ability is considered to become an excellent dressing for wound occlusion and tissue adhesive in urgent hemostasis situations...
  44. ncbi request reprint Photodynamic therapy with PAD-S31, a new hydrophilic chlorin photosensitizer, in an orthotopic rat bladder tumor model
    Hiroshi Asanuma
    Department of Urology, School of Medicine, Faculty of Science and Technology, Keio University, Tokyo, Japan
    J Urol 174:2016-21. 2005
    ..Using an orthotopic rat bladder tumor model we investigated the biodistribution of PAD-S31 and assessed the antitumor effects of photodynamic therapy (PDT) with PAD-S31...
  45. ncbi request reprint Endovascular treatment using low-power ultraviolet laser for delayed vasospasm in the rabbit carotid artery model
    Kanji Nakai
    Department of Radiology, University of Rochester Medical Center, Rochester, NY, USA
    AJNR Am J Neuroradiol 23:1725-31. 2002
    ..The purpose of this study was to investigate the preventive effect of endovascular UV light on vasospasm after blood immersion by using the same animal model...
  46. ncbi request reprint Myocardium tissue ablation with high-peak-power nanosecond 1,064- and 532-nm pulsed lasers: influence of laser-induced plasma
    Makoto Ogura
    Department of Electronics and Electrical Engineering, Keio University, 3 14 1, Hiyoshi, Kohoku Ku, Yokohama shi 223 8522, Japan
    Lasers Surg Med 31:136-41. 2002
    ..0 GW/cm(2). Particular attention was paid to study the influence of the laser-induced plasma on the ablation characteristics. The applicability of these two lasers to transmyocardial laser revascularization (TMLR) was discussed...
  47. ncbi request reprint Measurement of the surface temperature of the cornea during ArF excimer laser ablation by thermal radiometry with a 15-nanosecond time response
    Miya Ishihara
    Department of Medical Engineering, National Defense Medical College, Saitama, Japan
    Lasers Surg Med 30:54-9. 2002
    ..The purpose of this work was to develop a temperature measurement system with a nanosecond time response to monitor the transient temperature of the corneal surface during laser refractive surgery...
  48. ncbi request reprint Assessment of expressions of heat shock protein (HSP 72) and apoptosis after ArF excimer laser ablation of the cornea
    Miya Ishihara
    Department of Medical Engineering, National Defense Medical College, Saitama, Japan
    J Biomed Opt 9:187-92. 2004
    ..HSP 72 and apoptosis could be seen up to a few hundred micrometers into the stroma, only at a fluence with an optical breakdown emission. This could have been caused by shock waves induced by the optical breakdown...
  49. ncbi request reprint Sonodynamic therapy decreased neointimal hyperplasia after stenting in the rabbit iliac artery
    Koh Arakawa
    Internal Medicine I, National Defense Medical College, Saitama, Japan
    Circulation 105:149-51. 2002
    ..PAD-S31 is known to be a water-soluble, chlorin-derivative sonochemical sensitizer. We assessed the efficacy of sonodynamic therapy using this sensitizer on neointimal hyperplasia in a rabbit stent model...
  50. ncbi request reprint Intracellular kinetics of ATX-S10.Na(II) and its correlation with photochemical reaction dynamics during a pulsed photosensitization process: effect of pulse repetition rate
    Satoko Kawauchi
    National Defense Medical College, Department of Medical Engineering, Saitama, Japan
    J Biomed Opt 11:014005. 2006
    ..The pulse frequency-dependent intracellular kinetics of the sensitizer also explains our previous results showing higher cytotoxicity at 5 Hz than at 10 and 30 Hz...
  51. ncbi request reprint Rabbit model of airway stenosis induced by scraping of the tracheal mucosa
    Yoshinori Nakagishi
    Department of Medical Engineering, National Defense Medical College, Saitama, Japan
    Laryngoscope 115:1087-92. 2005
    ..Prolonged endotracheal intubation in children often induces intractable airway stenosis. The aim of the present study was to establish a new model of airway stenosis for developing an effective method of treatment...
  52. ncbi request reprint Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacy
    Woo Dong Jang
    Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Angew Chem Int Ed Engl 44:419-23. 2005
  53. ncbi request reprint Polyion complex micelles for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating property
    Woo Dong Jang
    Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    J Control Release 113:73-9. 2006
    ....
  54. ncbi request reprint Noncontact vital sign monitoring system for isolation unit (casualty care system)
    Takemi Matsui
    Department of Management Systems Engineering, Tokyo Metropolitan University, 6 6, Asahigaoka, Tokyo, Japan
    Mil Med 171:639-43. 2006
    ..7 degrees C and 36.2 +/- 0.4 degrees C, respectively. The results show that our system is promising for future prehospital application in determining casualty conditions for fluid infusions by the Casualty Care System intravenous lines...
  55. ncbi request reprint Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia model
    Masanori Fujita
    Department of Medical Engineering, National Defense Medical College, Saitama, Japan
    Wound Repair Regen 15:58-65. 2007
    ..These results indicate that the controlled release of biologically active FGF-2 molecules from FGF-2/CH-LA/IO4-heparin induces angiogenesis and possibly collateral circulation in db/db mice and the ischemic limbs of rats...
  56. ncbi request reprint Effects of growth factors on heparin-carrying polystyrene-coated atelocollagen scaffold for articular cartilage tissue engineering
    Masato Sato
    Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    J Biomed Mater Res B Appl Biomater 83:181-8. 2007
    ..These results suggest that an ACHMS-scaffold immobilized with HCPS can be a HpECM for cartilage regeneration to retain the heparin-binding growth factors within the scaffolds...
  57. ncbi request reprint Osteogenic potential of human adipose tissue-derived stromal cells as an alternative stem cell source
    Hidemi Hattori
    Division of Biomedical Engineering, Research Institute, National Defense Medical College, Saitama, Japan
    Cells Tissues Organs 178:2-12. 2004
    ..Furthermore, osteoblastic lining in vivo was examined using ATSC-seeded or BMSC-seeded scaffolds in nude mice. The present results show that ATSCs have a similar ability to differentiate into osteoblasts to that of BMSCs...
  58. ncbi request reprint Successful diagnosis of orthotopic rat superficial bladder tumor model by ultrathin cystoscopy
    Hiroshi Asanuma
    Department of Urology, School of Medicine, Faculty of Science and Technology, Keio University, Tokyo, Japan
    J Urol 169:718-20. 2003
    ..To our knowledge we present the first diagnosis of orthotopic rat superficial bladder tumor model by ultrathin cystoscopy...
  59. ncbi request reprint Adsorption of inflammatory cytokines using a heparin-coated extracorporeal circuit
    Masanori Fujita
    Department of Surgery II, National Defense Medical College, Tokorzawa, Saitama, Japan
    Artif Organs 26:1020-5. 2002
    ..Therefore, the adsorption of inflammatory cytokines, especially TNF-alpha, onto the inner heparin-coated surface of an extracorporeal circuit may partly account for a reduction in inflammatory responses...
  60. ncbi request reprint Facial pattern categories of sleep breathing-disordered children using Ricketts analysis
    Makoto Kikuchi
    Cosmos Orthodontic Office, Narita, Chiba, Japan
    Psychiatry Clin Neurosci 56:329-30. 2002
    ..The facial pattern of children with sleep breathing disorders was discovered to be the dolico facial pattern...
  61. ncbi request reprint Intravesical ultrasonography for tumor staging in an orthotopically implanted rat model of bladder cancer
    Hiroyuki Satoh
    Department of Urology, School of Medicine, Faculty of Science and Technology, Keio University, Tokyo, Japan
    J Urol 177:1169-73. 2007
    ..However, to our knowledge a reliable method has not been established. We determined the usefulness of intravesical ultrasonography for tumor staging and volumetric assessment in an animal model...
  62. ncbi request reprint Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde
    Hidekazu Fujimaki
    National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2, Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 197:1-13. 2004
    ..These results provide the first experimental evidence that low levels of long-term formaldehyde inhalation can induce differential immunogenic and neurogenic responses in allergic mice...