Research Topics
| Makoto KikuchiSummaryAffiliation: National Defense Medical College Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Biomedical engineering's contribution to defending the homelandMakoto Kikuchi
National Defense Medical College Research Institute (NDMCRI, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
IEEE Eng Med Biol Mag 23:175-86. 2004- Simultaneous measurement of changes in light absorption due to the reduction of cytochrome c oxidase and light scattering in rat brains during loss of tissue viabilitySatoko Kawauchi
Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
Appl Opt 47:4164-76. 2008..These findings suggest that the simultaneous measurement of absorption signals related to the redox changes in the CcO and the scattering signal is useful for monitoring tissue viability in the brain... - Development of a diagnostic system for osteoarthritis using a photoacoustic measurement methodMiya Ishihara
Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
Lasers Surg Med 38:249-55. 2006..The purpose of this study was to develop a practical photoacoustic measurement system for diagnosis of osteoarthritis (OA) by viscoelastic characterization of articular cartilage... - Controlled release of paclitaxel from photocrosslinked chitosan hydrogels and its subsequent effect on subcutaneous tumor growth in miceKiyohaya Obara
Department of Surgery II, National Defense Medical College, Tokorozawa, Saitama, Japan
J Control Release 110:79-89. 2005..These results suggested that application of paclitaxel-incorporated Az-CH-LA hydrogel has an inhibitory activity on angiogenesis and tumor growth... - Photodynamic therapy with PAD-S31, a new hydrophilic chlorin photosensitizer, in an orthotopic rat bladder tumor modelHiroshi Asanuma
Department of Urology, School of Medicine, Faculty of Science and Technology, Keio University, Tokyo, Japan
J Urol 174:2016-21. 2005..These experimental results suggest that this therapy could be a clinically promising method for the treatment of patients with bladder cancer... - Usefulness of photoacoustic measurements for evaluation of biomechanical properties of tissue-engineered cartilageMiya Ishihara
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
Tissue Eng 11:1234-43. 2005..To our knowledge, this is the first report on noninvasive and time-dependent viscoelastic evaluation of engineered tissue for determining functions of engineered tissues... - Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold)Kazunori Masuoka
Department of Orthopaedic Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
J Biomed Mater Res B Appl Biomater 75:177-84. 2005..These results indicate that implantation of allogenic chondrocytes cultured in ACHMS scaffolds may be effective in repairing articular cartilage defects... - Rabbit model of airway stenosis induced by scraping of the tracheal mucosaYoshinori Nakagishi
Department of Medical Engineering, National Defense Medical College, Saitama, Japan
Laryngoscope 115:1087-92. 2005..Prolonged endotracheal intubation in children often induces intractable airway stenosis. The aim of the present study was to establish a new model of airway stenosis for developing an effective method of treatment... - Efficacy of photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 in a rabbit model of chronic myocardial infarctionMasanori Fujita
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
J Surg Res 126:27-33. 2005..However, no effective delivery system for growth factor administration is yet known to induce important therapeutic angiogenic responses in ischemic myocardium... - A real time non-invasive monitoring system for detection of hypovolemic state using RR interval variability in very low frequency rangesTakemi Matsui
National Defense Medical College, 3 2 Namiki, 359 8513 Tokorozawa, Japan
Biomed Pharmacother 58:S28-30. 2004..5 +/- 1.2 degrees centigrade (p < 0.05) within 1 hour after blood withdrawal. Our monitoring system appears promising for the detection of hypovolemic state resulting from massive hemorrhage using a one-channel ECG monitor... - Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with polyethylene glycol to enhance intracellular photodynamic efficacyWoo-Dong Jang
Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
Angew Chem Int Ed Engl 44:419-23. 2005 - Intracellular kinetics of ATX-S10.Na(II) and its correlation with photochemical reaction dynamics during a pulsed photosensitization process: effect of pulse repetition rateSatoko Kawauchi
National Defense Medical College, Department of Medical Engineering, Saitama, Japan
J Biomed Opt 11:014005. 2006..The pulse frequency-dependent intracellular kinetics of the sensitizer also explains our previous results showing higher cytotoxicity at 5 Hz than at 10 and 30 Hz... - Medium (DMEM/F12)-containing chitosan hydrogel as adhesive and dressing in autologous skin grafts and accelerator in the healing processTetsuro Kiyozumi
Department of Traumatology and Critical Care Medicine, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
J Biomed Mater Res B Appl Biomater 79:129-36. 2006..Therefore, the medium (DMEM/F12)-containing chitosan hydrogel may become commonly accepted as a beneficial wound dressing and tissue adhesive in extensive wound management and skin grafts... - Chitosan hydrogel as a drug delivery carrier to control angiogenesisMasayuki Ishihara
Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, 359 8513, Japan
J Artif Organs 9:8-16. 2006..g., FGF-2 and paclitaxel) to control angiogenesis. It is thus proposed that chitosan hydrogel may be a promising new local carrier for drugs such as FGF-2 and paclitaxel to control vascularization... - Photodynamic therapy for airway stenosis in rabbit modelsYoshinori Nakagishi
Department of Medical Engineering, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
Chest 133:123-30. 2008..We examined whether endoscope-assisted photodynamic therapy (PDT) is effective for airway stenosis in animal models of which the pathophysiologic progressions are similar to those of clinical cases showing rapid deterioration... - Effectiveness of narrow-band ultraviolet-B phototherapy for prevention of intimal hyperplasia in a rat carotid balloon injury modelShinya Kohyama
Department of Radiology, National Defense Medical College, Saitama, Japan 359 8513
Lasers Surg Med 39:659-66. 2007..We assessed the effects of NBUVB irradiation for prevention of intimal hyperplasia... - Accumulation of photofrin in lesions of airway stenosis rabbit modelsYoshinori Nakagishi
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama, Japan
Photochem Photobiol 83:1220-5. 2007..Photofrin preferentially accumulated in the lesion of airway stenosis. A preliminary experiment on PDT using transtracheal illumination showed an amelioration of airway stenosis, resulting in reduction in respiratory stridor... - Detection of skin perforators by indocyanine green fluorescence nearly infrared angiographyRyuichi Azuma
Department of Plastic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
Plast Reconstr Surg 122:1062-7. 2008 - The effect of chitosan hydrogel containing DMEM/F12 medium on full-thickness skin defects after deep dermal burnTetsuro Kiyozumi
Department of Traumatology and Critical Care Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
Burns 33:642-8. 2007..These findings suggest that early degradative and angiogenic activities of medium-Az-CH-LA may be beneficial for granulation tissue formation in deep dermal burn wounds... - Effects of growth factors on heparin-carrying polystyrene-coated atelocollagen scaffold for articular cartilage tissue engineeringMasato Sato
Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
J Biomed Mater Res B Appl Biomater 83:181-8. 2007..These results suggest that an ACHMS-scaffold immobilized with HCPS can be a HpECM for cartilage regeneration to retain the heparin-binding growth factors within the scaffolds... - Therapeutic angiogenesis induced by controlled release of fibroblast growth factor-2 from injectable chitosan/non-anticoagulant heparin hydrogel in a rat hindlimb ischemia modelMasanori Fujita
Department of Medical Engineering, National Defense Medical College, Saitama, Japan
Wound Repair Regen 15:58-65. 2007..These results indicate that the controlled release of biologically active FGF-2 molecules from FGF-2/CH-LA/IO4-heparin induces angiogenesis and possibly collateral circulation in db/db mice and the ischemic limbs of rats... - Controlled releases of FGF-2 and paclitaxel from chitosan hydrogels and their subsequent effects on wound repair, angiogenesis, and tumor growthMasayuki Ishihara
Research Institute, National Defense Medical Collage, Tokorozawa, Saitama 359 8513, Japan
Curr Drug Deliv 3:351-8. 2006..It is thus proposed that the chitosan hydrogels may be a promising new local carrier for drugs such as FGF-2 and paclitaxel... - Noncontact vital sign monitoring system for isolation unit (casualty care system)Takemi Matsui
Department of Management Systems Engineering, Tokyo Metropolitan University, 6 6, Asahigaoka, Tokyo, Japan
Mil Med 171:639-43. 2006..7 degrees C and 36.2 +/- 0.4 degrees C, respectively. The results show that our system is promising for future prehospital application in determining casualty conditions for fluid infusions by the Casualty Care System intravenous lines... - Polyion complex micelles for photodynamic therapy: incorporation of dendritic photosensitizer excitable at long wavelength relevant to improved tissue-penetrating propertyWoo-Dong Jang
Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
J Control Release 113:73-9. 2006.... - A novel method to prevent secondary exposure of medical and rescue personnel to toxic materials under biochemical hazard conditions using microwave radar and infrared thermographyTakemi Matsui
Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3 2 Namiki, Tokorozawa, Japan
IEEE Trans Biomed Eng 51:2184-8. 2004..A toxic condition was induced by intravenous administration of lipopolysaccharide (LPS) in rabbits. The exposure to LPS was determined by linear discriminant analysis using non-contact derived variables... - An experimental study of the regeneration of the intervertebral disc with an allograft of cultured annulus fibrosus cells using a tissue-engineering methodMasato Sato
Department of Orthopaedic Surgery, National Defense Medical College, Tokorozawa, Saitama, Japan
Spine (Phila Pa 1976) 28:548-53. 2003..Regeneration of the intervertebral disc was assessed based on the viability and histologic status of the allografted annulus fibrosus cells, as well as the prevention of narrowing disc space... - Myocardium tissue ablation with high-peak-power nanosecond 1,064- and 532-nm pulsed lasers: influence of laser-induced plasmaMakoto Ogura
Department of Electronics and Electrical Engineering, Keio University, 3 14 1, Hiyoshi, Kohoku Ku, Yokohama shi 223 8522, Japan
Lasers Surg Med 31:136-41. 2002..0 GW/cm(2). Particular attention was paid to study the influence of the laser-induced plasma on the ablation characteristics. The applicability of these two lasers to transmyocardial laser revascularization (TMLR) was discussed... - Controlled release of fibroblast growth factors and heparin from photocrosslinked chitosan hydrogels and subsequent effect on in vivo vascularizationMasayuki Ishihara
National Defense Medical College, Research Institute, Division of Biomedical Engineering, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
J Biomed Mater Res A 64:551-9. 2003..These results indicate that the controlled release of biologically active FGF-1 and FGF-2 with heparin is caused by biodegradation of the chitosan hydrogel, and subsequent induction of vascularization... - A novel ferromagnetic thermo-stent for plaque stabilization that self-regulates the temperatureTakemi Matsui
Division of Biomedical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Japan
IEEE Trans Biomed Eng 49:621-3. 2002..Stent implants of this type in human blood vessels could potentially enable thermotherapy and temperature determination without catheterization... - Preliminary study of laser welding for aortic dissection in a porcine model using a diode laser with indocyanine greenMasanori Fujita
Department of Medical Engineering, National Defense Medical College, Japan
Lasers Surg Med 32:341-5. 2003..The objective of this study was to determine whether a dissected aorta could be welded by a diode laser with a solder using an in vitro porcine aortic dissection model... - Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db miceKiyohaya Obara
Department of Surgery II, National Defence Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
Biomaterials 24:3437-44. 2003..Histological examination also has demonstrated an advanced granulation tissue formation, capillary formation and epithelialization in wounds treated with FGF-2-incorporated chitosan hydrogels in db/db mice... - Vascularization in vivo caused by the controlled release of fibroblast growth factor-2 from an injectable chitosan/non-anticoagulant heparin hydrogelMasanori Fujita
Department of Surgery II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
Biomaterials 25:699-706. 2004..These results indicate that the controlled release of biologically active FGF-2 molecules is caused by biodegradation of the hydrogel, and that subsequent induction of the vascularization occurs... - Long-term effects of UV light on contractility of rat arteries in vivoYuji Morimoto
Department of Medical Engineering, National Defense Medical College, Namiki 3 2, Tokorozawa, Saitama 359 8513, Japan
Photochem Photobiol 78:372-6. 2003..Acetylcholine-induced relaxations were not altered by UV treatment. These results suggest that the long-term effect of UV light is an attenuation of smooth muscle contractility without impairment of endothelial function... - Measurement of the surface temperature of the cornea during ArF excimer laser ablation by thermal radiometry with a 15-nanosecond time responseMiya Ishihara
Department of Medical Engineering, National Defense Medical College, Saitama, Japan
Lasers Surg Med 30:54-9. 2002..The purpose of this work was to develop a temperature measurement system with a nanosecond time response to monitor the transient temperature of the corneal surface during laser refractive surgery... - Assessment of expressions of heat shock protein (HSP 72) and apoptosis after ArF excimer laser ablation of the corneaMiya Ishihara
Department of Medical Engineering, National Defense Medical College, Saitama, Japan
J Biomed Opt 9:187-92. 2004..HSP 72 and apoptosis could be seen up to a few hundred micrometers into the stroma, only at a fluence with an optical breakdown emission. This could have been caused by shock waves induced by the optical breakdown... - Usefulness of photocrosslinkable chitosan for endoscopic cancer treatment in alimentary tractTakuya Hayashi
Division of Environmental Medicine, National Defense Medical College Research Institute, Tokorozawa, Saitama, Japan
J Biomed Mater Res B Appl Biomater 71:367-72. 2004..Thus, the photocrosslinkable chitosan developed holds promise for use in EMR as a submucosal injection agent that avoids complications... - Inhibition of vascular prosthetic graft infection using a photocrosslinkable chitosan hydrogelMasanori Fujita
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8513, Japan
J Surg Res 121:135-40. 2004..coli). The antibacterial activity by adhering a photocrosslinkable chitosan hydrogel to Dacron grafts was investigated in vitro and in vivo using a rabbit model... - Correlation between oxygen consumption and photobleaching during in vitro photodynamic treatment with ATX-S10.Na(II) using pulsed light excitation: dependence of pulse repetition rate and irradiation timeSatoko Kawauchi
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Saitama 359 8913, Japan
Photochem Photobiol 80:216-23. 2004..We presumed that the change in the reaction mechanism was associated with the local concentrations of the photosensitizer and oxygen in cells during irradiation... - Photocrosslinkable chitosan as a dressing for wound occlusion and accelerator in healing processMasayuki Ishihara
Research Institute, National Defense Medical College, Saitama, Japan
Biomaterials 23:833-40. 2002..The chitosan hydrogel due to its accelerating healing ability is considered to become an excellent dressing for wound occlusion and tissue adhesive in urgent hemostasis situations... - A new rabbit model of myocardial infarction without endotracheal intubationMasanori Fujita
Department of Medical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Saitama, Japan
J Surg Res 116:124-8. 2004..However, it is difficult to carry out endotracheal intubation due to the rabbit anatomy. We therefore attempted to develop a myocardial infarction model in rabbits without endotracheal intubation... - Sonodynamic therapy decreased neointimal hyperplasia after stenting in the rabbit iliac arteryKoh Arakawa
Internal Medicine I, National Defense Medical College, Saitama, Japan
Circulation 105:149-51. 2002..PAD-S31 is known to be a water-soluble, chlorin-derivative sonochemical sensitizer. We assessed the efficacy of sonodynamic therapy using this sensitizer on neointimal hyperplasia in a rabbit stent model... - Endovascular treatment using low-power ultraviolet laser for delayed vasospasm in the rabbit carotid artery modelKanji Nakai
Department of Radiology, University of Rochester Medical Center, Rochester, NY, USA
AJNR Am J Neuroradiol 23:1725-31. 2002..001). CONCLUSION: These results suggest that endovascular UV irradiation after blood exposure has a prophylactic effect on vasospasm and suggest a dependence on irradiation wavelength and duration of irradiation... 
Liposome-encapsulated hemoglobin transfusion rescues rats undergoing progressive hemodilution from lethal organ hypoxia without scavenging nitric oxideYashiro Nogami
Department of Surgery, National Defense Medical College Research Institute, Tokorozawa, Japan
Ann Surg 248:310-9. 2008..To investigate the efficacy of liposome-encapsulated hemoglobin (LHb) transfusion in rats undergoing lethal progressive hemodilution...- Facial pattern categories of sleep breathing-disordered children using Ricketts analysisMakoto Kikuchi
Cosmos Orthodontic Office, Narita, Chiba, Japan
Psychiatry Clin Neurosci 56:329-30. 2002..The facial pattern of children with sleep breathing disorders was discovered to be the dolico facial pattern... - Intravesical ultrasonography for tumor staging in an orthotopically implanted rat model of bladder cancerHiroyuki Satoh
Department of Urology, School of Medicine, Faculty of Science and Technology, Keio University, Tokyo, Japan
J Urol 177:1169-73. 2007..However, to our knowledge a reliable method has not been established. We determined the usefulness of intravesical ultrasonography for tumor staging and volumetric assessment in an animal model... - Adsorption of inflammatory cytokines using a heparin-coated extracorporeal circuitMasanori Fujita
Department of Surgery II, National Defense Medical College, Tokorzawa, Saitama, Japan
Artif Organs 26:1020-5. 2002..Therefore, the adsorption of inflammatory cytokines, especially TNF-alpha, onto the inner heparin-coated surface of an extracorporeal circuit may partly account for a reduction in inflammatory responses... - An atelocollagen honeycomb-shaped scaffold with a membrane seal (ACHMS-scaffold) for the culture of annulus fibrosus cells from an intervertebral discMasato Sato
Department of Orthopaedic Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
J Biomed Mater Res A 64:248-56. 2003..These results indicate that the AF cells are able to grow and remain phenotypically stable in the scaffold... - Successful diagnosis of orthotopic rat superficial bladder tumor model by ultrathin cystoscopyHiroshi Asanuma
Department of Urology, School of Medicine, Faculty of Science and Technology, Keio University, Tokyo, Japan
J Urol 169:718-20. 2003..CONCLUSIONS: The orthotopic rat superficial bladder tumor model and the diagnostic procedure by ultrathin cystoscopy would be ideal system for preclinical evaluation of new potential intravesical therapies... - Osteogenic potential of human adipose tissue-derived stromal cells as an alternative stem cell sourceHidemi Hattori
Division of Biomedical Engineering, Research Institute, National Defense Medical College, Saitama, Japan
Cells Tissues Organs 178:2-12. 2004..Furthermore, osteoblastic lining in vivo was examined using ATSC-seeded or BMSC-seeded scaffolds in nude mice. The present results show that ATSCs have a similar ability to differentiate into osteoblasts to that of BMSCs... - Inhibition of neointimal proliferation in balloon-injured arteries using non-anticoagulant heparin-carrying polystyreneMasanori Fujita
Department of Medical Engineering, Morimoto, National Defense Medical College, Tokorozawa, Saitazma, Japan
J Cardiovasc Pharmacol 43:31-8. 2004.... - Bone formation using human adipose tissue-derived stromal cells and a biodegradable scaffoldHidemi Hattori
Division of Biomedical Engineering, Research Institute, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
J Biomed Mater Res B Appl Biomater 76:230-9. 2006..The present results show that ATSCs have a similar ability to differentiate into osteoblasts and to synthesize bone in beta-TCP disk as have BMSCs... - Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehydeHidekazu Fujimaki
National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2, Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicology 197:1-13. 2004..These results provide the first experimental evidence that low levels of long-term formaldehyde inhalation can induce differential immunogenic and neurogenic responses in allergic mice... - Discrimination between normal and malignant human gastric tissues by Fourier transform infrared spectroscopyNaoko Fujioka
Department of Medical Engineering, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan
Cancer Detect Prev 28:32-6. 2004..6% accuracy. The present results suggest that FTIR spectroscopy is a useful tool for screening gastric cancer... - Novel lymphography using indocyanine green dye for near-infrared fluorescence labelingFusa Ogata
Department of Medical Engineering, National Defense Medical College, Tokorozawa, Japan
Ann Plast Surg 58:652-5. 2007..These results suggest that this imaging technique is acceptable as an evaluation method for the lymphatic system...