Toru Kawada

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. Kawada T, Sonobe T, Hayama Y, Nishikawa T, Miyamoto T, Akiyama T, et al. Accentuated antagonism of vagal heart rate control and less potent prejunctional inhibition of vagal acetylcholine release during sympathetic nerve stimulation in the rat. Auton Neurosci. 2019;218:25-30 pubmed publisher
    ..30 ± 0.72 vs. 3.80 ± 0.75 nM, P < 0.01, a 12% attenuation). In conclusion, SNS exerted only a moderate inhibitory effect on the VNS-induced myocardial interstitial ACh release in the in vivo beating heart. ..
  2. Kawada T, Hayama Y, Nishikawa T, Yamamoto H, Tanaka K, Sugimachi M. Even weak vasoconstriction from rilmenidine can be unmasked in vivo by opening the baroreflex feedback loop. Life Sci. 2019;219:144-151 pubmed publisher
  3. Kawada T, Akiyama T, Sonobe T, Shimizu S, Hayama Y, Pearson J, et al. Central activation of cardiac vagal nerve by α2-adrenergic stimulation is impaired in streptozotocin-induced type 1 diabetic rats. Auton Neurosci. 2019;216:39-45 pubmed publisher
    ..The impairment of central vagal activation may lead to relative sympathetic predominance and promote cardiovascular complications in diabetes. ..
  4. Kawada T, Shimizu S, Uemura K, Hayama Y, Yamamoto H, Shishido T, et al. Ivabradine preserves dynamic sympathetic control of heart rate despite inducing significant bradycardia in rats. J Physiol Sci. 2019;69:211-222 pubmed publisher
    ..Preserved dynamic sympathetic control of HR, with coexisting bradycardia, may contribute to some of the beneficial effects of ivabradine previously reported in clinical application. ..
  5. Kawada T, Sata Y, Shimizu S, Turner M, Fukumitsu M, Sugimachi M. Effects of tempol on baroreflex neural arc versus peripheral arc in normotensive and spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2015;308:R957-64 pubmed publisher
    ..The effect of modulating oxidative redox signaling on the peripheral arc contributed to the determination of AP in SHR but not in WKY. ..
  6. Kawada T, Sugimachi M. Open-loop static and dynamic characteristics of the arterial baroreflex system in rabbits and rats. J Physiol Sci. 2016;66:15-41 pubmed publisher
    ..Quantitative understanding of the arterial baroreflex function under diseased conditions would help develop new treatment strategies such as electrical activation of the carotid sinus baroreflex for drug-resistant hypertension. ..
  7. Kawada T, Shimizu S, Turner M, Fukumitsu M, Yamamoto H, Sugimachi M. Systematic understanding of acute effects of intravenous guanfacine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation. Life Sci. 2016;149:72-8 pubmed publisher
    ..Reducing the dose of acutely administered intravenous guanfacine does not aid in separating the central sympathoinhibitory effect from the peripheral vasoconstrictive effect on AP in anesthetized rats in vivo. ..
  8. Kawada T, Akiyama T, Li M, Zheng C, Turner M, Shirai M, et al. Acute arterial baroreflex-mediated changes in plasma catecholamine concentrations in a chronic rat model of myocardial infarction. Physiol Rep. 2016;4: pubmed publisher
  9. Kawada T, Akiyama T, Shimizu S, Fukumitsu M, Kamiya A, Sugimachi M. Desipramine increases cardiac parasympathetic activity via α2-adrenergic mechanism in rats. Auton Neurosci. 2017;205:21-25 pubmed publisher

More Information

Publications14

  1. Kawada T, Turner M, Shimizu S, Fukumitsu M, Kamiya A, Sugimachi M. Aortic depressor nerve stimulation does not impede the dynamic characteristics of the carotid sinus baroreflex in normotensive or spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol. 2017;312:R787-R796 pubmed publisher
    ..542; and 17.37 ± 1.01 vs. 17.47 ± 1.64 dB/decade in SHR, P = 0.946). These results indicate that the tonic ADN stimulation does not significantly modify the dynamic characteristics of the carotid sinus baroreflex. ..
  2. Kawada T, Shimizu S, Yamamoto H, Miyamoto T, Kamiya A, Shishido T, et al. Effects of different input pressure waveforms on the carotid sinus baroreflex-mediated sympathetic arterial pressure response in rats. J Appl Physiol (1985). 2017;123:914-921 pubmed publisher
    ..The finding could be applied to designing an artificial pulsatile pressure such as that generated by left ventricular assist devices. ..
  3. Kawada T, Shimizu S, Yamamoto H, Miyamoto T, Shishido T, Sugimachi M. Peripheral versus central effect of intravenous moxonidine on rat carotid sinus baroreflex-mediated sympathetic arterial pressure regulation. Life Sci. 2017;190:103-109 pubmed publisher
    ..The present study aimed to quantify a peripheral effect of moxonidine on carotid sinus baroreflex-mediated sympathetic arterial pressure (AP) regulation separately from its central effect...
  4. Kawada T, Turner M, Shimizu S, Kamiya A, Shishido T, Sugimachi M. Tonic aortic depressor nerve stimulation does not impede baroreflex dynamic characteristics concomitantly mediated by the stimulated nerve. Am J Physiol Regul Integr Comp Physiol. 2017;:ajpregu.00328.2017 pubmed publisher
    ..Short-term AP regulation by the arterial baroreflex may be preserved during the baroreflex activation therapy...
  5. Uemura K, Kawada T, Zheng C, Li M, Sugimachi M. Computer-controlled closed-loop drug infusion system for automated hemodynamic resuscitation in endotoxin-induced shock. BMC Anesthesiol. 2017;17:145 pubmed publisher
    ..Our system is potentially an attractive clinical tool for rescuing patients with septic shock. ..