M Katoh

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. Katoh Y, Katoh M. Identification and characterization of rat Wnt6 and Wnt10a genes in silico. Int J Mol Med. 2005;15:527-31 pubmed
    ..GATA, FOXA2, and TGIF binding sites were located within the conserved region of rat Wnt6 and human WNT6 promoters. This is the first report on rat Wnt6 and Wnt10a genes as well as on the conserved promoter region of Wnt6 orthologs. ..
  2. Katoh M, Katoh M. Identification and characterization of the human FMN1 gene in silico. Int J Mol Med. 2004;14:121-6 pubmed
    ..1% total amino-acid identity with mouse Fmn1, was found consisting of FMH1, FMH2, FH1 and FH2 domains. This is the first report on the identification and characterization of the human FMN1 gene as well as the FMH1 and FMH2 domains. ..
  3. Katoh M. Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells. Int J Oncol. 2003;22:209-12 pubmed
    ..WNT1 was found to be one of estrogen target genes in human MCF-7 cells, which in part explains Wnt1-induced mammary carcinogenesis in ERalpha knockout mice. ..
  4. Katoh M. Molecular cloning and characterization of OSR1 on human chromosome 2p24. Int J Mol Med. 2002;10:221-5 pubmed
    ..Among 10 cases of primary gastric cancer, OSR1 mRNA was up-regulated in 5 cases, and was down-regulated in 2 cases. This is the first report on molecular cloning and characterization of human OSR1. ..
  5. Katoh M. Molecular cloning, gene structure, and expression analyses of NKD1 and NKD2. Int J Oncol. 2001;19:963-9 pubmed
    ..Up-regulation of NKD1 or NKD2 might be due to a negative feed-back mechanism. Alternatively, genetic alteration of NKD1 or NKD2 might lead to activation of the WNT - beta-catenin - TCF signaling pathway. ..
  6. Katoh M. Molecular cloning and characterization of WRCH2 on human chromosome 15q15. Int J Oncol. 2002;20:977-82 pubmed
    ..Because Wrch1 can activate PAK1 and JNK1, and induce filopodium formation and stress fiber dissolution, over-expression of WRCH2 mRNA in human cancer cells might also lead to more malignant phenotype. ..
  7. Katoh M. Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23. Int J Oncol. 2002;20:1197-203 pubmed
    ..Loss-of-function mutation of STB1 gene might lead to carcinogenesis through activation of the WNT - beta-catenin signaling pathway. ..
  8. Katoh M, Katoh M. Identification and characterization of ASXL2 gene in silico. Int J Oncol. 2003;23:845-50 pubmed
    ..Based on functional conservation and human chromosomal localization, ASXL2 and ASXL1 genes were predicted cancer-associated genes. ..
  9. Katoh M, Katoh M. Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. Int J Oncol. 2003;22:907-13 pubmed
    ..Based on evolutionary and functional conservation of WNT signaling molecules as well as human chromosomal localization, DAPPER1 and DAPPER2 genes are predicted to be potent cancer-associated genes. ..

More Information

Publications59

  1. Katoh M. Molecular cloning and characterization of Strabismus 2 (STB2). Int J Oncol. 2002;20:993-8 pubmed
    ..On the other hand, STB2 mRNA was significantly down-regulated in a pancreatic cancer cell line AsPC-1. This is the first report on molecular cloning and characterization of STB2. ..
  2. Katoh M, Katoh M. Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico. Int J Oncol. 2004;25:765-70 pubmed
    ..Because DFNA5 and MLZE are cancer-associated genes, DFNA5L, GSDM, and GSDML are predicted cancer associated genes. ..
  3. Katoh M, Katoh M. Identification and characterization of rat Ankrd6 gene in silico. Int J Mol Med. 2005;15:359-63 pubmed
    ..Due to the molecular evolution, functions of vertebrate Ankrd6 orthologs were predicted to partially differ from those of Drosophila Dgo. ..
  4. Katoh M. Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper. Biochem Biophys Res Commun. 2001;282:1038-44 pubmed
    ..Although substrates of ubiquitination mediated by RNF26 remain to be elucidated, RNF26 upregulation in several types of human cancer might be implicated in carcinogenesis through dysregulation of its substrates. ..
  5. Katoh Y, Katoh M. Comparative integromics on Angiopoietin family members. Int J Mol Med. 2006;17:1145-9 pubmed
    ..Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signaling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine. ..
  6. Katoh M, Katoh M. KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain. Int J Oncol. 2003;23:145-50 pubmed
    ..0 kb. KIAA1735 gene on human chromosome 11q23.1 was located between D11S1391 and D11S1347 loci, the region deleted in sporadic breast cancer. This is the first report on comprehensive characterization of the KIAA1735 gene. ..
  7. Katoh M, Katoh M. Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26. Int J Mol Med. 2003;11:579-83 pubmed
    ..Therefore, comparative genomics might be applicable to identification of recombination hot spots and genes related to cancer. ..
  8. Katoh M, Katoh M. Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico. Int J Mol Med. 2004;14:747-51 pubmed
  9. Katoh M, Katoh M. Characterization of RUSC1 and RUSC2 genes in silico. Oncol Rep. 2004;12:933-8 pubmed
    ..RUSC1, RUSC2, RIPX, RUFY1, RUFY2, RUTBC1, RUTBC2, RUTBC3, RUB6IP1, and PLEKHM1 were RUN domain proteins within the human proteome. This is the first report on comprehensive characterization of RUSC1 and RUSC2 orthologs. ..
  10. Katoh M. Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. Int J Mol Med. 2002;9:221-7 pubmed
    ..This is the first report on structural comparison of WNT gene clusters in human genome and in mouse genome. ..
  11. Katoh M, Katoh M. Identification and characterization of TMEM24 family genes in silico. Int J Oncol. 2004;25:759-64 pubmed
    ..Human TMEM24, C21orf25 and their mouse homologs were type II transmembrane proteins with extracellular TM24H1 and TM24H2 domains. This is the first report on identification and characterization of the TMEM24 family. ..
  12. Katoh M. Molecular evolution of Wnt2b orthologs. Int J Oncol. 2005;26:1135-9 pubmed
    ..This is the first report on the rat Wnt2b gene as well as on molecular evolution of the Wnt2b orthologs. ..
  13. Katoh M. Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review). Int J Mol Med. 2002;10:683-7 pubmed
    ..The author proposes the threshold model of WNT action. ..
  14. Katoh M, Kirikoshi H, Saitoh T, Sagara N, Koike J. Alternative splicing of the WNT-2B/WNT-13 gene. Biochem Biophys Res Commun. 2000;275:209-16 pubmed
    ..These results indicate that the WNT-2B1 and WNT-2B2 mRNAs are transcribed due to alternative splicing with distinct expression profile. This is the first report on the WNT isoforms derived from the same gene due to alternative splicing. ..
  15. Katoh M. WNT/PCP signaling pathway and human cancer (review). Oncol Rep. 2005;14:1583-8 pubmed
    ..Antibody, RNAi, or small molecule compounds to regulate the function of WNT/PCP signaling molecules mentioned above are good candidates for development as novel cancer therapeutics. ..
  16. Katoh M. WNT2 and human gastrointestinal cancer (review). Int J Mol Med. 2003;12:811-6 pubmed
    ..WNT2 gene is one of the targets for pharmacogenomics in the field of oncology. ..
  17. Katoh M. Differential regulation of WNT2 and WNT2B expression in human cancer. Int J Mol Med. 2001;8:657-60 pubmed
    ..Up-regulation of WNT2 mRNA by estrogen might play a key role in some cases of human breast cancer through activation of the beta-catenin - TCF signaling pathway. ..
  18. Katoh M. Molecular cloning and characterization of human WNT3. Int J Oncol. 2001;19:977-82 pubmed
    ..These results strongly suggest that WNT3 might play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT - beta-catenin - TCF signaling pathway, similar to mouse Wnt-3. ..
  19. Katoh M, Katoh M. NUMB is a break of WNT-Notch signaling cycle. Int J Mol Med. 2006;18:517-21 pubmed
  20. Katoh M, Katoh M. FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26. Int J Oncol. 2003;22:1155-9 pubmed
    ..Tumor suppressor genes closely linked to oncogenes might be excluded from amplicon through a breakage-fusion-bridge process during oncogene amplification. ..
  21. Katoh M, Katoh M. Identification and characterization of rat Ror1 and Ror2 genes in silico. Int J Mol Med. 2005;15:533-8 pubmed
    ..This is the first report on rat Ror1 and Ror2 genes as well as on molecular evolution of Ror1 and Ror2 homologs. ..
  22. Katoh M. Molecular cloning and characterization of human WINS1 and mouse Wins2, homologous to Drosophila segment polarity gene Lines (Lin). Int J Mol Med. 2002;10:155-9 pubmed
    ..8-kb in size was expressed in adult testis, prostate, spleen, thymus, skeletal muscle, fetal kidney and brain. This is the first report on molecular cloning and initial characterization of human WINS1 and mouse Wins2 ..
  23. Katoh M. Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31. Int J Oncol. 2002;20:1247-53 pubmed
  24. Katoh M. Epithelial-mesenchymal transition in gastric cancer (Review). Int J Oncol. 2005;27:1677-83 pubmed
    ..Personalized medicine based on the combination of genetic screening and novel therapeutic agents could dramatically improve the prognosis of gastric cancer patients in the future. ..
  25. Katoh M, Katoh M. Identification and characterization of human FOXK1 gene in silico. Int J Mol Med. 2004;14:127-32 pubmed
    ..At least 42 FOX family genes, including FOXK1, FOXN5 (FOXR1) and FOXN6 (FOXR2), have been identified within the human genome. ..
  26. Katoh M. WNT2B: comparative integromics and clinical applications (Review). Int J Mol Med. 2005;16:1103-8 pubmed
    ..Anti-WNT2B monoclonal antibodies, WNT2B RNAi compounds, or small molecule WNT2B inhibitors could be developed as novel therapeutic agents for gastric cancer and esophageal cancer in the field of clinical oncology. ..
  27. Katoh M, Katoh M. Identification and characterization of TMEM16H gene in silico. Int J Mol Med. 2005;15:353-8 pubmed
    ..This is the first report on identification and characterization of the TMEM16H gene as well as on the molecular evolution of TMEM16H. ..
  28. Katoh M, Katoh M. Human FOX gene family (Review). Int J Oncol. 2004;25:1495-500 pubmed
  29. Katoh M, Katoh M. Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23. Int J Oncol. 2003;23:1219-24 pubmed
    ..FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate tumor suppressor genes of neuroblastoma. ..
  30. Katoh M, Katoh M. Identification and characterization of JMJD2 family genes in silico. Int J Oncol. 2004;24:1623-8 pubmed
    ..This is the first report on identification and characterization of human JMJD2 gene family. ..
  31. Katoh M, Katoh M. Identification and characterization of human PDZRN4L gene and mouse Pdzrn4l gene in silico. Int J Mol Med. 2004;13:923-7 pubmed
    ..9% total-amino-acid identity with human PDZRN4S. PDZ, PR34H1 and PR34H2 domains were conserved between PDZRN4L and PDZRN4S. This is the first report on human PDZRN4L and mouse Pdzrn4l genes. ..
  32. Katoh M. Molecular cloning and characterization of human SOX17. Int J Mol Med. 2002;9:153-7 pubmed
    ..This is the first report on molecular cloning and characterization of human SOX17. ..
  33. Katoh M. Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45. Int J Oncol. 2002;20:373-7 pubmed
    ..WNT3A, down-regulated by retinoic acid in NT2 cells, might play key roles in the maintenance of NT2 cells in the undifferentiated proliferation stage through activation of the beta-catenin - TCF signaling pathway. ..
  34. Katoh M. GIPC gene family (Review). Int J Mol Med. 2002;9:585-9 pubmed
    ..Therefore, GIPC1, GIPC2 and GIPC3 might play key roles in carcinogenesis and embryogenesis through modulation of growth factor signaling and cell adhesion. ..
  35. Katoh M, Katoh M. Identification and characterization of human FNBP3 gene in silico. Int J Mol Med. 2003;12:651-6 pubmed
    ..On the other hand, FNBP3 with nuclear localization signals and two tyrosine phosphorylation sites might transduce extracellular signals to the nucleus. This is the first report on comprehensive characterization of human FNBP3 gene. ..
  36. Katoh M, Katoh M. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. Int J Mol Med. 2003;12:643-9 pubmed
    ..BCL9L gene was located between BLR1 and UPK2 genes within the commonly deleted region of neuroblastoma at human chromosome 11q23.3. This is the first report on human BCL9L and mouse Bcl9l. ..
  37. Katoh M, Katoh M. MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain. Int J Oncol. 2003;22:1369-74 pubmed
    ..This is the first report on comprehensive characterization of the amplicon around the PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12. ..
  38. Katoh M, Katoh M. FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products. Int J Oncol. 2003;22:1375-81 pubmed
    ..This is the first report on comprehensive characterization of the FLJ10261 gene located within the CCND1-ORAOV1-FGF19-FGF4-FGF3-FLJ10261-FADD-PPFIA1-EMS1 locus on human chromosome 11q13. ..
  39. Katoh M. Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type Frizzled-related protein. Biochem Biophys Res Commun. 2001;282:116-23 pubmed
    ..Thus, MFRP with CRD might play key roles in medulla oblongata as a regulator of the WNT signaling pathway. ..
  40. Katoh M. Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain. Int J Mol Med. 2001;8:611-5 pubmed
  41. Katoh M. WNT and FGF gene clusters (review). Int J Oncol. 2002;21:1269-73 pubmed
    ..WNT gene clusters on human chromosome 1q42, 2q35, 12q13, and 17q21 as well as FGF gene cluster on human chromosome 12p13 might be amplified or translocated in human cancer just like FGF gene cluster on human chromosome 11q13. ..
  42. Katoh M, Katoh M. Identification and characterization of human DAAM2 gene in silico. Int J Oncol. 2003;22:915-20 pubmed
    ..Therefore, it was concluded that FMNL1, FMNL2, DIAPH1, DIAPH2, DAAM1 and DAAM2 proteins constitute the Formin-homology FDD subfamily. ..
  43. Katoh M, Katoh M. Identification and characterization of mouse Erbb2 gene in silico. Int J Oncol. 2003;23:831-5 pubmed
    ..This is the first report on the complete coding sequence of mouse Erbb2 gene as well as on the comprehensive comparison of Ppp1r1b-Grb7 locus within the human and mouse genomes. ..
  44. Katoh M, Katoh M. Identification and characterization of FBXL19 gene in silico. Int J Mol Med. 2004;14:1109-14 pubmed
    ..FBXL19 consists of FBXHA and FBXHB domains, while FBXL10 and FBXL11 consist of Jumonji C (JmjC), FBXHA and FBXHB domains. This is the first report on human FBXL19 gene as well as FBXHA and FBXHB domains. ..
  45. Katoh M, Katoh M. Characterization of human TMEM16G gene in silico. Int J Mol Med. 2004;14:759-64 pubmed
    ..Human TMEM16G with altered membrane topology might show functional divergence compared with other members of the TMEM16 family. ..
  46. Katoh Y, Katoh M. Identification and characterization of CDC50A, CDC50B and CDC50C genes in silico. Oncol Rep. 2004;12:939-43 pubmed
    ..Mammalian CDC50 homologs were predicted components of phospholipid-translocators just like yeast Cdc50p and Lem3p. ..
  47. Katoh M, Katoh M. Identification and characterization of TRIP8 gene in silico. Int J Mol Med. 2003;12:817-21 pubmed
    ..This is the first report on comprehensive characterization of the TRIP8 gene. ..
  48. Katoh M, Katoh M. Identification and characterization of PDZRN3 and PDZRN4 genes in silico. Int J Mol Med. 2004;13:607-13 pubmed
    ..PDZRN family proteins were classified into the LNX-PDZRN1 subfamily and the PDZRN3-PDZRN4 subfamily. This is the first report on the PDZRN3 and PDZRN4 genes. ..
  49. Katoh M, Katoh M. Identification and characterization of human FHOD3 gene in silico. Int J Mol Med. 2004;13:615-20 pubmed
    ..Human FHOD3, FHOD1 and Drosophila CG32030 were found to share the conserved domain structure consisting of FHDHN, FH1, FH2, and FHDHC domains. This is the first report on the FHOD3 gene as well as on the novel FHDHN and FHDHC domains. ..
  50. Katoh M, Katoh M. Identification and characterization of human FCHSD1 and FCHSD2 genes in silico. Int J Mol Med. 2004;13:749-54 pubmed
    ..This is the first report on identification and characterization of the FCHSD family genes. ..