M Katoh

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit
    Hiroyuki Kirikoshi
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:571-6. 2002
  2. ncbi Expression of human SOX18 in normal tissues and tumors
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:339-44. 2002
  3. ncbi MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:235-41. 2003
  4. ncbi Comparative genomics on Wnt7a orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:777-80. 2005
  5. ncbi Comparative genomics on FGF20 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:287-90. 2005
  6. ncbi Comparative genomics on FGF8, FGF17, and FGF18 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 16:493-6. 2005
  7. ncbi Identification and characterization of TMEM16H gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:353-8. 2005
  8. ncbi Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:765-70. 2004
  9. ncbi Identification and characterization of TMEM24 family genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:759-64. 2004
  10. ncbi Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 20:1247-53. 2002

Detail Information

Publications170 found, 100 shown here

  1. ncbi Molecular cloning and characterization of human GIPC2, a novel gene homologous to human GIPC1 and Xenopus Kermit
    Hiroyuki Kirikoshi
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:571-6. 2002
    ..This is the first report on molecular cloning of GIPC2, the second member of the GIPC gene family, which is down-regulated in human primary kidney and colorectal tumors...
  2. ncbi Expression of human SOX18 in normal tissues and tumors
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:339-44. 2002
    ..Expression level of SOX18 mRNA in NT2 cells was down-regulated by all-trans retinoic acid. This is the first report on comprehensive expression analyses of SOX18 mRNA in normal human tissues and tumors...
  3. ncbi MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:235-41. 2003
    ..MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues...
  4. ncbi Comparative genomics on Wnt7a orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:777-80. 2005
    ..Therefore, biological functions of rodent Wnt7a are not always consistent with those of human WNT7A due to promoter evolution. This is the first report on the rat Wnt7a gene and comparative genomics for Wnt7a orthologs...
  5. ncbi Comparative genomics on FGF20 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:287-90. 2005
    ..Double TCF/LEF binding sites, double EVI1-binding sites, TGIF, PAX4, E47 and AREB6-binding sites were conserved between human FGF20 promoter and mouse Fgf20 promoter...
  6. ncbi Comparative genomics on FGF8, FGF17, and FGF18 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 16:493-6. 2005
    ..These facts indicate that FGF18 orthologs were evolutionarily conserved targets of the WNT/beta-catenin signaling pathway...
  7. ncbi Identification and characterization of TMEM16H gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:353-8. 2005
    ..This is the first report on identification and characterization of the TMEM16H gene as well as on the molecular evolution of TMEM16H...
  8. ncbi Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:765-70. 2004
    ..Because DFNA5 and MLZE are cancer-associated genes, DFNA5L, GSDM, and GSDML are predicted cancer associated genes...
  9. ncbi Identification and characterization of TMEM24 family genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 25:759-64. 2004
    ..Human TMEM24, C21orf25 and their mouse homologs were type II transmembrane proteins with extracellular TM24H1 and TM24H2 domains. This is the first report on identification and characterization of the TMEM24 family...
  10. ncbi Molecular cloning and characterization of ST7R (ST7-like, ST7L) on human chromosome 1p13, a novel gene homologous to tumor suppressor gene ST7 on human chromosome 7q31
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 20:1247-53. 2002
    ....
  11. ncbi Strabismus (STB)/Vang-like (VANGL) gene family (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:11-5. 2002
    ..STB1 and STB2 might be suitable targets for tissue engineering in the field of re-generative medicine and for chemoprevention and treatment in the field of clinical oncology...
  12. ncbi Molecular cloning and characterization of human WINS1 and mouse Wins2, homologous to Drosophila segment polarity gene Lines (Lin)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:155-9. 2002
    ..8-kb in size was expressed in adult testis, prostate, spleen, thymus, skeletal muscle, fetal kidney and brain. This is the first report on molecular cloning and initial characterization of human WINS1 and mouse Wins2..
  13. ncbi Molecular cloning and characterization of OSR1 on human chromosome 2p24
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:221-5. 2002
    ..Among 10 cases of primary gastric cancer, OSR1 mRNA was up-regulated in 5 cases, and was down-regulated in 2 cases. This is the first report on molecular cloning and characterization of human OSR1...
  14. ncbi Identification and characterization of human FOXK1 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:127-32. 2004
    ..At least 42 FOX family genes, including FOXK1, FOXN5 (FOXR1) and FOXN6 (FOXR2), have been identified within the human genome...
  15. ncbi Molecular cloning and characterization of WRCH2 on human chromosome 15q15
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:977-82. 2002
    ..Because Wrch1 can activate PAK1 and JNK1, and induce filopodium formation and stress fiber dissolution, over-expression of WRCH2 mRNA in human cancer cells might also lead to more malignant phenotype...
  16. ncbi Characterization of RUSC1 and RUSC2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Oncol Rep 12:933-8. 2004
    ..RUSC1, RUSC2, RIPX, RUFY1, RUFY2, RUTBC1, RUTBC2, RUTBC3, RUB6IP1, and PLEKHM1 were RUN domain proteins within the human proteome. This is the first report on comprehensive characterization of RUSC1 and RUSC2 orthologs...
  17. ncbi Identification and characterization of human HESL, rat Hesl and rainbow trout hesl genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:747-51. 2004
    ....
  18. ncbi Identification and characterization of FBXL19 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 14:1109-14. 2004
    ..FBXL19 consists of FBXHA and FBXHB domains, while FBXL10 and FBXL11 consist of Jumonji C (JmjC), FBXHA and FBXHB domains. This is the first report on human FBXL19 gene as well as FBXHA and FBXHB domains...
  19. ncbi Human FOX gene family (Review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 25:1495-500. 2004
    ....
  20. ncbi Molecular cloning and characterization of human SOX17
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 9:153-7. 2002
    ..This is the first report on molecular cloning and characterization of human SOX17...
  21. ncbi Regulation of WNT3 and WNT3A mRNAs in human cancer cell lines NT2, MCF-7, and MKN45
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:373-7. 2002
    ..WNT3A, down-regulated by retinoic acid in NT2 cells, might play key roles in the maintenance of NT2 cells in the undifferentiated proliferation stage through activation of the beta-catenin - TCF signaling pathway...
  22. ncbi Structure and expression of Strabismus 1 gene on human chromosome 1q21-q23
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 20:1197-203. 2002
    ..Loss-of-function mutation of STB1 gene might lead to carcinogenesis through activation of the WNT - beta-catenin signaling pathway...
  23. ncbi Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 9:221-7. 2002
    ..This is the first report on structural comparison of WNT gene clusters in human genome and in mouse genome...
  24. ncbi Characterization of human TMEM16G gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:759-64. 2004
    ..Human TMEM16G with altered membrane topology might show functional divergence compared with other members of the TMEM16 family...
  25. ncbi Expression of human SOX7 in normal tissues and tumors
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 9:363-8. 2002
    ..SOX7 gene might be one of cancer-associated genes on human chromosome 8p22...
  26. ncbi WNT and FGF gene clusters (review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 21:1269-73. 2002
    ..WNT gene clusters on human chromosome 1q42, 2q35, 12q13, and 17q21 as well as FGF gene cluster on human chromosome 12p13 might be amplified or translocated in human cancer just like FGF gene cluster on human chromosome 11q13...
  27. ncbi Paradigm shift in gene-finding method: From bench-top approach to desk-top approach (review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:677-82. 2002
    ....
  28. ncbi Trefoil factors and human gastric cancer (review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 12:3-9. 2003
    ..TFF1, TFF2 and TFF3 proteins might be applicable for chemoprevention of gastrointestinal cancer associated with chronic persistent inflammation...
  29. ncbi Identification and characterization of human FHOD3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:615-20. 2004
    ..Human FHOD3, FHOD1 and Drosophila CG32030 were found to share the conserved domain structure consisting of FHDHN, FH1, FH2, and FHDHC domains. This is the first report on the FHOD3 gene as well as on the novel FHDHN and FHDHC domains...
  30. ncbi Identification and characterization of mouse Erbb2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:831-5. 2003
    ..This is the first report on the complete coding sequence of mouse Erbb2 gene as well as on the comprehensive comparison of Ppp1r1b-Grb7 locus within the human and mouse genomes...
  31. ncbi Identification and characterization of ASXL2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:845-50. 2003
    ..Based on functional conservation and human chromosomal localization, ASXL2 and ASXL1 genes were predicted cancer-associated genes...
  32. ncbi Identification and characterization of PDZRN3 and PDZRN4 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:607-13. 2004
    ..PDZRN family proteins were classified into the LNX-PDZRN1 subfamily and the PDZRN3-PDZRN4 subfamily. This is the first report on the PDZRN3 and PDZRN4 genes...
  33. ncbi Identification and characterization of FLJ10737 and CAMTA1 genes on the commonly deleted region of neuroblastoma at human chromosome 1p36.31-p36.23
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:1219-24. 2003
    ..FLJ10737 and CAMTA1 genes on 1p36.31-p36.23 are candidate tumor suppressor genes of neuroblastoma...
  34. ncbi Identification and characterization of human FNBP3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:651-6. 2003
    ..On the other hand, FNBP3 with nuclear localization signals and two tyrosine phosphorylation sites might transduce extracellular signals to the nucleus. This is the first report on comprehensive characterization of human FNBP3 gene...
  35. ncbi Identification and characterization of TRIP8 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 12:817-21. 2003
    ..This is the first report on comprehensive characterization of the TRIP8 gene...
  36. ncbi FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1375-81. 2003
    ..This is the first report on comprehensive characterization of the FLJ10261 gene located within the CCND1-ORAOV1-FGF19-FGF4-FGF3-FLJ10261-FADD-PPFIA1-EMS1 locus on human chromosome 11q13...
  37. ncbi MGC9753 gene, located within PPP1R1B-STARD3-ERBB2-GRB7 amplicon on human chromosome 17q12, encodes the seven-transmembrane receptor with extracellular six-cystein domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1369-74. 2003
    ..This is the first report on comprehensive characterization of the amplicon around the PPP1R1B-STARD3-TCAP-PNMT-MGC9753-ERBB2-MGC14832-GRB7 locus on human chromosome 17q12...
  38. ncbi Regulation of WNT signaling molecules by retinoic acid during neuronal differentiation in NT2 cells: threshold model of WNT action (review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 10:683-7. 2002
    ..The author proposes the threshold model of WNT action...
  39. ncbi Expression and regulation of WNT1 in human cancer: up-regulation of WNT1 by beta-estradiol in MCF-7 cells
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 22:209-12. 2003
    ..WNT1 was found to be one of estrogen target genes in human MCF-7 cells, which in part explains Wnt1-induced mammary carcinogenesis in ERalpha knockout mice...
  40. ncbi Identification and characterization of the human FMN1 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:121-6. 2004
    ..1% total amino-acid identity with mouse Fmn1, was found consisting of FMH1, FMH2, FH1 and FH2 domains. This is the first report on the identification and characterization of the human FMN1 gene as well as the FMH1 and FMH2 domains...
  41. ncbi Identification and characterization of human PDZRN4L gene and mouse Pdzrn4l gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 13:923-7. 2004
    ..9% total-amino-acid identity with human PDZRN4S. PDZ, PR34H1 and PR34H2 domains were conserved between PDZRN4L and PDZRN4S. This is the first report on human PDZRN4L and mouse Pdzrn4l genes...
  42. ncbi Identification and characterization of human DAPPER1 and DAPPER2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:907-13. 2003
    ..Based on evolutionary and functional conservation of WNT signaling molecules as well as human chromosomal localization, DAPPER1 and DAPPER2 genes are predicted to be potent cancer-associated genes...
  43. ncbi Identification and characterization of human DAAM2 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:915-20. 2003
    ..Therefore, it was concluded that FMNL1, FMNL2, DIAPH1, DIAPH2, DAAM1 and DAAM2 proteins constitute the Formin-homology FDD subfamily...
  44. ncbi FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1155-9. 2003
    ..Tumor suppressor genes closely linked to oncogenes might be excluded from amplicon through a breakage-fusion-bridge process during oncogene amplification...
  45. ncbi Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 11:579-83. 2003
    ..Therefore, comparative genomics might be applicable to identification of recombination hot spots and genes related to cancer...
  46. ncbi WNT2 and human gastrointestinal cancer (review)
    Masaru Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 12:811-6. 2003
    ..WNT2 gene is one of the targets for pharmacogenomics in the field of oncology...
  47. ncbi NUMB is a break of WNT-Notch signaling cycle
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 18:517-21. 2006
    ....
  48. ncbi Alternative splicing of the WNT-2B/WNT-13 gene
    M Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo, 104 0045, Japan
    Biochem Biophys Res Commun 275:209-16. 2000
    ..These results indicate that the WNT-2B1 and WNT-2B2 mRNAs are transcribed due to alternative splicing with distinct expression profile. This is the first report on the WNT isoforms derived from the same gene due to alternative splicing...
  49. ncbi Identification and characterization of JMJD2 family genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:1623-8. 2004
    ..This is the first report on identification and characterization of human JMJD2 gene family...
  50. ncbi Molecular cloning and characterization of MFRP, a novel gene encoding a membrane-type Frizzled-related protein
    M Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo, 104 0045, Japan
    Biochem Biophys Res Commun 282:116-23. 2001
    ..Thus, MFRP with CRD might play key roles in medulla oblongata as a regulator of the WNT signaling pathway...
  51. ncbi KIAA1735 gene on human chromosome 11q23.1 encodes a novel protein with myosine-tail homologous domain and C-terminal DIX domain
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:145-50. 2003
    ..0 kb. KIAA1735 gene on human chromosome 11q23.1 was located between D11S1391 and D11S1347 loci, the region deleted in sporadic breast cancer. This is the first report on comprehensive characterization of the KIAA1735 gene...
  52. ncbi Molecular cloning and characterization of RNF26 on human chromosome 11q23 region, encoding a novel RING finger protein with leucine zipper
    M Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo, 104 0045, Japan
    Biochem Biophys Res Commun 282:1038-44. 2001
    ..Although substrates of ubiquitination mediated by RNF26 remain to be elucidated, RNF26 upregulation in several types of human cancer might be implicated in carcinogenesis through dysregulation of its substrates...
  53. ncbi Epithelial-mesenchymal transition in gastric cancer (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 27:1677-83. 2005
    ..Personalized medicine based on the combination of genetic screening and novel therapeutic agents could dramatically improve the prognosis of gastric cancer patients in the future...
  54. ncbi WNT/PCP signaling pathway and human cancer (review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncol Rep 14:1583-8. 2005
    ..Antibody, RNAi, or small molecule compounds to regulate the function of WNT/PCP signaling molecules mentioned above are good candidates for development as novel cancer therapeutics...
  55. ncbi WNT2B: comparative integromics and clinical applications (Review)
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Mol Med 16:1103-8. 2005
    ..Anti-WNT2B monoclonal antibodies, WNT2B RNAi compounds, or small molecule WNT2B inhibitors could be developed as novel therapeutic agents for gastric cancer and esophageal cancer in the field of clinical oncology...
  56. ncbi Comparative integromics on Angiopoietin family members
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 17:1145-9. 2006
    ..Human ANGPTL7, characterized as potent target gene of WNT/ beta-catenin signaling pathway, is a pharmacogenomics target in the fields of oncology and regenerative medicine...
  57. ncbi FGF signaling network in the gastrointestinal tract (review)
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 29:163-8. 2006
    ..Personalized prevention and personalized medicine based on the combination of genetic screening and novel therapeutic agents could dramatically improve the prognosis of cancer patients...
  58. ncbi Comparative genomics on Wnt5a and Wnt5b genes
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:749-53. 2005
    ..This is the first report on rat Wnt5a and Wnt5b genes as well as on comparative genomics for Wnt5a and Wnt5b orthologs...
  59. ncbi Comparative genomics on Wnt3-Wnt9b gene cluster
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Mol Med 15:743-7. 2005
    ..This is the first report on the rat Wnt3 and Wnt9b genes as well as on comparative genomics on the Wnt3-Wnt9b gene cluster...
  60. ncbi Molecular evolution of Wnt2b orthologs
    Masaru Katoh
    Genetics and Cell Biology Section, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 26:1135-9. 2005
    ..This is the first report on the rat Wnt2b gene as well as on molecular evolution of the Wnt2b orthologs...
  61. ncbi Identification and characterization of rat Bcl9l gene in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 26:835-40. 2005
    ..Phylogenetic analysis revealed that mammalian Bcl9l homologs were more related to human BCL9 than to Drosophila lgs. This is the first report on rat Bcl9l gene...
  62. ncbi Identification and characterization of rat Ror1 and Ror2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:533-8. 2005
    ..This is the first report on rat Ror1 and Ror2 genes as well as on molecular evolution of Ror1 and Ror2 homologs...
  63. ncbi Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer
    M Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 19:1003-7. 2001
    ..Frequent up-regulation of WNT2 in primary gastric cancer and colorectal cancer might play a key role in carcinogenesis through activation of the WNT - beta-catenin - TCF signaling pathway...
  64. ncbi Molecular cloning and characterization of LZIC, a novel gene encoding ICAT homologous protein with leucine zipper domain
    M Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Int J Mol Med 8:611-5. 2001
    ....
  65. ncbi Identification and characterization of rat Wnt1 and Wnt10b genes in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 26:841-5. 2005
    ..Wnt1-Wnt10b IGCR was predicted as regulatory element rather than gene because cDNA or EST derived from Wnt1-Wnt10b IGCR was not identified. This is the first report on rat Wnt1 and Wnt10b genes as well as on Wnt1-Wnt10b IGCR...
  66. ncbi Molecular cloning and characterization of human WNT3
    M Katoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 19:977-82. 2001
    ..These results strongly suggest that WNT3 might play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT - beta-catenin - TCF signaling pathway, similar to mouse Wnt-3...
  67. ncbi Identification and characterization of rat Wnt6 and Wnt10a genes in silico
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:527-31. 2005
    ..GATA, FOXA2, and TGIF binding sites were located within the conserved region of rat Wnt6 and human WNT6 promoters. This is the first report on rat Wnt6 and Wnt10a genes as well as on the conserved promoter region of Wnt6 orthologs...
  68. ncbi Identification and characterization of rat Ankrd6 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:359-63. 2005
    ..Due to the molecular evolution, functions of vertebrate Ankrd6 orthologs were predicted to partially differ from those of Drosophila Dgo...
  69. ncbi Molecular cloning and characterization of human WNT5B on chromosome 12p13.3 region
    T Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 19:347-51. 2001
    ..WNT5B might be implicated in human carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway, just like Wnt5a...
  70. ncbi Comparative genomics on SOX2 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:797-800. 2005
    ..Due to the pivotal role of SOX2 in the early embryogenesis, SOX2 promoter and SOX2 protein were well conserved during vertebrate evolution. This is the first report on comparative integromics analyses on the SOX2 orthologs...
  71. ncbi Comparative genomics on Wnt16 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:771-5. 2005
    ..Double CCAAT motifs were conserved among mammalian Wnt16 promoters. This is the first report on the rat Wnt16 and zebrafish wnt16 genes, as well as the double CCAAT motifs within the core promoter regions of mammalian Wnt16 orthologs...
  72. ncbi Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 20:269-73. 2007
    ....
  73. ncbi Molecular cloning and characterization of human GIPC3, a novel gene homologous to human GIPC1 and GIPC2
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:577-82. 2002
    ..This is the first report on molecular cloning of GIPC3, the third member of the GIPC gene family...
  74. ncbi Comparative genomics on Dkk1 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Oncol 27:275-9. 2005
    ..Double TCF/LEF-binding sites within the proximal promoter region of mammalian Dkk1 orthologs are implicated in the negative feed back mechanism of WNT/beta-catenin signaling pathway...
  75. ncbi Identification and characterization of ARHGAP24 and ARHGAP25 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:333-8. 2004
    ..This is the first report on identification and characterization of the ARHGAP24 and ARHGAP25 genes...
  76. ncbi Comparative genomics on Fgf11 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:291-4. 2005
    ..Human FGF11 mRNA was expressed in embryonic stem (ES) cells, neuroblastoma, retinoblastoma, and brain tumors. This is the first report on the dog Fgf11 gene as well as on comparative genomics analyses of Fgf11 orthologs...
  77. ncbi Identification and characterization of rat Dact1 and Dact2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:1045-9. 2005
    ..DAPH3 domain was the Serine rich region. DAPH7 domain was the C-terminal PDZ binding region. This is the first report on the rat Dact1 and Dact2 genes...
  78. ncbi Molecular cloning and characterization of human WNT11
    H Kirikoshi
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Mol Med 8:651-6. 2001
    ..Up-regulation of WNT11 mRNA might play an important role in human carcinogenesis through activation of the WNT signaling pathway...
  79. ncbi Germ-line mutation of Foxn5 gene in mouse lineage
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:463-7. 2004
    ..This is the first report on identification and characterization of mouse Foxn5 gene as well as on species specific germ-line mutation of the Fox family gene...
  80. ncbi Comparative genomics on SFRP2 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:783-7. 2005
    ..This is the first report on comparative integromics analyses on SFRP2 orthologs...
  81. ncbi Identification and characterization of human LL5A gene and mouse Ll5a gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:1477-83. 2003
    ..LL5alpha protein might be a transducer of PtdIns(3,4,5)P3 levels to the intracellular trafficking system...
  82. ncbi Identification and characterization of human FMNL1, FMNL2 and FMNL3 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 22:1161-8. 2003
    ..FMNL1, FMNL2 and FMNL3 might be implicated in polarity control, invasion, migration, or metastasis through regulation of the Rho-related signaling pathway...
  83. ncbi FRAT1 and FRAT2, clustered in human chromosome 10q24.1 region, are up-regulated in gastric cancer
    T Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Int J Oncol 19:311-5. 2001
    ..Up-regulation of FRAT1 and FRAT2 in gastric cancer might lead to carcinogenesis through activation of WNT--beta-catenin--TCF signaling pathway...
  84. ncbi Notch ligand, JAG1, is evolutionarily conserved target of canonical WNT signaling pathway in progenitor cells
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113-0033, Japan
    Int J Mol Med 17:681-5. 2006
    ..JAG1, functioning as WNT-dependent Notch signaling activator, is the key molecule maintaining the homeostasis of stem and progenitor cells...
  85. ncbi Identification and characterization of Crumbs homolog 2 gene at human chromosome 9q33.3
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:743-9. 2004
    ..3 and CRB1-MGC27044-LHX9-NEK7 locus at human chromosome 1q31.3 were paralogous regions within the human genome. This is the first report on identification and characterization of the CRB2 gene...
  86. ncbi Expression and regulation of WNT8A and WNT8B mRNAs in human tumor cell lines: up-regulation of WNT8B mRNA by beta-estradiol in MCF-7 cells, and down-regulation of WNT8A and WNT8B mRNAs by retinoic acid in NT2 cells
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:999-1003. 2002
    ..WNT8A and WNT8B might play key roles in embryonal tumors and embryonic stem cells through synergistic activation of the beta-catenin - TCF signaling pathway...
  87. ncbi Up-regulation of WNT8B mRNA in human gastric cancer
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Oncol 20:343-8. 2002
    ..WNT8B might play key roles in gastric cancer through activation of the beta-catenin - TCF signaling pathway...
  88. ncbi Comparative genomics on SFRP1 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Oncol 27:861-5. 2005
    ..Match program revealed that AP1, COMP1, and double ETS1-binding sites were conserved between human SFRP1 and rat Sfrp1 promoters. This is the first report on comparative integromics analyses on Sfrp1 orthologs...
  89. ncbi Identification and characterization of TMEM16E and TMEM16F genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:1345-9. 2004
    ..TMEM16 family members were eight-transmenbrane proteins with TM16H1-TM16H3 domains and a conserved Asn glycosylation site. This is the first report on TMEM16E and TMEM16F genes...
  90. ncbi Comparative genomics on Fzd7 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 15:1051-5. 2005
    ..These facts indicate that experimental data obtained by using FzE3 cDNA do not always reflect the functions of Fzd7 orthologs...
  91. ncbi Identification and characterization of ASXL3 gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 24:1617-22. 2004
    ..1 and ASXL2-DTNB locus at 2p23.3 were paralogous regions within the human genome. ASXL3 was a predicted cancer-associated gene, just like ASXL1 and ASXL2. This is the first report on identification and characterization of the ASXL3 gene...
  92. ncbi Comparative genomics on mammalian Fgf3-Fgf4 locus
    Masuko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Oncol 27:281-5. 2005
    ..11) and the NFAM1 locus (22q13.2). FGF34Rep2 was characterized by the CCA(T/C) repeats. This is the first report on comparative genomics analyses on the Fgf3-Fgf4 locus within human, rat and mouse genomes...
  93. ncbi Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Oncol Rep 12:423-7. 2004
    ..CKTSF1B1, CKTSF1B2, CKTSF1B3 and CER1 constitute the CKTSF1B family among secreted-type cysteine knot superfamily proteins. This is the first report on identification and characterization of the human CKTSF1B2 and CKTSF1B3 genes...
  94. ncbi Comparative genomics on Wnt9a orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 13:989-92. 2005
    ..This is the first report on rat Wnt9a gene as well as on comparative genomics for Wnt9a orthologs...
  95. ncbi Comparative genomics on FGF7, FGF10, FGF22 orthologs, and identification of fgf25
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Int J Mol Med 16:767-70. 2005
    ..This is the first report on fgf25 gene and also on the comparative integromics analyses of FGF7, FGF10 and FGF22 orthologs...
  96. ncbi Identification and characterization of human FCHO2 and mouse Fcho2 genes in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 14:327-31. 2004
    ..elegans 2B609 were found consisting of N-terminal FCH domain and C-terminal FOH domain. This is the first report on identification and characterization of evolutionarily conserved FCHO homologs as well as the novel FOH domain...
  97. ncbi Comparative genomics on SNAI1, SNAI2, and SNAI3 orthologs
    Masuko Katoh
    M and M Medical BioInformatics, Hongo 113 0033, Japan
    Oncol Rep 14:1083-6. 2005
    ..SNAI1, functioning as E-cadherin repressor, is implicated in the malignant infiltrating phenotype of diffuse type gastric cancer through the induction of EMT or fibroblastoid transformation...
  98. ncbi Identification and characterization of human KIAA1391 and mouse Kiaa1391 genes encoding novel RhoGAP family proteins with RA domain and ANXL repeats
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Oncol 23:1471-6. 2003
    ..This is the first report on the comprehensive characterization of human KIAA1391 gene and mouse Kiaa1391 gene, encoding RhoGAP proteins with RA domain and two ANXL repeats...
  99. ncbi Identification and characterization of human SNAIL3 (SNAI3) gene in silico
    Masuko Katoh
    M and M Medical BioInformatics, Narashino 275 0022, Japan
    Int J Mol Med 11:383-8. 2003
    ..Because SNAG zinc-finger proteins are transcriptional repressors implicated in carcinogenesis and embryogenesis, SNAI3 gene might be a potent target of pharmacogenomics in the field of oncology and regenerative medicine...
  100. ncbi Molecular cloning and characterization of mouse Gipc3
    Tetsuroh Saitoh
    Genetics and Cell Biology Section, Genetics Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Int J Mol Med 9:251-6. 2002
    ..This is the first report on molecular cloning and initial characterization of mouse Gipc3...
  101. ncbi Comparative genomics on DKK2 and DKK4 orthologs
    Yuriko Katoh
    M and M Medical BioInformatics, Hongo, Japan
    Int J Mol Med 16:477-81. 2005
    ..DKK4 orthologs are implicated in the negative feed back mechanism of the WNT/beta-catenin signaling pathway (the canonical WNT signaling pathway)...