Atsushi Kato

Summary

Affiliation: National Research Institute for Child Health and Development
Country: Japan

Publications

  1. pmc Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    BMC Immunol 4:8. 2003
  2. ncbi request reprint Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
    Toshiki Homma
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Am J Respir Cell Mol Biol 31:463-9. 2004
  3. ncbi request reprint CpG oligodeoxynucleotides directly induce CXCR3 chemokines in human B cells
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Biochem Biophys Res Commun 320:1139-47. 2004
  4. ncbi request reprint CpG oligodeoxynucleotide prolongs eosinophil survival through activation of contaminating B cells and plasmacytoid dendritic cells in vitro
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 140:42-50. 2006
  5. ncbi request reprint Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 172:6185-94. 2004
  6. ncbi request reprint Eosinophil degranulation during pregnancy and after delivery by cesarean section
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 131:34-9. 2003
  7. ncbi request reprint Culture of human mast cells from peripheral blood progenitors
    Hirohisa Saito
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya ku 157 8535, Tokyo, Japan
    Nat Protoc 1:2178-83. 2006
  8. ncbi request reprint [Role of mast cells in allergy]
    Hirohisa Saito
    Department of Allergy and Immunology, National Research Institute for Child Health and Development
    Nihon Rinsho 67:2083-7. 2009
  9. pmc Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression
    Toru Kubota
    Department of Virology III, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo, Japan
    J Biol Chem 283:25660-70. 2008
  10. ncbi request reprint Ancient ubiquitous protein 1 and Syk link cytoplasmic tails of the integrin alpha(IIb)beta(3)
    Atsushi Kato
    Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Platelets 20:105-10. 2009

Collaborators

Detail Information

Publications31

  1. pmc Interferon-alpha/beta receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    BMC Immunol 4:8. 2003
    ..Although several genes have been reported, no comprehensive study of the gene expression profiles in human cells after stimulation with CpG ODN has been reported...
  2. ncbi request reprint Corticosteroid and cytokines synergistically enhance toll-like receptor 2 expression in respiratory epithelial cells
    Toshiki Homma
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Am J Respir Cell Mol Biol 31:463-9. 2004
    ..These results provide evidence for a novel function of corticosteroids in airway inflammatory disorders, and indicate that the use of inhaled corticosteroids in such disorders may have a beneficial role in host defense mechanisms...
  3. ncbi request reprint CpG oligodeoxynucleotides directly induce CXCR3 chemokines in human B cells
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 3 35 31 Taishido, Setagaya Ku, Tokyo 154 8567, Japan
    Biochem Biophys Res Commun 320:1139-47. 2004
    ..Induction of CXCR3 chemokines was blocked by two NF-kappaB inhibitors and a p38 inhibitor. These results strongly suggest that CXCR3 chemokines are directly induced by CpG ODN via NF-kappaB- and p38-dependent pathways in human B cells...
  4. ncbi request reprint CpG oligodeoxynucleotide prolongs eosinophil survival through activation of contaminating B cells and plasmacytoid dendritic cells in vitro
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 140:42-50. 2006
    ....
  5. ncbi request reprint Lipopolysaccharide-binding protein critically regulates lipopolysaccharide-induced IFN-beta signaling pathway in human monocytes
    Atsushi Kato
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    J Immunol 172:6185-94. 2004
    ..This critical role for LBP implies the presence of possible mechanisms linking LBP to the intracellular signaling between Toll-like receptor 4 and IRF-3, leading to the induction of IFN-beta by LPS...
  6. ncbi request reprint Eosinophil degranulation during pregnancy and after delivery by cesarean section
    Kenji Matsumoto
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan
    Int Arch Allergy Immunol 131:34-9. 2003
    ....
  7. ncbi request reprint Culture of human mast cells from peripheral blood progenitors
    Hirohisa Saito
    Department of Allergy and Immunology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya ku 157 8535, Tokyo, Japan
    Nat Protoc 1:2178-83. 2006
    ..When these cells are cultured using methylcellulose medium supplemented with stem cell factor and interleukin 6, 10(3)-10(4) mast cell colonies are formed in 6 weeks. The total mast cell number at 6 weeks of culture will be 10(6)-10(7)...
  8. ncbi request reprint [Role of mast cells in allergy]
    Hirohisa Saito
    Department of Allergy and Immunology, National Research Institute for Child Health and Development
    Nihon Rinsho 67:2083-7. 2009
    ..Pharmaceutical development of safer drugs is expected to treat mast cell-mediated allergic disorders...
  9. pmc Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression
    Toru Kubota
    Department of Virology III, National Institute of Infectious Diseases, Gakuen 4 7 1, Musashi Murayama, Tokyo, Japan
    J Biol Chem 283:25660-70. 2008
    ..Together, SUMO modification is an integral part of IRF3 and IRF7 activity that contributes to postactivation attenuation of IFN production...
  10. ncbi request reprint Ancient ubiquitous protein 1 and Syk link cytoplasmic tails of the integrin alpha(IIb)beta(3)
    Atsushi Kato
    Division of Hematology, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Platelets 20:105-10. 2009
    ....
  11. doi request reprint Comparison between Sendai virus and adenovirus vectors to transduce HIV-1 genes into human dendritic cells
    Noriaki Hosoya
    Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    J Med Virol 80:373-82. 2008
    ..Our data suggest that SeV could be one of the reliable vectors for immuno-genetherapy for HIV-1 infected patients...
  12. pmc TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA
    Hiroyasu Konno
    Division of Cellular and Molecular Biology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    PLoS ONE 4:e5674. 2009
    ..However, the contribution of TRAF6 to the detection of cytosolic viral nucleic acids has been controversial, and the involvement of TRAF6 in IRF activation has not been adequately addressed...
  13. ncbi request reprint Differential type I IFN-inducing abilities of wild-type versus vaccine strains of measles virus
    Masashi Shingai
    Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
    J Immunol 179:6123-33. 2007
    ..Thus, the stem-loop structure, rather than full genome replication or specific internal sequences of the MV genome, is required for an early phase of type I IFN induction by MV in host cells...
  14. pmc Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity
    Atsushi Kato
    Division of Allergy Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Curr Opin Immunol 19:711-20. 2007
    ..Improved understanding of epithelial immune and inflammatory responses will hopefully suggest new strategies for therapeutic intervention...
  15. ncbi request reprint Clinical significance of alpha-fetoprotein: involvement in proliferation, angiogenesis, and apoptosis of hepatocellular carcinoma
    Noboru Mitsuhashi
    Section for Medical Nanotechniques, Research Center for Frontier Medical Engineering, Chiba University, Chiba, Japan
    J Gastroenterol Hepatol 23:e189-97. 2008
    ..However, there have been few reports on the reasons for poor prognosis...
  16. pmc Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism
    Atsushi Kato
    Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 177:7164-72. 2006
    ..The production of BAFF and APRIL by epithelial cells may contribute to local accumulation, activation, class switch recombination, and Ig synthesis by B cells in the airways...
  17. ncbi request reprint Paramyxovirus Sendai virus V protein counteracts innate virus clearance through IRF-3 activation, but not via interferon, in mice
    Katsuhiro Kiyotani
    Department of Virology, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Virology 359:82-91. 2007
    ..These results indicate that SeV V protein counteracts IRF-3-mediated innate antiviral immunity for efficient virus replication and pathogenesis in mice, but it is not IFN...
  18. pmc TLR3- and Th2 cytokine-dependent production of thymic stromal lymphopoietin in human airway epithelial cells
    Atsushi Kato
    Allergy Immunology Division, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    J Immunol 179:1080-7. 2007
    ..This implies that respiratory viral infection and the recruitment of Th2 cytokine producing cells may amplify Th2 inflammation via the induction of TSLP in the asthmatic airway...
  19. ncbi request reprint Circulating cytokines, chemokines, and stress hormones are increased in patients with organ dysfunction following liver resection
    Fumio Kimura
    Department of General Surgery, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
    J Surg Res 133:102-12. 2006
    ....
  20. ncbi request reprint Promotion of hepatic ischemia/reperfusion injury by IL-12 is independent of STAT4
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Transplantation 73:1142-5. 2002
    ..IL-12 mediates its effects through the transcription factor, signal transducer and activator of transcription-4 (STAT4). Therefore, we investigated the response to hepatic ischemia/reperfusion in STAT4-deficient mice...
  21. pmc The amino-terminal half of Sendai virus C protein is not responsible for either counteracting the antiviral action of interferons or down-regulating viral RNA synthesis
    Atsushi Kato
    Department of Viral Diseases and Vaccine Control, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 76:7114-24. 2002
    ..These data indicated that the activities of the C protein to counteract the antiviral action of IFNs and to down-regulate viral RNA synthesis were not encoded within a region of at least 98 amino acids in its amino-terminal half...
  22. ncbi request reprint A novel P gene missense mutation in a Japanese patient with oculocutaneous albinism type II (OCA2)
    Atsushi Kato
    Department of Dermatology, Osaka City University Graduate School of Medicine, 1 4 3, Asahimachi Abenoku, Osaka 545 8585, Japan
    J Dermatol Sci 31:189-92. 2003
    ..Mutations in P gene have been shown to result in OCA2. So far, two cases have been reported from Japan...
  23. ncbi request reprint Cytotoxic C-benzylated dihydrochalcones from Uvaria acuminata
    Momoyo Ichimaru
    Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Chem Pharm Bull (Tokyo) 52:138-41. 2004
    ..The structural elucidation of compounds 1 and 2 in spectroscopic studies is described. C-Benzylated dihydrochalcones, especially 1, 2, 4, and 6, showed considerable cytotoxicity toward human promyelocytic leukemia HL-60 cells...
  24. pmc Characterization of the amino acid residues of sendai virus C protein that are critically involved in its interferon antagonism and RNA synthesis down-regulation
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases, Musashi Murayama, Tokyo 208 0011, Japan
    J Virol 78:7443-54. 2004
    ..Thus, amino acid sequence requirements differ greatly between IFN antagonism and RNA synthesis inhibition. In addition, we confirmed that another SeV accessory protein, V, does not antagonize IFN...
  25. ncbi request reprint Induction of apoptosis in human promyelocytic leukemia cell line HL-60 by C-benzylated dihydrochalcones, uvaretin, isouvaretin and diuvaretin
    Noriyoshi Nakatani
    Department of Natural Medicinal Chemistry, Kobe Pharmaceutical University, Japan
    Biol Pharm Bull 28:83-6. 2005
    ..The cytotoxicity of uvaretin and diuvaretin was stronger than that of isouvaretin, which suggest that the 5'-substitution of the 2-hydroxybenzyl group increased the cytotoxicity...
  26. ncbi request reprint [Sendai virus proteins counteracting the host innate immunity]
    Atsushi Kato
    Department of Virology 3, National Institute of Infectious Diseases 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Uirusu 54:179-88. 2004
    ..Both V and C proteins were thus appeared to be important for counteracting host innate immunity generated in the early phase of viral infection...
  27. ncbi request reprint Decreased cell-mediated immune status in colorectal cancer patients with hepatic metastasis
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 52:1106-9. 2005
    ..Depression of cell-mediated immunity frequently accompanies solid tumor malignancy, and appears to be worsened as the disease progresses. In this study, we investigated cell-mediated immune status in colorectal cancer patients...
  28. ncbi request reprint Extended cold preservation of the graft liver enhances neutrophil-mediated pulmonary injury after liver transplantation
    Hiroaki Shimizu
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Hepatogastroenterology 52:1172-5. 2005
    ..The precise mechanisms of pulmonary injury after liver transplantation, especially those associated with cold ischemia time, are not yet clear...
  29. ncbi request reprint [Complications of hematopoietic stem cell transplantation and the treatment: graft-versus-host disease]
    Atsushi Kato
    Nihon Naika Gakkai Zasshi 94:1337-43. 2005
  30. ncbi request reprint Renal function is well maintained after use of left renal vein graft for vascular reconstruction in hepatobiliary-pancreatic surgery
    Takeshi Suzuki
    Department of General Surgery, Chiba University Graduate School of Medicine, Chiba, Japan
    J Am Coll Surg 202:87-92. 2006
    ..We used a left renal vein graft to reconstruct resected vessels in some patients. In this study, we evaluated early and late renal complications of this procedure...
  31. ncbi request reprint Mechanisms of hypothermic protection against ischemic liver injury in mice
    Atsushi Kato
    Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 282:G608-16. 2002
    ..These data suggest that hypothermia suppresses the hepatic inflammatory response through selective inhibition of JNK and AP-1...