Research Topics
Genomes and Genes | Yoshiaki KamadaSummaryAffiliation: National Institute for Basic Biology Country: Japan Publications
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Publications
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarizationYoshiaki Kamada
Department of Cell Biology, National Institute for Basic Biology, Maiodaiji Cho, Okazaki, Japan
Mol Cell Biol 25:7239-48. 2005..In contrast, Ypk2(D239A) has increased and TOR2-independent activity in vivo. Thus, we propose that Ypk protein kinases are direct and essential targets of TORC2, coupling TORC2 to the cell integrity cascade...- Tor directly controls the Atg1 kinase complex to regulate autophagyYoshiaki Kamada
Division of Molecular Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
Mol Cell Biol 30:1049-58. 2010..Our findings suggest that the direct control of the Atg1 complex by TORC1 induces autophagy... 
Prime-numbered Atg proteins act at the primary step in autophagy: unphosphorylatable Atg13 can induce autophagy without TOR inactivationYoshiaki Kamada
National Institute for Basic Biology, Okazaki, Japan
Autophagy 6:415-6. 2010..These findings suggest that formation of the Atg1 complex is a primary step at induction of autophagy, and that dephosphorylation of Atg13 acts as a molecular switch to turn on starvation-induced autophagy...- Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagyYukiko Kabeya
Division of Molecular Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
Mol Biol Cell 16:2544-53. 2005..Taken together, these results indicate that Atg17-Atg13 complex formation plays an important role in normal autophagosome formation via binding to and activating the Atg1 kinase... - Organization of the pre-autophagosomal structure responsible for autophagosome formationTomoko Kawamata
Department of Cell Biology, National Institute for Basic Biology, and School of Life Science, The Graduate University for Advanced Studies, Okazaki 444 8585, Japan
Mol Biol Cell 19:2039-50. 2008..Our results suggest that Atg1 complex and the autophagy-unique Atg proteins cooperatively organize the PAS in response to starvation signals... - Studies of cargo delivery to the vacuole mediated by autophagosomes in Saccharomyces cerevisiaeKuninori Suzuki
Department of Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji cho, Okazaki 444 8585, Japan
Dev Cell 3:815-24. 2002..This indicates that Cvt19p mediates association between the Cvt complex and the PAS... - The yeast Tor signaling pathway is involved in G2/M transition via polo-kinaseAkio Nakashima
Biosignal Research Center, Kobe University, Kobe, Japan
PLoS ONE 3:e2223. 2008..The C-terminal polo-box domain of Cdc5 has an inhibitory role in nuclear translocation. Taken together, our results indicate a novel function of Tor in the regulation of cell cycle and proliferation... - [Autophagy related genes in yeast, S. cerevisiae]Yoshinori Ohsumi
Tanpakushitsu Kakusan Koso 51:1453-6. 2006 - [Historical overview of autophagy]Yoshinori Ohsumi
Tanpakushitsu Kakusan Koso 51:1444-7. 2006 - Structure-function relationship of Atg12, a ubiquitin-like modifier essential for autophagyTakao Hanada
Division of Molecular Cell Biology, National Institute for Basic Biology, Okazaki, Japan
Autophagy 1:110-8. 2005..Gel filtration analysis suggests that F154 plays a critical role in the assembly of a functional Atg12-Atg5.Atg16 complex that is requisite for autophagosome formation... - Protein turnoverYoshinori Ohsumi
Division of Molecular Cell Biology, National Institute for Basic Biology, Okazaki, Japan
IUBMB Life 58:363-9. 2006..However, for a long time, protein degradation was neglected by most biologists, and was thought of as a rather passive cellular process... - Two newly identified sites in the ubiquitin-like protein Atg8 are essential for autophagyNira Amar
Department of Biological Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
EMBO Rep 7:635-42. 2006..These two newly identified distinct sites that are essential for Atg8 activity provide an explanation for the many protein-protein interactions of this low-molecular-weight protein... - Assortment of phosphatidylinositol 3-kinase complexes--Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiaeKeisuke Obara
Division of Molecular Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki 444 8585, Japan
Mol Biol Cell 17:1527-39. 2006..Together, these results indicate that complexes I and II function in distinct biological processes by localizing to specific compartments in a manner mediated by specific components of each complex, Atg14p and Vps38p, respectively... - Crystallization of Saccharomyces cerevisiae aminopeptidase 1, the major cargo protein of the Cvt pathwayWakana Adachi
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12, W 6, Kita ku, Sapporo 060 0812, Japan
Acta Crystallogr Sect F Struct Biol Cryst Commun 63:200-3. 2007..Self-rotation functions and the volume-to-weight ratio values suggest that forms I and II contain 12 and four mApe1 molecules per asymmetric unit, respectively, and that mApe1 exists as a tetrahedral dodecamer in both crystal forms... - Dynamics and function of PtdIns(3)P in autophagyKeisuke Obara
Faculty of Pharmaceutical Sciences, Hokkaido University, Kitaku, Sapporo, Japan
Autophagy 4:952-4. 2008..Based on these results we discuss the function of PtdIns(3)P in autophagy... - Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvationJun Onodera
Division of Molecular Cell Biology, National Institute for Basic Biology, and Department of Basic Biology, School of Life Science, The Graduate University for Advanced Studies, Nishigonaka 38, Myodaiji-cho, Okazaki 444-8585, Japan
J Biol Chem 280:31582-6. 2005..Autophagy-defective cells fail to maintain physiologic amino acid levels, and their inability to synthesize new proteins may explain most phenotypes associated with autophagy mutants at least partly... - [Involvement of the secretory pathway in the autophagosome formation]Maho Hamasaki
Tanpakushitsu Kakusan Koso 51:1469-73. 2006 - Expression, purification and crystallization of the Atg5-Atg16 complex essential for autophagyMinako Matsushita
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12, W 6, Kita ku, Sapporo 060 0812, Japan
Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1021-3. 2006..Form IV belongs to space group P4(2)2(1)2, with unit-cell parameters a = 73.3, c = 148.1 A. Diffraction data were collected from all crystal forms and high-resolution data to beyond 2.0 A resolution were obtained from a form IV crystal... 
Novel families of vacuolar amino acid transportersTakayuki Sekito
Department of Applied Bioscience, Faculty of Agriculture, Tarumi 3 5 7, Ehime University, Matsuyama, Ehime, Japan
IUBMB Life 60:519-25. 2008..cerevisiae. Homologous genes for these transporters are also found in plant and mammalian genomes. The physiological significance in response to nitrogen starvation can now be discussed...- [Key questions about membrane dynamics during autophagy]Keisuke Obara
Division of Molecular Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji-cho, Okazaki 444-8585, Japan
Seikagaku 80:215-23. 2008 - The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagyTakao Hanada
Division of Molecular Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, Japan
J Biol Chem 282:37298-302. 2007..These results indicate that the Atg12-Atg5 conjugate is a ubiquitin-protein ligase (E3)-like enzyme for Atg8-PE conjugation reaction, distinctively promoting protein-lipid conjugation... - Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusionHitoshi Nakatogawa
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
Cell 130:165-78. 2007..Our results provide further insights into the mechanisms underlying the unique membrane dynamics of autophagy and also indicate the functional versatility of ubiquitin-like proteins... - Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiaeKuninori Suzuki
Department of Cell Biology, Division of Molecular Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Okazaki, Aichi 444 8585 Japan
FEBS Lett 581:2156-61. 2007..In this review, we will give an overview of recent studies on the mechanisms of autophagosome formation and discuss these unresolved questions... - Cis1/Atg31 is required for autophagosome formation in Saccharomyces cerevisiaeYukiko Kabeya
Division of Molecular Cell Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444 8585, Japan
Biochem Biophys Res Commun 356:405-10. 2007..Coimmunoprecipitation experiments indicated that Atg31 interacts with Atg17. Together, Atg31 is a novel protein that, in concert with Atg17, is required for proper autophagosome formation... - Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiaeKeisuke Obara
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
Genes Cells 13:537-47. 2008..We also found a possible enrichment of PtdIns(3)P on the inner autophagosomal membrane compared to the outer membrane. Based on these results we discuss the function of PtdIns(3)P in autophagy... - The Atg18-Atg2 complex is recruited to autophagic membranes via phosphatidylinositol 3-phosphate and exerts an essential functionKeisuke Obara
Department of Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji cho, Okazaki 444 8585, Japan
J Biol Chem 283:23972-80. 2008..Taken together, Atg18 forms a complex with Atg2 irrespective of PtdIns(3)P binding, associates tightly to autophagic membranes by interacting with PtdIns(3)P, and plays an essential role... - The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidationYuya Yamada
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12, W 6, Kita ku, Sapporo 060 0812, Japan
J Biol Chem 282:8036-43. 2007..The structure of Atg3 provides a molecular basis for understanding the unique lipidation reaction that Atg3 carries out... - An Arabidopsis homolog of yeast ATG6/VPS30 is essential for pollen germinationYuki Fujiki
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
Plant Physiol 143:1132-9. 2007..We propose that Arabidopsis Atg6/Vps30 functions not only in autophagy, but also plays a pivotal role in pollen germination... - A family of basic amino acid transporters of the vacuolar membrane from Saccharomyces cerevisiaeMasamitsu Shimazu
Department of Applied Chemistry, Muroran Institute of Technology, Muroran 050 8585, Japan
J Biol Chem 280:4851-7. 2005..These three VBA genes are closely related phylogenetically and constitute a new family of basic amino acid transporters in the yeast vacuole... - Leaf senescence and starvation-induced chlorosis are accelerated by the disruption of an Arabidopsis autophagy geneHideki Hanaoka
Department of Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji cho, Okazaki 444 8585, Japan
Plant Physiol 129:1181-93. 2002..These results imply that autophagy is required for maintenance of the cellular viability under nutrient-limited conditions and for efficient nutrient use as a whole plant... - In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome markerNoboru Mizushima
Department of Cell Biology, National Institute for Basic Biology, Okazaki 444-8585, Japan
Mol Biol Cell 15:1101-11. 2004..Our results suggest that the regulation of autophagy is organ dependent and the role of autophagy is not restricted to the starvation response. This transgenic mouse model is a useful tool to study mammalian autophagy... - Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy geneXueping Qu
Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
J Clin Invest 112:1809-20. 2003..Thus, mutation of beclin 1 or other autophagy genes may contribute to the pathogenesis of human cancers... - Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid methodNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, 332 0012, Kawaguchi, Japan
FEBS Lett 532:450-4. 2002..This novel two-hybrid method, which we have named 'conjugation-mediated yeast two-hybrid', proves to be a simple and useful technique with which to analyze protein-protein conjugation... - Modification of a ubiquitin-like protein Paz2 conducted micropexophagy through formation of a novel membrane structureHiroyuki Mukaiyama
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa-Oiwake, Sakyo-ku, Kyoto 606-8502, Japan
Mol Biol Cell 15:58-70. 2004..We herein show that Paz2 and its modification system conduct micropexophagy through formation of the membrane structure, which explains the convergence between micropexophagy and macroautophagy with regard to de novo membrane formation... - Crystallization and preliminary X-ray analysis of LC3-IKenji Sugawara
Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812, Japan
Acta Crystallogr D Biol Crystallogr 59:1464-5. 2003..39, c = 36.89 A. The other form belongs to space group P4(1) or P4(3), with unit-cell parameters a = 60.48, c = 35.28 A. From the latter form, a complete diffraction data set was collected to 2.1 A resolution... - [The pre-autophagosomal structure (PAS), required for the formation of autophagosome membrane]Kuninori Suzuki
Department of Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji-cho, Okazaki, Aichi 444-8585, Japan
Seikagaku 75:492-9. 2003 - Role of the Apg12 conjugation system in mammalian autophagyNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, 332-0012, Kawaguchi, Japan
Int J Biochem Cell Biol 35:553-61. 2003..Discovery of the Apg12 system has facilitated our understanding of the molecular mechanism of autophagosome formation... - Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugateNoboru Mizushima
PRESTO, Japan Science and Technology Corporation, Kawaguchi 332 0012, Japan
J Cell Sci 116:1679-88. 2003..Because WD-repeat proteins provide a platform for protein-protein interactions, the approximately 800 kDa complex is expected to function in autophagosome formation, further interacting with other proteins in mammalian cells... - The early secretory pathway contributes to autophagy in yeastMaho Hamasaki
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji-cho, Okazaki 444-8585, Japan
Cell Struct Funct 28:49-54. 2003.... - Autophagosome formation in mammalian cellsNoboru Mizushima
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
Cell Struct Funct 27:421-9. 2002..These findings are now being applied to studies on the physiological roles of autophagy in mammals... - apg15-1, a UGA mutant allele in the Saccharomyces cerevisiae APG16 gene, and its suppression by a cytoplasmic factorHiroshi Okazaki
Department of Bioscience, Teikyo University of Science and Technology, Uenohara, Kitatsuru-gun, Yamanashi 409-0193, Japan
Biosci Biotechnol Biochem 68:1541-8. 2004..Since apg15-1 is a mutation highly sensitive to termination suppression, it can be used as a tool to detect weak termination suppressors... - A sorting nexin PpAtg24 regulates vacuolar membrane dynamics during pexophagy via binding to phosphatidylinositol-3-phosphateYoshitaka Ano
Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
Mol Biol Cell 16:446-57. 2005.... - Characterization of a novel autophagy-specific gene, ATG29Tomoko Kawamata
Department of Biology, Graduate School of Science and Technology, Kobe University, Kobe 657 8501, Japan
Biochem Biophys Res Commun 338:1884-9. 2005..Additionally, an Atg29-GFP fusion protein was observed to localize to the PAS. From these results, we propose that Atg29 functions in autophagosome formation at the PAS in collaboration with other Atg proteins... - Interrelationships among Atg proteins during autophagy in Saccharomyces cerevisiaeKuninori Suzuki
Department of Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Myodaiji-cho, Okazaki 444-8585, Japan
Yeast 21:1057-65. 2004..Subsequent analyses revealed epistatic interrelationships among Atg proteins during the process of autophagosome formation... - In vivo and in vitro reconstitution of Atg8 conjugation essential for autophagyYoshinobu Ichimura
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki, 444 8585, Japan
J Biol Chem 279:40584-92. 2004..In vitro system developed here will provide a powerful system for further understanding the precise role of lipidation and interaction of two ubiquitin-like systems essential for autophagy... - The crystal structure of microtubule-associated protein light chain 3, a mammalian homologue of Saccharomyces cerevisiae Atg8Kenji Sugawara
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan
Genes Cells 9:611-8. 2004..We also propose the functional implications of the ubiquitin fold as a recognition module of target proteins... - Two ubiquitin-like conjugation systems essential for autophagyYoshinori Ohsumi
Department of Cell Biology, National Institute for Basic Biology, Myodaiji-cho, Okazaki 444-8585, Japan
Semin Cell Dev Biol 15:231-6. 2004 - LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formationYukiko Kabeya
Department of Cell Biology, National Institute for Basic Biology, Myodaiji 38, Okazaki 444 8585, Japan
J Cell Sci 117:2805-12. 2004..Generation of the form II correlates with autophagosome association of GABARAP and GATE16. These results suggest that all mammalian Atg8 homologues receive a common modification to associate with autophagosomal membrane as the form II... - Formation of the approximately 350-kDa Apg12-Apg5.Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeastAkiko Kuma
Department of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaiji, Okazaki 444 8585, Japan
J Biol Chem 277:18619-25. 2002..These results suggest that the Apg12-Apg5 conjugate and Apg16 form a multimeric complex mediated by the Apg16 homo-oligomer, and formation of the approximately 350-kDa complex is required for autophagy in yeast... - Transcriptomic and proteomic analysis of a 14-3-3 gene-deficient yeastTohru Ichimura
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Hachioji shi, Tokyo 192 0397, Japan
Biochemistry 43:6149-58. 2004..This study presents the first comprehensive overview of the genes and proteins that are affected by the depletion of Bmh1/2p and extends the scope of knowledge of the regulatory roles of Bmh1/2p in S. cerevisiae... - SKD1 AAA ATPase-dependent endosomal transport is involved in autolysosome formationAtsuki Nara
Department of Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, Japan
Cell Struct Funct 27:29-37. 2002..These results indicate that SKD1-dependent endosomal membrane trafficking is required for formation of autolysosomes... - Processing of ATG8s, ubiquitin-like proteins, and their deconjugation by ATG4s are essential for plant autophagyKohki Yoshimoto
Department of Cell Biology, National Institute for Basic Biology, Myodaiji-cho, Okazaki 444-8585, Japan
Plant Cell 16:2967-83. 2004..The phenotypic analysis of atg4a4b-1 indicated that plant autophagy contributes to the development of a root system under conditions of nutrient limitation... - The first molecular evidence that autophagy relates rimmed vacuole formation in chloroquine myopathyTakashi Suzuki
Department of Life Science, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902
J Biochem (Tokyo) 131:647-51. 2002..Therefore, we concluded that autophagy plays an important role in rimmed vacuole formation in certain muscular atrophies... - Yeast autophagosomes: de novo formation of a membrane structureTakeshi Noda
Dept of Cell Biology, National Institute for Basic Biology, 38 Nishigonaka, Myodaijicho, Okazaki, 444-8585, Japan
Trends Cell Biol 12:231-5. 2002..The concerted action of several Apg/Aut/Cvt proteins around a characteristic subcellular structure (the preautophagosomal structure) is the key to understanding this novel type of membrane-formation process... - Physiological pH and acidic phospholipids contribute to substrate specificity in lipidation of Atg8Kyoko Oh-oka
Department of Cell Biology, National Institute for Basic Biology, Graduate University for Advanced Studies, Okazaki 444 8585, Japan
J Biol Chem 283:21847-52. 2008..We propose that these factors contribute to the selective formation of Atg8-PE in the cell... - In vitro reconstitution of plant Atg8 and Atg12 conjugation systems essential for autophagyYuko Fujioka
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 21, W 11, Kita ku, Sapporo 001 0021, Japan
J Biol Chem 283:1921-8. 2008..The in vitro conjugation systems reported here will afford a tool with which to investigate the cross-talk mechanism between two conjugation systems... - Hierarchy of Atg proteins in pre-autophagosomal structure organizationKuninori Suzuki
Department of Cell Biology, Division of Molecular Cell Biology, National Institute for Basic Biology, Nishigonaka 38, Okazaki, 444 8585 Japan
Genes Cells 12:209-18. 2007.... - Structure of Atg5.Atg16, a complex essential for autophagyMinako Matsushita
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 21, W 11, Kita ku, Sapporo 001 0021, Japan
J Biol Chem 282:6763-72. 2007..These results taken together suggest that the direct interaction between Atg5 and Atg16 is crucial to the performance of their roles in autophagy... - Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiaeJun Onodera
Department of Cell Biology, National Institute for Basic Biology, The Graduate University for Advanced Studies, Nishigonaka, Okazaki, Japan
J Biol Chem 279:16071-6. 2004..Ald6p enzymatic activity may be disadvantageous for survival under nitrogen starvation; therefore, yeast cells may preferentially eliminate Ald6p via autophagy... - Crystallization and preliminary X-ray analysis of Atg3Yuya Yamada
Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N-12, W-6, Kita-ku, Sapporo 060-0812, Japan
Acta Crystallograph Sect F Struct Biol Cryst Commun 62:1016-7. 2006..5 A resolution. The crystals belong to space group P4(1) or P4(3), with unit-cell parameters a = 59.33, c = 115.22 A, and are expected to contain one protein molecule per asymmetric unit... - [Physiological role of autophagy for starvation-adaptation in yeast]Jun Onodera
Tanpakushitsu Kakusan Koso 51:1499-502. 2006 - Starvation triggers the delivery of the endoplasmic reticulum to the vacuole via autophagy in yeastMaho Hamasaki
National Institute for Basic Biology, Department of Cell Biology, 38 Nishigonaka, Myodaiji-cho, Okazaki, 444-8585, Japan
Traffic 6:56-65. 2005..This phenomenon was explained by the appearance of fragmented ER membrane structures in almost all autophagosomes. Furthermore, ER dynamism is required for this process: ER uptake by autophagosomes occurs in an actin-dependent manner... - Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceMasaaki Komatsu
Department of Molecular Oncology, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
J Cell Biol 169:425-34. 2005..Our results indicate the important role of autophagy in starvation response and the quality control of proteins and organelles in quiescent cells... - Starved cells eat ribosomesHitoshi Nakatogawa
Nat Cell Biol 10:505-7. 2008