Yoshihiro Kaku

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. pmc Altered specificity of single-chain antibody fragments bound to pandemic H1N1-2009 influenza virus after conversion of the phage-bound to the soluble form
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
    BMC Res Notes 5:483. 2012
  2. doi request reprint Antigen capture ELISA system for henipaviruses using polyclonal antibodies obtained by DNA immunization
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Arch Virol 157:1605-9. 2012
  3. ncbi request reprint [Nipah virus infection]
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infections Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Uirusu 54:237-42. 2004
  4. ncbi request reprint Antigenic properties of porcine teschovirus 1 (PTV-1) Talfan strain and molecular strategy for serotyping of PTVs
    Y Kaku
    Department of Exotic Diseases, National Institute of Animal Health, Tokyo, Japan
    Arch Virol 152:929-40. 2007
  5. doi request reprint Inhibition of rabies virus propagation in mouse neuroblastoma cells by an intrabody against the viral phosphoprotein
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan
    Antiviral Res 91:64-71. 2011
  6. doi request reprint A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan
    J Virol Methods 160:7-13. 2009
  7. doi request reprint Second generation of pseudotype-based serum neutralization assay for Nipah virus antibodies: sensitive and high-throughput analysis utilizing secreted alkaline phosphatase
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    J Virol Methods 179:226-32. 2012
  8. ncbi request reprint Gene expression analysis of host innate immune responses in the central nervous system following lethal CVS-11 infection in mice
    Naoko Sugiura
    Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan
    Jpn J Infect Dis 64:463-72. 2011
  9. doi request reprint Effect of cellular cholesterol depletion on rabies virus infection
    Kozue Hotta
    Department of Veterinary Science, National Institute of Infectious Diseases, 162 8640 Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Virus Res 139:85-90. 2009
  10. ncbi request reprint [Diagnostic tests: Nipah virus (NiV)]
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases
    Nihon Rinsho 63:324-5. 2005

Collaborators

Detail Information

Publications14

  1. pmc Altered specificity of single-chain antibody fragments bound to pandemic H1N1-2009 influenza virus after conversion of the phage-bound to the soluble form
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, Shinjuku, Tokyo, Japan
    BMC Res Notes 5:483. 2012
    ..Aiming to establish H1N1pdm-specific detection tools rapidly, we employed phage display libraries to select H1N1pdm-specific single-chain variable fragments (scFvs)...
  2. doi request reprint Antigen capture ELISA system for henipaviruses using polyclonal antibodies obtained by DNA immunization
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Arch Virol 157:1605-9. 2012
    ..5 × 10(4) TCID(50). Considering the recent emergence of genetic variants of henipaviruses and the resultant problems that arise for PCR-based detection, this system could serve as an alternative rapid diagnostic and detection assay...
  3. ncbi request reprint [Nipah virus infection]
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infections Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    Uirusu 54:237-42. 2004
    ..In this article, the epidemiological comparison between two outbreaks in Malaysia and Bangladesh, and the new-trends of virological studies of NiV will be discussed...
  4. ncbi request reprint Antigenic properties of porcine teschovirus 1 (PTV-1) Talfan strain and molecular strategy for serotyping of PTVs
    Y Kaku
    Department of Exotic Diseases, National Institute of Animal Health, Tokyo, Japan
    Arch Virol 152:929-40. 2007
    ..This RT-PCR-based strategy appears to be a reliable surrogate for serotyping and could facilitate the diagnosis and epidemiological study of PTV infection...
  5. doi request reprint Inhibition of rabies virus propagation in mouse neuroblastoma cells by an intrabody against the viral phosphoprotein
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan
    Antiviral Res 91:64-71. 2011
    ..Although the mechanism of RABV inhibition by scFv-P19 is not clear, this scFv-based intracellular immunization could be a candidate for future RABV therapeutic studies if combined with appropriate delivery and application systems...
  6. doi request reprint A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, Toyama, Shinjuku, Tokyo, Japan
    J Virol Methods 160:7-13. 2009
    ....
  7. doi request reprint Second generation of pseudotype-based serum neutralization assay for Nipah virus antibodies: sensitive and high-throughput analysis utilizing secreted alkaline phosphatase
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku, Tokyo 162 8640, Japan
    J Virol Methods 179:226-32. 2012
    ..The results suggest that this novel VSV-NiV-SEAP assay is safe, useful for high-throughput screening of sera using an ELISA plate reader, and has high sensitivity and specificity...
  8. ncbi request reprint Gene expression analysis of host innate immune responses in the central nervous system following lethal CVS-11 infection in mice
    Naoko Sugiura
    Department of Veterinary Science, National Institute of Infectious Diseases, Tokyo, Japan
    Jpn J Infect Dis 64:463-72. 2011
    ..The presence of perforin and granzymes both in the Purkinje cells and CD3 T lymphocytes strongly suggested that apoptosis of the former cells was induced by the latter cells...
  9. doi request reprint Effect of cellular cholesterol depletion on rabies virus infection
    Kozue Hotta
    Department of Veterinary Science, National Institute of Infectious Diseases, 162 8640 Toyama 1 23 1, Shinjuku ku, Tokyo 162 8640, Japan
    Virus Res 139:85-90. 2009
    ..These results suggest that RABV enters BHK-21 or HEp-2 cells through ports of entry other than those located on cholesterol-rich microdomains and raise the possibility that RABV uses different mechanisms to enter the non-neuronal cells...
  10. ncbi request reprint [Diagnostic tests: Nipah virus (NiV)]
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases
    Nihon Rinsho 63:324-5. 2005
  11. ncbi request reprint Immunohistochemical distribution of viral antigens in pigs naturally infected with porcine teschovirus
    Manabu Yamada
    National Institute of Animal Health, Tsukuba, Ibaraki, Japan
    J Vet Med Sci 70:305-8. 2008
    ..In the other examined organ, PTV antigens were observed in bronchiolar epithelial cells in the lung, hepatocytes in the liver, epithelial cells in the tonsils and the myenteric nerve plexus in the small and large intestine...
  12. ncbi request reprint [Nipah virus infection]
    Yoshihiro Kaku
    Department of Veterinary Science, National Institute of Infectious Diseases
    Nihon Rinsho 65:154-6. 2007
  13. ncbi request reprint Polymerase chain reaction-based genetic typing of Japanese porcine reproductive and respiratory syndrome viruses
    Masaaki Yoshii
    National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, Japan
    J Vet Diagn Invest 16:342-7. 2004
    ..These mismatches appeared to be responsible for the nonreactivity of the former primers to these viruses...
  14. pmc Unique characteristics of a picornavirus internal ribosome entry site from the porcine teschovirus-1 talfan
    Yoshihiro Kaku
    Department of Infectious Diseases, National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Virol 76:11721-8. 2002
    ..The PTV IRES has a unique set of properties and represents a new class of picornavirus IRES element...