H Ito

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. pmc Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 7:e46488. 2012
  2. doi request reprint Relationship between baseline cerebral blood flow and vascular responses to changes in PaCO2 measured by positron emission tomography in humans: implication of inter-individual variations of cerebral vascular tone
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Acta Physiol (Oxf) 193:325-30. 2008
  3. ncbi request reprint Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:355-60. 2007
  4. doi request reprint No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 12:667-75. 2009
  5. ncbi request reprint Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University
    Ann Nucl Med 20:493-8. 2006
  6. doi request reprint A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 49:578-86. 2010
  7. ncbi request reprint Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Neuroimage 39:555-65. 2008
  8. ncbi request reprint Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Departments of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 27:723-31. 2006
  9. doi request reprint Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
  10. doi request reprint Relation between presynaptic and postsynaptic dopaminergic functions measured by positron emission tomography: implication of dopaminergic tone
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 31:7886-90. 2011

Detail Information

Publications106 found, 100 shown here

  1. pmc Effects of dopamine D2 receptor partial agonist antipsychotic aripiprazole on dopamine synthesis in human brain measured by PET with L-[β-11C]DOPA
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 7:e46488. 2012
    ..The therapeutic effects of aripiprazole in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  2. doi request reprint Relationship between baseline cerebral blood flow and vascular responses to changes in PaCO2 measured by positron emission tomography in humans: implication of inter-individual variations of cerebral vascular tone
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Acta Physiol (Oxf) 193:325-30. 2008
    ..In the present study, the relationship between CBF and cerebral vascular tone to inter-individual variation at rest condition was investigated using positron emission tomography (PET)...
  3. ncbi request reprint Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:355-60. 2007
    ..In the present study, we developed a simple method for calculating an indicator of the dopamine synthesis rate with L-[beta-11C]DOPA on a voxel-by-voxel basis for parametric mapping...
  4. doi request reprint No regional difference in dopamine D2 receptor occupancy by the second-generation antipsychotic drug risperidone in humans: a positron emission tomography study
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 12:667-75. 2009
    ..Thus, limbic and cortical selectivity was not observed by one of the second-generation antipsychotics, risperidone...
  5. ncbi request reprint Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: comparison of radiopharmaceuticals marketed by different companies in Japan
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University
    Ann Nucl Med 20:493-8. 2006
    ..Two IMPs (IMPA and IMPB) produced by different radiopharmaceutical companies are marketed in Japan. In the present study, whole-body distributions including brain and blood of the two IMPs were compared in the same human subjects...
  6. doi request reprint A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 49:578-86. 2010
    ..This method can be used to distinguish graphically whether the radioligand binding includes specific binding or not...
  7. ncbi request reprint Normal database of dopaminergic neurotransmission system in human brain measured by positron emission tomography
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Neuroimage 39:555-65. 2008
    ..This database could also be used to investigate regional abnormalities of dopaminergic neurotransmission in neuropsychiatric disorders...
  8. ncbi request reprint Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Departments of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 27:723-31. 2006
    ..In the present study, the regional kinetics of L-[beta-C]DOPA in normal human brain and the accuracy of the method for quantifying L-[beta-C]DOPA kinetics, employing reference regions, were investigated...
  9. doi request reprint Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  10. doi request reprint Relation between presynaptic and postsynaptic dopaminergic functions measured by positron emission tomography: implication of dopaminergic tone
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 31:7886-90. 2011
    ....
  11. ncbi request reprint Error analysis for quantification of [(11)C]FLB 457 binding to extrastriatal D(2) dopamine receptors in the human brain
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Neuroimage 13:531-9. 2001
    ..We concluded that the reference tissue model method is most suitable for calculating BP of extrastriatal D(2) dopamine receptors with [(11)C]FLB 457...
  12. ncbi request reprint Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia
    Ryosuke Arakawa
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Psychopharmacology (Berl) 197:229-35. 2008
    ..Paliperidone ER is a novel antipsychotic drug in an extended-release (ER) formulation. As with all antipsychotics, careful dose setting is necessary to avoid side effects...
  13. ncbi request reprint Effects of scatter correction on regional distribution of cerebral blood flow using I-123-IMP and SPECT
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Japan
    Ann Nucl Med 13:331-6. 1999
    ..The regional distribution of CBF obtained by scatter corrected SPECT was similar to that obtained by O-15 water PET. The scatter correction is needed for the assessment of CBF using SPECT...
  14. ncbi request reprint Effect of intravenous dipyridamole on cerebral blood flow in humans. A PET study
    H Ito
    Department of Radiology, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Stroke 30:1616-20. 1999
    ..However, the effects of dipyridamole on cerebral circulation is not pronounced. This study investigates the effects of intravenous dipyridamole on cerebral blood flow (CBF) in humans with use of positron emission tomography (PET)...
  15. pmc Measurement error analysis for the determination of dopamine D(2) receptor occupancy using the agonist radioligand [(11)C]MNPA
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 30:187-95. 2010
    ..Results showed that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely in region of interest analysis by SRTM with a longer than 60-min [(11)C]MNPA PET scan duration...
  16. doi request reprint Error analysis for PET measurement of dopamine D2 receptor occupancy by antipsychotics with [11C]raclopride and [11C]FLB 457
    Yoko Ikoma
    Molecular Imaging Center, National Institute of Radiological Sciences 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Neuroimage 42:1285-94. 2008
    ..These results demonstrated that dopamine D(2) receptor occupancy by antipsychotics can be estimated precisely with an optimal scan duration with [(11)C]raclopride and [(11)C]FLB 457...
  17. ncbi request reprint Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction
    Kentaro Inoue
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 20:139-46. 2006
    ....
  18. doi request reprint Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216
    Michie Miyoshi
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Nucl Med 50:1095-101. 2009
    ..The aim of this study was to evaluate a quantification method of (11)C-AC-5216 binding in the human brain...
  19. ncbi request reprint Arterial fraction of cerebral blood volume in humans measured by positron emission tomography
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Japan
    Ann Nucl Med 15:111-6. 2001
    ..The venous plus capillary fraction of CBV was 63-70% which is a important factor for the measurement of CMRO2 with MRI...
  20. ncbi request reprint Changes in human regional cerebral blood flow and cerebral blood volume during visual stimulation measured by positron emission tomography
    H Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    J Cereb Blood Flow Metab 21:608-12. 2001
    ..This observation is consistent with reported findings obtained during hypercapnia...
  21. ncbi request reprint Database of normal human cerebral blood flow measured by SPECT: I. Comparison between I-123-IMP, Tc-99m-HMPAO, and Tc-99m-ECD as referred with O-15 labeled water PET and voxel-based morphometry
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 20:131-8. 2006
    ..The regional distribution of tissue fractions of gray matter determined by voxel-based morphometry was also compared with SPECT and PET CBF distributions...
  22. ncbi request reprint Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Neuroimage 34:1643-9. 2007
    ..Our findings suggest that dopamine D2 receptors in the hippocampus might affect the local hippocampal function, but also brain functions outside the hippocampus such as the prefrontal cortex...
  23. ncbi request reprint Database of normal human cerebral blood flow, cerebral blood volume, cerebral oxygen extraction fraction and cerebral metabolic rate of oxygen measured by positron emission tomography with 15O-labelled carbon dioxide or water, carbon monoxide and oxygen:
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Eur J Nucl Med Mol Imaging 31:635-43. 2004
    ..However, the overall inter-individual variation in CBF, CBV, OEF and CMRO(2) was acceptably small. Building a database of normal cerebral haemodynamics obtained by the(15)O-PET methods may be practicable...
  24. ncbi request reprint Effect of regional tracer delay on CBF in healthy subjects measured with dynamic susceptibility contrast-enhanced MRI: comparison with 15O-PET
    Masanobu Ibaraki
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, 6 10 Senshu Kubota machi, Akita 010 0874, Japan
    Magn Reson Med Sci 4:27-34. 2005
    ..SVD-CBFs with and without correction for the delay were compared with CBF measured by positron emission tomography (PET-CBF), which is regarded as the gold standard for quantification of CBF...
  25. doi request reprint Positron emission tomography measurement of dopamine D₂ receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Clin Psychiatry 71:1131-7. 2010
    ..However, the magnitude of hyperprolactinemia differs among antipsychotics, and there is no reliable mechanism-related marker for the risk of hyperprolactinemia that would allow us to characterize antipsychotics...
  26. ncbi request reprint Reproducibility of [11 C]FLB 457 binding in extrastriatal regions
    Y Sudo
    Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 22:1215-21. 2001
    ..These results support the suitability of using [11C]FLB 457 for the quantitative evaluation of extrastriatal D2 receptors and for protocols requiring repeated measurements in the same individual...
  27. doi request reprint Quantitative PET analysis of the dopamine D2 receptor agonist radioligand 11C-(R)-2-CH3O-N-n-propylnorapomorphine in the human brain
    Tatsui Otsuka
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 50:703-10. 2009
    ..In the present study, the kinetics of (11)C-MNPA were examined for the first time, to our knowledge, in the human brain and analyzed using quantitative approaches with or without an arterial input function...
  28. ncbi request reprint Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization
    Takuya Morimoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Ann Nucl Med 20:237-43. 2006
    ..In this study we compared mean regional radioactivity concentration in the late phase and binding potential (BP) between FBP and OSEM algorithms in neurotransmission PET studies for [11C]raclopride and [11C]DASB...
  29. ncbi request reprint Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
    ..However, there was no correlation between BP with NLS and DV with NLS, GA, and MA, because of the variation of K(1)/k(2) between individuals. In conclusion, BP is estimated most reliably by NLS with the two-tissue compartment model...
  30. ncbi request reprint beta-estradiol 3-benzoate affects spermatogenesis in the adult mouse
    Y Toyama
    Department of Anatomy and Developmental Biology, School of Medicine, Chiba University, Chiba, Japan
    Mol Cell Endocrinol 178:161-8. 2001
    ..It is concluded that the chemical seems to affect round spermatids metabolically, but the morphological effect can be detected only from the spermatids older than step 6. The effects of the chemical on adult mice were reversible...
  31. doi request reprint Decreased binding of [11C]NNC112 and [11C]SCH23390 in patients with chronic schizophrenia
    Jun Kosaka
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Life Sci 86:814-8. 2010
    ..However, the results of previous positron emission tomography (PET) studies of dopamine D1 receptor in schizophrenia were not consistent...
  32. doi request reprint Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Psychopharmacology (Berl) 209:285-90. 2010
    ..There has been no investigation of dopamine D(2) receptor occupancy in patients with schizophrenia and the time course of occupancy by antipsychotics with perospirone-like properties...
  33. doi request reprint Extrastriatal dopamine D(2) receptor occupancy in olanzapine-treated patients with schizophrenia
    Ryosuke Arakawa
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, 263 8555, Japan
    Eur Arch Psychiatry Clin Neurosci 260:345-50. 2010
    ..In conclusion, although the subjects and methods were different from previous striatal occupancy studies, these results suggest that limbic occupancy by olanzapine may not be so different from that in the striatum...
  34. ncbi request reprint Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
    Yoko Ikoma
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1531-7. 2006
    ..In this study, we validated the quantification methods of (11)C-verapamil transfer from plasma to the brain in humans...
  35. ncbi request reprint Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain
    Yota Fujimura
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:43-50. 2006
    ..To our knowledge, this is the first study to investigate the (18)F-FEDAA1106 binding to PBR in living human brain by PET. We also aimed to evaluate various analytic methods to quantify the density of PBR...
  36. ncbi request reprint GABAA/Benzodiazepine receptor binding in patients with schizophrenia using [11C]Ro15-4513, a radioligand with relatively high affinity for alpha5 subunit
    Yoshiyuki Asai
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Schizophr Res 99:333-40. 2008
    ..GABA(A)/BZ receptor including alpha5 subunit in the prefrontal cortex and hippocampus might be involved in the pathophysiology of negative symptoms of schizophrenia...
  37. ncbi request reprint Effects of tissue heterogeneity on cerebral vascular response to acetazolamide stress measured by an I-123-IMP autoradiographic method with single-photon emission computed tomography
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980 8575, Japan
    Ann Nucl Med 19:251-60. 2005
    ..Correction for effects of tissue heterogeneity in SPECT data was also attempted...
  38. ncbi request reprint Error analysis of measured cerebral vascular response to acetazolamide stress by I-123-IMP autoradiographic method with single photon emission computed tomography: errors due to distribution volume of I-123-IMP
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 18:221-6. 2004
    ..However, differences between true Vd and assumed Vd results in errors in calculated CBF. In the present study, errors in the CBF response to acetazolamide stress as calculated by the ARG method were investigated...
  39. ncbi request reprint Human cerebral circulation: positron emission tomography studies
    Hiroshi Ito
    Department of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Ann Nucl Med 19:65-74. 2005
    ..These findings should be considered in future studies of the pathophysiology of cerebrovascular diseases...
  40. ncbi request reprint Regional differences in distribution volume of I-123 IMP in the human brain: effect on CBF calculated by ARG method
    Kentaro Inoue
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 16:311-6. 2002
    ..Our purpose was to evaluate regional differences in Vd in the human brain, or possible effects of regional differences in Vd on CBF calculated by the ARG method...
  41. ncbi request reprint The long-term outcome of cystinuria in Japan
    K Akakura
    Department of Urology, Chiba University School of Medicine, Chiba, Japan
    Urol Int 61:86-9. 1998
    ..Prognosis of urinary stone in Japanese patients with cystinuria was relatively good with large variation. The medical treatment to reduce urinary cystine concentration would be useful for the management of cystinuria...
  42. ncbi request reprint Different brain morphologies from different genotypes in a single teleost species, the medaka (Oryzias latipes)
    Y Ishikawa
    Division of Biology, National Institute of Radiological Sciences, Chiba, Japan
    Brain Behav Evol 53:2-9. 1999
    ..This is the first report to demonstrate that there exists intraspecific genetic variation in the gross brain morphology of a wild-type vertebrate...
  43. ncbi request reprint The structure and organization of the human NPAT gene
    T Imai
    Genome Research Group, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Genomics 42:388-92. 1997
    ..The results of the LA-PCR analysis using NPAT- and ACAT-specific primers and human genomic DNA allowed us to map ACAT 12 kb centromeric to NPAT...
  44. ncbi request reprint Brain structures of a medaka mutant, el (eyeless), in which eye vesicles do not evaginate
    Y Ishikawa
    National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Brain Behav Evol 58:173-84. 2001
    ..Thus, the el mutation affects not only the brain structures that are related to the visual system but also those related to the reproductive system...
  45. ncbi request reprint Identification and characterization of a new gene physically linked to the ATM gene
    T Imai
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Genome Res 6:439-47. 1996
    ..It may be possible to propose the idea that the promoter region could be shared by both housekeeping genes and that each gene could influence the expression of the other...
  46. doi request reprint Improvement of likelihood estimation in Logan graphical analysis using maximum a posteriori for neuroreceptor PET imaging
    Miho Shidahara
    National Institute of Radiological Sciences, Molecular Imaging Center, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Ann Nucl Med 23:163-71. 2009
    ..To reduce variance of the total volume of distribution (V (T)) image, we improved likelihood estimation in graphical analysis (LEGA) for dynamic positron emission tomography (PET) images using maximum a posteriori (MAP)...
  47. ncbi request reprint Effects of the reference tissue setting on the parametric image of 11C-WAY 100635
    Akihiro Takano
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 28:193-8. 2007
    ..In this study, regions of interest (ROIs) of the cerebellum for C-WAY 100635 were determined in five different approaches for six healthy male volunteers, and the effects on binding potential parametric images were compared...
  48. ncbi request reprint Progressive changes of pre- and post-synaptic dopaminergic biomarkers in conscious MPTP-treated cynomolgus monkeys measured by positron emission tomography
    Yuji Nagai
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba 263 8555, Japan
    Synapse 61:809-19. 2007
    ....
  49. doi request reprint Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rate
    Miho Shidahara
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Ann Nucl Med 22:667-75. 2008
    ..Our objective in this study was to optimize the scan time for 15O2 gas study for accurate estimation of OEF and CMRO2...
  50. doi request reprint Regional dopamine synthesis in patients with schizophrenia using L-[beta-11C]DOPA PET
    Shoko Nozaki
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Schizophr Res 108:78-84. 2009
    ..Patients with schizophrenia showed higher dopamine synthesis in the left caudate nucleus, and dopaminergic transmission in the thalamus and right temporal cortex might be implicated in the expression of symptoms in schizophrenia...
  51. ncbi request reprint Regional distribution of human cerebral vascular mean transit time measured by positron emission tomography
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Neuroimage 19:1163-9. 2003
    ..Simulation studies showed that errors in CBF and thus MTT caused by regional differences in regional tracer appearance time, distribution volume, and gray-white matter mixing were negligible...
  52. doi request reprint Serotonergic neurotransmission in the living human brain: a positron emission tomography study using [¹¹C]dasb and [¹¹C]WAY100635 in young healthy men
    Harumasa Takano
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Synapse 65:624-33. 2011
    ..05). These databases facilitate the understanding of the regional distribution of serotonergic neurotransmission function in the living human brain and the pathophysiology of various neuropsychiatric disorders...
  53. doi request reprint Regional heterogeneity and age-related change in sub-regions of internal capsule evaluated by diffusion tensor imaging
    Hiroshi Kawaguchi
    Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Japan
    Brain Res 1354:30-9. 2010
    ..Evaluation using eigenvalues (lambda(L) and lambda(T)), as well as FA and MD, may provide important information towards understanding age-related changes and may also be useful for clinical diagnosis of diseased IC...
  54. doi request reprint Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models
    Chie Seki
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Ann Nucl Med 24:249-60. 2010
    ..The aim of this study was to evaluate the applicability of quantification methods using reference tissue models for [(11)C]PE2I...
  55. doi request reprint Norepinephrine transporter occupancy by antidepressant in human brain using positron emission tomography with (S,S)-[18F]FMeNER-D2
    Mizuho Sekine
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Psychopharmacology (Berl) 210:331-6. 2010
    ..Central norepinephrine transporter (NET) is one of the main targets of antidepressants. Although the measurement of NET occupancy has been attempted in humans, the outcomes have been inconclusive...
  56. doi request reprint Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106
    Fumihiko Yasuno
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 64:835-41. 2008
    ..The role of activated microglia in AD is an important topic in the pathophysiology of AD. The aim of this study was to quantify PBR in AD brain with a new high-sensitive PBR ligand, [(11)C]DAA1106...
  57. doi request reprint Contribution of dopamine D1 and D2 receptors to amygdala activity in human
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Neurosci 30:3043-7. 2010
    ..DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective...
  58. ncbi request reprint Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with (18)F-FEDAA1106
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Eur J Nucl Med Mol Imaging 35:416-23. 2008
    ..We evaluated the noise reduction capability of wavelet denoising for estimated binding potential (BP) images (k (3)/k (4)) of the peripheral benzodiazepine receptor using (18)F-FEDAA1106 and nonlinear least-square fitting...
  59. doi request reprint Differential contributions of prefrontal and hippocampal dopamine D(1) and D(2) receptors in human cognitive functions
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Inage, Chiba 263 8555, Japan
    J Neurosci 28:12032-8. 2008
    ..Our findings suggest that orchestration of prefrontal D(1) receptors and hippocampal D(2) receptors might be necessary for human executive function including working memory...
  60. ncbi request reprint Enhanced dopamine release by nicotine in cigarette smokers: a double-blind, randomized, placebo-controlled pilot study
    Hidehiko Takahashi
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Int J Neuropsychopharmacol 11:413-7. 2008
    ..These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system...
  61. ncbi request reprint Changes in cerebral blood flow and cerebral oxygen metabolism during neural activation measured by positron emission tomography: comparison with blood oxygenation level-dependent contrast measured by functional magnetic resonance imaging
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    J Cereb Blood Flow Metab 25:371-7. 2005
    ..This supports the assumption on which BOLD contrast studies during neural activation are based...
  62. ncbi request reprint Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil
    Akihiro Takano
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1427-33. 2006
    ..In the present study, we investigated the P-gp functional differences at the BBB between the haplotypes (1236TT, 2677TT, 3435TT vs. 1236CC, 2677GG, 3435CC) of the MDR1 gene with different quantitative analyses of (11)C-verapamil...
  63. ncbi request reprint Cerebral vascular mean transit time in healthy humans: a comparative study with PET and dynamic susceptibility contrast-enhanced MRI
    Masanobu Ibaraki
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    J Cereb Blood Flow Metab 27:404-13. 2007
    ..This underlying difference may influence interpretation of MTT determined by PET or by DSC-MRI for patients with cerebrovascular disease...
  64. ncbi request reprint Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster
    Y Matsuda
    Genome Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, 263, Japan
    Genomics 34:347-52. 1996
    ..This type of inversion appeared to be conserved in the three rodent species, mouse, rat, and Syrian hamster, using additional comparative mapping data with the Rck gene...
  65. pmc Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system
    Masaki Tokunaga
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 29:1887-96. 2009
    ....
  66. ncbi request reprint Regional changes in human cerebral blood flow during dipyridamole stress: neural activation in the thalamus and prefrontal cortex
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    Neuroimage 16:788-93. 2002
    ....
  67. doi request reprint Quantitative analysis of norepinephrine transporter in the human brain using PET with (S,S)-18F-FMeNER-D2
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 49:1270-6. 2008
    ..In this study, a norepinephrine transporter was visualized in the human brain using this radioligand with PET and quantified by several methods...
  68. doi request reprint Reduced serotonin transporter binding in the insular cortex in patients with obsessive-compulsive disorder: a [11C]DASB PET study
    Ryohei Matsumoto
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Neuroimage 49:121-6. 2010
    ..The change in [(11)C]DASB binding in the insular cortex suggests that dysfunction of the serotonergic system in the limbic area might be involved in the pathophysiology of OCD...
  69. ncbi request reprint Hemodynamic changes during neural deactivation in human brain: a positron emission tomography study of crossed cerebellar diaschisis
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Japan
    Ann Nucl Med 16:249-54. 2002
    ..The increased OEF along with the decreased CBV on the CCD side might indicate that neural deactivation primarily causes vasoconstriction rather than a reduction of oxygen metabolism...
  70. doi request reprint Increase in thalamic binding of [(11)C]PE2I in patients with schizophrenia: a positron emission tomography study of dopamine transporter
    Ryosuke Arakawa
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Psychiatr Res 43:1219-23. 2009
    ..75), positive (r=0.78) and negative PANSS scores (r=0.82). Altered DAT in the thalamus might be related to the pathophysiology and clinical symptoms of schizophrenia...
  71. ncbi request reprint PET measurements of CBF, OEF, and CMRO2 without arterial sampling in hyperacute ischemic stroke: method and error analysis
    Masanobu Ibaraki
    Department of Radiology and Nuclear Medicine, Akita Research Institute, of Brain and Blood Vessels, Japan
    Ann Nucl Med 18:35-44. 2004
    ....
  72. ncbi request reprint Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  73. ncbi request reprint Decrease in glucose metabolism in frontal cortex associated with deterioration of microstructure of corpus callosum measured by diffusion tensor imaging in healthy elderly
    Kentaro Inoue
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Hum Brain Mapp 29:375-84. 2008
    ..The results indicate that neuronal activity in the frontal cortices may decrease with the disruption of the microstructures of the CC without corresponding gray matter atrophy...
  74. ncbi request reprint Changes in human cerebral blood flow and myocardial blood flow during mental stress measured by dual positron emission tomography
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Ann Nucl Med 17:381-6. 2003
    ..Sympathetic stimulation is reported to cause cerebral vasoconstriction and reduce CBF in animals. Although such a sympathetic response was observed in relation to mental stress, no significant change in CBF was observed in our subjects...
  75. ncbi request reprint Scatter and cross-talk correction for one-day acquisition of 123I-BMIPP and 99mtc-tetrofosmin myocardial SPECT
    Tomohiro Kaneta
    Department of Radiology, Graduate School of Medicine, Tohoku University, Japan
    Ann Nucl Med 18:647-52. 2004
    ..These observations indicate that scatter and cross-talk correction is required for one-day acquisition of 123I-BMIPP and 99mTc-tetrofosmin SPECT...
  76. ncbi request reprint Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[beta-11C]DOPA
    Miho Ota
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Life Sci 79:730-6. 2006
    ..These results indicate that the previously demonstrated age-related decline in striatal dopamine synthesis extends to several extrastriatal regions in normal human brain...
  77. ncbi request reprint Postnatal development of the testis in Japanese children based on observations of undescended testes
    J Yuasa
    Department of Urology, Chiba University School of Medicine, Chiba, Japan
    Int J Urol 8:490-4. 2001
    ..Immature Leydig cells were found at 7 years of age and the cells matured by 13 years of age. CONCLUSION: A pattern of postnatal development of the testis in Japanese children was presented...
  78. pmc Head and neck MRI of Kimura disease
    T Horikoshi
    Department of Radiology, Chiba University Hospital, Chiba City, Chiba, Japan
    Br J Radiol 84:800-4. 2011
    ..The purpose of our study was to describe the MR appearance of Kimura disease and to interpret the differences in appearance from malignant parotid gland tumours...
  79. ncbi request reprint Effect of prostatic biopsy on free-to-total prostate-specific antigen ratio in patients with prostate cancer
    Y Furuya
    Department of Urology, Teikyo University School of Medicine, Ichihara Hospital, Chiba, Japan
    Int J Urol 7:49-53. 2000
    ....
  80. ncbi request reprint [Molecular imaging in the drug development of psychotropics using positron emission tomography]
    Harumasa Takano
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba City, 263 8555 Chiba, Japan
    Brain Nerve 59:215-20. 2007
    ....
  81. ncbi request reprint Effects of smoking on the lung accumulation of [11C]McN5652
    Akihiro Takano
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:349-54. 2007
    ..Various factors influence the accumulation of drugs. In this study, we investigated the effects of smoking on drug distribution to the lung using radiolabeled drugs...
  82. ncbi request reprint Development of the blood-testis barrier in the mouse is delayed by neonatally administered diethylstilbestrol but not by beta-estradiol 3-benzoate
    I Hosoi
    Graduate School of Medicine, Chiba University, Chiba, Japan
    Andrologia 34:255-62. 2002
    ..No delay of the blood-testis barrier formation was detected in the E2B-treated mice. Thus, DES and E2B, both of which are known as potent oestrogenic compounds, had different effects on the Sertoli cells...
  83. ncbi request reprint Aberrant expression of Pax-2 mRNA in renal cell carcinoma tissue and parenchyma of the affected kidney
    T Igarashi
    Department of Urology, Chiba University School of Medicine, Chiba, Japan
    Int J Urol 8:60-4. 2001
    ..In order to determine whether the expression of Pax-2 mRNA is a frequent and specific event in renal cell carcinoma, its expression in nephrectomized specimens and cell lines was investigated...
  84. ncbi request reprint Quantitative measurement of regional cerebrovascular reactivity to acetazolamide using 123I-N-isopropyl-p-iodoamphetamine autoradiography with SPECT: validation study using H2 15O with PET
    Kuniaki Ogasawara
    Department of Neurosurgery, Iwate Medical University, 19 1 Uchimaru, Morioka 020 8505, Japan
    J Nucl Med 44:520-5. 2003
    ..To validate the accuracy of (123)I-IMP-ARG for quantifying regional cerebrovascular reactivity (rCVR) to acetazolamide, we compared rCVR determined using (123)I-IMP-ARG with that determined using H(2)(15)O PET...
  85. ncbi request reprint Effects of repetitive transcranial magnetic stimulation on [11C]raclopride binding and cognitive function in patients with depression
    Yuko Kuroda
    Section of Psychiatry and Behavioral Science, Graduate School of Tokyo Medical and Dental University, Tokyo, Japan
    J Affect Disord 95:35-42. 2006
    ..We attempted to determine the effects of chronic rTMS on central dopaminergic function in depression using positron emission tomography (PET) with [11C]raclopride...
  86. ncbi request reprint Changes in the arterial fraction of human cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
    J Cereb Blood Flow Metab 25:852-7. 2005
    ..This indicates that changes in CBV during hypercapnia and hypocapnia are caused by changes in arterial blood volume without changes in venous and capillary blood volume...
  87. ncbi request reprint Apparent CBF decrease with normal aging due to partial volume effects: MR-based partial volume correction on CBF SPECT
    Kentaro Inoue
    Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    Ann Nucl Med 19:283-90. 2005
    ..Our present study demonstrated that age effects on CBF in healthy subjects could reflect morphological differences with age in grey matter...
  88. ncbi request reprint Changes in human cerebral blood flow and cerebral blood volume during hypercapnia and hypocapnia measured by positron emission tomography
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research of Brain and Blood Vessels, Akita, Japan
    J Cereb Blood Flow Metab 23:665-70. 2003
    ....
  89. ncbi request reprint Effect of aging on cerebral vascular response to Paco2 changes in humans as measured by positron emission tomography
    Hiroshi Ito
    Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Japan
    J Cereb Blood Flow Metab 22:997-1003. 2002
    ..Such aging effects should be considered when estimating cerebral perfusion reserve...
  90. ncbi request reprint N-isopropyl-4-[123I]iodoamphetamine (123I-IMP) products: a difference in radiochemical purity, unmetabolized fraction, and octanol extraction fraction in arterial blood and regional brain uptake in rats
    Yasukazu Kanai
    Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Ann Nucl Med 21:387-91. 2007
    ..The appropriate octanol extraction fractions for IMP(A) and IMP(B) should be determined in humans and employed for quantitative CBF measurement in clinical SPECT...
  91. ncbi request reprint Predicting human performance by channelized Hotelling observer in discriminating between Alzheimer's dementia and controls using statistically processed brain perfusion SPECT
    Miho Shidahara
    Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Seiryou machi 4 1, Aoba ku, Sendai, Miyagi 980 8575, Japan
    Ann Nucl Med 20:605-13. 2006
    ....
  92. ncbi request reprint Rationale and design of a study to examine lower targets for low-density lipoprotein-cholesterol and blood pressure in coronary artery disease patients
    Ryozo Nagai
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Circ J 72:515-20. 2008
    ....
  93. ncbi request reprint Trends in myocardial contrast echocardiography: parameteric versus volumetric imaging
    Hiroshi Ito
    Sakurabashi Watanabe Hospital, Division of Cardiology, Kita ku, Osaka 530 0001, Japan
    Expert Rev Cardiovasc Ther 3:133-42. 2005
    ..These quantitative techniques can provide comprehensive and easy-to-understand images, although the quality of the baseline image remains a critical factor...
  94. doi request reprint Maternal heart rate variability just before surgery significantly correlated with emergence behavior of children undergoing general anesthesia
    Young Chang P Arai
    Multidisciplinary Pain Center, Aichi Medical University, Aichi, Japan
    Paediatr Anaesth 18:167-71. 2008
    ..Mental stress affects the autonomic nervous system, thereby influencing heart rate variability (HRV). The present study tested the correlations between preanesthesia maternal HRV and perioperative child behavior...
  95. ncbi request reprint Should the inferior vena cava be reconstructed after resection for malignant tumors?
    Hiroyuki Yoshidome
    Department of General Surgery, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 0856 Japan
    Am J Surg 189:419-24. 2005
    ..Caval replacement after circumferential resection of the inferior vena cava remains controversial. The aim of the current study is to determine whether or not inferior vena cava replacement should be performed...
  96. ncbi request reprint Pancreatic juice cytology in the diagnosis of intraductal papillary mucinous neoplasm of the pancreas: significance of sampling by peroral pancreatoscopy
    Taketo Yamaguchi
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Japan
    Cancer 104:2830-6. 2005
    ..The current study was conducted to assess the diagnostic value of pancreatic juice cytology in IPMN and to examine the usefulness of peroral pancreatoscopy (POPS) in sampling pancreatic juice...
  97. doi request reprint Recurrent hyperperfusion in the right orbitofrontal cortex in obsessive-compulsive disorder
    Ryohei Matsumoto
    Prog Neuropsychopharmacol Biol Psychiatry 32:1082-4. 2008
  98. ncbi request reprint Long term effects of phlebotomy on biochemical and histological parameters of chronic hepatitis C
    Motoyoshi Yano
    Third Department of Internal Medicine, Nagoya University School of Medicine, Japan
    Am J Gastroenterol 97:133-7. 2002
    ..Known as iron reduction therapy, phlebotomy reduces serum ALT activity. This effect might continue with maintenance phlebotomy and result in slower progression of liver fibrosis...
  99. ncbi request reprint Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction
    Daisaku Nakatani
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Am J Cardiol 100:1212-7. 2007
    ..039), and those with stent implantation (HR 0.437, p = 0.034). In conclusion, in selected patients with high TIMI risk scores, an age > or =70 years, diabetes mellitus, or stenting, ICT is associated with a lower 30-day mortality rate...
  100. ncbi request reprint Computed tomographic angiography to evaluate the right gastroepiploic artery for coronary artery bypass grafting
    Toshiro Kobayashi
    Department of Surgery and Clinical Science, Division of Cardiac Surgery, Yamaguchi University Graduate School of Medicine, Ube, Japan
    Ann Thorac Cardiovasc Surg 14:166-71. 2008
    ..We evaluated the accuracy of preoperative three-dimensional computed tomographic angiography (3D-CTA) for assessing the suitability of RGEAs for CABG...
  101. ncbi request reprint Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...