Kikuo Isoda

Summary

Affiliation: National Defense Medical College
Country: Japan

Publications

  1. doi request reprint Deficiency of interleukin-1 receptor antagonist promotes spontaneous femoral artery aneurysm formation in mice
    Kikuo Isoda
    Department of Internal Medicine 1, National Defense Medical College, Tokorozawa, Japan
    Am J Pathol 180:1254-63. 2012
  2. doi request reprint Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Arterioscler Thromb Vasc Biol 30:708-15. 2010
  3. pmc Pulmonary intravascular lymphoma diagnosed by 18-fluorodeoxyglucose positron emission tomography-guided transbronchial lung biopsy in a man with long-term survival: a case report
    Tomiharu Niida
    Division of Cardiovascular Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Med Case Reports 5:295. 2011
  4. ncbi request reprint Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Arterioscler Thromb Vasc Biol 24:1068-73. 2004
  5. ncbi request reprint Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury
    Kikuo Isoda
    First Department of Internal Medicine, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Circulation 108:516-8. 2003
  6. ncbi request reprint Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice
    Manabu Kitagaki
    Medical Engineering, National Defense Medical College, Saitama, Japan
    J Atheroscler Thromb 19:36-46. 2012
  7. doi request reprint IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice
    Tomiharu Niida
    Department of Internal Medicine 1, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Cardiovasc Res 93:371-9. 2012
  8. ncbi request reprint Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Biol Chem 280:7002-9. 2005
  9. ncbi request reprint Deficiency of CuZn superoxide dismutase promotes inflammation and alters medial structure following vascular injury
    Norio Ishigami
    Department of Internal Medicine 1, National Defense Medical College, Saitama, Japan
    J Atheroscler Thromb 18:1009-17. 2011
  10. ncbi request reprint Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Circulation 107:679-81. 2003

Collaborators

Detail Information

Publications19

  1. doi request reprint Deficiency of interleukin-1 receptor antagonist promotes spontaneous femoral artery aneurysm formation in mice
    Kikuo Isoda
    Department of Internal Medicine 1, National Defense Medical College, Tokorozawa, Japan
    Am J Pathol 180:1254-63. 2012
    ..We believe that these mice will provide much information about the natural history and management of FAAs...
  2. doi request reprint Deficiency of interleukin-1 receptor antagonist induces aortic valve disease in BALB/c mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Arterioscler Thromb Vasc Biol 30:708-15. 2010
    ..However, the role of IL-1Ra in aortic valve stenosis (AS) remains poorly understood [corrected]...
  3. pmc Pulmonary intravascular lymphoma diagnosed by 18-fluorodeoxyglucose positron emission tomography-guided transbronchial lung biopsy in a man with long-term survival: a case report
    Tomiharu Niida
    Division of Cardiovascular Medicine, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    J Med Case Reports 5:295. 2011
    ..abstract:..
  4. ncbi request reprint Lack of interleukin-1 receptor antagonist modulates plaque composition in apolipoprotein E-deficient mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Arterioscler Thromb Vasc Biol 24:1068-73. 2004
    ..Interleukin (IL)-1 plays an important role in atherosclerosis. IL-1 receptor antagonist (IL-1Ra) is an endogenous inhibitor of IL-1. However, the role of IL-1Ra in the development of atherosclerosis is poorly understood...
  5. ncbi request reprint Deficiency of interleukin-1 receptor antagonist promotes neointimal formation after injury
    Kikuo Isoda
    First Department of Internal Medicine, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama, 359 8513, Japan
    Circulation 108:516-8. 2003
    ..Activity of this cytokine is modulated endogenously via the IL-1 receptor antagonist (IL-1Ra). The role of IL-1Ra in neointima formation after injury, however, is poorly understood...
  6. ncbi request reprint Novel TNF-α receptor 1 antagonist treatment attenuates arterial inflammation and intimal hyperplasia in mice
    Manabu Kitagaki
    Medical Engineering, National Defense Medical College, Saitama, Japan
    J Atheroscler Thromb 19:36-46. 2012
    ..This study aimed to determine the effect and mechanism of a novel TNFR1 antagonist in the suppression of arterial inflammation...
  7. doi request reprint IκBNS regulates interleukin-6 production and inhibits neointimal formation after vascular injury in mice
    Tomiharu Niida
    Department of Internal Medicine 1, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Cardiovasc Res 93:371-9. 2012
    ..IL-6 is an inflammatory biomarker for cardiovascular diseases. The aim of this study was to determine whether IκBNS changes arterial inflammation and intimal hyperplasia after vascular injury...
  8. ncbi request reprint Deficiency of interleukin-1 receptor antagonist deteriorates fatty liver and cholesterol metabolism in hypercholesterolemic mice
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, Tokorozawa 359 8513, Japan
    J Biol Chem 280:7002-9. 2005
    ..Therefore, we conclude that the lack of IL-1Ra deteriorates cholesterol homeostasis under atherogenic diet-induced inflammation...
  9. ncbi request reprint Deficiency of CuZn superoxide dismutase promotes inflammation and alters medial structure following vascular injury
    Norio Ishigami
    Department of Internal Medicine 1, National Defense Medical College, Saitama, Japan
    J Atheroscler Thromb 18:1009-17. 2011
    ..The anti-oxidant enzyme copper/zinc superoxide dismutase (CuZnSOD) metabolizes superoxide anion (O(2)(-)) in vascular cells. However, the role of CuZnSOD in vascular injury remains poorly understood...
  10. ncbi request reprint Osteopontin transgenic mice fed a high-cholesterol diet develop early fatty-streak lesions
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, Tokorozawa, Saitama, Japan
    Circulation 107:679-81. 2003
    ..Compared with the non-Tg mice, a 42% (P<0.01) and 73% (P<0.001) decrease in the IL-10 production was identified in the OPN-Tg mice either without or with lipopolysaccharide...
  11. ncbi request reprint Left ventricular hypertrophy in mice with a cardiac-specific overexpression of interleukin-1
    Kenichiro Nishikawa
    Internal Medicine 1, National Defense Medical College, 3 2 Namiki Tokorozawa Saitama, 359 0042, Japan
    Am J Physiol Heart Circ Physiol 291:H176-83. 2006
    ..Histological and echocardiographic analyses revealed concentric LV hypertrophy with preserved LV systolic function in the mice. Our results suggest that myocardial expression of IL-1 is sufficient to cause LV hypertrophy...
  12. pmc Hepatic extracellular signal-regulated kinase 2 suppresses endoplasmic reticulum stress and protects from oxidative stress and endothelial dysfunction
    Takehiko Kujiraoka
    Division of Cardiovascular Medicine, Department of Internal Medicine, National Defense Medical College, Sayama, Japan
    J Am Heart Assoc 2:e000361. 2013
    ..The liver plays a central role in metabolism, and hepatosteatosis is associated with vascular diseases. The aim of study was to elucidate the role of hepatic ERK2 in hepatosteatosis, metabolic remodeling, and endothelial dysfunction...
  13. ncbi request reprint Osteopontin plays an important role in the development of medial thickening and neointimal formation
    Kikuo Isoda
    First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Circ Res 91:77-82. 2002
    ....
  14. ncbi request reprint Late gadolinium enhanced high resolution magnetic resonance imaging reveals pathophysiological condition of cardiac sarcoidosis
    Tomiharu Niida
    Department of Internal Medicine I, National Defense Medical College, Saitama, Japan
    Int Heart J 50:263-6. 2009
    ..These findings indicate that high resolution late gadolinium enhanced MRI might be very useful as a guide for endomyocardial biopsy in patients with cardiac sarcoidosis...
  15. ncbi request reprint Interleukin-1 and occlusive arterial diseases
    Masatoshi Kusuhara
    First Department of Internal Medicine, National Defense Medical College, 3 2, Namiki, Tokorozawa, Saitama 359 0042, Japan
    Cardiovasc Hematol Agents Med Chem 4:229-35. 2006
    ..In this review, we will discuss the recent advances in our understanding of the mechanism of action of IL-1 in occlusive arterial diseases such as neointimal hyperplasia and atherosclerosis, specifically in a mouse model...
  16. ncbi request reprint The effect of interleukin-1 receptor antagonist on arteries and cholesterol metabolism
    Kikuo Isoda
    Internal Medicine I, National Defense Medical College, Tokorozawa, Saitama, Japan
    J Atheroscler Thromb 13:21-30. 2006
    ..Taken together, these results suggest that IL-1Ra plays important roles in restenosis after angioplasty, the development of atherosclerosis, and the metabolism of cholesterol in vivo...
  17. ncbi request reprint Oxidized low-density lipoprotein and high-density lipoprotein cholesterol modulate coronary arterial remodeling: an intravascular ultrasound study
    Satoru Yoneyama
    First Department of Internal Medicine, National Defense Medical College, Tokorozawa, Saitama, Japan
    Clin Cardiol 26:31-5. 2003
    ..Probucol (powerful antioxidant) reduced restenosis rate by improving constrictive remodeling. Thus, oxLDL may modulate coronary arterial remodeling...
  18. ncbi request reprint Characterization of the expression of TLR2 (toll-like receptor 2) and TLR4 on circulating monocytes in coronary artery disease
    Kazuhiro Ashida
    Internal Medicine I, National Defense Medical College, Saitama, Japan
    J Atheroscler Thromb 12:53-60. 2005
    ..In conclusions, TLR4 levels increased in both SA and UA. Monocytes in UA were characterized by elevated TLR2 levels and unresponsiveness of the TLR2 levels to TLR4 stimulation...
  19. ncbi request reprint Fluorescence analysis of biochemical constituents identifies atherosclerotic plaque with a thin fibrous cap
    Koh Arakawa
    Department of Internal Medicine I, National Defense Medical College, Saitama, Japan
    Arterioscler Thromb Vasc Biol 22:1002-7. 2002
    ....