Affiliation: National Defense Medical College
Ishizuka T, Goshima H, Ozawa A, Watanabe Y. Effect of nicotine on the proliferation and differentiation of mouse induced pluripotent stem cells. Curr Med Chem. 2012;19:5164-9 pubmed
Ishizuka T, Goshima H, Ozawa A, Watanabe Y. Involvement of ?-adrenoceptors in the differentiation of human induced pluripotent stem cells into mesodermal progenitor cells. Eur J Pharmacol. 2014;740:28-34 pubmed publisher
..These results suggest that ?-adrenoceptor stimulation in human iPS cells may enhance their differentiation into mesodermal progenitor cells via the activation of either protein kinase A or p38 MAPK. ..
Ishizuka T, Niwa A, Tabuchi M, Ooshima K, Higashino H. Acetylsalicylic acid provides cerebrovascular protection from oxidant damage in salt-loaded stroke-prone rats. Life Sci. 2008;82:806-15 pubmed publisher
..These results suggest that low-dose aspirin may exert protective effects against cerebrovascular inflammation and damage by salt loading through down-regulation of superoxide production and induction of nitric oxide synthesis. ..
Ishizuka T, Hinata T, Watanabe Y. Superoxide induced by a high-glucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells. J Endocrinol. 2011;208:147-59 pubmed publisher
Hirose W, Uchiyama T, Nemoto A, Harigai M, Itoh K, Ishizuka T, et al
. Diagnostic performance of measuring antibodies to the glycopeptidolipid core antigen specific to Mycobacterium avium complex in patients with rheumatoid arthritis: results from a cross-sectional observational study. Arthritis Res Ther. 2015;17:273 pubmed publisher
Ishizuka T, Watanabe Y. ??-Adrenoceptor stimulation enhances leukemia inhibitory factor-induced proliferation of mouse-induced pluripotent stem cells. Eur J Pharmacol. 2011;668:42-56 pubmed publisher
..These results suggest that stimulation with ?(1)-adrenoceptor may enhance DNA synthesis and proliferation of mouse iPS cells cultured with LIF via augmentation of both the MEK/MAPK and the PI3K/Akt pathways. ..
Ishizuka T, Goshima H, Ozawa A, Watanabe Y. Effect of angiotensin II on proliferation and differentiation of mouse induced pluripotent stem cells into mesodermal progenitor cells. Biochem Biophys Res Commun. 2012;420:148-55 pubmed publisher
Ishizuka T, Ozawa A, Goshima H, Watanabe Y. Involvement of nicotinic acetylcholine receptor in the proliferation of mouse induced pluripotent stem cells. Life Sci. 2012;90:637-48 pubmed publisher
..The present study indicates that stimulation of ?(4)-nAchR and ?(7)-nAchR may lead to a significant increase in the rate of mouse iPS cell proliferation through enhancement of the CaMK? signaling pathway. ..