Research Topics
Species | Y IshimiSummaryAffiliation: National Institute of Infectious Diseases Country: Japan Publications
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Detail Information
Publications
Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic miceYoshiko Ishimi
National Institute of Health and Nutrition, Tokyo 162 8636, Japan
J Nutr 140:1373S-6S. 2010..Our data suggest that prevention of bone loss and fat accumulation in early postmenopausal women by isoflavones may depend on an individual's equol-producing capacity...
Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiencyY Ishimi
Department of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
Endocrinology 140:1893-900. 1999..Phytoestrogens may be useful for preventing bone loss caused by estrogen deficiency in females...- Difference in effective dosage of genistein on bone and uterus in ovariectomized miceY Ishimi
Division of Food Science, National Institute of Health and Nutrition, Tokyo, 162 8636, Japan
Biochem Biophys Res Commun 274:697-701. 2000..3 nmol/ml) and 50-fold (20.4 nmol/ml) higher than that in OVX mice. These results suggest that there is a marked difference between genistein dosages that protect against bone loss and those that induce uterine hypertrophy... - Soybean isoflavones in bone healthYoshiko Ishimi
National Institute of Health and Nutrition, Tokyo, Japan
Forum Nutr 61:104-16. 2009..Further studies are required to address the numerous questions on the potential benefits, mechanisms of action, and safety of isoflavones... - Effects of spirulina, a blue-green alga, on bone metabolism in ovariectomized rats and hindlimb-unloaded miceYoshiko Ishimi
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
Biosci Biotechnol Biochem 70:363-8. 2006..These results suggest that the intake of spirulina decreased BMD in the trabecular bone of rodents under estrogen-deficient conditions... - Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male miceY Ishimi
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
Bone 31:180-5. 2002..These results suggest that soybean isoflavones prevent bone loss due to androgen deficiency in males... - Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized miceJ Wu
Division of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
J Bone Miner Res 16:1829-36. 2001..These results indicate that the combined intervention of moderate exercise and the submaximal dose of genistein administration show a cooperative effect in preventing bone loss in OVX mice... - The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3T Sato
Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
FEBS Lett 285:21-4. 1991.... - Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized miceHiroshige Chiba
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
J Nutr 133:1892-7. 2003..05) than in the OVX group fed the control diet. These results suggest a possible role for citrus flavonoids in the prevention of lifestyle-related diseases because of their beneficial effects on bone and lipids... - Differential effects of isoflavones on bone formation in growing male and female miceMaiko Fujioka
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
Metabolism 56:1142-8. 2007..These results suggest that daidzein has a specific, sexually dimorphic effect on bone formation and BMD during growth period in mice... - Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trialJian Wu
Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan
Menopause 14:866-74. 2007..This study aimed to investigate whether the effects of soy isoflavones on bone and fat mass are related to an individual's equol status... - Soybean isoflavones preserve bone mass in hindlimb-unloaded miceFumie Sugiyama
Division of Applied Food Research, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8636, Japan
J Bone Miner Metab 24:439-46. 2006..These results suggest that isoflavones might be promising food components that provide protection from bone loss and normalize stress-induced serum corticosterone during skeletal unloading... - [Prevention of osteoporosis by foods and dietary supplements. Soybean isoflavone and bone metabolism]Yoshiko Ishimi
National Institute of Health and Nutrition, Program of Nutritional Epidemiology, Project for Bio-index
Clin Calcium 16:1661-67. 2006..This report demonstrates the effects of isoflavones on bone metabolism and safety... - Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trialJian Wu
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo 162-8636, Japan
Metabolism 55:423-33. 2006..The findings of this study suggest that the preventive effects of isoflavones on bone loss depend on the individual's intestinal flora for equol production... - A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized miceAtsutane Ohta
Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado City, Saitama 350 0289, Japan
J Nutr 132:2048-54. 2002..These results suggest that FOS increase the bioavailability of isoflavones, leading to cooperative effects in the prevention of osteopenia in OVX mice... - Puerariae radix prevents bone loss in castrated male miceXinxiang Wang
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo 162-8636, Japan
Metabolism 54:1536-41. 2005..These results propose the possibility that estrogenic Chinese herbs such as PR can be one of the candidates for the treatment or prevention of osteoporosis in elderly men with hypogonadism... - Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fatYasutomi Kamei
National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
J Nutr Sci Vitaminol (Tokyo) 51:110-7. 2005..Thus a decrease in the expression of energy expenditure-related genes in adipose tissue and skeletal muscle could, in part, be responsible for obesity after ovariectomy... - Puerariae radix prevents bone loss in ovariectomized miceXinxiang Wang
Division of Food Science, National Institute of Health and Nutrition, 1-23-1 Toyama, 162-8636, Tokyo, Shinjyuku-ku, Japan
J Bone Miner Metab 21:268-75. 2003..Sp in OVX mice compared with that in the sham-operated mice. These results suggest that PR may represent a potential alternative medicine for hormone replacement therapy (HRT) in the prevention of osteoporosis in postmenopausal women... - High bone mass gained by exercise in growing male mice is increased by subsequent reduced exerciseJian Wu
Division of Applied Food Research, The National Institute of Health and Nutrition, Tokyo 162-8636, Japan
J Appl Physiol 97:806-10. 2004..These results suggest that the high bone formation gained through exercise can be maintained, and bone mass was further increased by subsequent exercise even if the exercise frequency is reduced... - Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized miceJian Wu
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
Metabolism 53:942-8. 2004.... - Combined intervention of exercise and genistein prevented androgen deficiency-induced bone loss in miceJian Wu
Division of Food Science, National Institute of Health and Nutrition, Tokyo 162 - 8636, Japan
J Appl Physiol 94:335-42. 2003..These results indicate that the combined intervention of moderate exercise and a low dose of genistein administration shows an additive effect in preventing bone loss in ORX mice similar to that in ovariectomized mice... - Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized miceMaiko Fujioka
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, 162-8636, Japan
J Nutr 134:2623-7. 2004..E(2) inhibited bone loss from all regions induced by OVX. These results suggest that equol, a major metabolite of daidzein, inhibits bone loss apparently without estrogenic activity in the reproductive organs of OVX mice... - Effects of genistein, an isoflavone, on pregnancy outcome and organ weights of pregnant and lactating rats and development of their suckling pupsYuko Tousen
Department of Human Life and Culture, Seitoku University, Matsudo 271 8555, Japan
J Nutr Sci Vitaminol (Tokyo) 52:174-82. 2006..However, the results indicated in many papers suggest the necessity of further study on the safety of genistein... - Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trialJian Wu
Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
J Bone Miner Res 21:780-9. 2006..Further studies over longer treatment duration that include assessment of BMD at various regions are necessary to ascertain the clinical significance of the combined intervention of isoflavone plus walking in postmenopausal women... - [The role of mevalonate pathway in osteogenic cells]Yoshiko Ishimi
Division of Applied Food Research, National Institute of Health and Nutrition
Nippon Rinsho 62:779-82. 2004 - Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature ratsJian Wu
Division of Applied Food Research, National Institute of Health and Nutrition, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan
J Bone Miner Metab 22:547-53. 2004..These results suggest that orally administered collagen peptide may provide beneficial effects on bone metabolism, especially in the calcium-deficient condition, without obvious undesirable effects... - Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formationXinxiang Wang
Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
J Bone Miner Res 17:91-100. 2002..These results indicate that GGA increases bone mass by maintaining a positive balance of bone turnover by inducing osteoblast differentiation and suppressing osteoclast formation...