Y Ishimi

Summary

Affiliation: National Institute of Infectious Diseases
Country: Japan

Publications

  1. pmc Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: a pilot study
    Yuko Tousen
    Department of Food Function and Labeling, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Nutr J 12:127. 2013
  2. ncbi request reprint Difference in effective dosage of genistein on bone and uterus in ovariectomized mice
    Y Ishimi
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, 162 8636, Japan
    Biochem Biophys Res Commun 274:697-701. 2000
  3. ncbi request reprint Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
    Y Ishimi
    Department of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    Endocrinology 140:1893-900. 1999
  4. ncbi request reprint Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice
    Y Ishimi
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    Bone 31:180-5. 2002
  5. doi request reprint Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic mice
    Yoshiko Ishimi
    National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Nutr 140:1373S-6S. 2010
  6. doi request reprint Soybean isoflavones in bone health
    Yoshiko Ishimi
    National Institute of Health and Nutrition, Tokyo, Japan
    Forum Nutr 61:104-16. 2009
  7. ncbi request reprint Effects of spirulina, a blue-green alga, on bone metabolism in ovariectomized rats and hindlimb-unloaded mice
    Yoshiko Ishimi
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Biosci Biotechnol Biochem 70:363-8. 2006
  8. ncbi request reprint Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice
    J Wu
    Division of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 16:1829-36. 2001
  9. ncbi request reprint The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3
    T Sato
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    FEBS Lett 285:21-4. 1991
  10. ncbi request reprint High bone mass gained by exercise in growing male mice is increased by subsequent reduced exercise
    Jian Wu
    Division of Applied Food Research, The National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Appl Physiol 97:806-10. 2004

Collaborators

Detail Information

Publications30

  1. pmc Effects of short-term fructooligosaccharide intake on equol production in Japanese postmenopausal women consuming soy isoflavone supplements: a pilot study
    Yuko Tousen
    Department of Food Function and Labeling, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Nutr J 12:127. 2013
    ..The purpose of the present study was to determine whether FOS supplementation increases equol production in equol producers and stimulates equol production in equol non-producers in Japanese postmenopausal women...
  2. ncbi request reprint Difference in effective dosage of genistein on bone and uterus in ovariectomized mice
    Y Ishimi
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, 162 8636, Japan
    Biochem Biophys Res Commun 274:697-701. 2000
    ..3 nmol/ml) and 50-fold (20.4 nmol/ml) higher than that in OVX mice. These results suggest that there is a marked difference between genistein dosages that protect against bone loss and those that induce uterine hypertrophy...
  3. ncbi request reprint Selective effects of genistein, a soybean isoflavone, on B-lymphopoiesis and bone loss caused by estrogen deficiency
    Y Ishimi
    Department of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    Endocrinology 140:1893-900. 1999
    ..Phytoestrogens may be useful for preventing bone loss caused by estrogen deficiency in females...
  4. ncbi request reprint Genistein, a soybean isoflavone, affects bone marrow lymphopoiesis and prevents bone loss in castrated male mice
    Y Ishimi
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    Bone 31:180-5. 2002
    ..These results suggest that soybean isoflavones prevent bone loss due to androgen deficiency in males...
  5. doi request reprint Dietary equol and bone metabolism in postmenopausal Japanese women and osteoporotic mice
    Yoshiko Ishimi
    National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Nutr 140:1373S-6S. 2010
    ..Our data suggest that prevention of bone loss and fat accumulation in early postmenopausal women by isoflavones may depend on an individual's equol-producing capacity...
  6. doi request reprint Soybean isoflavones in bone health
    Yoshiko Ishimi
    National Institute of Health and Nutrition, Tokyo, Japan
    Forum Nutr 61:104-16. 2009
    ..Further studies are required to address the numerous questions on the potential benefits, mechanisms of action, and safety of isoflavones...
  7. ncbi request reprint Effects of spirulina, a blue-green alga, on bone metabolism in ovariectomized rats and hindlimb-unloaded mice
    Yoshiko Ishimi
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Biosci Biotechnol Biochem 70:363-8. 2006
    ..These results suggest that the intake of spirulina decreased BMD in the trabecular bone of rodents under estrogen-deficient conditions...
  8. ncbi request reprint Cooperative effects of exercise training and genistein administration on bone mass in ovariectomized mice
    J Wu
    Division of Food Science, The National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 16:1829-36. 2001
    ..These results indicate that the combined intervention of moderate exercise and the submaximal dose of genistein administration show a cooperative effect in preventing bone loss in OVX mice...
  9. ncbi request reprint The specific production of the third component of complement by osteoblastic cells treated with 1 alpha,25-dihydroxyvitamin D3
    T Sato
    Department of Biochemistry, School of Dentistry, Showa University, Tokyo, Japan
    FEBS Lett 285:21-4. 1991
    ....
  10. ncbi request reprint High bone mass gained by exercise in growing male mice is increased by subsequent reduced exercise
    Jian Wu
    Division of Applied Food Research, The National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Appl Physiol 97:806-10. 2004
    ..These results suggest that the high bone formation gained through exercise can be maintained, and bone mass was further increased by subsequent exercise even if the exercise frequency is reduced...
  11. ncbi request reprint A combination of dietary fructooligosaccharides and isoflavone conjugates increases femoral bone mineral density and equol production in ovariectomized mice
    Atsutane Ohta
    Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado City, Saitama 350 0289, Japan
    J Nutr 132:2048-54. 2002
    ..These results suggest that FOS increase the bioavailability of isoflavones, leading to cooperative effects in the prevention of osteopenia in OVX mice...
  12. ncbi request reprint Combined intervention of exercise and genistein prevented androgen deficiency-induced bone loss in mice
    Jian Wu
    Division of Food Science, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    J Appl Physiol 94:335-42. 2003
    ..These results indicate that the combined intervention of moderate exercise and a low dose of genistein administration shows an additive effect in preventing bone loss in ORX mice similar to that in ovariectomized mice...
  13. ncbi request reprint Hesperidin, a citrus flavonoid, inhibits bone loss and decreases serum and hepatic lipids in ovariectomized mice
    Hiroshige Chiba
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    J Nutr 133:1892-7. 2003
    ..05) than in the OVX group fed the control diet. These results suggest a possible role for citrus flavonoids in the prevention of lifestyle-related diseases because of their beneficial effects on bone and lipids...
  14. ncbi request reprint Differential effects of isoflavones on bone formation in growing male and female mice
    Maiko Fujioka
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    Metabolism 56:1142-8. 2007
    ..These results suggest that daidzein has a specific, sexually dimorphic effect on bone formation and BMD during growth period in mice...
  15. ncbi request reprint Possible role of equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women: a double-blind, randomized, controlled trial
    Jian Wu
    Nutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan
    Menopause 14:866-74. 2007
    ..This study aimed to investigate whether the effects of soy isoflavones on bone and fat mass are related to an individual's equol status...
  16. ncbi request reprint Soybean isoflavones preserve bone mass in hindlimb-unloaded mice
    Fumie Sugiyama
    Division of Applied Food Research, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo, 162 8636, Japan
    J Bone Miner Metab 24:439-46. 2006
    ..These results suggest that isoflavones might be promising food components that provide protection from bone loss and normalize stress-induced serum corticosterone during skeletal unloading...
  17. ncbi request reprint [Prevention of osteoporosis by foods and dietary supplements. Soybean isoflavone and bone metabolism]
    Yoshiko Ishimi
    National Institute of Health and Nutrition, Program of Nutritional Epidemiology, Project for Bio index
    Clin Calcium 16:1661-67. 2006
    ..This report demonstrates the effects of isoflavones on bone metabolism and safety...
  18. ncbi request reprint Ovariectomy in mice decreases lipid metabolism-related gene expression in adipose tissue and skeletal muscle with increased body fat
    Yasutomi Kamei
    National Institute of Health and Nutrition, Shinjuku ku, Tokyo 162 8636, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:110-7. 2005
    ..Thus a decrease in the expression of energy expenditure-related genes in adipose tissue and skeletal muscle could, in part, be responsible for obesity after ovariectomy...
  19. ncbi request reprint Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women: a randomized placebo-controlled trial
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    Metabolism 55:423-33. 2006
    ..The findings of this study suggest that the preventive effects of isoflavones on bone loss depend on the individual's intestinal flora for equol production...
  20. ncbi request reprint Puerariae radix prevents bone loss in ovariectomized mice
    Xinxiang Wang
    Division of Food Science, National Institute of Health and Nutrition, 1 23 1 Toyama, 162 8636, Tokyo, Shinjyuku ku, Japan
    J Bone Miner Metab 21:268-75. 2003
    ..Sp in OVX mice compared with that in the sham-operated mice. These results suggest that PR may represent a potential alternative medicine for hormone replacement therapy (HRT) in the prevention of osteoporosis in postmenopausal women...
  21. ncbi request reprint Puerariae radix prevents bone loss in castrated male mice
    Xinxiang Wang
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo 162 8636, Japan
    Metabolism 54:1536-41. 2005
    ..These results propose the possibility that estrogenic Chinese herbs such as PR can be one of the candidates for the treatment or prevention of osteoporosis in elderly men with hypogonadism...
  22. ncbi request reprint Combined intervention of soy isoflavone and moderate exercise prevents body fat elevation and bone loss in ovariectomized mice
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    Metabolism 53:942-8. 2004
    ....
  23. ncbi request reprint Equol, a metabolite of daidzein, inhibits bone loss in ovariectomized mice
    Maiko Fujioka
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, 162 8636, Japan
    J Nutr 134:2623-7. 2004
    ..E(2) inhibited bone loss from all regions induced by OVX. These results suggest that equol, a major metabolite of daidzein, inhibits bone loss apparently without estrogenic activity in the reproductive organs of OVX mice...
  24. ncbi request reprint Effects of isoflavone and exercise on BMD and fat mass in postmenopausal Japanese women: a 1-year randomized placebo-controlled trial
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 21:780-9. 2006
    ..The combined intervention of isoflavone intake and walking exercise over 1 year in postmenopausal Japanese women exhibited a trend for a greater effect on prevention of bone loss at the total hip and Ward's triangle regions...
  25. ncbi request reprint Effects of geranylgeranoic acid in bone: induction of osteoblast differentiation and inhibition of osteoclast formation
    Xinxiang Wang
    Division of Food Science, National Institute of Health and Nutrition, Tokyo, Japan
    J Bone Miner Res 17:91-100. 2002
    ..These results indicate that GGA increases bone mass by maintaining a positive balance of bone turnover by inducing osteoblast differentiation and suppressing osteoclast formation...
  26. ncbi request reprint Assessment of effectiveness of oral administration of collagen peptide on bone metabolism in growing and mature rats
    Jian Wu
    Division of Applied Food Research, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo, Japan
    J Bone Miner Metab 22:547-53. 2004
    ..These results suggest that orally administered collagen peptide may provide beneficial effects on bone metabolism, especially in the calcium-deficient condition, without obvious undesirable effects...
  27. ncbi request reprint [The role of mevalonate pathway in osteogenic cells]
    Yoshiko Ishimi
    Division of Applied Food Research, National Institute of Health and Nutrition
    Nihon Rinsho 62:779-82. 2004
  28. ncbi request reprint Effects of genistein, an isoflavone, on pregnancy outcome and organ weights of pregnant and lactating rats and development of their suckling pups
    Yuko Tousen
    Department of Human Life and Culture, Seitoku University, Matsudo 271 8555, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:174-82. 2006
    ..However, the results indicated in many papers suggest the necessity of further study on the safety of genistein...