Yuji Ishii

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. doi request reprint Determination of lucidin-specific DNA adducts by liquid chromatography with tandem mass spectrometry in the livers and kidneys of rats given lucidin-3-O-primeveroside
    Yuji Ishii
    Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Chem Res Toxicol 25:1112-8. 2012
  2. doi request reprint Chemical structure determination of DNA bases modified by active metabolites of lucidin-3-O-primeveroside
    Yuji Ishii
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Chem Res Toxicol 23:134-41. 2010
  3. doi request reprint Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen
    Yuji Ishii
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 263:93-9. 2009
  4. doi request reprint A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate
    Keita Kanki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Pathol 36:353-61. 2008
  5. doi request reprint Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 104:274-82. 2008
  6. doi request reprint Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 257:46-52. 2009
  7. ncbi request reprint Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice
    Takashi Umemura
    Divisions of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 633:46-54. 2007
  8. doi request reprint Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice
    Daisuke Hibi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Toxicology 304:92-9. 2013
  9. doi request reprint Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
    Masako Tasaki
    Division of Pathology, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    Cancer Sci 101:2525-30. 2010
  10. ncbi request reprint Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
    Toshiya Okamura
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 35:709-20. 2010

Collaborators

Detail Information

Publications48

  1. doi request reprint Determination of lucidin-specific DNA adducts by liquid chromatography with tandem mass spectrometry in the livers and kidneys of rats given lucidin-3-O-primeveroside
    Yuji Ishii
    Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Chem Res Toxicol 25:1112-8. 2012
    ..10/10(9) dA, respectively. Dose-dependent increases of each adduct were observed in both organs. These quantitative data obtained with our newly developed analytical method might help to improve our understanding of MC carcinogenesis...
  2. doi request reprint Chemical structure determination of DNA bases modified by active metabolites of lucidin-3-O-primeveroside
    Yuji Ishii
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Chem Res Toxicol 23:134-41. 2010
    ..The precise determination of the modified DNA bases generated by LuP and the method for their analysis may contribute to further comprehension of the mode of action underlying carcinogenesis by MR and related anthraquinones...
  3. doi request reprint Dietary catechol causes increased oxidative DNA damage in the livers of mice treated with acetaminophen
    Yuji Ishii
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 263:93-9. 2009
    ..The overall data imply that antioxidants with a catechol structure can cause oxidative DNA damage under inflammatory conditions...
  4. doi request reprint A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate
    Keita Kanki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Pathol 36:353-61. 2008
    ..In conclusion, the present study showed that Nrf2 might play an important role in protecting cells from oxidative stress in the kidney through its regulation of antioxidant enzymes...
  5. doi request reprint Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 104:274-82. 2008
    ....
  6. doi request reprint Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 257:46-52. 2009
    ..The overall data indicated that while oxidative stress well correlates with induction of cell proliferation in females, its role in males and in generation of in vivo mutagenicity by KBrO(3) in both sexes is limited...
  7. ncbi request reprint Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice
    Takashi Umemura
    Divisions of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 633:46-54. 2007
    ....
  8. doi request reprint Effects of p53 knockout on ochratoxin A-induced genotoxicity in p53-deficient gpt delta mice
    Daisuke Hibi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Toxicology 304:92-9. 2013
    ..Additionally, the lower incidence of karyomegaly and apoptosis found in the p53-proficient gpt delta mice suggests that these phenomena may arise from OTA-induced DNA damage...
  9. doi request reprint Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency
    Masako Tasaki
    Division of Pathology, National Institute of Health Sciences, Kamiyoga, Setagaya Ku, Tokyo, Japan
    Cancer Sci 101:2525-30. 2010
    ..We conclude that reactive oxygen species, possibly produced through CYP catalytic pathways, likely induced genomic DNA damage but did not give rise to permanent gene mutation...
  10. ncbi request reprint Enhancing effects of carbon tetrachloride on in vivo mutagenicity in the liver of mice fed 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)
    Toshiya Okamura
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 35:709-20. 2010
    ..Thus, our data clearly demonstrate that this model could be a powerful tool for identifying the mechanisms underlying combinatorial effects on carcinogenesis...
  11. doi request reprint Possible involvement of sulfotransferase 1A1 in estragole-induced DNA modification and carcinogenesis in the livers of female mice
    Yuta Suzuki
    Division of Pathology, National Institute of Health Sciences, Setagayaku, Tokyo, Japan
    Mutat Res 749:23-8. 2012
    ..Thus, the overall data suggest that specific DNA modifications by the SULT1A1-mediated carbocation formation and the resultant genotoxicity are key events in the early stage of ES-induced hepatocarcinogenesis of mice...
  12. ncbi request reprint Antioxidant N-acetyl-L-cysteine (NAC) supplementation reduces reactive oxygen species (ROS)-mediated hepatocellular tumor promotion of indole-3-carbinol (I3C) in rats
    Keisuke Shimamoto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    J Toxicol Sci 36:775-86. 2011
    ..These results indicate that oxidative stress plays an important role for I3C's tumor promotion, and NAC suppresses induction of hepatocellular altered foci with suppressed cytoplasmic oxidative stress...
  13. ncbi request reprint Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Arch Toxicol 81:63-9. 2007
    ..These results suggest that genotoxicity, including oxidative DNA damage, is not involved in mouse hepatocarcinogenesis by FLU, which might rather solely exert tumor-promoting effects in the liver...
  14. ncbi request reprint Effects of co-treatment of dextran sulfate sodium and MeIQx on genotoxicity and possible carcinogenicity in the colon of p53-deficient mice
    Toshiya Okamura
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 35:731-41. 2010
    ..Our results indicate that MeIQx may take more than 7 weeks to induce genotoxicity in the colon and that the co-treatment of mice did not enhance colon tumorigenicity even in p53-deficient mice...
  15. ncbi request reprint Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action
    Hitomi Hayashi
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Toxicol Sci 37:491-501. 2012
    ..These results indicate that OPZ, CYP1A inducer, is a liver tumor promoter in rats, but oxidative stress is not involved in the liver tumor promoting effect of OPZ...
  16. ncbi request reprint Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 97:368-73. 2006
    ..The overall data clearly indicate that IQ is a potent lung carcinogen in rats, in which oxidative stress may not be involved in lung carcinogenesis...
  17. ncbi request reprint In vivo genotoxicity of 1-methylnaphthalene from comprehensive toxicity studies with B6C3F1 gpt delta mice
    Meilan Jin
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 37:711-21. 2012
    ..These results suggest that 1-MN at a carcinogenic dose not induce overt toxicity for any organs and has no in vivo genotoxicity in the lungs...
  18. ncbi request reprint Molecular mechanisms underlying ochratoxin A-induced genotoxicity: global gene expression analysis suggests induction of DNA double-strand breaks and cell cycle progression
    Daisuke Hibi
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    J Toxicol Sci 38:57-69. 2013
    ..These results suggested that OTA induced DSB and cell cycle progression at the target site. These events other than oxidative stress could trigger genotoxicity leading to OTA-induced renal tumorigenicity...
  19. doi request reprint Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats
    Yuta Suzuki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Arch Toxicol 86:1593-601. 2012
    ..These results indicate that ES could be a possible genotoxic hepatocarcinogen in the rat, at least when given at high doses...
  20. ncbi request reprint In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Cancer Sci 97:829-35. 2006
    ..The two-step experiment shows that cells exposed to the alteration of the intranuclear status by oxidative stress including 8-OHdG formation might be able to form tumors with appropriate promotion...
  21. ncbi request reprint Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 99:7-13. 2008
    ..These findings suggest that the risk of excessive intake of a combination of nitrite and antioxidants for esophageal carcinogenesis is appreciable, particularly in patients with reflux esophagitis...
  22. doi request reprint Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year
    Masako Tasaki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 250:143-50. 2008
    ..Based on the present data demonstrating nodular liver lesions only at the high dose of both sexes, we conclude that the no-observed-adverse-effect level (NOAEL) is 0.4% (303 mg/kg/day for males, and 472 mg/kg/day for females)...
  23. doi request reprint Simultaneous induction of non-neoplastic and neoplastic lesions with highly proliferative hepatocytes following dietary exposure of rats to tocotrienol for 2 years
    Masako Tasaki
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo, 158 8501, Japan
    Arch Toxicol 83:1021-30. 2009
    ..Thus, the overall data clearly suggested that NHH is successively enlarged by further long-term exposure to TT, but does not become neoplastic. In contrast, TT induces low levels of hepatocellular adenomas in female rats...
  24. ncbi request reprint Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action
    Yuri Hojo
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Toxicol Sci 37:297-306. 2012
    ....
  25. ncbi request reprint A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 90:111-9. 2006
    ..These data suggest that Nrf2 plays a key role in prevention of PCP-induced oxidative stress and cell proliferation...
  26. doi request reprint Site-specific in vivo mutagenicity in the kidney of gpt delta rats given a carcinogenic dose of ochratoxin A
    Daisuke Hibi
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Sci 122:406-14. 2011
    ..In addition, the reporter gene mutation assay using DNA from target sites could be a more powerful tool to investigate in vivo genotoxicities...
  27. ncbi request reprint Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'- nitro-N-nitrosoguanidine
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Cancer Sci 98:949-57. 2007
    ..However, no influence was exerted in the glandular stomach...
  28. doi request reprint In vivo genotoxicity of methyleugenol in gpt delta transgenic rats following medium-term exposure
    Meilan Jin
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Sci 131:387-94. 2013
    ..These results suggest the possible participation of genotoxic mechanisms in MEG-induced hepatocarcinogenesis...
  29. doi request reprint Lack of promotion activity of diacylglycerol oil on 4-nitroquinoline 1-oxide induced carcinogenesis in the oral cavity of SD rats
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:3206-12. 2008
    ..Thus, in contrast to the positive data using rasTg rats, DAG had no potential for enhancing 4NQO-induced tumorigenesis in their back strain...
  30. ncbi request reprint Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 8 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 241:275-80. 2006
    ..Our data suggest that the naturally occurring isothiocyanates BITC and SFN can block BOP-initiation of hamster pancreatic carcinogenesis...
  31. doi request reprint Detection and quantification of specific DNA adducts by liquid chromatography-tandem mass spectrometry in the livers of rats given estragole at the carcinogenic dose
    Yuji Ishii
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Chem Res Toxicol 24:532-41. 2011
    ..5 ± 0.4, 4.8 ± 0.8, and 20.5 ± 1.6/10(6) dG or dA in the livers of ES-treated rats. This quantitative data and newly developed technique for adduct observation in vivo might be helpful for ES hepatocarcinogenesis investigations...
  32. ncbi request reprint Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 231:314-8. 2006
    ..The data overall suggest the rasH2/BHT model to be a powerful screening tool for genotoxic lung carcinogens...
  33. doi request reprint Cell cycle progression, but not genotoxic activity, mainly contributes to citrinin-induced renal carcinogenesis
    Ken Kuroda
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 311:216-24. 2013
    ..The overall data clearly demonstrated the molecular events underlying CTN-induced cell cycle progression, which could be helpful to understand CTN-induced renal carcinogenesis. ..
  34. ncbi request reprint Reporter gene mutation in the livers of gpt delta mice treated with 5-(hydroxymethyl)-2-furfural, a contaminant of various foods
    Kohei Matsushita
    Division of Pathology, National Institute of Health Sciences
    J Toxicol Sci 37:1077-82. 2012
    ..In view of the lack of carcinogenicity in rats, HMF may be considered to be a weak carcinogen. These results help us to understand the underlying mechanisms of action of HMF carcinogenesis...
  35. ncbi request reprint Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage
    Kazushi Okazaki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 97:175-82. 2006
    ....
  36. pmc Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity
    Kohei Matsushita
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Toxicol Pathol 26:19-27. 2013
    ..The validation results indicate that the GPG46 model could be a powerful tool in understanding chemical carcinogenesis and provide valuable information regarding human risk hazards...
  37. ncbi request reprint Safe and quick distal pancreatectomy using a staggered six-row stapler
    Takeyuki Misawa
    Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
    Am J Surg 195:115-8. 2008
    ..The use of stapling devices for distal pancreatectomy remains controversial, due to concerns about the development of postoperative pancreatic fistula (POPF) and hemorrhage...
  38. doi request reprint Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats
    Reiko Morita
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu, Tokyo, Japan
    Arch Toxicol 85:1475-84. 2011
    ..These results indicate that EMIQ suppressed the liver tumor-promoting activity of PB by inhibiting nuclear translocation of CAR, and not by suppression of oxidative stress...
  39. doi request reprint Transplantation of liver organoids in the omentum and kidney
    Ryota Saito
    Department of Surgery, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    Artif Organs 35:80-3. 2011
    ..Tyrosine aminotransferase appeared only in the omentum group. The results suggested that the functions of liver organoids differed depending on the transplanted site in the recipient animals...
  40. doi request reprint F2-isoprostanes and 2-arachidonylglycerol as biomarkers of lipid peroxidation in pigs with hepatic ischemia/reperfusion injury
    Yuji Ishii
    Department of Surgery, Jikei University School of Medicine, Tokyo, Japan
    J Surg Res 161:139-45. 2010
    ....
  41. doi request reprint Characterization of nitrated phenolic compounds for their anti-oxidant, pro-oxidant, and nitration activities
    Yusuke Iwasaki
    Department of Analytical Chemistry, Hoshi University, Ebara, Shinagawa ku, Tokyo, Japan
    Arch Biochem Biophys 513:10-8. 2011
    ..However, one nitrated CaA compound that has a furoxan ring showed the ability to release NO(2)(-) in the neutral condition...
  42. doi request reprint Anti-angiogenic therapy on hepatocellular carcinoma development and progression
    Yuji Ishii
    Department of Surgery, Jikei University School of Medicine, Minato ku, Tokyo, Japan
    J Surg Res 158:69-76. 2010
    ..We aimed to investigate the efficacy of anti-angiogenetic therapy for the prevention and treatment of HCC...
  43. doi request reprint Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats
    Ryuichi Yamamoto
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Exp Toxicol Pathol 65:845-52. 2013
    ....
  44. doi request reprint Assessment of blood-products use as predictor of pulmonary complications and surgical-site infection after hepatectomy for hepatocellular carcinoma
    Hiroaki Shiba
    Department of Surgery, Jikei University School of Medicine, Minato, Tokyo, Japan
    J Hepatobiliary Pancreat Surg 16:69-74. 2009
    ..However, several studies have suggested a correlation between blood products and pulmonary complications or surgical-site infection (SSI)...
  45. pmc Hepatic reconstruction from fetal porcine liver cells using a radial flow bioreactor
    Yuji Ishii
    Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan
    World J Gastroenterol 14:2740-7. 2008
    ..To examine the efficacy of the radial flow bioreactor (RFB) as an extracorporeal bioartificial liver (BAL) and the reconstruction of liver organoids using embryonic pig liver cells...
  46. doi request reprint Miscoding properties of 8-chloro-2'-deoxyguanosine, a hypochlorous acid-induced DNA adduct, catalysed by human DNA polymerases
    Akira Sassa
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Mutagenesis 28:81-8. 2013
    ..These results indicate that 8-Cl-dG is a mutagenic lesion; the miscoding frequency and specificity varies depending on the DNA polymerase used. Thus, HOCl-induced 8-Cl-dG adduct may be involved in inflammation-driven carcinogenesis...
  47. ncbi request reprint Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 84:243-8. 2005
    ..05 or 0.01) different from the DSS alone value (0%). Thus our results clearly indicate that, in addition to PhIP, MeIQx and IQ can induce colon tumors in mice under an experimental condition promoting colon tumors...
  48. ncbi request reprint Systemic inflammatory response syndrome after hand-assisted laparoscopic distal pancreatectomy
    Takeyuki Misawa
    Department of Surgery, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, Tokyo, 105 8461, Japan
    Surg Endosc 21:1446-9. 2007
    ..We assessed the clinical benefits and invasiveness of hand-assisted laparoscopic distal pancreatectomy (HALS-DP) in relation to the occurrence of post-operative systemic inflammatory response syndrome (SIRS)...