Ken Inoue

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint [Congenital cerebral hypomyelination---Pelizaeus-Merzbacher disease and associated disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo
    No To Hattatsu 43:435-42. 2011
  2. ncbi request reprint PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005
  3. ncbi request reprint Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine
    Toshifumi Morimura
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi machi, Kodaira shi, Tokyo 187 8502, Japan
    Exp Biol Med (Maywood) 239:489-501. 2014
  4. ncbi request reprint Epidemiological, clinical, and genetic landscapes of hypomyelinating leukodystrophies
    Yurika Numata
    National Institute of Neuroscience, National Center for Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo, 187 8502, Japan
    J Neurol 261:752-8. 2014
  5. pmc Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease
    Yurika Numata
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi machi, Kodaira shi, Tokyo 187 8502, Japan
    J Biol Chem 288:7451-66. 2013
  6. doi request reprint Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease
    Li Hua Yu
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Mol Genet Metab 106:108-14. 2012
  7. ncbi request reprint GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease
    Leo Gotoh
    Department of Mental Retardation and Birth Defects Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Genet Metab 111:393-8. 2014
  8. ncbi request reprint [Chromosomal abnormalities and genomic disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP
    Nihon Rinsho 63:64-9. 2005
  9. ncbi request reprint Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, TX 77030, USA
    Hum Mol Genet 15:2250-65. 2006
  10. ncbi request reprint Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 59:398-403. 2006

Collaborators

  • Toshiyuki Yamamoto
  • G M Hobson
  • James Garbern
  • M E Hodes
  • Yurika Numata
  • Leo Gotoh
  • Jennifer A Lee
  • Toshifumi Morimura
  • Yu Ich Goto
  • James R Lupski
  • Shoko Nakamura
  • Eriko Hirano
  • Hitoshi Osaka
  • Kimiko Deguchi
  • Yu ichi Goto
  • Li Hua Yu
  • Sau W Cheung
  • Sara Mora
  • Kenji Kurosawa
  • Guy Helman
  • Sarah H Evans
  • Makoto Urushitani
  • Janet S Soul
  • Jun ichi Takanashi
  • Miriam Bloom
  • Ljubica Caldovic
  • Adeline Vanderver
  • Akiko Iwaki
  • Kiran Maski
  • Shigeo Kure
  • Naoko Inoue
  • Barbara Antalfy
  • Ryoko Yamamoto
  • Carolyn M Ritterson
  • Karen Sperle
  • Chad A Shaw
  • Pawel Stankiewicz
  • Ricardo E Madrid
  • Patricia A Ward

Detail Information

Publications12

  1. ncbi request reprint [Congenital cerebral hypomyelination---Pelizaeus-Merzbacher disease and associated disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo
    No To Hattatsu 43:435-42. 2011
    ..Here, we review the recent findings on congenital cerebral hypomyelination, which includes 11 diseases, with a novel disease classification and diagnostic criteria with flow charts...
  2. ncbi request reprint PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005
    ..Here, I review the previous and current knowledge of the molecular pathogenesis of PMD/SPG2 and delineate future directions for PMD/SPG2 studies...
  3. ncbi request reprint Attenuation of endoplasmic reticulum stress in Pelizaeus-Merzbacher disease by an anti-malaria drug, chloroquine
    Toshifumi Morimura
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi machi, Kodaira shi, Tokyo 187 8502, Japan
    Exp Biol Med (Maywood) 239:489-501. 2014
    ..These findings indicate that chloroquine is an ER stress attenuator with potential use in treating PMD and possibly other ER stress-related diseases...
  4. ncbi request reprint Epidemiological, clinical, and genetic landscapes of hypomyelinating leukodystrophies
    Yurika Numata
    National Institute of Neuroscience, National Center for Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo, 187 8502, Japan
    J Neurol 261:752-8. 2014
    ..Our results constitute the first nationwide survey of congenital hypomyelinating disorders, and provide the epidemiological, clinical, and genetic landscapes of these disorders...
  5. pmc Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease
    Yurika Numata
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi machi, Kodaira shi, Tokyo 187 8502, Japan
    J Biol Chem 288:7451-66. 2013
    ..We propose that depletion of ER chaperones and GA fragmentation induced by mutant misfolded proteins contribute to the pathogenesis of inherited ER stress-related diseases and affect the disease severity...
  6. doi request reprint Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease
    Li Hua Yu
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Mol Genet Metab 106:108-14. 2012
    ..Nonetheless, curcumin may serve as a potential therapeutic compound for PMD caused by PLP1 point mutations...
  7. ncbi request reprint GJC2 promoter mutations causing Pelizaeus-Merzbacher-like disease
    Leo Gotoh
    Department of Mental Retardation and Birth Defects Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Genet Metab 111:393-8. 2014
    ..167G>A) in the promoter region is hypothesized to disrupt a putative SOX10 binding site; however, the lack of additional mutations in this region and contradictory functional data have limited the interpretation of this variant...
  8. ncbi request reprint [Chromosomal abnormalities and genomic disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP
    Nihon Rinsho 63:64-9. 2005
  9. ncbi request reprint Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, TX 77030, USA
    Hum Mol Genet 15:2250-65. 2006
    ....
  10. ncbi request reprint Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 59:398-403. 2006
    ..To report an association between spastic paraplegia type 2 with axonal peripheral neuropathy and apparent proteolipid protein gene (PLP1) silencing in a family...
  11. ncbi request reprint Prenatal diagnosis of PLP1 copy number by array comparative genomic hybridization
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Prenat Diagn 25:1188-91. 2005
    ..To report a family with a history of Pelizaeus-Merzbacher disease (PMD) for which prenatal diagnosis of PLP1 gene duplication status was attempted by the use of custom array comparative genomic hybridization (aCGH)...
  12. pmc Genomic rearrangements resulting in PLP1 deletion occur by nonhomologous end joining and cause different dysmyelinating phenotypes in males and females
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 71:838-53. 2002
    ..In one family, junction sequences revealed a complex recombination event. Our data suggest that PLP1 deletions are likely caused by nonhomologous end joining...