Ken Inoue

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005
  2. ncbi request reprint [Congenital cerebral hypomyelination---Pelizaeus-Merzbacher disease and associated disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo
    No To Hattatsu 43:435-42. 2011
  3. pmc Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in pelizaeus-merzbacher disease
    Yurika Numata
    From the Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi machi, Kodaira shi, Tokyo 187 8502
    J Biol Chem 288:7451-66. 2013
  4. doi request reprint Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease
    Li Hua Yu
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Mol Genet Metab 106:108-14. 2012
  5. ncbi request reprint [Chromosomal abnormalities and genomic disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP
    Nihon Rinsho 63:64-9. 2005
  6. pmc Genomic rearrangements resulting in PLP1 deletion occur by nonhomologous end joining and cause different dysmyelinating phenotypes in males and females
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 71:838-53. 2002
  7. ncbi request reprint Prenatal diagnosis of PLP1 copy number by array comparative genomic hybridization
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Prenat Diagn 25:1188-91. 2005
  8. ncbi request reprint Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 59:398-403. 2006
  9. ncbi request reprint Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, TX 77030, USA
    Hum Mol Genet 15:2250-65. 2006

Collaborators

  • Toshiyuki Yamamoto
  • James Garbern
  • G M Hobson
  • M E Hodes
  • Jennifer A Lee
  • Yurika Numata
  • James R Lupski
  • Toshifumi Morimura
  • Li Hua Yu
  • Sau W Cheung
  • Yu Ich Goto
  • Shigeo Kure
  • Eriko Hirano
  • Shoko Nakamura
  • Kimiko Deguchi
  • Barbara Antalfy
  • Yu ichi Goto
  • Ryoko Yamamoto
  • Hitoshi Osaka
  • Naoko Inoue
  • Carolyn M Ritterson
  • Pawel Stankiewicz
  • Ricardo E Madrid
  • Chad A Shaw
  • Karen Sperle
  • Patricia A Ward

Detail Information

Publications9

  1. ncbi request reprint PLP1-related inherited dysmyelinating disorders: Pelizaeus-Merzbacher disease and spastic paraplegia type 2
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurogenetics 6:1-16. 2005
    ..Here, I review the previous and current knowledge of the molecular pathogenesis of PMD/SPG2 and delineate future directions for PMD/SPG2 studies...
  2. ncbi request reprint [Congenital cerebral hypomyelination---Pelizaeus-Merzbacher disease and associated disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo
    No To Hattatsu 43:435-42. 2011
    ..Here, we review the recent findings on congenital cerebral hypomyelination, which includes 11 diseases, with a novel disease classification and diagnostic criteria with flow charts...
  3. pmc Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in pelizaeus-merzbacher disease
    Yurika Numata
    From the Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP, 4 1 1 Ogawahigashi machi, Kodaira shi, Tokyo 187 8502
    J Biol Chem 288:7451-66. 2013
    ..We propose that depletion of ER chaperones and GA fragmentation induced by mutant misfolded proteins contribute to the pathogenesis of inherited ER stress-related diseases and affect the disease severity...
  4. doi request reprint Effect of curcumin in a mouse model of Pelizaeus-Merzbacher disease
    Li Hua Yu
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Mol Genet Metab 106:108-14. 2012
    ..Nonetheless, curcumin may serve as a potential therapeutic compound for PMD caused by PLP1 point mutations...
  5. ncbi request reprint [Chromosomal abnormalities and genomic disorders]
    Ken Inoue
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry NCNP
    Nihon Rinsho 63:64-9. 2005
  6. pmc Genomic rearrangements resulting in PLP1 deletion occur by nonhomologous end joining and cause different dysmyelinating phenotypes in males and females
    Ken Inoue
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Am J Hum Genet 71:838-53. 2002
    ..In one family, junction sequences revealed a complex recombination event. Our data suggest that PLP1 deletions are likely caused by nonhomologous end joining...
  7. ncbi request reprint Prenatal diagnosis of PLP1 copy number by array comparative genomic hybridization
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Prenat Diagn 25:1188-91. 2005
    ..To report a family with a history of Pelizaeus-Merzbacher disease (PMD) for which prenatal diagnosis of PLP1 gene duplication status was attempted by the use of custom array comparative genomic hybridization (aCGH)...
  8. ncbi request reprint Spastic paraplegia type 2 associated with axonal neuropathy and apparent PLP1 position effect
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA
    Ann Neurol 59:398-403. 2006
    ..To report an association between spastic paraplegia type 2 with axonal peripheral neuropathy and apparent proteolipid protein gene (PLP1) silencing in a family...
  9. ncbi request reprint Role of genomic architecture in PLP1 duplication causing Pelizaeus-Merzbacher disease
    Jennifer A Lee
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Room 604B, Houston, TX 77030, USA
    Hum Mol Genet 15:2250-65. 2006
    ....