Research Topics
Species | Ken ichiro InoueSummaryAffiliation: National Institute for Environmental Studies Country: Japan Publications
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Detail Information
Publications
Role of metallothionein in coagulatory disturbance and systemic inflammation induced by lipopolysaccharide in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
FASEB J 20:533-5. 2006..Our results suggest that MT protects against coagulatory and fibrinolytic disturbance and multiple organ damages induced by LPS, at least partly, via the inhibition of the expression of proinflammatory proteins...- Effects of inhaled nanoparticles on acute lung injury induced by lipopolysaccharide in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicology 238:99-110. 2007..These results suggest that acute exposure to diesel nanoparticles exacerbates lung inflammation induced by LPS... 
Protective role of urinary trypsin inhibitor in lung expression of proinflammatory cytokines accompanied by lethal liver injury in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Immunopharmacol Immunotoxicol 31:446-50. 2009..01). These results suggest that UTI protects against the local inflammatory response accompanied by severe liver injury, which supports its anti-inflammatory properties in vivo...- Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Exp Biol Med (Maywood) 234:200-9. 2009..e., enhancement effects on APC including DC and on antigen-specific Th response, which culminate in the promotion of local and systemic dysregulated Th immunity... - Size effects of latex nanomaterials on lung inflammation in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Toxicol Appl Pharmacol 234:68-76. 2009..These results suggest that latex nanomaterials differentially affect two types of (innate and adaptive immunity-dominant) lung inflammation... - Role of metallothionein in lung inflammation induced by ozone exposure in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Free Radic Biol Med 45:1714-22. 2008..Collectively, MT protects against O(3)-induced lung inflammation, at least partly, via the regulation of pulmonary endothelial and epithelial integrity and its antioxidative property... - Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Exp Biol Med (Maywood) 233:1583-90. 2008.... - Antioxidative role of interleukin-6 in septic lung injury in miceK Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Int J Immunopathol Pharmacol 21:501-7. 2008..These data suggest that the possible mechanisms in which endogenous IL-6 protects against septic lung injury induced by LPS involve, at least in part, its antioxidative properties... 
Effects of nano particles on antigen-related airway inflammation in miceKen ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Respir Res 6:106. 2005..We investigated the effects of nano particles with a diameter of 14 nm or 56 nm on antigen-related airway inflammation...- Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic miceKen ichiro Inoue
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Immunopharmacol Immunotoxicol 31:71-4. 2009..Furthermore, the number was significantly greater in the DEP + OVA than in the DEP or the OVA group. Taken together, in vivo DEP exposure amplified extrathoracic CD4 polarization in asthmatic subjects... - Effects of volatile constituents of rosemary extract on lung inflammation induced by diesel exhaust particlesKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
Basic Clin Pharmacol Toxicol 99:52-7. 2006..The preventive effect is mediated, at least partly, through the inhibition of the enhanced lung expressions of macrophage inflammatory protein-1alpha, macrophage chemoattractant protein-1, and keratinocyte chemoattractants... - Effects of diesel exhaust on lung inflammation related to bacterial endotoxin in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
Basic Clin Pharmacol Toxicol 99:346-52. 2006..These results suggest that short-term exposure to diesel exhaust did not exacerbate lung inflammation related to bacterial endotoxin... - Size effects of nanomaterials on lung inflammation and coagulatory disturbanceK Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
Int J Immunopathol Pharmacol 21:197-206. 2008..These results suggest that nanomaterials exacerbate lung inflammation related to LPS with systemic inflammation and coagulatory disturbance, and that the exacerbation is more prominent with smaller nanomaterials than with larger ones... - Effects of diesel exhaust particles on cytokine production by splenocytes stimulated with lipopolysaccharideKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
J Appl Toxicol 27:95-100. 2007..These results suggest that DEP suppress cytokine production from mononuclear cells stimulated with LPS and provide a possible hint for DEP facilitation on inflammatory conditions, especially related to Th2 response, in vivo... - Effects of nanoparticles on lung physiology in the presence or absence of antigenK Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Int J Immunopathol Pharmacol 20:737-44. 2007..These data suggest that carbon nanoparticles can enhance lung hyperresponsiveness, especially in the presence of antigen. The effects may be mediated, at least partly, through the enhanced lung expression of Muc5ac... - Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation modelKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
Toxicol Appl Pharmacol 237:306-16. 2009..In addition, the exacerbation may be partly through the inappropriate activation of antigen-presenting cells including DC... - Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stressKen ichiro Inoue
National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Free Radic Biol Med 48:924-34. 2010..In addition, this exacerbation may be partly through the inappropriate activation of antigen-presenting cells, including DC... - Soluble cell wall beta-glucan of Candida induces/enhances apoptosis and oxidative stress in murine lungKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Immunopharmacol Immunotoxicol 31:140-5. 2009..CSBG significantly induced HO-1 in the lung. Taken together, CSBG induces/enhances apoptosis and oxidative stress in the lung in association with lung inflammation/injury... - Pulmonary exposure to soluble cell wall beta-(1, 3)-glucan of aspergillus induces proinflammatory response in miceK Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Int J Immunopathol Pharmacol 22:287-97. 2009..These results suggest that pulmonary exposure to ASBG confers lung inflammation, at least partly, via the enhanced local expression of proinflammatory cytokines, likely through NF-kB-dependent pathway... - Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disordersKen ichiro Inoue
National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2 Onogawa, Tsukuba 305 8506, Japan
Expert Opin Investig Drugs 19:513-20. 2010..However, the therapeutic effects of UTI in vivo remain unclarified, as commercial UTI has been developed to act against humans, with the activity and selectivity toward the relevant animal UTI being less characterized... - Candida soluble cell wall beta-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cellsKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
Respir Res 10:68. 2009..In the present study, the effects of CSBG exposure on airway immunopathology in the presence or absence of other immunogenic allergen was investigated in vivo, and their cellular mechanisms were analyzed both in vivo and in vitro... - Metallothionein as an anti-inflammatory mediatorKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Mediators Inflamm 2009:101659. 2009..Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions... - Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthmaKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Int Immunopharmacol 9:1281-8. 2009..Our findings implicate an alternative therapeutic value of Prx I in the treatment of Th2-skewed allergic airway inflammatory diseases such as atopic asthma... - Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharideKen ichiro Inoue
Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Int J Mol Med 15:221-4. 2005..These results directly indicate that IL-6 is protective against liver injury induced by bacterial endotoxin, at least partly, via the modulation of proinflammatory cytokines and chemokines... - Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharideKen ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Mol Pharmacol 67:673-80. 2005.... - Antioxidative role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharideKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Kyoto Prefectural University of Medicine, Kyoto, Japan
Int J Mol Med 16:1029-33. 2005..These results indicate that endogenous UTI is protective against acute lung injury induced by bacterial endotoxin, at least partly, via the antioxidative properties... - Protective role of interleukin-6 in coagulatory and hemostatic disturbance induced by lipopolysaccharide in miceKen ichiro Inoue
Inhalation Toxicology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Thromb Haemost 91:1194-201. 2004..These results directly indicate that IL-6 is protective against coagulatory and hemostatic disturbance and subsequent pulmonary hemorrhage induced by bacterial endotoxin, at least partly, via the modulation of proinflammatory processes... - Effects of components derived from diesel exhaust particles on lung physiology related to antigenKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Immunopharmacol Immunotoxicol 29:403-12. 2007..These data suggest that carboneous component in DEP, rather than organic chemical one, can be attributable to the enhancement of lung hyperresponsiveness in allergic asthma... - Gene expression analysis of murine lungs following pulmonary exposure to Asian sand dust particlesRie Yanagisawa
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Exp Biol Med (Maywood) 232:1109-18. 2007..Furthermore, microarray analysis should be effective for identifying potentially novel genes, sensitive biomarkers, and pathways involved in the health effects of the exposure to environmental particles (e.g., ASDPs)... - Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
Arch Toxicol 81:575-81. 2007..These results indicate that NQ can enhance airway hyperresponsiveness in the presence or absence of an antigen. Also, amplified lung expressions of IL-13 and MUC5AC might partly contribute to the deterioration of asthma features by NQ... - Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga miceRie Yanagisawa
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Exp Biol Med (Maywood) 234:314-22. 2009..Furthermore, TiO(2) nanoparticles can play a significant role in the initiation and/or progression of skin diseases following the barrier dysfunction/defect by histamine release even in the absence of allergen... - Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitroEiko Koike
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Environ Health Perspect 118:472-8. 2010..However, the effects of DINP on allergic diseases have not been fully elucidated... - Nitrogen dioxide air pollution near ambient levels is an atherogenic risk primarily in obese subjects: a brief communicationHirohisa Takano
Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba 305 0053, Japan
Exp Biol Med (Maywood) 229:361-4. 2004..Nitrogen dioxide air pollution near ambient levels is an atherogenic risk primarily in obese subjects... - Di-(2-ethylhexyl) phthalate enhances atopic dermatitis-like skin lesions in miceHirohisa Takano
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Environ Health Perspect 114:1266-9. 2006..DEHP could be at least partly responsible for the recent increase in atopic dermatitis... - Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cellsEiko Koike
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Chemosphere 73:371-6. 2008..In addition, BMDC-mediated MLR might be useful assay for in vitro screening for adjuvant activity of environmental toxicants... - Urinary trypsin inhibitor protects against liver injury and coagulation pathway dysregulation induced by lipopolysaccharide/D-galactosamine in miceHirohisa Takano
Division of Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Japan
Lab Invest 89:833-9. 2009.... - Role of interleukin-6 in toll-like receptor 4 and 2 expressions induced by lipopolysaccharide in the lungKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Immunopharmacol Immunotoxicol 29:63-8. 2007..These results suggest that the protective role of IL-6 against LPS-induced hemorrhagic lung inflammation might be explained, in part, by inhibition of the enhanced lung expressions of TLR4 and 2... - Effects of nano particles on cytokine expression in murine lung in the absence or presence of allergenKen-ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, 305-8506, Tsukuba, Japan
Arch Toxicol 80:614-9. 2006..The enhancing effects are more prominent with smaller particles... - Di-(2-ethylhexyl) phthalate affects immune cells from atopic prone mice in vitroEiko Koike
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
Toxicology 259:54-60. 2009..The enhancement might contribute to the aggravating effect of DEHP on allergic disorders... - Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone miceEiko Koike
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Int Immunopharmacol 8:1737-43. 2008..The enhancement of differentiation and function of DC caused by genetic background may be related, at least partly, to the induction or aggravation of allergic/atopic diseases... - Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharideKen ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Arzneimittelforschung 55:167-71. 2005..These results suggest that the enhancing effects of 15d-PG J2 on the production of mucin-producing cells might be related, at least in part, to the activation of GATA-3... - Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspringRie Yanagisawa
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Environ Health Perspect 116:1136-41. 2008..Although maternal exposure to DEHP during fetal and/or neonatal periods reportedly affects reproductive and developmental systems, its effects on allergic diseases in offspring remain to be determined... - Effects of organic chemicals derived from ambient particulate matter on lung inflammation related to lipopolysaccharideKen-ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506 Ibaraki, Japan
Arch Toxicol 80:833-8. 2006..These results suggest that the extracted organic chemicals from PM exacerbate infectious lung inflammation. The mechanisms underlying the enhancing effects are not mediated via the enhanced local expression of proinflammatory cytokines... - Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate mattersKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Int Immunopharmacol 10:1380-9. 2010..Furthermore, this bioassay may be applied to future investigations that evaluate new therapeutic agents or risk factors for pulmonary emphysema... - Pulmonary exposure to diesel exhaust particles induces airway inflammation and cytokine expression in NC/Nga miceKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan
Arch Toxicol 79:595-9. 2005..These results indicate that intratracheal exposure to DEP induces the recruitment of inflammatory cells, at least partially, through the local expression of IL-4 and chemokines in NC/Nga mice... - Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposureRie Yanagisawa
Center for Environmental Health Sciences, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
J Biochem 152:595-601. 2012..Our results suggest that PrxI is not an effective protector against O(3)-induced oxidative damages reportedly caused by harmful lipid metabolites but plays a positive role in the initiation of lung inflammation following O(3) exposure... - 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-κB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formationDaigo Sumi
Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
J Toxicol Sci 35:891-8. 2010..Taken together, these results suggest that 1,2-NQ reduces iNOS-catalyzed NO production through 1) an uncoupling reaction, as reported previously, and/or 2) disruption of IKKβ/NF-κB signaling... - Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in miceKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki, Japan
Int J Mol Med 16:315-9. 2005..These results suggest that i.t. exposure to VR can, at least partially, prevent allergic airway inflammation induced by HDM. The preventive effect is associated with inhibition of the enhanced local expression of IL-13... - Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cellsTomohiro Ito
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
J Appl Toxicol 32:142-8. 2012..Taken together, these results suggest that DEHP can modulate the differentiation and maturation of mouse PBMC-derived DCs at least partially through activation of the estrogen receptor under our experimental conditions... - Pulmonary exposure to diesel exhaust particles enhances coagulatory disturbance with endothelial damage and systemic inflammation related to lung inflammationKen-ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan
Exp Biol Med (Maywood) 231:1626-32. 2006.... - Effects of a single intratracheal administration of phenanthraquinone on murine lungKyoko Hiyoshi
Major of Human Care Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
J Appl Toxicol 25:47-51. 2005..These results indicate that intratracheal exposure to phenanthraquinone induces recruitment of inflammatory cells, at least partly, through the local expression of IL-5 and eotaxin... - Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in miceKen-ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
Environ Health Perspect 114:1325-30. 2006..Furthermore, nanoparticles can promote coagulatory disturbance accompanied by lung inflammation... - Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese miceMakoto Tomaru
Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
Nutrition 23:351-5. 2007..The present study examined whether dietary supplementation with cacao liquor proanthocyanidins (CLPr) could prevent elevation of blood glucose levels in mice with diabetes mellitus and obesity... - Protective role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharideKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-0053, Japan
Exp Biol Med (Maywood) 230:281-7. 2005..These results suggest that UTI protects against acute lung injury induced by bacterial endotoxin, at least partly, through the inhibition of the enhanced local expression of proinflammatory cytokines, chemokines, and ICAM-1... - Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humansHirohisa Takano
First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
Exp Biol Med (Maywood) 229:247-54. 2004..Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases... - Lung expression of cytochrome P450 1A1 as a possible biomarker of exposure to diesel exhaust particlesHirohisa Takano
CREST, JST Japan Science and Technology Corporation, Tokyo, Japan
Arch Toxicol 76:146-51. 2002..These results suggest that the lung expression of Cyp 1A1 can be a biomarker of acute inhalation exposure to DEP and may be implicated in an accelerated production of ROS and the subsequent aggravation of lung injury... - Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxinKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki, Japan
J Appl Toxicol 24:415-8. 2004.... - Impact of diesel exhaust particles on th2 response in the lung in asthmatic miceKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
J Clin Biochem Nutr 43:199-200. 2008..The result suggests that in asthmatic subjects, DEP promote Th2-prone milieu in the lung, which additively/synergistically augment asthma pathophysiology in vivo... - Extensive Analysis of Elastase-Induced Pulmonary Emphysema in Rats: ALP in the Lung, a New Biomarker for Disease Progression?Ken ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
J Clin Biochem Nutr 46:168-76. 2010..In particular, ALP in lung homogenates might be a new biomarker for the disease progression/exacerbation... - Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharideKen ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
J Clin Biochem Nutr 43:139-42. 2008..UTI may therefore present an attractive "rescue" therapeutic option for systemic inflammatory response syndromes such as DIC, acute lung injury, and multiple organ dysfunction... - Role of metallothionein in antigen-related airway inflammationKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba 305-8506, Japan
Exp Biol Med (Maywood) 230:75-81. 2005..Our findings suggest that MT may be a therapeutic target for the treatment of antigen-related airway inflammatory diseases such as bronchial asthma... - Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharideKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Arzneimittelforschung 54:711-4. 2004..In contrast, 15d-PG J2 did not affect the COX-1 expression. These results suggest that the enhancing effects of 15d-PG J2 on LPS-induced acute lung injury might be explained, at least in part, by those on the lung expression of COX-2... - Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharideKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Clin Exp Pharmacol Physiol 32:230-2. 2005..4. These results suggest that the enhancing effects of 15d-PGJ2 on LPS-induced acute lung injury may be explained, at least in part, by its effect on the lung expression of TLR4 and 2... - The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particlesKen-ichiro Inoue
Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-8506, Japan
Arch Toxicol 80:275-9. 2006..These results suggest that TLR-4 is one of recognition receptors against DEP in the airways... - Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual particles after extraction differently affect respiratory diseasesHirohisa Takano
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
J Clin Biochem Nutr 40:101-7. 2007..It is suggested that DEP components diversely affect various types of respiratory diseases, while the combination of organic chemicals and carbonaceous nuclei (whole DEP) mostly aggravate respiratory diseases... - Complementary DNA microarray analysis in acute lung injury induced by lipopolysaccharide and diesel exhaust particlesRie Yanagisawa
Pathophysiology Research Team, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki, 305-8506, Japan
Exp Biol Med (Maywood) 229:1081-7. 2004.... - Effect of 15-deoxy-delta 12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in miceKen-ichiro Inoue
Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki 305-0053, Tsukuba, Japan
Eur J Pharmacol 481:261-9. 2003..Our data suggest that 15d-prostaglandin J(2) may not be useful but potentially harmful for the therapeutic option of acute lung injury... - Role of interleukin-6 in fibrinolytic changes induced by lipopolysaccharide in miceKen-ichiro Inoue
Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
Blood Coagul Fibrinolysis 17:307-9. 2006..These results indicate that IL-6 can, at least partly, inhibit the lipopolysaccharide-enhanced fibrinolysis via the enhanced alpha2-plasmin inhibitor activity... - Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient miceYuji Naito
Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Int J Mol Med 14:191-6. 2004..These data suggest that persistent and marked blockade of IL-6 bioactivity provides some beneficial effects on intestinal inflammation... - A novel water-soluble vitamin E derivative prevents acute lung injury by bacterial endotoxinKazuhiko Uchiyama
First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
Clin Exp Pharmacol Physiol 31:226-30. 2004..The therapeutic effect of TMG may be mediated, at least in part, by suppression of the local expression of chemokines, possibly through its strong anti-oxidant activity... - Rosmarinic acid inhibits lung injury induced by diesel exhaust particlesChiaki Sanbongi
Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
Free Radic Biol Med 34:1060-9. 2003..These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects... - Role of interleukin-6 in bleomycin-induced lung inflammatory changes in miceFumitake Saito
Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Am J Respir Cell Mol Biol 38:566-71. 2008..These results indicate that IL-6 may play an important role in the pathogenesis of BLM-induced lung injury and subsequent fibrotic changes... - Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanismNaomi Osakabe
Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5-3-1, Chiyoda Sakado 350-0289, Japan. co.jp
Biofactors 21:127-31. 2004..RA is an effective intervention for SAR that is mediated by inhibition of PMNL infiltration. This effect of RA is due to two independent mechanisms: inhibition of the inflammatory response and scavenging of ROS... - Suppression of Th1 and Th2 immune responses in mice by Sinomenine, an alkaloid extracted from the chinese medicinal plant Sinomenium acutumHuang Feng
Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan
Planta Med 72:1383-8. 2006..TGF-beta may at least in part contribute to the suppression of Th1 as well as Th2 immune responses... - Interleukin-8 neutralization for COPDKen-ichiro Inoue
Chest 128:464-5; author reply 465. 2005 - Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic miceMakoto Tomaru
Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Int J Mol Med 19:17-22. 2007..These results suggest that pulmonary exposure to DEP, PM, enhances steatosis in the liver of obese diabetic subjects possibly via enhanced oxidative stress... - Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenineFeng Huang
Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan
Int Immunopharmacol 8:502-7. 2008..These results suggested that SIN might suppress the antigen-induced activation of RBL-2H3 cells via a Ca2+ independent pathway... - Interleukin-6, obstructive sleep apnea, and obesityKen-ichiro Inoue
Chest 124:1621-2; author reply 1622-3. 2003 - Effects of tumor necrosis factor-alpha inhibitors on lung lesions with rheumatoid arthritisKen-ichiro Inoue
Chest 124:413-4; author reply 414. 2003 - Enhancement of allergic responses in vivo and in vitro by butylated hydroxytolueneKouya Yamaki
Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo 658 8558, Japan
Toxicol Appl Pharmacol 223:164-72. 2007.... - Comments on the common coldKen-ichiro Inoue
Lancet 361:782. 2003 - Pin1 blockade in asthma by naphthoquinone?Ken ichiro Inoue
J Allergy Clin Immunol 121:1064; author reply 1065. 2008 - Protective role of metallothionein in coagulatory disturbance accompanied by acute liver injury induced by LPS/D-GalNKen-ichiro Inoue
Thromb Haemost 99:980-3. 2008 - Anti-inflammatory Effect of PentoxifyllineKen-ichiro Inoue
Chest 126:321. 2004 - Air pollution and pulmonary diseasesKen-ichiro Inoue
Chest 128:1075. 2005 - Surgical stress in ARDS open-lung biopsyKen-ichiro Inoue
Chest 126:1383-4; author reply 1384. 2004 - Vitamin E as a regulator of host defense against infectionKen-ichiro Inoue
Chest 126:1390. 2004 - Eosinophilic pneumonia and arthritisKen-ichiro Inoue
Chest 127:2294-5. 2005 - Statin, inflammation, and sepsisKen-ichiro Inoue
Chest 125:2365; author reply 2365. 2004 - Peroxisome proliferator-activated receptor-gamma expression in lungKen-ichiro Inoue
Chest 122:386-7. 2002