Ken ichiro Inoue

Summary

Affiliation: National Institute for Environmental Studies
Country: Japan

Publications

  1. ncbi Role of metallothionein in coagulatory disturbance and systemic inflammation induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    FASEB J 20:533-5. 2006
  2. pmc Extensive Analysis of Elastase-Induced Pulmonary Emphysema in Rats: ALP in the Lung, a New Biomarker for Disease Progression?
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    J Clin Biochem Nutr 46:168-76. 2010
  3. pmc Impact of diesel exhaust particles on th2 response in the lung in asthmatic mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    J Clin Biochem Nutr 43:199-200. 2008
  4. pmc Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    J Clin Biochem Nutr 43:139-42. 2008
  5. pmc Candida soluble cell wall beta-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Respir Res 10:68. 2009
  6. ncbi Effects of nanoparticles on lung physiology in the presence or absence of antigen
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 20:737-44. 2007
  7. doi Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
    Toxicol Appl Pharmacol 237:306-16. 2009
  8. doi Size effects of latex nanomaterials on lung inflammation in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Toxicol Appl Pharmacol 234:68-76. 2009
  9. ncbi Effects of volatile constituents of rosemary extract on lung inflammation induced by diesel exhaust particles
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Basic Clin Pharmacol Toxicol 99:52-7. 2006
  10. doi Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders
    Ken ichiro Inoue
    National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Expert Opin Investig Drugs 19:513-20. 2010

Collaborators

Detail Information

Publications90

  1. ncbi Role of metallothionein in coagulatory disturbance and systemic inflammation induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    FASEB J 20:533-5. 2006
    ..Our results suggest that MT protects against coagulatory and fibrinolytic disturbance and multiple organ damages induced by LPS, at least partly, via the inhibition of the expression of proinflammatory proteins...
  2. pmc Extensive Analysis of Elastase-Induced Pulmonary Emphysema in Rats: ALP in the Lung, a New Biomarker for Disease Progression?
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    J Clin Biochem Nutr 46:168-76. 2010
    ..In particular, ALP in lung homogenates might be a new biomarker for the disease progression/exacerbation...
  3. pmc Impact of diesel exhaust particles on th2 response in the lung in asthmatic mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    J Clin Biochem Nutr 43:199-200. 2008
    ..The result suggests that in asthmatic subjects, DEP promote Th2-prone milieu in the lung, which additively/synergistically augment asthma pathophysiology in vivo...
  4. pmc Protective effects of urinary trypsin inhibitor on systemic inflammatory response induced by lipopolysaccharide
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    J Clin Biochem Nutr 43:139-42. 2008
    ..UTI may therefore present an attractive "rescue" therapeutic option for systemic inflammatory response syndromes such as DIC, acute lung injury, and multiple organ dysfunction...
  5. pmc Candida soluble cell wall beta-glucan facilitates ovalbumin-induced allergic airway inflammation in mice: Possible role of antigen-presenting cells
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Respir Res 10:68. 2009
    ..In the present study, the effects of CSBG exposure on airway immunopathology in the presence or absence of other immunogenic allergen was investigated in vivo, and their cellular mechanisms were analyzed both in vivo and in vitro...
  6. ncbi Effects of nanoparticles on lung physiology in the presence or absence of antigen
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 20:737-44. 2007
    ..These data suggest that carbon nanoparticles can enhance lung hyperresponsiveness, especially in the presence of antigen. The effects may be mediated, at least partly, through the enhanced lung expression of Muc5ac...
  7. doi Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
    Toxicol Appl Pharmacol 237:306-16. 2009
    ..In addition, the exacerbation may be partly through the inappropriate activation of antigen-presenting cells including DC...
  8. doi Size effects of latex nanomaterials on lung inflammation in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Toxicol Appl Pharmacol 234:68-76. 2009
    ..These results suggest that latex nanomaterials differentially affect two types of (innate and adaptive immunity-dominant) lung inflammation...
  9. ncbi Effects of volatile constituents of rosemary extract on lung inflammation induced by diesel exhaust particles
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Basic Clin Pharmacol Toxicol 99:52-7. 2006
    ..The preventive effect is mediated, at least partly, through the inhibition of the enhanced lung expressions of macrophage inflammatory protein-1alpha, macrophage chemoattractant protein-1, and keratinocyte chemoattractants...
  10. doi Urinary trypsin inhibitor as a therapeutic option for endotoxin-related inflammatory disorders
    Ken ichiro Inoue
    National Institute for Environmental Studies, Environmental Health Sciences Division, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Expert Opin Investig Drugs 19:513-20. 2010
    ..However, the therapeutic effects of UTI in vivo remain unclarified, as commercial UTI has been developed to act against humans, with the activity and selectivity toward the relevant animal UTI being less characterized...
  11. pmc Metallothionein as an anti-inflammatory mediator
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Mediators Inflamm 2009:101659. 2009
    ..Also, MT expression in various organs/tissues can be enhanced by inflammatory stimuli, implicating in inflammatory diseases. In this paper, we review the role of MT of various inflammatory conditions...
  12. pmc Effects of nano particles on antigen-related airway inflammation in mice
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Respir Res 6:106. 2005
    ..We investigated the effects of nano particles with a diameter of 14 nm or 56 nm on antigen-related airway inflammation...
  13. ncbi Effects of diesel exhaust particles on cytokine production by splenocytes stimulated with lipopolysaccharide
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    J Appl Toxicol 27:95-100. 2007
    ..These results suggest that DEP suppress cytokine production from mononuclear cells stimulated with LPS and provide a possible hint for DEP facilitation on inflammatory conditions, especially related to Th2 response, in vivo...
  14. doi Protective role of urinary trypsin inhibitor in lung expression of proinflammatory cytokines accompanied by lethal liver injury in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Immunopharmacol Immunotoxicol 31:446-50. 2009
    ..01). These results suggest that UTI protects against the local inflammatory response accompanied by severe liver injury, which supports its anti-inflammatory properties in vivo...
  15. doi Peroxiredoxin I is a negative regulator of Th2-dominant allergic asthma
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Int Immunopharmacol 9:1281-8. 2009
    ..Our findings implicate an alternative therapeutic value of Prx I in the treatment of Th2-skewed allergic airway inflammatory diseases such as atopic asthma...
  16. doi Soluble cell wall beta-glucan of Candida induces/enhances apoptosis and oxidative stress in murine lung
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 31:140-5. 2009
    ..CSBG significantly induced HO-1 in the lung. Taken together, CSBG induces/enhances apoptosis and oxidative stress in the lung in association with lung inflammation/injury...
  17. doi Effects of pulmonary exposure to diesel exhaust particles on extrathoracic CD4 polarization in asthmatic mice
    Ken ichiro Inoue
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 31:71-4. 2009
    ..Furthermore, the number was significantly greater in the DEP + OVA than in the DEP or the OVA group. Taken together, in vivo DEP exposure amplified extrathoracic CD4 polarization in asthmatic subjects...
  18. ncbi Antioxidative role of interleukin-6 in septic lung injury in mice
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 21:501-7. 2008
    ..These data suggest that the possible mechanisms in which endogenous IL-6 protects against septic lung injury induced by LPS involve, at least in part, its antioxidative properties...
  19. ncbi Size effects of nanomaterials on lung inflammation and coagulatory disturbance
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Int J Immunopathol Pharmacol 21:197-206. 2008
    ..These results suggest that nanomaterials exacerbate lung inflammation related to LPS with systemic inflammation and coagulatory disturbance, and that the exacerbation is more prominent with smaller nanomaterials than with larger ones...
  20. ncbi Effects of inhaled nanoparticles on acute lung injury induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 238:99-110. 2007
    ..These results suggest that acute exposure to diesel nanoparticles exacerbates lung inflammation induced by LPS...
  21. doi Effects of pulmonary exposure to carbon nanotubes on lung and systemic inflammation with coagulatory disturbance induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Exp Biol Med (Maywood) 233:1583-90. 2008
    ....
  22. doi Effects of diesel exhaust particles on antigen-presenting cells and antigen-specific Th immunity in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Exp Biol Med (Maywood) 234:200-9. 2009
    ..e., enhancement effects on APC including DC and on antigen-specific Th response, which culminate in the promotion of local and systemic dysregulated Th immunity...
  23. doi Repeated pulmonary exposure to single-walled carbon nanotubes exacerbates allergic inflammation of the airway: Possible role of oxidative stress
    Ken ichiro Inoue
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Free Radic Biol Med 48:924-34. 2010
    ..In addition, this exacerbation may be partly through the inappropriate activation of antigen-presenting cells, including DC...
  24. doi Role of metallothionein in lung inflammation induced by ozone exposure in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Free Radic Biol Med 45:1714-22. 2008
    ..Collectively, MT protects against O(3)-induced lung inflammation, at least partly, via the regulation of pulmonary endothelial and epithelial integrity and its antioxidative property...
  25. ncbi Effects of diesel exhaust on lung inflammation related to bacterial endotoxin in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Basic Clin Pharmacol Toxicol 99:346-52. 2006
    ..These results suggest that short-term exposure to diesel exhaust did not exacerbate lung inflammation related to bacterial endotoxin...
  26. ncbi Pulmonary exposure to soluble cell wall beta-(1, 3)-glucan of aspergillus induces proinflammatory response in mice
    K Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Immunopathol Pharmacol 22:287-97. 2009
    ..These results suggest that pulmonary exposure to ASBG confers lung inflammation, at least partly, via the enhanced local expression of proinflammatory cytokines, likely through NF-kB-dependent pathway...
  27. ncbi Effects of nano particles on cytokine expression in murine lung in the absence or presence of allergen
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Japan
    Arch Toxicol 80:614-9. 2006
    ..The enhancing effects are more prominent with smaller particles...
  28. ncbi Protective role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 0053, Japan
    Exp Biol Med (Maywood) 230:281-7. 2005
    ..These results suggest that UTI protects against acute lung injury induced by bacterial endotoxin, at least partly, through the inhibition of the enhanced local expression of proinflammatory cytokines, chemokines, and ICAM-1...
  29. ncbi Effects of volatile constituents of a rosemary extract on allergic airway inflammation related to house dust mite allergen in mice
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki, Japan
    Int J Mol Med 16:315-9. 2005
    ..These results suggest that i.t. exposure to VR can, at least partially, prevent allergic airway inflammation induced by HDM. The preventive effect is associated with inhibition of the enhanced local expression of IL-13...
  30. ncbi Effects of organic chemicals derived from ambient particulate matter on lung inflammation related to lipopolysaccharide
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506 Ibaraki, Japan
    Arch Toxicol 80:833-8. 2006
    ..These results suggest that the extracted organic chemicals from PM exacerbate infectious lung inflammation. The mechanisms underlying the enhancing effects are not mediated via the enhanced local expression of proinflammatory cytokines...
  31. ncbi Pulmonary exposure to diesel exhaust particles enhances coagulatory disturbance with endothelial damage and systemic inflammation related to lung inflammation
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Exp Biol Med (Maywood) 231:1626-32. 2006
    ....
  32. ncbi Pulmonary exposure to diesel exhaust particles induces airway inflammation and cytokine expression in NC/Nga mice
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Arch Toxicol 79:595-9. 2005
    ..These results indicate that intratracheal exposure to DEP induces the recruitment of inflammatory cells, at least partially, through the local expression of IL-4 and chemokines in NC/Nga mice...
  33. pmc Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Environ Health Perspect 114:1325-30. 2006
    ..Although adverse health effects of particulate matter with a diameter of < 100 nm (nanoparticles) have been proposed, molecular and/or experimental evidence for their facilitation of lung inflammation in vivo is not fully defined...
  34. ncbi Effects of 15-deoxy-delta12,14-prostaglandin J2 on the cyclooxygenase-2 expression in the murine lung in the presence of lipopolysaccharide
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Arzneimittelforschung 54:711-4. 2004
    ..In contrast, 15d-PG J2 did not affect the COX-1 expression. These results suggest that the enhancing effects of 15d-PG J2 on LPS-induced acute lung injury might be explained, at least in part, by those on the lung expression of COX-2...
  35. ncbi Cytoprotection by interleukin-6 against liver injury induced by lipopolysaccharide
    Ken ichiro Inoue
    Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int J Mol Med 15:221-4. 2005
    ..These results directly indicate that IL-6 is protective against liver injury induced by bacterial endotoxin, at least partly, via the modulation of proinflammatory cytokines and chemokines...
  36. ncbi Urinary trypsin inhibitor protects against systemic inflammation induced by lipopolysaccharide
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Mol Pharmacol 67:673-80. 2005
    ....
  37. ncbi Antioxidative role of urinary trypsin inhibitor in acute lung injury induced by lipopolysaccharide
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Mol Med 16:1029-33. 2005
    ..These results indicate that endogenous UTI is protective against acute lung injury induced by bacterial endotoxin, at least partly, via the antioxidative properties...
  38. ncbi Components of diesel exhaust particles differentially affect lung expression of cyclooxygenase-2 related to bacterial endotoxin
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki, Japan
    J Appl Toxicol 24:415-8. 2004
    ....
  39. ncbi Role of metallothionein in antigen-related airway inflammation
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Exp Biol Med (Maywood) 230:75-81. 2005
    ..Our findings suggest that MT may be a therapeutic target for the treatment of antigen-related airway inflammatory diseases such as bronchial asthma...
  40. ncbi Complementary DNA microarray analysis in acute lung injury induced by lipopolysaccharide and diesel exhaust particles
    Rie Yanagisawa
    Pathophysiology Research Team, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    Exp Biol Med (Maywood) 229:1081-7. 2004
    ....
  41. ncbi Protective role of interleukin-6 in coagulatory and hemostatic disturbance induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Inhalation Toxicology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Thromb Haemost 91:1194-201. 2004
    ..These results directly indicate that IL-6 is protective against coagulatory and hemostatic disturbance and subsequent pulmonary hemorrhage induced by bacterial endotoxin, at least partly, via the modulation of proinflammatory processes...
  42. ncbi Effects of a single intratracheal administration of phenanthraquinone on murine lung
    Kyoko Hiyoshi
    Major of Human Care Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
    J Appl Toxicol 25:47-51. 2005
    ..These results indicate that intratracheal exposure to phenanthraquinone induces recruitment of inflammatory cells, at least partly, through the local expression of IL-5 and eotaxin...
  43. ncbi Effects of components derived from diesel exhaust particles on lung physiology related to antigen
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 29:403-12. 2007
    ..These data suggest that carboneous component in DEP, rather than organic chemical one, can be attributable to the enhancement of lung hyperresponsiveness in allergic asthma...
  44. ncbi Role of interleukin-6 in fibrinolytic changes induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Blood Coagul Fibrinolysis 17:307-9. 2006
    ..These results indicate that IL-6 can, at least partly, inhibit the lipopolysaccharide-enhanced fibrinolysis via the enhanced alpha2-plasmin inhibitor activity...
  45. ncbi Gene expression analysis of murine lungs following pulmonary exposure to Asian sand dust particles
    Rie Yanagisawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Exp Biol Med (Maywood) 232:1109-18. 2007
    ..Furthermore, microarray analysis should be effective for identifying potentially novel genes, sensitive biomarkers, and pathways involved in the health effects of the exposure to environmental particles (e.g., ASDPs)...
  46. doi Peroxiredoxin I null mice exhibits reduced acute lung inflammation following ozone exposure
    Rie Yanagisawa
    Center for Environmental Health Sciences, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    J Biochem 152:595-601. 2012
    ..Our results suggest that PrxI is not an effective protector against O(3)-induced oxidative damages reportedly caused by harmful lipid metabolites but plays a positive role in the initiation of lung inflammation following O(3) exposure...
  47. ncbi Effects of naphthoquinone on airway responsiveness in the presence or absence of antigen in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    Arch Toxicol 81:575-81. 2007
    ..These results indicate that NQ can enhance airway hyperresponsiveness in the presence or absence of an antigen. Also, amplified lung expressions of IL-13 and MUC5AC might partly contribute to the deterioration of asthma features by NQ...
  48. ncbi Effect of 15-deoxy-delta 12,14-prostaglandin J2 on acute lung injury induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Pathophysiology Research Team, National Institute for Environmental Studies, Ibaraki 305 0053, Tsukuba, Japan
    Eur J Pharmacol 481:261-9. 2003
    ..Our data suggest that 15d-prostaglandin J(2) may not be useful but potentially harmful for the therapeutic option of acute lung injury...
  49. ncbi The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Japan
    Arch Toxicol 80:275-9. 2006
    ..These results suggest that TLR-4 is one of recognition receptors against DEP in the airways...
  50. ncbi Effects of 15-deoxy-Delta12,14-prostaglandin J2 on the expression of Toll-like receptor 4 and 2 in the murine lung in the presence of lipopolysaccharide
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Clin Exp Pharmacol Physiol 32:230-2. 2005
    ..4. These results suggest that the enhancing effects of 15d-PGJ2 on LPS-induced acute lung injury may be explained, at least in part, by its effect on the lung expression of TLR4 and 2...
  51. doi Titanium dioxide nanoparticles aggravate atopic dermatitis-like skin lesions in NC/Nga mice
    Rie Yanagisawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Exp Biol Med (Maywood) 234:314-22. 2009
    ..Furthermore, TiO(2) nanoparticles can play a significant role in the initiation and/or progression of skin diseases following the barrier dysfunction/defect by histamine release even in the absence of allergen...
  52. pmc Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro
    Eiko Koike
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Environ Health Perspect 118:472-8. 2010
    ..However, the effects of DINP on allergic diseases have not been fully elucidated...
  53. ncbi Nitrogen dioxide air pollution near ambient levels is an atherogenic risk primarily in obese subjects: a brief communication
    Hirohisa Takano
    Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba 305 0053, Japan
    Exp Biol Med (Maywood) 229:361-4. 2004
    ..Nitrogen dioxide air pollution near ambient levels is an atherogenic risk primarily in obese subjects...
  54. pmc Di-(2-ethylhexyl) phthalate enhances atopic dermatitis-like skin lesions in mice
    Hirohisa Takano
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Environ Health Perspect 114:1266-9. 2006
    ..DEHP could be at least partly responsible for the recent increase in atopic dermatitis...
  55. doi Urinary trypsin inhibitor protects against liver injury and coagulation pathway dysregulation induced by lipopolysaccharide/D-galactosamine in mice
    Hirohisa Takano
    Division of Environmental Health Sciences, National Institute for Environmental Studies, Tsukuba, Japan
    Lab Invest 89:833-9. 2009
    ....
  56. doi Carbon black nanoparticles promote the maturation and function of mouse bone marrow-derived dendritic cells
    Eiko Koike
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Chemosphere 73:371-6. 2008
    ..In addition, BMDC-mediated MLR might be useful assay for in vitro screening for adjuvant activity of environmental toxicants...
  57. ncbi Role of interleukin-6 in toll-like receptor 4 and 2 expressions induced by lipopolysaccharide in the lung
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Immunopharmacol Immunotoxicol 29:63-8. 2007
    ..These results suggest that the protective role of IL-6 against LPS-induced hemorrhagic lung inflammation might be explained, in part, by inhibition of the enhanced lung expressions of TLR4 and 2...
  58. doi Di-(2-ethylhexyl) phthalate affects immune cells from atopic prone mice in vitro
    Eiko Koike
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Toxicology 259:54-60. 2009
    ..The enhancement might contribute to the aggravating effect of DEHP on allergic disorders...
  59. doi Accelerated differentiation of bone marrow-derived dendritic cells in atopic prone mice
    Eiko Koike
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Int Immunopharmacol 8:1737-43. 2008
    ..The enhancement of differentiation and function of DC caused by genetic background may be related, at least partly, to the induction or aggravation of allergic/atopic diseases...
  60. ncbi Effects of 15-deoxy-delta(12,14)-prostaglandin J2 on nuclear localization of GATA-3 in the murine lung in the presence of lipopolysaccharide
    Ken ichiro Inoue
    Inhalation Toxicology and Pathophysiology Research Team, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Arzneimittelforschung 55:167-71. 2005
    ..These results suggest that the enhancing effects of 15d-PG J2 on the production of mucin-producing cells might be related, at least in part, to the activation of GATA-3...
  61. pmc Effects of maternal exposure to di-(2-ethylhexyl) phthalate during fetal and/or neonatal periods on atopic dermatitis in male offspring
    Rie Yanagisawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Environ Health Perspect 116:1136-41. 2008
    ..Although maternal exposure to DEHP during fetal and/or neonatal periods reportedly affects reproductive and developmental systems, its effects on allergic diseases in offspring remain to be determined...
  62. ncbi 1,2-Naphthoquinone suppresses lipopolysaccharide-dependent activation of IKKβ/NF-κB/NO signaling: an alternative mechanism for the disturbance of inducible NO synthase-catalyzed NO formation
    Daigo Sumi
    Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Toxicol Sci 35:891-8. 2010
    ..Taken together, these results suggest that 1,2-NQ reduces iNOS-catalyzed NO production through 1) an uncoupling reaction, as reported previously, and/or 2) disruption of IKKβ/NF-κB signaling...
  63. doi Comprehensive analysis of elastase-induced pulmonary emphysema in mice: effects of ambient existing particulate matters
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Int Immunopharmacol 10:1380-9. 2010
    ..Furthermore, this bioassay may be applied to future investigations that evaluate new therapeutic agents or risk factors for pulmonary emphysema...
  64. doi Phthalate esters modulate the differentiation and maturation of mouse peripheral blood mononuclear cell-derived dendritic cells
    Tomohiro Ito
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    J Appl Toxicol 32:142-8. 2012
    ..Taken together, these results suggest that DEHP can modulate the differentiation and maturation of mouse PBMC-derived DCs at least partially through activation of the estrogen receptor under our experimental conditions...
  65. ncbi Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Nutrition 23:351-5. 2007
    ..The present study examined whether dietary supplementation with cacao liquor proanthocyanidins (CLPr) could prevent elevation of blood glucose levels in mice with diabetes mellitus and obesity...
  66. ncbi Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans
    Hirohisa Takano
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Exp Biol Med (Maywood) 229:247-54. 2004
    ..Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases...
  67. ncbi Lung expression of cytochrome P450 1A1 as a possible biomarker of exposure to diesel exhaust particles
    Hirohisa Takano
    CREST, JST Japan Science and Technology Corporation, Tokyo, Japan
    Arch Toxicol 76:146-51. 2002
    ..These results suggest that the lung expression of Cyp 1A1 can be a biomarker of acute inhalation exposure to DEP and may be implicated in an accelerated production of ROS and the subsequent aggravation of lung injury...
  68. pmc Components of diesel exhaust particles diversely enhance a variety of respiratory diseases related to infection or allergy: extracted organic chemicals and the residual particles after extraction differently affect respiratory diseases
    Hirohisa Takano
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    J Clin Biochem Nutr 40:101-7. 2007
    ..It is suggested that DEP components diversely affect various types of respiratory diseases, while the combination of organic chemicals and carbonaceous nuclei (whole DEP) mostly aggravate respiratory diseases...
  69. ncbi Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan co jp
    Biofactors 21:127-31. 2004
    ..In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models...
  70. ncbi A novel water-soluble vitamin E derivative prevents acute lung injury by bacterial endotoxin
    Kazuhiko Uchiyama
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Clin Exp Pharmacol Physiol 31:226-30. 2004
    ..The therapeutic effect of TMG may be mediated, at least in part, by suppression of the local expression of chemokines, possibly through its strong anti-oxidant activity...
  71. ncbi Interleukin-8 neutralization for COPD
    Ken ichiro Inoue
    Chest 128:464-5; author reply 465. 2005
  72. ncbi Suppression of Th1 and Th2 immune responses in mice by Sinomenine, an alkaloid extracted from the chinese medicinal plant Sinomenium acutum
    Huang Feng
    Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan
    Planta Med 72:1383-8. 2006
    ..TGF-beta may at least in part contribute to the suppression of Th1 as well as Th2 immune responses...
  73. ncbi Role of interleukin-6 in bleomycin-induced lung inflammatory changes in mice
    Fumitake Saito
    Division of Pulmonary Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Respir Cell Mol Biol 38:566-71. 2008
    ..These results indicate that IL-6 may play an important role in the pathogenesis of BLM-induced lung injury and subsequent fibrotic changes...
  74. ncbi Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Mol Med 19:17-22. 2007
    ..These results suggest that pulmonary exposure to DEP, PM, enhances steatosis in the liver of obese diabetic subjects possibly via enhanced oxidative stress...
  75. ncbi Rosmarinic acid inhibits lung injury induced by diesel exhaust particles
    Chiaki Sanbongi
    Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Free Radic Biol Med 34:1060-9. 2003
    ..These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects...
  76. ncbi Reduced intestinal inflammation induced by dextran sodium sulfate in interleukin-6-deficient mice
    Yuji Naito
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Int J Mol Med 14:191-6. 2004
    ..These data suggest that persistent and marked blockade of IL-6 bioactivity provides some beneficial effects on intestinal inflammation...
  77. ncbi Effects of tumor necrosis factor-alpha inhibitors on lung lesions with rheumatoid arthritis
    Ken ichiro Inoue
    Chest 124:413-4; author reply 414. 2003
  78. ncbi Interleukin-6, obstructive sleep apnea, and obesity
    Ken ichiro Inoue
    Chest 124:1621-2; author reply 1622-3. 2003
  79. ncbi Anti-inflammatory Effect of Pentoxifylline
    Ken ichiro Inoue
    Chest 126:321. 2004
  80. ncbi Comments on the common cold
    Ken ichiro Inoue
    Lancet 361:782. 2003
  81. ncbi Surgical stress in ARDS open-lung biopsy
    Ken ichiro Inoue
    Chest 126:1383-4; author reply 1384. 2004
  82. ncbi Vitamin E as a regulator of host defense against infection
    Ken ichiro Inoue
    Chest 126:1390. 2004
  83. doi Protective role of metallothionein in coagulatory disturbance accompanied by acute liver injury induced by LPS/D-GalN
    Ken ichiro Inoue
    Thromb Haemost 99:980-3. 2008
  84. ncbi Statin, inflammation, and sepsis
    Ken ichiro Inoue
    Chest 125:2365; author reply 2365. 2004
  85. ncbi Eosinophilic pneumonia and arthritis
    Ken ichiro Inoue
    Chest 127:2294-5. 2005
  86. ncbi Air pollution and pulmonary diseases
    Ken ichiro Inoue
    Chest 128:1075. 2005
  87. ncbi Enhancement of allergic responses in vivo and in vitro by butylated hydroxytoluene
    Kouya Yamaki
    Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo 658 8558, Japan
    Toxicol Appl Pharmacol 223:164-72. 2007
    ....
  88. doi Inhibition of the antigen-induced activation of RBL-2H3 cells by sinomenine
    Feng Huang
    Department of Pharmacology, Kobe Pharmaceutical University, Kobe, Hyogo, Japan
    Int Immunopharmacol 8:502-7. 2008
    ..These results suggested that SIN might suppress the antigen-induced activation of RBL-2H3 cells via a Ca2+ independent pathway...
  89. doi Pin1 blockade in asthma by naphthoquinone?
    Ken ichiro Inoue
    J Allergy Clin Immunol 121:1064; author reply 1065. 2008
  90. ncbi Peroxisome proliferator-activated receptor-gamma expression in lung
    Ken ichiro Inoue
    Chest 122:386-7. 2002