Tatsuhiko Imaoka

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. doi request reprint Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma
    Tatsuhiko Imaoka
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 85:1134-40. 2013
  2. doi request reprint Progesterone stimulates proliferation of a long-lived epithelial cell population in rat mammary gland
    T Imaoka
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    J Endocrinol Invest 35:828-34. 2012
  3. ncbi request reprint Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
    J Radiat Res 49:349-60. 2008
  4. ncbi request reprint High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Anagawa, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:194-203. 2007
  5. ncbi request reprint Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis
    Tatsuhiko Imaoka
    Low Dose Radiation Effects Research Project, Research Center for Radiation Safety, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    In Vivo 20:353-8. 2006
  6. ncbi request reprint Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence
    Tatsuhiko Imaoka
    Low Dose Radiation Effects Research Project, Research Center for Radiation Safety, National Institute of Radiological Sciences, Chiba, Japan
    Radiat Res 165:165-73. 2006
  7. ncbi request reprint Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis?
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Japan
    J Radiat Res 50:281-93. 2009
  8. doi request reprint Pre- and postpubertal irradiation induces mammary cancers with distinct expression of hormone receptors, ErbB ligands, and developmental genes in rats
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    Mol Carcinog 50:539-52. 2011
  9. ncbi request reprint Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation
    Tatsuhiko Imaoka
    Research Center for Radiation Safety, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Int J Cancer 115:187-93. 2005
  10. doi request reprint DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas
    Daisuke Iizuka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, 263 8555, Japan
    Radiat Res 174:206-15. 2010

Collaborators

Detail Information

Publications19

  1. doi request reprint Influence of age on the relative biological effectiveness of carbon ion radiation for induction of rat mammary carcinoma
    Tatsuhiko Imaoka
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    Int J Radiat Oncol Biol Phys 85:1134-40. 2013
    ..Susceptibility of the fetus to particle radiation-induced cancer is also unclear. The present study is aimed to investigate the effect of carbon-ion irradiation in childhood on breast carcinogenesis...
  2. doi request reprint Progesterone stimulates proliferation of a long-lived epithelial cell population in rat mammary gland
    T Imaoka
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    J Endocrinol Invest 35:828-34. 2012
    ..Some evidence suggests that pre-menopausal administration of progesterone confers a long-term increased risk of breast cancer...
  3. ncbi request reprint Gene expression profiling distinguishes between spontaneous and radiation-induced rat mammary carcinomas
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences
    J Radiat Res 49:349-60. 2008
    ..Thus, gene expression analysis distinguished between spontaneous and radiogenic carcinomas, suggesting possible differences in their carcinogenic mechanism...
  4. ncbi request reprint High relative biologic effectiveness of carbon ion radiation on induction of rat mammary carcinoma and its lack of H-ras and Tp53 mutations
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Anagawa, Chiba, Japan
    Int J Radiat Oncol Biol Phys 69:194-203. 2007
    ..We undertook the present study to clarify the RBE of therapeutic carbon ion radiation and molecular changes that occur in the rat mammary cancer model...
  5. ncbi request reprint Persistent cell proliferation of terminal end buds precedes radiation-induced rat mammary carcinogenesis
    Tatsuhiko Imaoka
    Low Dose Radiation Effects Research Project, Research Center for Radiation Safety, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    In Vivo 20:353-8. 2006
    ....
  6. ncbi request reprint Mammary tumorigenesis in ApcMin/+ mice is enhanced by X irradiation with a characteristic age dependence
    Tatsuhiko Imaoka
    Low Dose Radiation Effects Research Project, Research Center for Radiation Safety, National Institute of Radiological Sciences, Chiba, Japan
    Radiat Res 165:165-73. 2006
    ....
  7. ncbi request reprint Radiation-induced mammary carcinogenesis in rodent models: what's different from chemical carcinogenesis?
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Japan
    J Radiat Res 50:281-93. 2009
    ..Identification of the target cell type and relevant translational research for human risk management may be among the important issues that are addressed by radiation carcinogenesis models.JRRS Incentive Award in 2009...
  8. doi request reprint Pre- and postpubertal irradiation induces mammary cancers with distinct expression of hormone receptors, ErbB ligands, and developmental genes in rats
    Tatsuhiko Imaoka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    Mol Carcinog 50:539-52. 2011
    ..In contrast, the mechanism of MNU-induced carcinogenesis was less influenced by the age at exposure...
  9. ncbi request reprint Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation
    Tatsuhiko Imaoka
    Research Center for Radiation Safety, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Int J Cancer 115:187-93. 2005
    ....
  10. doi request reprint DNA copy number aberrations and disruption of the p16Ink4a/Rb pathway in radiation-induced and spontaneous rat mammary carcinomas
    Daisuke Iizuka
    Experimental Radiobiology for Children s Health Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, 263 8555, Japan
    Radiat Res 174:206-15. 2010
    ....
  11. doi request reprint Molecular characterization of cancer reveals interactions between ionizing radiation and chemicals on rat mammary carcinogenesis
    Tatsuhiko Imaoka
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Japan Radiation Effect Accumulation and Prevention Project, Fukushima Project Headquarters, National Institute of Radiological Sciences, Japan
    Int J Cancer 134:1529-38. 2014
    ..These results suggest that a complex, multilevel interaction underlies the combinatorial action of radiation and chemical carcinogens in the experimental model. ..
  12. pmc Loss of the BRCA1-interacting helicase BRIP1 results in abnormal mammary acinar morphogenesis
    Kazuhiro Daino
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan Radiation Effect Accumulation and Prevention Project, Fukushima Project Headquarters, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 8:e74013. 2013
    ..Loss of BRIP1 thus disrupts normal mammary morphogenesis and causes neoplastic-like changes, possibly via dysregulating multiple cellular signaling pathways functioning in the normal development of mammary glands. ..
  13. ncbi request reprint Aberrant expression and phosphorylation of 4E-BP1, a main target of mTOR signaling, in rat mammary carcinomas: an association with etiology
    Masaru Takabatake
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    In Vivo 25:853-60. 2011
    ....
  14. doi request reprint Ikaros is a critical target during simultaneous exposure to X-rays and N-ethyl-N-nitrosourea in mouse T-cell lymphomagenesis
    Shinobu Hirano
    Radiobiology for Children s Health Program, Research Center for Radiation Protection, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Int J Cancer 132:259-68. 2013
    ..Furthermore, concomitant alterations of multiple tumor-associated genes may contribute to enhanced lymphomagenesis after simultaneous exposure...
  15. ncbi request reprint Effect of carbon ions on life span shortening and tumorigenesis in mice
    Shizuko Kakinuma
    Low Dose Radiation Effect Project, National Institute of Radiological Sciences
    Biol Sci Space 18:190. 2004
    ..The relative biological effectiveness for the 50% life span shortening was about 1.4. The large effect of carbon ions encourages the study on tumor induction at low doses in the space...
  16. ncbi request reprint Loss of heterozygosity in heavy-ion-induced murine T-cell lymphomas
    Shizuko Kakinuma
    Low Dose Radiation Effect Project, National Institute of Radiological Sciences
    Biol Sci Space 17:187. 2003
    ..These results indicate that mechanistic differences may exist between carbon-ion- and X-ray-induced lymphomagenesis...
  17. ncbi request reprint Mild inflammation accelerates colon carcinogenesis in Mlh1-deficient mice
    Kazuki Taniguchi
    Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    Oncology 71:124-30. 2006
    ..The interaction between inflammation and mismatch repair deficiency, however, remains unclear. The aim of this study was to determine the effect of inflammation on colorectal carcinogenesis in Mlh1-deficient mice...
  18. ncbi request reprint Serotonin regulates mammary gland development via an autocrine-paracrine loop
    Manabu Matsuda
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, OH 45221, USA
    Dev Cell 6:193-203. 2004
    ..Thus, autocrine-paracrine serotonin signaling is an important regulator of mammary homeostasis and early involution...
  19. ncbi request reprint Cortactin-binding protein 90 (CBP90) expression in the mouse mammary glands during prolactin-induced lobuloalveolar development
    Tatsuhiko Imaoka
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan
    Zoolog Sci 19:443-8. 2002
    ..Thus, from the unique expression pattern, CBP90 may be useful as a molecular marker for the hormone-stimulated development of mammary alveolar buds...