Yoko Ikoma

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. doi request reprint Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Neuroimage 47:1639-48. 2009
  2. doi request reprint PET kinetic analysis: error consideration of quantitative analysis in dynamic studies
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, 565 8565, Japan
    Ann Nucl Med 22:1-11. 2008
  3. pmc Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cereb Blood Flow Metab 30:663-73. 2010
  4. ncbi request reprint PET kinetic analysis--compartmental model
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 20:583-8. 2006
  5. ncbi request reprint Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
  6. ncbi request reprint Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization
    Takuya Morimoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Ann Nucl Med 20:237-43. 2006
  7. ncbi request reprint Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
    Yoko Ikoma
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1531-7. 2006
  8. ncbi request reprint PET kinetic analysis --pitfalls and a solution for the Logan plot
    Yuichi Kimura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo 173 0022, Japan
    Ann Nucl Med 21:1-8. 2007
  9. ncbi request reprint PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:379-86. 2007
  10. ncbi request reprint [Diagnosis and treatment of gynecological cancers]
    Kazuo Kuzuya
    Aichi Cancer Center Hospital
    Nihon Rinsho 62:28-34. 2004

Collaborators

Detail Information

Publications16

  1. doi request reprint Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Neuroimage 47:1639-48. 2009
    ..An advantage of the proposed method is the shortened scan period for the quantitative assessment of the BP(ND) change for neurotransmitter competition studies...
  2. doi request reprint PET kinetic analysis: error consideration of quantitative analysis in dynamic studies
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, 565 8565, Japan
    Ann Nucl Med 22:1-11. 2008
    ..This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models...
  3. pmc Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cereb Blood Flow Metab 30:663-73. 2010
    ..Estimated B(max) and K(d) values of D(2) receptors in normal or partially dopamine-depleted striatum were comparable to the previously reported values...
  4. ncbi request reprint PET kinetic analysis--compartmental model
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 20:583-8. 2006
    ..We also discussed advanced applications of the compartmental analysis with PET...
  5. ncbi request reprint Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
    ..However, there was no correlation between BP with NLS and DV with NLS, GA, and MA, because of the variation of K(1)/k(2) between individuals. In conclusion, BP is estimated most reliably by NLS with the two-tissue compartment model...
  6. ncbi request reprint Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization
    Takuya Morimoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Ann Nucl Med 20:237-43. 2006
    ..In this study we compared mean regional radioactivity concentration in the late phase and binding potential (BP) between FBP and OSEM algorithms in neurotransmission PET studies for [11C]raclopride and [11C]DASB...
  7. ncbi request reprint Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
    Yoko Ikoma
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1531-7. 2006
    ..In this study, we validated the quantification methods of (11)C-verapamil transfer from plasma to the brain in humans...
  8. ncbi request reprint PET kinetic analysis --pitfalls and a solution for the Logan plot
    Yuichi Kimura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo 173 0022, Japan
    Ann Nucl Med 21:1-8. 2007
    ..In this paper, we describe the basic concept of the Logan plot in detail and introduce three algorithms for the Logan plot. By comparing these algorithms, we demonstrate the pitfalls of the Logan plot and discuss the solution...
  9. ncbi request reprint PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:379-86. 2007
    ..The application of wavelet denoising to radio-ligand and kinetic analysis is still in the development stage, but even so, it is thought that wavelet techniques will have a substantial impact on nuclear medicine in the near future...
  10. ncbi request reprint [Diagnosis and treatment of gynecological cancers]
    Kazuo Kuzuya
    Aichi Cancer Center Hospital
    Nihon Rinsho 62:28-34. 2004
  11. ncbi request reprint Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain
    Yota Fujimura
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:43-50. 2006
    ..To our knowledge, this is the first study to investigate the (18)F-FEDAA1106 binding to PBR in living human brain by PET. We also aimed to evaluate various analytic methods to quantify the density of PBR...
  12. ncbi request reprint Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with (18)F-FEDAA1106
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Eur J Nucl Med Mol Imaging 35:416-23. 2008
    ..We evaluated the noise reduction capability of wavelet denoising for estimated binding potential (BP) images (k (3)/k (4)) of the peripheral benzodiazepine receptor using (18)F-FEDAA1106 and nonlinear least-square fitting...
  13. ncbi request reprint Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  14. ncbi request reprint A dose-finding study of duloxetine based on serotonin transporter occupancy
    Akihiro Takano
    Molecular Imaging Center, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba, 263 8555, Japan
    Psychopharmacology (Berl) 185:395-9. 2006
    ..To evaluate the dosage of antidepressants such as selective serotonin reuptake inhibitors, serotonin transporter occupancy (5-HTT) is also a useful index...
  15. ncbi request reprint Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Departments of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 27:723-31. 2006
    ..In the present study, the regional kinetics of L-[beta-C]DOPA in normal human brain and the accuracy of the method for quantifying L-[beta-C]DOPA kinetics, employing reference regions, were investigated...
  16. ncbi request reprint Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 7:19-26. 2004
    ..3 h respectively. Using plasma pharmacokinetics and in-vivo ED50, the time-course of receptor occupancy could be calculated. Simulation of drug kinetics at receptors would provide useful information for the evaluation of antipsychotics...