Yoko Ikoma

Summary

Affiliation: National Cardiovascular Center
Country: Japan

Publications

  1. ncbi Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Neuroimage 47:1639-48. 2009
  2. ncbi PET kinetic analysis: error consideration of quantitative analysis in dynamic studies
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, 565 8565, Japan
    Ann Nucl Med 22:1-11. 2008
  3. ncbi Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cereb Blood Flow Metab 30:663-73. 2010
  4. ncbi PET kinetic analysis--compartmental model
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 20:583-8. 2006
  5. ncbi Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
  6. ncbi Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization
    Takuya Morimoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan
    Ann Nucl Med 20:237-43. 2006
  7. ncbi Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
    Yoko Ikoma
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1531-7. 2006
  8. ncbi PET kinetic analysis --pitfalls and a solution for the Logan plot
    Yuichi Kimura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo 173 0022, Japan
    Ann Nucl Med 21:1-8. 2007
  9. ncbi PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:379-86. 2007
  10. ncbi [Diagnosis and treatment of gynecological cancers]
    Kazuo Kuzuya
    Aichi Cancer Center Hospital
    Nippon Rinsho 62:28-34. 2004

Collaborators

  • Hiroshi Watabe
  • Yuichi Kimura
  • Hidehiro Iida
  • Fumihiko Yasuno
  • Chie Seki
  • H Ito
  • Ming Rong Zhang
  • Ryuji Nakao
  • Akihiro Takano
  • Tetsuya Suhara
  • Miho Shidahara
  • Yota Fujimura
  • Ryohei Matsumoto
  • Kazutoshi Suzuki
  • Mika Naganawa
  • Miho Ota
  • Shoko Nozaki
  • Takuya Morimoto
  • Jun Kosaka
  • Jun Maeda
  • Kazuo Kuzuya
  • Iwao Kanno
  • Terushi Haradahira
  • Makoto Higuchi
  • Kenji Fukui
  • Ryosuke Arakawa
  • Jeff Kershaw
  • Hidehiko Takahashi
  • Katsuyuki Tanimoto
  • Akira Ando
  • Takahiro Shiraishi
  • Shuji Tanada
  • Takashi Okauchi
  • Taiga Yamaya
  • Nobumasa Kato
  • Yoshiro Okubo
  • Makoto Inoue
  • Tetsuya Ichimiya
  • Yasuhiko Sudo

Detail Information

Publications16

  1. ncbi Quantitative evaluation of changes in binding potential with a simplified reference tissue model and multiple injections of [11C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Suita, Osaka, Japan
    Neuroimage 47:1639-48. 2009
    ..An advantage of the proposed method is the shortened scan period for the quantitative assessment of the BP(ND) change for neurotransmitter competition studies...
  2. ncbi PET kinetic analysis: error consideration of quantitative analysis in dynamic studies
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, 565 8565, Japan
    Ann Nucl Med 22:1-11. 2008
    ..This review describes the reliability of parameter estimates for various analysis methods in reversible and irreversible models...
  3. ncbi Measurement of density and affinity for dopamine D(2) receptors by a single positron emission tomography scan with multiple injections of [(11)C]raclopride
    Yoko Ikoma
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, Osaka 565 8565, Japan
    J Cereb Blood Flow Metab 30:663-73. 2010
    ..Estimated B(max) and K(d) values of D(2) receptors in normal or partially dopamine-depleted striatum were comparable to the previously reported values...
  4. ncbi PET kinetic analysis--compartmental model
    Hiroshi Watabe
    Department of Investigative Radiology, National Cardiovascular Center Research Institute, 5 7 1 Fujishiro dai, Suita, Osaka 565 8565, Japan
    Ann Nucl Med 20:583-8. 2006
    ..We also discussed advanced applications of the compartmental analysis with PET...
  5. ncbi Quantitative analysis for estimating binding potential of the peripheral benzodiazepine receptor with [(11)C]DAA1106
    Yoko Ikoma
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Cereb Blood Flow Metab 27:173-84. 2007
    ..However, there was no correlation between BP with NLS and DV with NLS, GA, and MA, because of the variation of K(1)/k(2) between individuals. In conclusion, BP is estimated most reliably by NLS with the two-tissue compartment model...
  6. ncbi Effects of image reconstruction algorithm on neurotransmission PET studies in humans: comparison between filtered backprojection and ordered subsets expectation maximization
    Takuya Morimoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba 263-8555, Japan
    Ann Nucl Med 20:237-43. 2006
    ..This study indicates that OSEM can be used for human neurotransmission PET studies for calculating BP although OSEM was not necessarily superior to FBP in the present study...
  7. ncbi Quantitative analysis of 11C-verapamil transfer at the human blood-brain barrier for evaluation of P-glycoprotein function
    Yoko Ikoma
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:1531-7. 2006
    ....
  8. ncbi PET kinetic analysis --pitfalls and a solution for the Logan plot
    Yuichi Kimura
    Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, 1 1, Naka, Itabashi, Tokyo 173 0022, Japan
    Ann Nucl Med 21:1-8. 2007
    ..In this paper, we describe the basic concept of the Logan plot in detail and introduce three algorithms for the Logan plot. By comparing these algorithms, we demonstrate the pitfalls of the Logan plot and discuss the solution...
  9. ncbi PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:379-86. 2007
    ..The application of wavelet denoising to radio-ligand and kinetic analysis is still in the development stage, but even so, it is thought that wavelet techniques will have a substantial impact on nuclear medicine in the near future...
  10. ncbi [Diagnosis and treatment of gynecological cancers]
    Kazuo Kuzuya
    Aichi Cancer Center Hospital
    Nippon Rinsho 62:28-34. 2004
  11. ncbi Quantitative analyses of 18F-FEDAA1106 binding to peripheral benzodiazepine receptors in living human brain
    Yota Fujimura
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 47:43-50. 2006
    ..CONCLUSION: The simulation studies indicated that NLS is a suitable method for the estimation of (18)F-FEDAA1106 binding to PBRs...
  12. ncbi Wavelet denoising for voxel-based compartmental analysis of peripheral benzodiazepine receptors with (18)F-FEDAA1106
    Miho Shidahara
    Biophysics Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage, Chiba, Japan
    Eur J Nucl Med Mol Imaging 35:416-23. 2008
    ..We evaluated the noise reduction capability of wavelet denoising for estimated binding potential (BP) images (k (3)/k (4)) of the peripheral benzodiazepine receptor using (18)F-FEDAA1106 and nonlinear least-square fitting...
  13. ncbi Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  14. ncbi A dose-finding study of duloxetine based on serotonin transporter occupancy
    Akihiro Takano
    Molecular Imaging Center, National Institute of Radiological Sciences, 9-1, Anagawa 4-Chome, Inage-ku, Chiba, 263-8555, Japan
    Psychopharmacology (Berl) 185:395-9. 2006
    ..CONCLUSIONS: Based on 5-HTT occupancy, 40 mg and more of duloxetine was needed to attain 80% occupancy, and 60 mg of duloxetine could maintain a high level of 5-HTT occupancy with a once-a-day administration schedule...
  15. ncbi Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Departments of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 27:723-31. 2006
    ..In the present study, the regional kinetics of L-[beta-C]DOPA in normal human brain and the accuracy of the method for quantifying L-[beta-C]DOPA kinetics, employing reference regions, were investigated...
  16. ncbi Estimation of the time-course of dopamine D2 receptor occupancy in living human brain from plasma pharmacokinetics of antipsychotics
    Akihiro Takano
    Brain Imaging Project, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 7:19-26. 2004
    ..3 h respectively. Using plasma pharmacokinetics and in-vivo ED50, the time-course of receptor occupancy could be calculated. Simulation of drug kinetics at receptors would provide useful information for the evaluation of antipsychotics...