Toshiyuki Ikoma

Summary

Affiliation: National Institute for Materials Science
Country: Japan

Publications

  1. ncbi request reprint Microstructure, mechanical, and biomimetic properties of fish scales from Pagrus major
    Toshiyuki Ikoma
    Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Struct Biol 142:327-33. 2003
  2. ncbi request reprint Physical properties of type I collagen extracted from fish scales of Pagrus major and Oreochromis niloticas
    Toshiyuki Ikoma
    Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Int J Biol Macromol 32:199-204. 2003
  3. ncbi request reprint Collagen coating on hydroxyapatite surfaces modified with organosilane by chemical vapor deposition method
    Akira Monkawa
    National Institute for Materials Science, Biomaterials Center, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Nanosci Nanotechnol 7:833-8. 2007
  4. ncbi request reprint Three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticity
    Shunji Yunoki
    Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Biomater Sci Polym Ed 18:393-409. 2007
  5. ncbi request reprint Phenotype and gene expression pattern of osteoblast-like cells cultured on polystyrene and hydroxyapatite with pre-adsorbed type-I collagen
    Nobutaka Hanagata
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    J Biomed Mater Res A 83:362-71. 2007
  6. ncbi request reprint Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen composites
    Shunji Yunoki
    Biomaterial Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Mater Sci Mater Med 18:2179-83. 2007
  7. ncbi request reprint Synthesis and characterization of metal ions containing hydroxyapatite microparticles with high specific surface area
    Toru Tonegawa
    Graduate School of Pure and Applied Science, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, lbaraki, Japan
    J Nanosci Nanotechnol 7:839-43. 2007
  8. doi request reprint A collagen sponge incorporating a hydroxyapatite/chondroitinsulfate composite as a scaffold for cartilage tissue engineering
    Yohimi Ohyabu
    National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Biomater Sci Polym Ed 20:1861-74. 2009
  9. doi request reprint Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery
    Yufang Zhu
    International Center for Young Scientists ICYS, National Institute for Materials Science NIMS, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    Small 6:471-8. 2010
  10. doi request reprint Minerals and aligned collagen fibrils in tilapia fish scales: structural analysis using dark-field and energy-filtered transmission electron microscopy and electron tomography
    Mitsuhiro Okuda
    Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    Microsc Microanal 17:788-98. 2011

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Microstructure, mechanical, and biomimetic properties of fish scales from Pagrus major
    Toshiyuki Ikoma
    Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Struct Biol 142:327-33. 2003
    ..5-0.6 microm in length and 0.1-0.2 microm in width. The textured inorganic material remains intact when heated to 1473 K, although the size of the constituent crystals increases as a result of thermal sintering...
  2. ncbi request reprint Physical properties of type I collagen extracted from fish scales of Pagrus major and Oreochromis niloticas
    Toshiyuki Ikoma
    Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Int J Biol Macromol 32:199-204. 2003
    ..The enthalpy and entropy estimated from thermal analyses could be correlated to amino acid sequences (Gly-Pro-Hyp) of type I collagens and the number of methionine amino acid residues...
  3. ncbi request reprint Collagen coating on hydroxyapatite surfaces modified with organosilane by chemical vapor deposition method
    Akira Monkawa
    National Institute for Materials Science, Biomaterials Center, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Nanosci Nanotechnol 7:833-8. 2007
    ....
  4. ncbi request reprint Three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticity
    Shunji Yunoki
    Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Biomater Sci Polym Ed 18:393-409. 2007
    ..The porous composite fabricated has good flexibility and rubber-like elasticity, and is a promising bone regenerative material...
  5. ncbi request reprint Phenotype and gene expression pattern of osteoblast-like cells cultured on polystyrene and hydroxyapatite with pre-adsorbed type-I collagen
    Nobutaka Hanagata
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    J Biomed Mater Res A 83:362-71. 2007
    ..In addition, comprehensive gene expression analyses revealed that HAp and HAp/NCs specifically up-regulated Ly6a and Tmem37 genes, while down-regulated Ifitm5 gene...
  6. ncbi request reprint Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen composites
    Shunji Yunoki
    Biomaterial Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Mater Sci Mater Med 18:2179-83. 2007
    ..The bioresorbability in vivo was almost matched to the in vitro test using enzymatic reaction of collagenase...
  7. ncbi request reprint Synthesis and characterization of metal ions containing hydroxyapatite microparticles with high specific surface area
    Toru Tonegawa
    Graduate School of Pure and Applied Science, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, lbaraki, Japan
    J Nanosci Nanotechnol 7:839-43. 2007
    ..The microparticles with higher specific surface area will be applicable for the drug delivery carriers of proteins...
  8. doi request reprint A collagen sponge incorporating a hydroxyapatite/chondroitinsulfate composite as a scaffold for cartilage tissue engineering
    Yohimi Ohyabu
    National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Biomater Sci Polym Ed 20:1861-74. 2009
    ..From these results, pCol-HAp/ChS is expected to be a candidate for a scaffold for cartilage tissue engineering in place of collagen sponge...
  9. doi request reprint Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug delivery
    Yufang Zhu
    International Center for Young Scientists ICYS, National Institute for Materials Science NIMS, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    Small 6:471-8. 2010
    ..These results indicate the potential of Fe(3)O(4)@SiO(2) hollow mesoporous spheres for drug loading and delivery into cancer cells to induce cell death...
  10. doi request reprint Minerals and aligned collagen fibrils in tilapia fish scales: structural analysis using dark-field and energy-filtered transmission electron microscopy and electron tomography
    Mitsuhiro Okuda
    Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    Microsc Microanal 17:788-98. 2011
    ....
  11. ncbi request reprint Structural analysis of hydroxyapatite coating on magnetite nanoparticles using energy filter imaging and electron tomography
    Mitsuhiro Okuda
    Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki, 305 0047, Japan
    J Electron Microsc (Tokyo) 59:173-9. 2010
    ..The dissolution of iron ion from MNPs and the interfacial interaction of HAp and magnetite could cause the needlelike morphology of HAp nanocrystals...
  12. ncbi request reprint Preparation and characterization of hydroxyapatite/collagen nanocomposite gel
    Shunji Yunoki
    National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Nanosci Nanotechnol 7:818-21. 2007
    ..8+/-4.4 nm (mean +/- SD) along the fibers were observed. The gelation of the HAp/Col nanocomposite in the buffer is attributed to the physical cross-linking through entanglement of the reconstituted Col fibrils...
  13. ncbi request reprint Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatite
    Toshiyuki Ikoma
    National Institute for Materials Science, Biomaterials Center, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Nanosci Nanotechnol 7:822-7. 2007
    ..Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp...
  14. doi request reprint Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesion
    Motohiro Tagaya
    Department of Metallurgy and Ceramics Science, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo, Japan
    Macromol Biosci 11:1586-93. 2011
    ....
  15. ncbi request reprint Fabrication of hydroxyapatite ultra-thin layer on gold surface and its application for quartz crystal microbalance technique
    Akira Monkawa
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    Biomaterials 27:5748-54. 2006
    ..The study indicates that the hydroxyapatite sensor is applicable for qualitative and conformational analysis of protein adsorption...
  16. ncbi request reprint An improved method to prepare hyaluronic acid and type II collagen composite matrices
    Tetsushi Taguchi
    Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    J Biomed Mater Res 61:330-6. 2002
    ..The HyA-collagen composite matrices using this improved method will be useful in the preparation of cartilage regenerative scaffolds, and this methodology may be applied to other polyanion-polycation combinations as well...
  17. doi request reprint Elemental distribution analysis of type I collagen fibrils in tilapia fish scale with energy-filtered transmission electron microscope
    Mitsuhiro Okuda
    Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    Micron 40:665-8. 2009
    ..Our results indicated that the hole zones preferentially attract calcium and phosphate ions and thus serve as possible nucleation sites for mineralization...
  18. doi request reprint Transfection efficiency for size-separated cells synchronized in cell cycle by microfluidic device
    Satoshi Migita
    Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
    Biomed Microdevices 13:725-9. 2011
    ..The manipulation of cell cycle status could increase transfection efficiency in non-viral system, indicating size-based cell cycle synchronization is a powerful tool as a noninvasive method for bioscience and biotechnology...
  19. ncbi request reprint Fabrication and mechanical and tissue ingrowth properties of unidirectionally porous hydroxyapatite/collagen composite
    Shunji Yunoki
    Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
    J Biomed Mater Res B Appl Biomater 80:166-73. 2007
    ..The subcutaneous implantations revealed that when compared with the random pores, the unidirectional pores promote the ingrowth of the surrounding tissues into the pores...
  20. doi request reprint Intraosseous delivery of paclitaxel-loaded hydroxyapatitealginate composite beads delaying paralysis caused by metastatic spine cancer in rats
    Tetsuya Abe
    Department of Orthopedic Surgery, and Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
    J Neurosurg Spine 9:502-10. 2008
    ..The authors have developed a local delivery system of paclitaxel in the form of hydroxyapatite-alginate composite beads. This study was conducted to clarify the therapeutic effect in a rat model of metastatic spine cancer...
  21. ncbi request reprint Pre-adsorbed type-I collagen structure-dependent changes in osteoblastic phenotype
    Nobutaka Hanagata
    Biomaterials Center, National Institute for Materials Science 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
    Biochem Biophys Res Commun 344:1234-40. 2006
    ..This study suggests that the structures of collagen affect proliferation and mineralization of osteoblast-like cells...
  22. ncbi request reprint Preparation and characterization of multilayered hydroxyapatite/silk fibroin film
    Rikako Kino
    Faculty and Graduate School of Engineering, Hokkaido University, Kita 13, Nishi 9, Kita ku, Sapporo, Hokkaido 060 8628, Japan
    J Biosci Bioeng 103:514-20. 2007
    ..The results indicate that HAp-deposited SF films and SF films show similar degrees of cell adhesion and alkaline phosphatase activities...
  23. ncbi request reprint Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugs
    Yutaka Mizushima
    DDS Institute, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato, Tokyo 105 8461, Japan
    J Control Release 110:260-5. 2006
    ..In conclusion, the SP-HAp seems to be useful as a biodegradable and subcutaneously injectable drug carrier. It is suggested that the reinforcement of the SP-HAp is very effective on the sustained release of drugs...
  24. ncbi request reprint Surface structural biomimetics and the osteoinduction of calcium phosphate biomaterials
    Hongsong Fan
    National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
    J Nanosci Nanotechnol 7:808-13. 2007
    ....
  25. ncbi request reprint Dextran templating for the synthesis of metallic and metal oxide sponges
    Dominic Walsh
    School of Chemistry, University of Bristol, Bristol BS8 1TS, UK
    Nat Mater 2:386-90. 2003
    ....