Research Topics
| Toshiyuki IkomaSummaryAffiliation: National Institute for Materials Science Country: Japan Publications
| Collaborators
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Detail Information
Publications
Microstructure, mechanical, and biomimetic properties of fish scales from Pagrus majorToshiyuki Ikoma
Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Struct Biol 142:327-33. 2003..5-0.6 microm in length and 0.1-0.2 microm in width. The textured inorganic material remains intact when heated to 1473 K, although the size of the constituent crystals increases as a result of thermal sintering...- Physical properties of type I collagen extracted from fish scales of Pagrus major and Oreochromis niloticasToshiyuki Ikoma
Biomaterials Center, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
Int J Biol Macromol 32:199-204. 2003..The enthalpy and entropy estimated from thermal analyses could be correlated to amino acid sequences (Gly-Pro-Hyp) of type I collagens and the number of methionine amino acid residues... - Collagen coating on hydroxyapatite surfaces modified with organosilane by chemical vapor deposition methodAkira Monkawa
National Institute for Materials Science, Biomaterials Center, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Nanosci Nanotechnol 7:833-8. 2007.... - Three-dimensional porous hydroxyapatite/collagen composite with rubber-like elasticityShunji Yunoki
Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Biomater Sci Polym Ed 18:393-409. 2007..The porous composite fabricated has good flexibility and rubber-like elasticity, and is a promising bone regenerative material... - Phenotype and gene expression pattern of osteoblast-like cells cultured on polystyrene and hydroxyapatite with pre-adsorbed type-I collagenNobutaka Hanagata
Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
J Biomed Mater Res A 83:362-71. 2007..In addition, comprehensive gene expression analyses revealed that HAp and HAp/NCs specifically up-regulated Ly6a and Tmem37 genes, while down-regulated Ifitm5 gene... - Effect of collagen fibril formation on bioresorbability of hydroxyapatite/collagen compositesShunji Yunoki
Biomaterial Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Mater Sci Mater Med 18:2179-83. 2007..The bioresorbability in vivo was almost matched to the in vitro test using enzymatic reaction of collagenase... - Synthesis and characterization of metal ions containing hydroxyapatite microparticles with high specific surface areaToru Tonegawa
Graduate School of Pure and Applied Science, University of Tsukuba, 1 1 1 Tennoudai, Tsukuba, lbaraki, Japan
J Nanosci Nanotechnol 7:839-43. 2007..The microparticles with higher specific surface area will be applicable for the drug delivery carriers of proteins... 
A collagen sponge incorporating a hydroxyapatite/chondroitinsulfate composite as a scaffold for cartilage tissue engineeringYohimi Ohyabu
National Institute of Advanced Industrial Science and Technology, Higashi, Tsukuba, Ibaraki 305 8566, Japan
J Biomater Sci Polym Ed 20:1861-74. 2009..From these results, pCol-HAp/ChS is expected to be a candidate for a scaffold for cartilage tissue engineering in place of collagen sponge...- Rattle-type Fe(3)O(4)@SiO(2) hollow mesoporous spheres as carriers for drug deliveryYufang Zhu
International Center for Young Scientists ICYS, National Institute for Materials Science NIMS, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
Small 6:471-8. 2010..These results indicate the potential of Fe(3)O(4)@SiO(2) hollow mesoporous spheres for drug loading and delivery into cancer cells to induce cell death... - Minerals and aligned collagen fibrils in tilapia fish scales: structural analysis using dark-field and energy-filtered transmission electron microscopy and electron tomographyMitsuhiro Okuda
Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
Microsc Microanal 17:788-98. 2011.... - Structural analysis of hydroxyapatite coating on magnetite nanoparticles using energy filter imaging and electron tomographyMitsuhiro Okuda
Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki, 305 0047, Japan
J Electron Microsc (Tokyo) 59:173-9. 2010..The dissolution of iron ion from MNPs and the interfacial interaction of HAp and magnetite could cause the needlelike morphology of HAp nanocrystals... - Preparation and characterization of hydroxyapatite/collagen nanocomposite gelShunji Yunoki
National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Nanosci Nanotechnol 7:818-21. 2007..8+/-4.4 nm (mean +/- SD) along the fibers were observed. The gelation of the HAp/Col nanocomposite in the buffer is attributed to the physical cross-linking through entanglement of the reconstituted Col fibrils... - Drug-supported microparticles of calcium carbonate nanocrystals and its covering with hydroxyapatiteToshiyuki Ikoma
National Institute for Materials Science, Biomaterials Center, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Nanosci Nanotechnol 7:822-7. 2007..Spherical microparticles of calcite cores and petal-shaped hydroxyapatite (HAp) outer layers were fabricated by soaking calcite into the SBF, or a supersaturated solution of phosphate ions to enhance the crystal growth of HAp... - Nano/microstructural effect of hydroxyapatite nanocrystals on hepatocyte cell aggregation and adhesionMotohiro Tagaya
Department of Metallurgy and Ceramics Science, Graduate School of Science and Engineering, Tokyo Institute of Technology, Tokyo, Japan
Macromol Biosci 11:1586-93. 2011.... - Fabrication of hydroxyapatite ultra-thin layer on gold surface and its application for quartz crystal microbalance techniqueAkira Monkawa
Biomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
Biomaterials 27:5748-54. 2006..The study indicates that the hydroxyapatite sensor is applicable for qualitative and conformational analysis of protein adsorption... - An improved method to prepare hyaluronic acid and type II collagen composite matricesTetsushi Taguchi
Biomaterials Center, National Institute for Materials Science, 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
J Biomed Mater Res 61:330-6. 2002..The HyA-collagen composite matrices using this improved method will be useful in the preparation of cartilage regenerative scaffolds, and this methodology may be applied to other polyanion-polycation combinations as well... - Elemental distribution analysis of type I collagen fibrils in tilapia fish scale with energy-filtered transmission electron microscopeMitsuhiro Okuda
Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
Micron 40:665-8. 2009..Our results indicated that the hole zones preferentially attract calcium and phosphate ions and thus serve as possible nucleation sites for mineralization... - Transfection efficiency for size-separated cells synchronized in cell cycle by microfluidic deviceSatoshi Migita
Biomaterials Center, National Institute for Materials Science, 1 2 1 Sengen, Tsukuba, Ibaraki 305 0047, Japan
Biomed Microdevices 13:725-9. 2011..The manipulation of cell cycle status could increase transfection efficiency in non-viral system, indicating size-based cell cycle synchronization is a powerful tool as a noninvasive method for bioscience and biotechnology... - Fabrication and mechanical and tissue ingrowth properties of unidirectionally porous hydroxyapatite/collagen compositeShunji Yunoki
Biomaterials Center, National Institute for Materials Science, Namiki 1 1, Tsukuba, Ibaraki 305 0044, Japan
J Biomed Mater Res B Appl Biomater 80:166-73. 2007..The subcutaneous implantations revealed that when compared with the random pores, the unidirectional pores promote the ingrowth of the surrounding tissues into the pores... - Intraosseous delivery of paclitaxel-loaded hydroxyapatitealginate composite beads delaying paralysis caused by metastatic spine cancer in ratsTetsuya Abe
Department of Orthopedic Surgery, and Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
J Neurosurg Spine 9:502-10. 2008..The authors have developed a local delivery system of paclitaxel in the form of hydroxyapatite-alginate composite beads. This study was conducted to clarify the therapeutic effect in a rat model of metastatic spine cancer... - Pre-adsorbed type-I collagen structure-dependent changes in osteoblastic phenotypeNobutaka Hanagata
Biomaterials Center, National Institute for Materials Science 1 1 Namiki, Tsukuba, Ibaraki 305 0044, Japan
Biochem Biophys Res Commun 344:1234-40. 2006..This study suggests that the structures of collagen affect proliferation and mineralization of osteoblast-like cells... - Preparation and characterization of multilayered hydroxyapatite/silk fibroin filmRikako Kino
Faculty and Graduate School of Engineering, Hokkaido University, Kita 13, Nishi 9, Kita ku, Sapporo, Hokkaido 060 8628, Japan
J Biosci Bioeng 103:514-20. 2007..The results indicate that HAp-deposited SF films and SF films show similar degrees of cell adhesion and alkaline phosphatase activities... - Injectable porous hydroxyapatite microparticles as a new carrier for protein and lipophilic drugsYutaka Mizushima
DDS Institute, Jikei University School of Medicine, 3 25 8, Nishi Shimbashi, Minato, Tokyo 105 8461, Japan
J Control Release 110:260-5. 2006..In conclusion, the SP-HAp seems to be useful as a biodegradable and subcutaneously injectable drug carrier. It is suggested that the reinforcement of the SP-HAp is very effective on the sustained release of drugs... - Surface structural biomimetics and the osteoinduction of calcium phosphate biomaterialsHongsong Fan
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
J Nanosci Nanotechnol 7:808-13. 2007.... - Dextran templating for the synthesis of metallic and metal oxide spongesDominic Walsh
School of Chemistry, University of Bristol, Bristol BS8 1TS, UK
Nat Mater 2:386-90. 2003....