Tetsuya Hori

Summary

Affiliation: National Institute of Genetics
Country: Japan

Publications

  1. pmc CENP-O class proteins form a stable complex and are required for proper kinetochore function
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima 411 8540, Japan
    Mol Biol Cell 19:843-54. 2008
  2. doi request reprint Establishment of the vertebrate kinetochores
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Chromosome Res 20:547-61. 2012
  3. ncbi request reprint [Dynamics of the kinetochore proteins which target to the chromatin of centromeres]
    Tetsuya Hori
    Tanpakushitsu Kakusan Koso 51:326-34. 2006
  4. ncbi request reprint The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
  5. pmc The constitutive centromere component CENP-50 is required for recovery from spindle damage
    Yukinori Minoshima
    National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 25:10315-28. 2005
  6. ncbi request reprint CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 135:1039-52. 2008
  7. pmc CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold
    Tatsuya Nishino
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 148:487-501. 2012
  8. pmc CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly
    Mi Sun Kwon
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Shizuoka 411 8540, Japan
    Mol Biol Cell 18:2155-68. 2007
  9. pmc The CENP-S complex is essential for the stable assembly of outer kinetochore structure
    Miho Amano
    Department of Molecular Genetics, National Institute of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 186:173-82. 2009
  10. pmc The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis
    Yoshikazu Mikami
    PRESTO of JST, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 25:1958-70. 2005

Collaborators

Detail Information

Publications21

  1. pmc CENP-O class proteins form a stable complex and are required for proper kinetochore function
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima 411 8540, Japan
    Mol Biol Cell 19:843-54. 2008
    ..This suggests that CENP-O class proteins are involved in the prevention of premature sister chromatid separation during recovery from spindle damage...
  2. doi request reprint Establishment of the vertebrate kinetochores
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Chromosome Res 20:547-61. 2012
    ..Here, we review recent progress with regard to the molecular architecture of the kinetochore and discuss the future directions for centromere biology...
  3. ncbi request reprint [Dynamics of the kinetochore proteins which target to the chromatin of centromeres]
    Tetsuya Hori
    Tanpakushitsu Kakusan Koso 51:326-34. 2006
  4. ncbi request reprint The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Nat Cell Biol 8:446-57. 2006
    ....
  5. pmc The constitutive centromere component CENP-50 is required for recovery from spindle damage
    Yukinori Minoshima
    National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 25:10315-28. 2005
    ..We also observed severe mitotic defects in CENP-50-deficient cells with apparent premature sister chromatid separation when the mitotic checkpoint was activated, indicating that CENP-50 is required for recovery from spindle damage...
  6. ncbi request reprint CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 135:1039-52. 2008
    ..In total, our results suggest that the CENP-T/CENP-W complex is directly involved in establishment of centromere chromatin structure coordinately with CENP-A...
  7. pmc CENP-T-W-S-X forms a unique centromeric chromatin structure with a histone-like fold
    Tatsuya Nishino
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Cell 148:487-501. 2012
    ..These data suggest that the CENP-T-W-S-X complex forms a unique nucleosome-like structure to generate contacts with DNA, extending the "histone code" beyond canonical nucleosome proteins...
  8. pmc CENP-C is involved in chromosome segregation, mitotic checkpoint function, and kinetochore assembly
    Mi Sun Kwon
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Shizuoka 411 8540, Japan
    Mol Biol Cell 18:2155-68. 2007
    ..These results suggest that centromere localization of CENP-C in interphase nuclei occurs upstream of localization of the Mis12 complex and downstream of localization of the CENP-H complex...
  9. pmc The CENP-S complex is essential for the stable assembly of outer kinetochore structure
    Miho Amano
    Department of Molecular Genetics, National Institute of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 186:173-82. 2009
    ..In addition, we found that intrakinetochore distance was increased in CENP-S- and CENP-X-deficient cells. These results suggest that the CENP-S complex is essential for the stable assembly of the outer kinetochore...
  10. pmc The functional region of CENP-H interacts with the Nuf2 complex that localizes to centromere during mitosis
    Yoshikazu Mikami
    PRESTO of JST, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Mol Cell Biol 25:1958-70. 2005
    ..On the basis of these results and previously published data, we propose that the Nuf2 complex functions as a connector between the inner and outer kinetochores...
  11. pmc The CCAN recruits CENP-A to the centromere and forms the structural core for kinetochore assembly
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 200:45-60. 2013
    ..Based on the analysis of these different engineered kinetochores, we conclude that the CCAN has two distinct roles: recruiting CENP-A to establish the kinetochore and serving as a structural core to directly recruit kinetochore proteins...
  12. pmc CENP-T provides a structural platform for outer kinetochore assembly
    Tatsuya Nishino
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Shizuoka 411 8540, Japan
    EMBO J 32:424-36. 2013
    ..Our results provide a model for how the multiple protein complexes at kinetochores associate in a phospho-regulated manner...
  13. pmc The centromeric nucleosome-like CENP-T-W-S-X complex induces positive supercoils into DNA
    Kozo Takeuchi
    Department of Molecular Genetics, National Institute of Genetics, Mishima, Shizuoka 411 8540, Japan, The Graduate University for Advanced Studies Sokendai, Mishima, Shizuoka 411 8540, Japan, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Fukuoka 812 8581, Japan, JST, PRESTO, Fukuoka 812 8582, Japan and Laboratory of Structural Biology, Graduate School of Advanced Science and Engineering, Waseda University, Shinjuku ku, Tokyo 162 8480, Japan
    Nucleic Acids Res 42:1644-55. 2014
    ..In summary, our work reveals the structural features and properties of the CENP-T-W-S-X complex for its localization to centromeres...
  14. pmc Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins
    Aussie Suzuki
    Department of Molecular Genetics, National Institute of Genetics, The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    J Cell Biol 193:125-40. 2011
    ....
  15. pmc Histone H4 Lys 20 Monomethylation of the CENP-A Nucleosome Is Essential for Kinetochore Assembly
    Tetsuya Hori
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 29:740-9. 2014
    ..We conclude that H4K20me1 modification of CENP-A nucleosomes contributes to functional kinetochore assembly. ..
  16. pmc Chromosome engineering allows the efficient isolation of vertebrate neocentromeres
    Wei Hao Shang
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Dev Cell 24:635-48. 2013
    ..In summary, our experimental system provides valuable insights for understanding how neocentromeres form...
  17. pmc Chickens possess centromeres with both extended tandem repeats and short non-tandem-repetitive sequences
    Wei Hao Shang
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies SOKENDAI, Mishima, Shizuoka 411 8540, Japan
    Genome Res 20:1219-28. 2010
    ....
  18. ncbi request reprint Dynamic behavior of Nuf2-Hec1 complex that localizes to the centrosome and centromere and is essential for mitotic progression in vertebrate cells
    Tetsuya Hori
    PRESTO, The Japan Science and Technology Corporation, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    J Cell Sci 116:3347-62. 2003
    ..Furthermore, photobleaching experiments revealed that the Nuf2-Hec1 complex is stably associated with the centromere and that interaction of this complex with the centrosome is dynamic...
  19. ncbi request reprint The DT40 system as a tool for analyzing kinetochore assembly
    Masahiro Okada
    Department of Molecular Genetics, National Institute of Genetics and The Graduate University for Advanced Studies, Mishima, Shizuoka 411 8540, Japan
    Subcell Biochem 40:91-106. 2006
    ..The DT40 system is a powerful and reliable tool for study of kinetochore assembly. Herein, we review recent advances in our understanding of the mechanisms underlying kinetochore assembly in DT40 cells...
  20. pmc KNL1 and the CENP-H/I/K complex coordinately direct kinetochore assembly in vertebrates
    Iain M Cheeseman
    Ludwig Institute for Cancer Research, and Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 19:587-94. 2008
    ..These findings explain discrepancies in kinetochore assembly pathways between different organisms and reveal a surprising plasticity in the assembly mechanism of an essential cell division organelle...
  21. pmc The human Mis12 complex is required for kinetochore assembly and proper chromosome segregation
    Susan L Kline
    Ludwig Institute for Cancer Research, Department of Cellular and Molecular Medicine, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    J Cell Biol 173:9-17. 2006
    ..These results indicate that a four-subunit Mis12 complex plays an essential role in chromosome segregation in vertebrates and contributes to mitotic kinetochore assembly...