Hiroaki Hori

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint Temperament and character in remitted and symptomatic patients with schizophrenia: Modulation by the COMT Val158Met genotype
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan Electronic address
    J Psychiatr Res 56:82-9. 2014
  2. doi request reprint Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    J Affect Disord 158:90-6. 2014
  3. ncbi request reprint Psychological coping in depressed outpatients: association with cortisol response to the combined dexamethasone/CRH test
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan CREST Core Research of Evolutional Science and Technology, JST Japan Science and Technology Agency, Tokyo, Japan Electronic address
    J Affect Disord 152:441-7. 2014
  4. ncbi request reprint A latent profile analysis of schizotypy, temperament and character in a nonclinical population: association with neurocognition
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Electronic address
    J Psychiatr Res 48:56-64. 2014
  5. ncbi request reprint Moderating effect of schizotypy on the relationship between smoking and neurocognition
    H Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan Electronic address
    Eur Psychiatry 28:457-62. 2013
  6. doi request reprint Relationship of temperament and character with cortisol reactivity to the combined dexamethasone/CRH test in depressed outpatients
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    J Affect Disord 147:128-36. 2013
  7. doi request reprint Schizotypal trait in healthy women is associated with a shift away from dextrality on a spatial motor control task, but not on a force control task
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychiatry Res 200:629-34. 2012
  8. doi request reprint Schizotypy and genetic loading for schizophrenia impact upon neuropsychological status in bipolar II and unipolar major depressive disorders
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Affect Disord 142:225-32. 2012
  9. pmc Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Sci Rep 2:634. 2012
  10. doi request reprint Relationships between season of birth, schizotypy, temperament, character and neurocognition in a non-clinical population
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Psychiatry Res 195:69-75. 2012

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Temperament and character in remitted and symptomatic patients with schizophrenia: Modulation by the COMT Val158Met genotype
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan Electronic address
    J Psychiatr Res 56:82-9. 2014
    ..The COMT Val158Met polymorphism might have a modulating effect on the relationship between personality and remission. ..
  2. doi request reprint Cognitive effects of the ANK3 risk variants in patients with bipolar disorder and healthy individuals
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan Electronic address
    J Affect Disord 158:90-6. 2014
    ..We investigated whether genetic variants of ANK3 would be associated with an array of cognitive functions in patients with bipolar disorder and healthy individuals...
  3. ncbi request reprint Psychological coping in depressed outpatients: association with cortisol response to the combined dexamethasone/CRH test
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan CREST Core Research of Evolutional Science and Technology, JST Japan Science and Technology Agency, Tokyo, Japan Electronic address
    J Affect Disord 152:441-7. 2014
    ..We aimed to examine whether dysfunctional coping styles in depression would be associated with abnormal cortisol reactivity...
  4. ncbi request reprint A latent profile analysis of schizotypy, temperament and character in a nonclinical population: association with neurocognition
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Electronic address
    J Psychiatr Res 48:56-64. 2014
    ....
  5. ncbi request reprint Moderating effect of schizotypy on the relationship between smoking and neurocognition
    H Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan Electronic address
    Eur Psychiatry 28:457-62. 2013
    ..Moreover, possible moderating effects of schizotypy on the relationship between smoking and cognition have not been well documented...
  6. doi request reprint Relationship of temperament and character with cortisol reactivity to the combined dexamethasone/CRH test in depressed outpatients
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    J Affect Disord 147:128-36. 2013
    ..Another line of research has demonstrated that personality is associated with HPA axis alteration. It is thus hypothesized that different personality pathology in depression would be associated with distinct cortisol reactivity...
  7. doi request reprint Schizotypal trait in healthy women is associated with a shift away from dextrality on a spatial motor control task, but not on a force control task
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychiatry Res 200:629-34. 2012
    ..These results indicate that schizotypal traits in healthy women are associated with a shift away from dextrality, supporting the fully dimensional model of schizotypy...
  8. doi request reprint Schizotypy and genetic loading for schizophrenia impact upon neuropsychological status in bipolar II and unipolar major depressive disorders
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Affect Disord 142:225-32. 2012
    ..Although these conditions are known to be associated with neurocognitive impairments, such an association has not been studied in patients with bipolar II disorder (BPII) or unipolar major depressive disorder (UP)...
  9. pmc Effects of the CACNA1C risk allele on neurocognition in patients with schizophrenia and healthy individuals
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Sci Rep 2:634. 2012
    ..These results add to the literature suggesting that rs1006737 may be associated with schizophrenia through its detrimental effect on endophenotypic traits...
  10. doi request reprint Relationships between season of birth, schizotypy, temperament, character and neurocognition in a non-clinical population
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Psychiatry Res 195:69-75. 2012
    ..These results support the notion that schizotypy and schizophrenia are neurodevelopmental conditions on the same continuum...
  11. doi request reprint Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/ corticotropin-releasing hormone test
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropsychobiology 63:232-41. 2011
    ....
  12. doi request reprint Attitudes toward schizophrenia in the general population, psychiatric staff, physicians, and psychiatrists: a web-based survey in Japan
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Res 186:183-9. 2011
    ..Psychiatrists had the least negative attitudes toward schizophrenia, which was followed by the psychiatric staff, and attitudes of the general population and of physicians were equally stigmatizing...
  13. doi request reprint Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 56:613-6. 2011
    ..These results suggest that IL-1β gene variation may have a role in cognitive functions in aging females as well as males...
  14. doi request reprint Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neural Transm 119:313-8. 2012
    ..Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory...
  15. doi request reprint Failure to confirm an association between Epsin 4 and schizophrenia in a Japanese population
    Misty Richards
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Neural Transm 115:1347-54. 2008
    ..Our results suggest that the examined region of Epsin 4 does not have a major influence on susceptibility to schizophrenia in Japanese...
  16. doi request reprint Difference in Temperament and Character Inventory scores between depressed patients with bipolar II and unipolar major depressive disorders
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    J Affect Disord 132:319-24. 2011
    ..Although some core personality variables are known to be characteristic of unipolar or bipolar depression, few studies have compared the personality profile between these two disorders...
  17. doi request reprint Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Schizophr Res 139:201-6. 2012
    ..Previous studies also suggest altered oxytocin function in patients with schizophrenia and depression. However, few studies have examined the central oxytocin levels in these disorders...
  18. pmc Possible association between interleukin-1β gene and schizophrenia in a Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Behav Brain Funct 7:35. 2011
    ..Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms...
  19. doi request reprint Blood CADPS2ΔExon3 expression is associated with intelligence and memory in healthy adults
    Kotaro Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo187 8502, Japan
    Biol Psychol 89:117-22. 2012
    ..019; η(p)(2)=0.032), lower verbal memory (p=0.026; η(p)(2)=0.026) and delayed recall (p=0.042; η(p)(2)=0.021) of WMS-R. Our results suggest that CADPS2ΔExon3 affects intelligence and memory in the non-clinical population...
  20. doi request reprint Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 38:341-4. 2012
    ..We hypothesized that the Trp64Arg polymorphism may be associated with increased risk of schizophrenia and depression...
  21. doi request reprint Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 46:555-9. 2012
    ..5, df = 1, p = 0.0037, OR 1.50, 95%CI 1.14-1.98). Our results suggest that the T3435 allele or carrying two copies of this allele confers susceptibility to MDD in the Japanese population...
  22. doi request reprint Support for association between the Ser205Leu polymorphism of p75(NTR) and major depressive disorder
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 56:806-9. 2011
    ....
  23. ncbi request reprint Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1257-63. 2011
    ..Our findings further suggest that the mediation model would work better than the bivariate approach in investigating the relationship between sleep, distress and HPA axis reactivity...
  24. doi request reprint More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depression
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    J Affect Disord 136:1047-52. 2012
    ..In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls...
  25. doi request reprint Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1439-44. 2011
    ..Increased IL-6 levels without alterations in sIL-6R levels may result in excessive IL-6 signaling in schizophrenia...
  26. pmc Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Behav Brain Funct 7:23. 2011
    ..These findings prompted us to examine the possible association between IL-1β gene polymorphisms and HPA axis function assessed with the DEX/CRH test...
  27. doi request reprint Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    J Psychiatr Res 44:865-73. 2010
    ..These results point to the important role of enhanced suppression of cortisol, or blunted cortisol reactivity, in non-clinical psychopathology such as avoidant coping strategy and greater psychological distress...
  28. doi request reprint Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Psychiatry Res 160:175-83. 2008
    ....
  29. doi request reprint Genetic variations of human neuropsin gene and psychiatric disorders: polymorphism screening and possible association with bipolar disorder and cognitive functions
    Aiko Izumi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropsychopharmacology 33:3237-45. 2008
    ..016) and verbal IQ (P<0.001). Genetic variation of the hNP gene may contribute to molecular mechanisms of bipolar disorder and some aspects of memory and intelligence...
  30. ncbi request reprint Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    J Psychiatr Res 47:401-6. 2013
    ..The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded...
  31. doi request reprint Discrimination between schizophrenia and major depressive disorder by magnetic resonance imaging of the female brain
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 47:1383-8. 2013
    ..We tried to identify structural changes of the brain that best discriminate between schizophrenia and MDD on the basis of gray matter volume, ventricle volume, and diffusion tensor imaging (DTI)...
  32. doi request reprint IQ decline and memory impairment in Japanese patients with chronic schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Psychiatry Res 158:251-5. 2008
    ..Our results suggest that schizophrenia patients experience marked IQ decline due to the development of illness and their wide-ranging memory impairments are even more severe than the IQ decline...
  33. doi request reprint Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    J Psychiatr Res 45:47-53. 2011
    ..Our findings provide strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder...
  34. doi request reprint Benzodiazepines, benzodiazepine-like drugs, and typical antipsychotics impair manual dexterity in patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, 3 1 1 Asahi, Matsumoto 390 8621, Japan
    J Psychiatr Res 49:37-42. 2014
    ..Psychiatrists should be aware that some psychotropic medications may enhance the disability caused by the impairment of dexterity in patients with schizophrenia. ..
  35. doi request reprint ITIH3 polymorphism may confer susceptibility to psychiatric disorders by altering the expression levels of GLT8D1
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Nagano, 390 8621, Japan
    J Psychiatr Res 50:79-83. 2014
    ..Our findings suggest that rs2535629 influences the susceptibility to psychiatric disorders by affecting the expression level of GLT8D1. ..
  36. doi request reprint Multimodal image analysis of sensorimotor gating in healthy women
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Brain Res 1499:61-8. 2013
    ..This result was compatible with the previous suggestion that PPI would be modulated by the cortico-striato-thalamic-pallido-pontine circuit...
  37. doi request reprint Functional near-infrared spectroscopy reveals altered hemispheric laterality in relation to schizotypy during verbal fluency task
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1944-51. 2008
    ....
  38. ncbi request reprint Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: a pseudo-continuous arterial spin labeling (pCASL) study
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, 4 1 1, Ogawa Higashi, Kodaira, Tokyo, Japan Electronic address
    J Affect Disord 165:59-63. 2014
    ....
  39. ncbi request reprint Effect of L-theanine on sensorimotor gating in healthy human subjects
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 68:337-43. 2014
    ..Previously, we found that l-theanine attenuates MK-801-induced deficit in prepulse inhibition (PPI) in mice. In this study, we examined the effect of l-theanine in increasing the PPI in healthy humans...
  40. doi request reprint Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychoneuroendocrinology 42:89-97. 2014
    ....
  41. doi request reprint Hypothalamic-pituitary-adrenal axis hyperactivity and brain differences in healthy women
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    Neuropsychobiology 68:205-11. 2013
    ..However, few studies have examined the whole brain configuration for an association with HPA axis activity. We examined the relationship between HPA axis activity and the whole brain configuration...
  42. doi request reprint Discrimination of female schizophrenia patients from healthy women using multiple structural brain measures obtained with voxel-based morphometry
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, Japan
    Psychiatry Clin Neurosci 66:611-7. 2012
    ..To identify the correlative pattern of brain changes that best discriminate schizophrenia patients from healthy subjects, discriminant analysis techniques using voxel-based morphometry were applied...
  43. ncbi request reprint Antipsychotic medication and cognitive function in schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Schizophr Res 86:138-46. 2006
    ..Alternatively, poorer cognitive function may be due in part to polypharmacy or excessive dosing. Further investigations are required to draw any conclusions...
  44. ncbi request reprint Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
    Takeyuki Mori
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira City, Tokyo, 187 8551, Japan
    Psychiatry Res 154:133-45. 2007
    ..Our data confirmed decreased FA in schizophrenics, compared to controls in the widespread WM areas. Such decreased FA values in schizophrenia might be attributable, at least in part, to progressive changes after the onset of the illness...
  45. ncbi request reprint Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients
    Kotaro Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi cho, Kodaira, Tokyo, 187 8502 Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1738-43. 2011
    ..Chronic risperidone treatment did not alter the expression of CADPS2 in frontal cortex of mice. The observed increase in the expression of CADPS2 may be related to the impaired synaptic function in schizophrenia...
  46. doi request reprint Schizotypal traits and cognitive function in healthy adults
    Hiroko Noguchi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Psychiatry Res 161:162-9. 2008
    ....
  47. ncbi request reprint Pseudo-continuous arterial spin labeling MRI study of schizophrenic patients
    Miho Ota
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan Electronic address
    Schizophr Res 154:113-8. 2014
    ..With respect to the fractional anisotropy (FA) values in the DTI, there were significant FA reductions in the left superior temporal, left external capsule, and left inferior prefrontal regions in the patients compared to the controls...
  48. ncbi request reprint Failure to confirm an association between the PLXNA2 gene and schizophrenia in a Japanese population
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:873-7. 2007
    ..Furthermore, haplotype-based analyses did not provide evidence for an association. These results suggest that PLXNA2 may not play a major role in the development of schizophrenia in our Japanese sample...
  49. pmc Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    PLoS ONE 8:e54967. 2013
    ..Further studies are required to clarify how SNPs function in affecting the expression levels in whole blood as well as in other tissues...
  50. ncbi request reprint [The hypothalamic-pituitary-adrenal axis and depressive disorder: recent progress]
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 32:203-9. 2012
    ....
  51. ncbi request reprint Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Res 59:23-8. 2007
    ..Our results confirm impaired PPI in chronic schizophrenia patients compared with controls in Japanese...
  52. pmc Functional interactions between steroid hormones and neurotrophin BDNF
    Tadahiro Numakawa
    Tadahiro Numakawa, Misty Richards, Hiroaki Hori, Naoki Adachi, Hiroshi Kunugi, Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, 187 8502, Japan
    World J Biol Chem 1:133-43. 2010
    ..Here, we present a broad overview of the current knowledge concerning the association between BDNF expression/function and steroid hormones (glucocorticoids and estrogen)...
  53. ncbi request reprint Schizotypal traits in healthy women predict prefrontal activation patterns during a verbal fluency task: a near-infrared spectroscopy study
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropsychobiology 57:61-9. 2008
    ..The aim of this study was to examine the possible association between schizotypal traits at a nonclinical level and prefrontal activation patterns during a letter version of the verbal fluency task (VFT)...
  54. doi request reprint Cross-cultural comparisons of attitudes toward schizophrenia amongst the general population and physicians: a series of web-based surveys in Japan and the United States
    Misty Richards
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles UCLA, Los Angeles, CA 90024, USA Fulbright Foundation, New York, NY 10025, USA
    Psychiatry Res 215:300-7. 2014
    ..Our results suggest that culture may have an important role in shaping attitudes toward mental illness. Anti-stigma campaigns that target culture-specific biases are considered important. ..
  55. ncbi request reprint The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia
    Takashi Ohnishi
    Department of Radiology, National Center Hospital of Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
    Brain 129:399-410. 2006
    ..Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia...
  56. pmc The efficacy of pramipexole, a dopamine receptor agonist, as an adjunctive treatment in treatment-resistant depression: an open-label trial
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    ScientificWorldJournal 2012:372474. 2012
    ..No serious adverse events were observed. Our findings indicate that pramipexole augmentation therapy may be effective and well tolerated in refractory depressed patients...
  57. doi request reprint Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 64:447-59. 2010
    ..Based on these findings, an integrated schema of the pathological and recovery processes of depression is illustrated...