Hirohiko Hohjoh

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. pmc Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Nucleic Acids Res 38:5141-51. 2010
  2. pmc Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    PLoS ONE 3:e2248. 2008
  3. pmc Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klotho-deficient, senescence-model mouse
    Masaki Takahashi
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    PLoS ONE 7:e48974. 2012
  4. ncbi request reprint MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Methods Mol Biol 936:257-69. 2013
  5. ncbi request reprint Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Gene 391:39-44. 2007
  6. doi request reprint Molecular cloning and characterization of the common marmoset huntingtin gene
    Hirohiko Hohjoh
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Gene 432:60-6. 2009
  7. ncbi request reprint Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Immunogenetics 54:856-61. 2003
  8. ncbi request reprint Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neurogenetics 4:151-3. 2003
  9. doi request reprint Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Mol Biol Rep 39:903-9. 2012
  10. ncbi request reprint RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed
    Noriko Sago
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 319:50-7. 2004

Collaborators

Detail Information

Publications30

  1. pmc Small RNA class transition from siRNA/piRNA to miRNA during pre-implantation mouse development
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Tokyo, Japan
    Nucleic Acids Res 38:5141-51. 2010
    ..Taken together, our current study reveals a major reprogramming of functional small RNAs during early mouse development from oocyte to blastocyst...
  2. pmc Enhancement of allele discrimination by introduction of nucleotide mismatches into siRNA in allele-specific gene silencing by RNAi
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    PLoS ONE 3:e2248. 2008
    ....
  3. pmc Reduction of type IV collagen by upregulated miR-29 in normal elderly mouse and klotho-deficient, senescence-model mouse
    Masaki Takahashi
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    PLoS ONE 7:e48974. 2012
    ....
  4. ncbi request reprint MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    Methods Mol Biol 936:257-69. 2013
    ..Here, I describe procedures for detection of miRNAs in the course of neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells...
  5. ncbi request reprint Expression profile analysis of microRNA (miRNA) in mouse central nervous system using a new miRNA detection system that examines hybridization signals at every step of washing
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Gene 391:39-44. 2007
    ....
  6. doi request reprint Molecular cloning and characterization of the common marmoset huntingtin gene
    Hirohiko Hohjoh
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Gene 432:60-6. 2009
    ..Taken together, the data presented here may assist us in realizing a non-human primate HD model with the common marmoset...
  7. ncbi request reprint Recent divergence of the HLA-DRB1*04 allelic lineage from the DRB1*0701 lineage after the separation of the human and chimpanzee species
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Immunogenetics 54:856-61. 2003
    ....
  8. ncbi request reprint Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neurogenetics 4:151-3. 2003
    ..The frequency of the 129 threonine allele is significantly higher in the patients than in the controls ( P=0.0029). The data suggest that AA-NAT could be a susceptibility gene for DSPS...
  9. doi request reprint Active role of small non-coding RNAs derived from SINE/B1 retrotransposon during early mouse development
    Yusuke Ohnishi
    Department of Molecular Genetics, National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Mol Biol Rep 39:903-9. 2012
    ..Therefore, our present study suggested that the zygotically expressed SINE/B1 small RNAs in pre-implantation mouse embryos contain active small RNAs, which were presumably processed by Dicer and involved in gene silencing...
  10. ncbi request reprint RNAi induction and activation in mammalian muscle cells where Dicer and eIF2C translation initiation factors are barely expressed
    Noriko Sago
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 319:50-7. 2004
    ..Altogether, the data presented here suggest that muscle cells retain the ability to induce RNAi, although Dicer and eIF2C1 approximately 4 appear to be barely expressed in them...
  11. ncbi request reprint Influence of assembly of siRNA elements into RNA-induced silencing complex by fork-siRNA duplex carrying nucleotide mismatches at the 3'- or 5'-end of the sense-stranded siRNA element
    Yusuke Ohnishi
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 329:516-21. 2005
    ..In addition, we further suggest the possibility that there could be a positional effect of siRNA duplex on RNAi activity...
  12. doi request reprint Variation of gene silencing involving endogenous microRNA in mammalian cells
    Yoshiko Tamura
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Mol Biol Rep 36:1413-20. 2009
    ..The data presented here suggest that not only microRNA level but also target transcript level likely participate in the generation of a variety of gene silencing...
  13. ncbi request reprint Marked change in microRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonal carcinoma P19 cells
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 362:360-7. 2007
    ..Based on these observations, it is suggested that the miR-302 cluster and miR-124a may be useful molecular indicators in the assessment of degree of undifferentiation and/or differentiation in the course of neuronal differentiation...
  14. pmc Tailor-made RNAi knockdown against triplet repeat disease-causing alleles
    Masaki Takahashi
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 107:21731-6. 2010
    ....
  15. ncbi request reprint Association study of the chemokine, CXC motif, ligand 1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population
    Yoshiko Tamura
    National Center of Neurology and Psychiatry, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 379:149-51. 2005
    ..Therefore, the data presented here suggests that the CXCL1 gene could not be associated with the susceptibility to AD in a Japanese population...
  16. ncbi request reprint Alteration of microRNA expression in the process of mouse brain growth
    Akiko Eda
    National Institute of Neuroscience, NCNP, Ogawahigashi, Kodaira, Tokyo, Japan
    Gene 485:46-52. 2011
    ....
  17. doi request reprint Systematic gene regulation involving miRNAs during neuronal differentiation of mouse P19 embryonic carcinoma cell
    Akiko Eda
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 388:648-53. 2009
    ..The gene regulation involving miRNAs likely contributes to a rapid and programmed change in gene expression in neuronal differentiation of P19 cells...
  18. ncbi request reprint Long-lasting RNAi activity in mammalian neurons
    Kazuya Omi
    Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FEBS Lett 558:89-95. 2004
    ....
  19. ncbi request reprint Enhancement of RNAi activity by improved siRNA duplexes
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    FEBS Lett 557:193-8. 2004
    ....
  20. ncbi request reprint Gene Silencing Mediated by Endogenous MicroRNAs under Heat Stress Conditions in Mammalian Cells
    Masashi Fukuoka
    Department of Molecular Pharmacology, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, Japan
    PLoS ONE 9:e103130. 2014
    ..Our current findings suggested the possibility that gene silencing involving endogenous miRNAs might play a subsidiary role in heat-shocked cells for an aggressive inhibition of the expression of heat-denatured proteins. ..
  21. doi request reprint Allele-specific silencing by RNA interference
    Hirohiko Hohjoh
    National Institute of Neuroscience, NCNP, Tokyo, Japan
    Methods Mol Biol 623:67-79. 2010
    ....
  22. ncbi request reprint Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference
    Tokiko Sakai
    National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Cell Biol Int 30:952-6. 2006
    ..The results demonstrated that cell viability and neurite outgrowth of N2a cells undergoing knockdown of Aplp1 were significantly reduced, compared with N2a cells undergoing knockdown of either App or Aplp2...
  23. pmc Genomewide association analysis of human narcolepsy and a new resistance gene
    Minae Kawashima
    Department of Sleep Disorder Research Alfresa, Graduate School of Medicine, University of Tokyo, Japan
    Am J Hum Genet 79:252-63. 2006
    ..Therefore, NLC1-A is considered to be a new resistance gene for human narcolepsy...
  24. pmc Specific inhibition of tumor cells by oncogenic EGFR specific silencing by RNA interference
    Masaki Takahashi
    Department of Molecular Pharmacology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    PLoS ONE 8:e73214. 2013
    ....
  25. pmc Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity
    Tomohiro Kabuta
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 288:12615-26. 2013
    ..We concluded that UCH-L1 is a novel regulator of the kinase activities of CDKs. We believe that our findings from this study will significantly contribute to our understanding of cell cycle-associated diseases...
  26. pmc Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
    Yoshimitsu Doi
    Departments of Immunology and Molecular Genetics, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Proc Natl Acad Sci U S A 105:8381-6. 2008
    ..Thus, NR4A2 is an essential transcription factor for triggering the inflammatory cascade of MS/EAE and may serve as a therapeutic target...
  27. ncbi request reprint RNA interference (RNA(i)) induction with various types of synthetic oligonucleotide duplexes in cultured human cells
    Hirohiko Hohjoh
    Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Japan
    FEBS Lett 521:195-9. 2002
    ..e. short interfering RNAs (siRNAs), between human RNAi and invertebrate RNAi. The data further show that different siRNAs induce different levels of RNAi...
  28. doi request reprint Three human ARX mutations cause the lissencephaly-like and mental retardation with epilepsy-like pleiotropic phenotypes in mice
    Kunio Kitamura
    Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Hum Mol Genet 18:3708-24. 2009
    ....