S Hirohashi

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. doi Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas
    Satoru Kikuchi
    Chemotherapy Division, Cancer Proteomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Clin Cancer Res 14:5348-56. 2008
  2. pmc Prognostic significance of dysadherin expression in advanced colorectal carcinoma
    S Aoki
    Pathology Division, National Cancer Center Research Institute, Tokyo 1 1 Tsukiji 5 Chome, Chou ku, Japan
    Br J Cancer 88:726-32. 2003
  3. pmc Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
    S Hirohashi
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 153:333-9. 1998
  4. ncbi Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic and immunohistochemical study of eight cases
    N Fukushima
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Virchows Arch 439:6-13. 2001
  5. ncbi Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis
    Jeong Seok Nam
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1020-8. 2002
  6. pmc E-cadherin gene mutations in human gastric carcinoma cell lines
    T Oda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 91:1858-62. 1994
  7. ncbi Involvement of c-Src in carcinoma cell motility and metastasis
    M Sakamoto
    Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:941-6. 2001
  8. ncbi Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632
    M Takamura
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Hepatology 33:577-81. 2001
  9. ncbi Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma
    Y Yamamoto
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 7:297-303. 2001
  10. ncbi Altered expression of the ERM proteins in lung adenocarcinoma
    M Tokunou
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Lab Invest 80:1643-50. 2000

Collaborators

Detail Information

Publications133 found, 100 shown here

  1. doi Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas
    Satoru Kikuchi
    Chemotherapy Division, Cancer Proteomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Clin Cancer Res 14:5348-56. 2008
    ..Actinin-4 is an actin-binding protein associated with enhanced cell motility, invasive growth, and lymph node metastasis. Actinin-4 might play an important role in the development and progression of pancreatic cancer...
  2. pmc Prognostic significance of dysadherin expression in advanced colorectal carcinoma
    S Aoki
    Pathology Division, National Cancer Center Research Institute, Tokyo 1 1 Tsukiji 5 Chome, Chou ku, Japan
    Br J Cancer 88:726-32. 2003
    ..0028, log-rank test for overall and recurrence-free survival rate, respectively). These results suggest that increased dysadherin expression is a significant indicator of poor prognosis for patients with advanced colorectal carcinoma...
  3. pmc Inactivation of the E-cadherin-mediated cell adhesion system in human cancers
    S Hirohashi
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Pathol 153:333-9. 1998
    ..In conclusion, inactivation of the E-cadherin system by multiple mechanisms, including both genetic and epigenetic events, plays a significant role in multistage carcinogenesis...
  4. ncbi Invasive carcinoma derived from intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic and immunohistochemical study of eight cases
    N Fukushima
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Virchows Arch 439:6-13. 2001
    ..Some IPMCs might progress to invasive carcinoma via pathways that are different from those followed by ductal adenocarcinomas...
  5. ncbi Ras farnesylation inhibitor FTI-277 restores the E-cadherin/catenin cell adhesion system in human cancer cells and reduces cancer metastasis
    Jeong Seok Nam
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 93:1020-8. 2002
    ..Therefore, selective inhibition of Ras activation may be useful for preventing cancer metastasis...
  6. pmc E-cadherin gene mutations in human gastric carcinoma cell lines
    T Oda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 91:1858-62. 1994
    ..In addition, the wild-type allele of the E-cadherin locus was lost, suggesting that the E-cadherin gene had been inactivated by two hits (mutation and allele loss), similar to the mechanism for inactivation of tumor suppressor genes...
  7. ncbi Involvement of c-Src in carcinoma cell motility and metastasis
    M Sakamoto
    Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Jpn J Cancer Res 92:941-6. 2001
    ..These findings indicate that c-Src activation is critically involved in carcinoma cell migration and metastasis...
  8. ncbi Inhibition of intrahepatic metastasis of human hepatocellular carcinoma by Rho-associated protein kinase inhibitor Y-27632
    M Takamura
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Hepatology 33:577-81. 2001
    ..These findings confirm the importance of the Rho/p160ROCK signaling pathway in intrahepatic metastasis of human HCC, and indicate that Y-27632 may be useful for the prevention of intrahepatic metastasis of human HCC...
  9. ncbi Cloning and characterization of a novel gene, DRH1, down-regulated in advanced human hepatocellular carcinoma
    Y Yamamoto
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 7:297-303. 2001
    ..Although the function of DRH1 protein is still unknown, our findings suggest that DRH1 is related to the progression of HCC and may provide a new prognostic factor...
  10. ncbi Altered expression of the ERM proteins in lung adenocarcinoma
    M Tokunou
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Lab Invest 80:1643-50. 2000
    ..Although structurally related to radixin and moesin, ezrin may have a distinct function in tumor-cell invasion...
  11. ncbi Increased expression of laminin-5 and its prognostic significance in lung adenocarcinomas of small size. An immunohistochemical analysis of 102 cases
    Y Moriya
    Diagnostic Pathology, Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Cancer 91:1129-41. 2001
    ..The study concluded that overexpression of laminin-5 may be a useful prognostic factor in patients with small-sized lung adenocarcinoma, especially in Stage I cases...
  12. doi DEK oncoprotein regulates transcriptional modifiers and sustains tumor initiation activity in high-grade neuroendocrine carcinoma of the lung
    T Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Oncogene 29:4671-81. 2010
    ..Our study showed that DEK overexpression, partly through an increase in its gene dose, mediates the activity of global transcriptional regulators and is associated with tumor initiation activity and poor prognosis in HGNEC...
  13. ncbi MRNA expression of genes altered by 5-azacytidine treatment in cancer cell lines is associated with clinicopathological parameters of human cancers
    Y Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    J Cancer Res Clin Oncol 127:697-706. 2001
    ..CONCLUSIONS: These data suggest that DNA methylation may play a role in human multistage carcinogenesis through direct or indirect regulation of multiple tumor-related genes...
  14. pmc Vandetanib (ZD6474), an inhibitor of VEGFR and EGFR signalling, as a novel molecular-targeted therapy against cholangiocarcinoma
    D Yoshikawa
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 100:1257-66. 2009
    ..The absence of KRAS mutation and the presence of EGFR amplification may be potential predictive molecular marker of sensitivity to EGFR-targeted therapy in cholangiocarcinoma...
  15. ncbi Immunohistochemical study of c-erbB-2 oncoprotein overexpression in human major salivary gland carcinoma: an indicator of aggressiveness
    S Sugano
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Laryngoscope 102:923-7. 1992
    ..05). We conclude that immunohistochemical positivity for c-erbB-2 is an indicator of aggressiveness in both adenocarcinoma and adenocarcinoma in pleomorphic adenoma of the major salivary glands...
  16. pmc Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion
    K Honda
    Pathology Division, National Cancer Center Research Institute, Tokyo 104, Japan
    J Cell Biol 140:1383-93. 1998
    ..These findings suggest that cytoplasmic actinin-4 regulates the actin cytoskeleton and increases cellular motility and that its inactivation by transfer to the nucleus abolishes the metastatic potential of human cancers...
  17. ncbi Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation
    Y Naishiro
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 61:2751-8. 2001
    ..The loss of epithelial cell polarity may be a critical cellular event driving beta-catenin/TCF4-mediated intestinal tumorigenesis...
  18. ncbi Intraductal papillary components in invasive ductal carcinoma of the pancreas are associated with long-term survival of patients
    N Fukushima
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Hum Pathol 32:834-41. 2001
    ..002). IDPC is a morphologic feature associated with longer patient survival and should be taken into consideration in assessing the pathway of tumor progression...
  19. pmc Molecular cloning of a cell-surface glycoprotein that can potentially discriminate mesothelium from epithelium: its identification as vascular cell adhesion molecule 1
    T Yamada
    Pathology Division, National Cancer Center Hospital, Tokyo, Japan
    Br J Cancer 71:562-70. 1995
    ..This monoclonal antibody potentially discriminates mesothelium from epithelium and may become a tool for differential diagnosis of mesothelioma...
  20. ncbi Correlation of numerical and structural status of chromosome 16 with histological type and grade of non-invasive and invasive breast carcinomas
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 84:381-7. 1999
    ..Int. J. Cancer (Pred. Oncol.) 84:381-387, 1999...
  21. ncbi Cholangiocarcinomas in Japanese and Thai patients: difference in etiology and incidence of point mutation of the c-Ki-ras proto-oncogene
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 6:266-9. 1992
    ..On the other hand, point-mutational activation of the c-Ki-ras proto-oncogene may be involved in cholangiocarcinogenesis in liver without preexisting liver-fluke or viral infection...
  22. ncbi Integrin alpha6beta4 as a suppressor and a predictive marker for peritoneal dissemination in human gastric cancer
    Y Ishii
    Division of Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 118:497-506. 2000
    ..Because alterations of integrin expression in cancers contribute to cancer cell biology, we analyzed the association between the potential for peritoneal dissemination and integrin expression...
  23. ncbi Surgical treatment of intrahepatic cholangiocarcinoma: four patients surviving more than five years
    J Yamamoto
    Department of Surgery, National Cancer Center Hospital, Tokyo, Japan
    Surgery 111:617-22. 1992
    ..CONCLUSIONS. An anatomic and extensive liver resection should be performed for mass-forming ICC, whereas a hepatectomy with excision of the extrahepatic bile duct and hilar lymph nodal dissection is recommended for infiltrating ICC...
  24. ncbi Association of plakoglobin with APC, a tumor suppressor gene product, and its regulation by tyrosine phosphorylation
    T Shibata
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 203:519-22. 1994
    ..These results suggest that plakoglobin could play a role in mediating the signals of APC by mutual interaction and that this may be regulated by tyrosine phosphorylation...
  25. ncbi Loss of cell-cell contact is induced by integrin-mediated cell-substratum adhesion in highly-motile and highly-metastatic hepatocellular carcinoma cells
    T Genda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Lab Invest 80:387-94. 2000
    ..Modulation of this interaction might provide a new approach to prevent metastasis and recurrence of HCC...
  26. ncbi A clinical and radiologic study of primary liver cancer associated with extrahepatic primary cancer
    K Takayasu
    Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    Cancer 69:45-51. 1992
    ..5% at 3 years, and 40.5% and 40.1% at 5 years, respectively. There was no significant difference between the survival rates of those who underwent operations for PLC and extrahepatic primary cancer(s) synchronously and metachronously...
  27. ncbi Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma
    T Hasegawa
    Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Oncology 58:66-74. 2000
    ....
  28. ncbi Transarterial chemotherapy with zinostatin stimalamer for hepatocellular carcinoma
    T Okusaka
    Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan
    Oncology 55:276-83. 1998
    ..Transarterial chemotherapy with SMANCS, which is well tolerated, appears to have moderate antitumor effect in patients with HCC...
  29. ncbi Expression of vascular endothelial growth factor receptor 3 in blood and lymphatic vessels of lung adenocarcinoma
    T Niki
    Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    J Pathol 193:450-7. 2001
    ..Finally, proliferation of lymphatic endothelial cells may occur in association with lymphatic invasion by cancer cells...
  30. ncbi Overexpression of tetraspanin CO-029 in hepatocellular carcinoma
    K Kanetaka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Hepatol 35:637-42. 2001
    ..The molecules involved in the progression of hepatocellular carcinoma (HCC) are not fully understood. The aim of this study was to elucidate the crucial genes involved in cancer progression and metastasis...
  31. ncbi Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1
    T Yamamoto
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 193:681-7. 1993
    ..We suggest that the HFREP-1 gene is a new member of the fibrinogen family and that further data on the gene are important for a better understanding of the development of hepatocellular carcinomas...
  32. pmc Detection of genes expressed in primary colon cancers by in situ hybridisation: overexpression of RACK 1
    A Saito
    Pathology Division, National Cancer Center Research Institute, 1 1 Tsukiji, 5 Chome, Chuo Ku, Tokyo, 104 0045, Japan
    Mol Pathol 55:34-9. 2002
    ..In situ hybridisation (ISH) was used in a screening procedure to isolate these genes efficiently, using colon cancer as a model...
  33. ncbi Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line
    T Oda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 193:897-904. 1993
    ..These deletions were probably produced by an error of RNA splicing, presenting one possible mechanism for the loss of intact alpha-catenin expression...
  34. ncbi Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis
    Y Saito
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Hepatology 33:561-8. 2001
    ....
  35. pmc Clinicopathological and prognostic significance of EGFR, VEGF, and HER2 expression in cholangiocarcinoma
    D Yoshikawa
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Br J Cancer 98:418-25. 2008
    ..89; 95% CI, 1.05-3.39, P=0.0335) in IHCC. These results suggest that EGFR expression is associated with tumour progression and VEGF expression may be involved in haematogenic metastasis in cholangiocarcinoma...
  36. ncbi der(16)t(1;16)/der(1;16) in breast cancer detected by fluorescence in situ hybridization is an indicator of better patient prognosis
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 24:72-7. 1999
    ..05). der(16)t(1;16)/der(1;16) detected by FISH is considered helpful in identifying patients with a better prognosis and for stratification of patients in randomized clinical trials of adjuvant chemo-endocrine therapies...
  37. pmc Squamoid features and expression of involucrin in primary breast carcinoma associated with high histological grade, tumour cell necrosis and recurrence sites
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Chuo Ku, Tokyo, Japan
    Br J Cancer 75:1519-24. 1997
    ....
  38. ncbi Expression of Lewis blood group antigens in cancerous and non-cancerous liver
    T Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 78:968-76. 1987
    ....
  39. ncbi Expression of enamel proteins and LEF1 in adamantinomatous craniopharyngioma: evidence for its odontogenic epithelial differentiation
    S Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Histopathology 45:573-9. 2004
    ..The expression of these proteins is therefore indicative of odontogenic epithelial differentiation...
  40. ncbi Clinical late phase II trials of MultiHance (Gd-BOPTA) for the magnetic resonance imaging of liver tumors in Japan
    R Kuwatsuru
    Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan
    J Comput Assist Tomogr 23:S65-74. 1999
    ..The purpose of the study was to evaluate the safety and efficacy of Gd-BOPTA for liver imaging and to determine the most appropriate clinical dose to administer...
  41. ncbi DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers
    Y Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 91:205-12. 2001
    ....
  42. ncbi c-erbB-2 gene product directly associates with beta-catenin and plakoglobin
    Y Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Biochem Biophys Res Commun 208:1067-72. 1995
    ..These data suggest that c-erbB-2-induced signaling is also directly liked to the cadherin-mediated cell adhesion and "invasion-suppressor" system through beta-catenin and plakoglobin in cancers...
  43. ncbi E-cadherin gene mutations in signet ring cell carcinoma of the stomach
    H Muta
    Pathology Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 87:843-8. 1996
    ....
  44. ncbi Expression of laminin-5-gamma-2 chain in intraductal papillary-mucinous and invasive ductal tumors of the pancreas
    N Fukushima
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Mod Pathol 14:404-9. 2001
    ..Laminin-5-gamma-2 expression in the intraductal components of IPMTs tends to increase as tumors develop and may be a indicator of the potential invasiveness of the tumor cells...
  45. ncbi Pattern of chromosome 16q loss differs between an atypical proliferative lesion and an intraductal or invasive ductal carcinoma occurring subsequently in the same area of the breast
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 14:382-8. 2001
    ..Although atypical proliferative lesions were frequently confirmed to be of clonal nature with LOH on 16q, these lesions and carcinomas were considered to be clones, probably originated from a field with these clones...
  46. ncbi Cloning and characterization of the human beta4-integrin gene promoter and enhancers
    A S Takaoka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biol Chem 273:33848-55. 1998
    ..These findings should facilitate our understanding of the regulation of beta4-integrin gene expression in processes such as cell growth and differentiation, apoptosis, and cancer development and metastasis...
  47. ncbi Prognostic significance of histologic grade and nuclear expression of beta-catenin in synovial sarcoma
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Hum Pathol 32:257-63. 2001
    ..hum pathol 32:257-263...
  48. ncbi Evaluation of the therapeutic effect of transcatheter arterial embolization for hepatocellular carcinoma
    T Okusaka
    Department of Internal Medicine, National Cancer Center Hospital, Tokyo, Japan
    Oncology 58:293-9. 2000
    ..The reduction rate in serum AFP levels was also useful in patients with AFP levels >200 ng/ml before treatment...
  49. ncbi Preferential occurrence of breast carcinomas with loss of chromosome 16q and der (16) t (1;16) / der (1;16) in middle-aged patients with hyperplasia of mammary glands
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Cancer Res 91:692-9. 2000
    ..High-level estrogens and / or sensitivity of mammary glandular cells to estrogens might induce breast cancers with structural changes of chromosome 16...
  50. ncbi Implications of peritoneal washing cytology in patients with potentially resectable pancreatic cancer
    S Yachida
    Clinical Laboratory Division and Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital and Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Br J Surg 89:573-8. 2002
    ..The aim of this study was to assess the implications of positive peritoneal washing cytology for management of patients with potentially resectable pancreatic cancer...
  51. doi Expression profile of early lung adenocarcinoma: identification of MRP3 as a molecular marker for early progression
    S Hanada
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo, Japan
    J Pathol 216:75-82. 2008
    ..We conclude that MRP3 could be a novel molecular marker for LNMBAC, whose expression increases during the early progression of tumourigenesis...
  52. ncbi Genomic loss and epigenetic silencing of very-low-density lipoprotein receptor involved in gastric carcinogenesis
    H Takada
    Department of Molecular Cytogenetics, Medical Research Institute and Graduate School of Biomedical Science, Tokyo, Japan
    Oncogene 25:6554-62. 2006
    ..These results suggest that not only the expression of VLDLR but also genetic or epigenetic silencing of this gene may contribute to tumor formation and be involved in gastric carcinogenesis...
  53. ncbi Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma
    T Hasebe
    Pathology Division, National Cancer Center Research Institute, Chiba, Japan
    Virchows Arch 426:209-13. 1995
    ..It is possible that the adenoma-carcinoma sequence occurs in biliary tumours...
  54. pmc c-MET expression in myofibroblasts: role in autocrine activation and prognostic significance in lung adenocarcinoma
    M Tokunou
    Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan
    Am J Pathol 158:1451-63. 2001
    ..0019 by log-rank test). These data suggest that the HGF/c-MET system constitutes an autocrine activation loop in cancer-stromal myofibroblasts. This autocrine system may play a role in invasion and metastasis of lung adenocarcinoma...
  55. ncbi Multiple developmental pathways of highly aggressive breast cancers disclosed by comparison of histological grades and c-erbB-2 expression patterns in both the non-invasive and invasive portions
    H Tsuda
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 48:518-25. 1998
    ..The histological grade and c-erbB-2 overexpression appeared to be largely established during the early microscopic stages of a DCIS or invasive carcinoma...
  56. ncbi Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 50:731-8. 2000
    ....
  57. ncbi Detection of alterations in chromosomes 16 and 1 by fluorescence in situ hybridization in breast tumors cytologically or histologically equivocal for malignancy
    H Tsuda
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathobiology 66:268-73. 1998
    ..As a supportive diagnostic procedure, FISH analysis may give information about the nature of lesions, when the lesions are clinically or pathologically equivocal for cancer...
  58. ncbi Mutations of the p53 tumor suppressor gene and the ras gene family in intrahepatic cholangiocellular carcinomas in Japan and Thailand
    T Kiba
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Mol Carcinog 8:312-8. 1993
    ..Therefore, in contrast to the ras oncogenes, mutation of the p53 gene was frequently involved in the development of CCCs in both Japanese and Thai patients, irrespective of any difference in etiology...
  59. ncbi Identification of human cadherin-14, a novel neurally specific type II cadherin, by protein interaction cloning
    T Shibata
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Tokyo 104, Japan
    J Biol Chem 272:5236-40. 1997
    ..Cadherin-14 is a novel neurally specific cell-cell adhesion molecule and may regulate neural morphogenesis...
  60. ncbi Population-based mapping of pulmonary adenoma susceptibility 1 locus
    T A Dragani
    National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 60:5017-20. 2000
    ..001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer...
  61. ncbi Expression of cadherins and their undercoat proteins (alpha-, beta-, and gamma-catenins and p120) and accumulation of beta-catenin with no gene mutations in synovial sarcoma
    H Sato
    Pathology Division, National Cancer Center Research Institue, Tokyo, Japan
    Virchows Arch 438:23-30. 2001
    ..Furthermore, mechanisms other than mutation of exon 3 of the beta-catenin gene may activate the Wnt/Wingless signaling pathway in this type of tumor...
  62. ncbi Reduced p27Kip1 expression in hepatocellular carcinomas
    A M Hui
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Lett 132:67-73. 1998
    ..These findings suggest that reduced p27Kip1 expression may be at least partly responsible for human hepatocarcinogenesis...
  63. ncbi Clinicopathological significance of tumor nest configuration in patients with esophageal squamous cell carcinoma
    Y Nakanishi
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 91:1114-20. 2001
    ..CONCLUSIONS: This study showed that tumor nest configuration, which corresponded to the behavior of tumor cells against stromal cells, correlated well with the aggressiveness of the tumor...
  64. ncbi Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Mod Pathol 14:655-63. 2001
    ..These tumors, when arising in proximal locations, have a much worse prognosis than those arising in distal locations...
  65. ncbi Detection of numerical alterations of chromosome 1 in cytopathological specimens of breast tumors by chromogen in situ hybridization
    T Takarabe
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathol Int 51:786-91. 2001
    ..In addition, the CISH method was superior in the detection of numerical alterations in carcinoma cells by referring to the morphology of cells and in the detection of significant clones which might be missed under dark-field microscopy...
  66. ncbi Adult neuroblastoma of the retroperitoneum and abdomen: clinicopathologic distinction from primitive neuroectodermal tumor
    T Hasegawa
    Department of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Am J Surg Pathol 25:918-24. 2001
    ..Appropriate immunohistochemical studies and laboratory examination enable pathologists to distinguish ANB from other differential diagnoses, especially PNET...
  67. ncbi Deletion mapping of chromosome 2 in human lung carcinoma
    T Otsuka
    Biology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 16:113-9. 1996
    ..046). These results suggested that inactivation of tumor suppressor genes on chromosome 2 is involved in the phenotypic alterations of NSCLC cells into more aggressive ones...
  68. pmc Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas
    K Yoshiura
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Proc Natl Acad Sci U S A 92:7416-9. 1995
    ....
  69. ncbi Immature glandular features in squamous cell carcinoma of the uterine cervix as an independent indicator of resistance to radiotherapy
    S Okada
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Gynecol Cancer 12:277-85. 2002
    ..Nonetheless, the identification of "immature glandular features" was effective in predicting the radiotherapy resistance of cervical SCC and poorer patient prognosis...
  70. pmc Identification of semaphorin E as a non-MDR drug resistance gene of human cancers
    T Yamada
    Pathology Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104, Japan
    Proc Natl Acad Sci U S A 94:14713-8. 1997
    ..Recently, another member of the semaphorin family, CD100, was shown to significantly improve the viability of B lymphocytes. These results suggest the involvement of semaphorins in diverse cell survival mechanisms...
  71. ncbi A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2
    H Gomyo
    Radiobiology Division, Oncogene Division, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Genomics 62:139-46. 1999
    ..The IGSF4 gene, a novel gene that is shown to be located in the common loss of heterozygosity region, possesses a number of interesting features and may be good candidate for a tumor suppressor gene...
  72. ncbi Point mutation of the E-cadherin gene in invasive lobular carcinoma of the breast
    Y Kanai
    Pathology Division, National Cancer Center Research Institute, Tokyo
    Jpn J Cancer Res 85:1035-9. 1994
    ..This mutation may abolish the E-cadherin-mediated cell-cell adhesion and be at least partly responsible for the weak intercellular adhesiveness and scattered histological pattern of the tumor...
  73. ncbi Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas
    Y Shimoyama
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 49:2128-33. 1989
    ..Moreover, immunohistochemical examination of 44 lung carcinomas showed that both molecules were coexpressed in all of them, and suggested that expression of P-cadherin was closely related to the differentiation of carcinoma cells...
  74. pmc Chemokine (C-C motif) ligand 2 mediates the prometastatic effect of dysadherin in human breast cancer cells
    Jeong Seok Nam
    Laboratory of Cell Regulation and Carcinogenesis, National Cancer Institute, Bethesda, MD 20892 5055, USA
    Cancer Res 66:7176-84. 2006
    ..This study shows that dysadherin has prometastatic effects that are independent of E-cadherin expression and that CCL2 could play an important role in mediating the prometastatic effect of dysadherin in ER-negative breast cancer...
  75. ncbi Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
    Yae Kanai
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 28:2434-42. 2007
    ..Correction of DNA methylation status may offer a new strategy for prevention and therapy of cancers...
  76. ncbi Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression
    Teiyu Izumi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Am J Surg Pathol 31:85-94. 2007
    ..Dysadherin expression is considered to be one of the determinants of histologic subtype in synovial sarcoma. Moreover, dysadherin expression is an excellent and independent prognostic indicator...
  77. ncbi Frequent silencing of the candidate tumor suppressor PCDH20 by epigenetic mechanism in non-small-cell lung cancers
    Issei Imoto
    Department of Molecular Cytogenetics, Medical Research Institute and Graduate School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 66:4617-26. 2006
    ..These results suggest that epigenetic silencing by hypermethylation of the CpG-rich promoter region of PCDH20 leads to loss of PCDH20 function, which may be a factor in the carcinogenesis of NSCLC...
  78. ncbi Establishment of perineural invasion models and analysis of gene expression revealed an invariant chain (CD74) as a possible molecule involved in perineural invasion in pancreatic cancer
    Norimasa Koide
    Departments of Pathology and Surgery, School of Medicine, Keio University, USA
    Clin Cancer Res 12:2419-26. 2006
    ..We established perineural invasion models and analyzed the molecular mechanism of perineural invasion in pancreatic cancer...
  79. pmc Epigenetic instability and chromosomal instability in hepatocellular carcinoma
    Hiroto Katoh
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Am J Pathol 168:1375-84. 2006
    ..Our results have clinical relevance because epigenetic instability-dependent HCCs may respond well to methylation inhibitory therapies...
  80. ncbi Label-free quantitative proteomics using large peptide data sets generated by nanoflow liquid chromatography and mass spectrometry
    Masaya Ono
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Mol Cell Proteomics 5:1338-47. 2006
    ..39 and correlation coefficient of over 0.92 between duplicates), and accurate quantification with a wide dynamic range (over 10(3)) of our platform warrant its application to various types of experimental and translational proteomics...
  81. ncbi Regional DNA hypermethylation and DNA methyltransferase (DNMT) 1 protein overexpression in both renal tumors and corresponding nontumorous renal tissues
    Eri Arai
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Cancer 119:288-96. 2006
    ..Regional DNA hypermethylation may be associated with renal tumorigenesis from a precancerous condition to malignant progression and become a predictor of patient prognosis...
  82. ncbi Database of two-dimensional polyacrylamide gel electrophoresis of proteins labeled with CyDye DIGE Fluor saturation dye
    Kazuyasu Fujii
    Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 6:1640-53. 2006
    ....
  83. ncbi E-cadherin regulates the association between beta-catenin and actinin-4
    Yasuharu Hayashida
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 65:8836-45. 2005
    ..Shutting down the signals mediating this association may be worth considering as a therapeutic approach to cancer invasion and metastasis...
  84. ncbi Genetic classification of lung adenocarcinoma based on array-based comparative genomic hybridization analysis: its association with clinicopathologic features
    Tatsuhiro Shibata
    Pathology Division, National Cancer Center Research Institute, Tsukjii, Tokyo, Japan
    Clin Cancer Res 11:6177-85. 2005
    ....
  85. ncbi Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute and Division of Hepatobiliary and Pancreatic Surgery, National Cancer Center Central Hospital, Tokyo, Japan
    Clin Cancer Res 12:5423-34. 2006
    ..The aim of this study was to investigate the clinical significance and roles of TR in the progression and multistep carcinogenesis of pancreatic ductal adenocarcinoma...
  86. ncbi Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome
    Panayiotis Loukopoulos
    Pathology Division, National Cancer Center Research Institute, 51 1, Tsukiji, Chuo Ku, Tokyo, USA
    Cancer Sci 98:392-400. 2007
    ..Our results contribute to a complete description of genomic structural aberrations and the identification of potential therapeutic targets and genetic indicators that predict patient outcome in pancreatic adenocarcinoma...
  87. ncbi Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling
    Masashi Idogawa
    Chemotherapy Division and ADP Ribosylation in Oncology Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Res 67:911-8. 2007
    ..Identification of the functional interaction of Ku70 as well as PARP-1 with the TCF-4 and beta-catenin transcriptional complex may provide insights into a novel linkage between DNA damage recognition/repair and Wnt signaling...
  88. doi Genetic alteration of Keap1 confers constitutive Nrf2 activation and resistance to chemotherapy in gallbladder cancer
    Tatsuhiro Shibata
    Cancer Genomics Project, National Cancer Center Research Institute, Tokyo, Japan Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 135:1358-1368, 1368.e1-4. 2008
    ..We attempted to examine whether deregulation of Nrf2, a master transcriptional factor of various cytoprotective genes against oxidative stress, plays a role in the carcinogenesis of BTC...
  89. doi Frequent inactivation of a putative tumor suppressor, angiopoietin-like protein 2, in ovarian cancer
    Ryoko Kikuchi
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan
    Cancer Res 68:5067-75. 2008
    ..These results suggest that, at least partly, epigenetic silencing by hypermethylation of the ANGPTL2 promoter leads to a loss of ANGPTL2 function, which may be a factor in the carcinogenesis of OC in a stage-dependent manner...
  90. doi Genetic variation in PSCA is associated with susceptibility to diffuse-type gastric cancer
    Hiromi Sakamoto
    Nat Genet 40:730-40. 2008
    ..90, 95% CI = 1.56-2.33, P = 8.01 x 10(-11)). The polymorphism of the PSCA gene, which is possibly involved in regulating gastric epithelial-cell proliferation, influences susceptibility to diffuse-type gastric cancer...
  91. doi Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics
    Yoshiyuki Suehara
    Proteome Bioinformatics Project, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 14:1707-17. 2008
    ..We aimed to develop prognostic biomarkers for gastrointestinal stromal tumors (GIST) using a proteomic approach...
  92. doi Loss of Keap1 function activates Nrf2 and provides advantages for lung cancer cell growth
    Tsutomu Ohta
    Center for Medical Genomics, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Cancer Res 68:1303-9. 2008
    ..Thus, inhibition of NRF2 may provide new therapeutic approaches in lung cancers with activation of Nrf2...
  93. ncbi Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity
    Yukihiro Yoshida
    Cancer Genomics Project, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 37:907-12. 2007
    ..There is no consensus on the strategy for follow-up. Identification of the molecular mechanisms that are associated with the natural history of lung adenocarcinoma should provide useful information...
  94. doi Regulation of Wnt signaling by the nuclear pore complex
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 134:1961-71, 1971.e1-4. 2008
    ..However, beta-catenin has no nuclear localization signal, and the mechanisms by which beta-catenin is imported into the nucleus and forms a complex with the TCF-4 nuclear protein are poorly understood...
  95. ncbi Functional interaction of DNA topoisomerase IIalpha with the beta-catenin and T-cell factor-4 complex
    Lin Huang
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 133:1569-78. 2007
    ..DNA topoisomerase IIalpha (Topo IIalpha) is a component of the beta-catenin/T-cell factor-4 (TCF-4) nuclear complex. We examined the functional significance of Topo IIalpha in Wnt signaling...
  96. ncbi Promoter hypermethylation contributes to frequent inactivation of a putative conditional tumor suppressor gene connective tissue growth factor in ovarian cancer
    Ryoko Kikuchi
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Japan
    Cancer Res 67:7095-105. 2007
    ....
  97. ncbi Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 98:985-91. 2007
    ....
  98. ncbi Application of highly sensitive fluorescent dyes (CyDye DIGE Fluor saturation dyes) to laser microdissection and two-dimensional difference gel electrophoresis (2D-DIGE) for cancer proteomics
    Tadashi Kondo
    Proteome Bioinformatics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Nat Protoc 1:2940-56. 2006
    ..This protocol allows the execution of large-scale proteomics in a more efficient, accurate and reproducible way. The protocol can be used to examine a single sample in 5 d or to examine hundreds of samples in large-scale proteomics...
  99. ncbi Involvement of splicing factor-1 in beta-catenin/T-cell factor-4-mediated gene transactivation and pre-mRNA splicing
    Miki Shitashige
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 132:1039-54. 2007
    ....
  100. ncbi Genetic profile of hepatocellular carcinoma revealed by array-based comparative genomic hybridization: identification of genetic indicators to predict patient outcome
    Hiroto Katoh
    Pathology Division, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, and Department of Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 43:863-74. 2005
    ..We conducted an analysis of chromosomal numerical aberrations and their clinical significance in hepatocellular carcinoma...
  101. ncbi ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation
    Hisashi Takada
    Department of Molecular Cytogenetics, Medical Research Institute and School of Biomedical Science, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    Oncogene 24:8051-60. 2005
    ..These results suggest that genetic or epigenetic silencing by hypermethylation of the ADAM23 CpG-rich promoter region leads to loss of ADAM23 function, which may be a factor in gastric carcinogenesis...