T Hirobe

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Exp Zool 292:351-66. 2002
  2. doi request reprint The mouse ruby-eye 2(d) (ru2(d) /Hps5(ru2-d) ) allele inhibits eumelanin but not pheomelanin synthesis
    Tomohisa Hirobe
    Fukushima Restoration Support Headquarters, National Institute of Radiological Sciences, Chiba, Japan
    Pigment Cell Melanoma Res 26:723-6. 2013
  3. pmc Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb
    Tomohisa Hirobe
    The Fukushima Reconstruction Aid Headquarters, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 54:409-18. 2013
  4. doi request reprint Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture
    Tomohisa Hirobe
    Fukushima Restoration Support Headquarters, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Dermatol Sci 71:45-57. 2013
  5. doi request reprint Reduced proliferative and differentiative activity of mouse pink-eyed dilution melanoblasts is related to apoptosis
    Tomohisa Hirobe
    National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 29:725-32. 2012
  6. doi request reprint A new mutation of mouse ruby-eye 2, ru2(d)/Hps5(ru2-d) inhibits eumelanin synthesis but stimulates pheomelanin synthesis in melanocytes
    Tomohisa Hirobe
    Radiation Risk Reduction Research Program, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Zoolog Sci 29:652-61. 2012
  7. doi request reprint Mitochondria are more numerous and smaller in pink-eyed dilution melanoblasts and melanocytes than in wild-type melanocytes in the neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Zoolog Sci 25:1057-65. 2008
  8. ncbi request reprint Interleukin-1alpha stimulates the differentiation of melanocytes but inhibits the proliferation of melanoblasts from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:959-70. 2007
  9. ncbi request reprint Excess tyrosine restores the morphology and maturation of melanosomes affected by the murine slaty mutation
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:338-45. 2007
  10. ncbi request reprint Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:209-17. 2007

Detail Information

Publications44

  1. ncbi request reprint Effects of genic substitution at the pink-eyed dilution locus on the proliferation and differentiation of mouse epidermal melanocytes in vivo and in vitro
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Exp Zool 292:351-66. 2002
    ..These results suggest for the first time that p gene exerts its influence on the proliferative activities of mouse epidermal melanoblasts by affecting the regulatory mechanisms dependent on the function of ETs...
  2. doi request reprint The mouse ruby-eye 2(d) (ru2(d) /Hps5(ru2-d) ) allele inhibits eumelanin but not pheomelanin synthesis
    Tomohisa Hirobe
    Fukushima Restoration Support Headquarters, National Institute of Radiological Sciences, Chiba, Japan
    Pigment Cell Melanoma Res 26:723-6. 2013
    ....
  3. pmc Effects of low-dose heavy ions on embryonic development in mice and on melanocyte differentiation in the epidermis and hair bulb
    Tomohisa Hirobe
    The Fukushima Reconstruction Aid Headquarters, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 54:409-18. 2013
    ....
  4. doi request reprint Effects of fibroblast-derived factors on the proliferation and differentiation of human melanocytes in culture
    Tomohisa Hirobe
    Fukushima Restoration Support Headquarters, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Dermatol Sci 71:45-57. 2013
    ..Although keratinocyte-derived factors are known to promote the proliferation and differentiation of human epidermal melanocytes, it is not fully understood whether fibroblast-derived factors work in a similar way...
  5. doi request reprint Reduced proliferative and differentiative activity of mouse pink-eyed dilution melanoblasts is related to apoptosis
    Tomohisa Hirobe
    National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 29:725-32. 2012
    ..These results suggest that the increased apoptosis in keratinocytes and melanoblasts/melanocytes is related to the reduced proliferative and differentiative activity of p/p melanoblasts...
  6. doi request reprint A new mutation of mouse ruby-eye 2, ru2(d)/Hps5(ru2-d) inhibits eumelanin synthesis but stimulates pheomelanin synthesis in melanocytes
    Tomohisa Hirobe
    Radiation Risk Reduction Research Program, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Zoolog Sci 29:652-61. 2012
    ..These results suggest that the ru2(d) allele suppresses the differentiation of melanocytes through the inhibition of eumelanin synthesis, but stimulates pheomelanin synthesis in melanocytes...
  7. doi request reprint Mitochondria are more numerous and smaller in pink-eyed dilution melanoblasts and melanocytes than in wild-type melanocytes in the neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Zoolog Sci 25:1057-65. 2008
    ..These results suggest that L-Tyr and some unknown factors related to mitochondrial function may influence the differentiation of melanoblasts in the epidermis of p/p mice...
  8. ncbi request reprint Interleukin-1alpha stimulates the differentiation of melanocytes but inhibits the proliferation of melanoblasts from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:959-70. 2007
    ..The results also suggest that IL-1alpha inhibits the proliferation of differentiated melanocytes in cooperation with keratinocyte-derived factors...
  9. ncbi request reprint Excess tyrosine restores the morphology and maturation of melanosomes affected by the murine slaty mutation
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:338-45. 2007
    ..L-Tyr seems to restore both the morphology and maturation of melanosomes affected by the slaty mutation...
  10. ncbi request reprint Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Zoolog Sci 24:209-17. 2007
    ..Eumelanin and pheomelanin may accumulate with difficulty in slaty melanocytes and be easily released from them during skin development. L-Tyr may stimulate this release...
  11. ncbi request reprint Excess tyrosine rescues the reduced activity of proliferation and differentiation of cultured recessive yellow melanocytes derived from neonatal mouse epidermis
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Cell Biol 86:315-30. 2007
    ....
  12. ncbi request reprint Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Anat Rec (Hoboken) 290:981-93. 2007
    ..These results suggest that the slaty mutation blocks the melanosome maturation at stage III and affects the melanosome morphology (elliptical or spherical) in a developmental stage-specific manner...
  13. ncbi request reprint Ferrous ferric chloride stimulates the skin cell function and hair growth in mice
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Biol Pharm Bull 32:1347-53. 2009
    ..These results suggest that FFC can stimulate the proliferation and differentiation of keratinocytes, fibroblasts, and melanocytes in the skin as well as the hair growth, and, in addition, can inhibit the alopecia hair-loss...
  14. doi request reprint Life cycle of human melanocytes is regulated by endothelin-1 and stem cell factor in synergy with cyclic AMP and basic fibroblast growth factor
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Dermatol Sci 57:123-31. 2010
    ....
  15. doi request reprint Estrogen increases hair pigmentation in female recessive yellow mice
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Zoolog Sci 27:470-6. 2010
    ..These results suggest that estrogen is the main factor in determining the higher content of eumelanin and pheomelanin in female hair of Mc1r(e)/Mc1r(e) mice...
  16. doi request reprint The mouse pink-eyed dilution allele of the P-gene greatly inhibits eumelanin but not pheomelanin synthesis
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Melanoma Res 24:241-6. 2011
    ..These results suggest that the pink-eyed dilution allele greatly inhibits eumelanin synthesis, but not pheomelanin synthesis...
  17. ncbi request reprint Effects of low-dose heavy ions on the postnatal development of mice and the yield of white spots in the mid-ventrum and tail-tips
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba
    J Radiat Res 52:278-86. 2011
    ..3 (Si), 3.1 (Ar) and 4.5 (Fe). These results suggest that prenatal exposure to heavy ions possesses a greater effect on the postnatal development of mice as well as melanocyte development than does exposure to γ-rays...
  18. doi request reprint How are proliferation and differentiation of melanocytes regulated?
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan Graduate School of Science, Chiba University, Yayoi cho, Inage Ku, Chiba, Japan
    Pigment Cell Melanoma Res 24:462-78. 2011
    ..Thus, melanocyte proliferation and differentiation are not only regulated by genes encoding typical growth factors and their receptors but also by genes classically known for their role in pigment formation...
  19. doi request reprint Effects of low-dose γ-rays on the embryonic development of mouse melanoblasts and melanocytes in the epidermis and hair bulbs
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Anagawa, lnage Ku, Chiba 263 8555, Japan
    Zoolog Sci 28:389-96. 2011
    ..These results suggest that low-dose γ-rays provoke the death of melanoblasts and melanocytes, or inhibit the proliferation and differentiation of melanoblasts and melanocytes, even at the low dose...
  20. ncbi request reprint Stimulation of the proliferation and differentiation of skin cells by ferrous ferric chloride from a distance
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Biol Pharm Bull 34:987-95. 2011
    ..These results suggest that FFC can stimulate the proliferation and differentiation of skin cells from a distance of 1 cm without being added into culture media through physical factors rather than chemical factors...
  21. doi request reprint A novel deletion mutation of mouse ruby-eye 2 named ru2(d)/Hps5(ru2-d) inhibits melanocyte differentiation and its impaired differentiation is rescued by L-tyrosine
    Tomohisa Hirobe
    Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Zoolog Sci 28:790-801. 2011
    ..L-Tyr injected into ru2(d)/ru2(d) mice also stimulated melanocyte differentiation. These results suggest that the ru2(d) allele inhibits melanocyte differentiation, and that its impaired differentiation is rescued by excess Tyr...
  22. ncbi request reprint The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Dermatol Sci 45:55-62. 2007
    ....
  23. ncbi request reprint The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes
    Tomohisa Hirobe
    Radiation Effect Mechanism Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Pigment Cell Res 19:454-9. 2006
    ..These results suggest that the slaty mutation affects the morphology and maturation of melanosomes in mouse melanocytes...
  24. ncbi request reprint Steel factor controls the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 16:644-55. 2003
    ..These results suggest that SLF is one of the keratinocyte-derived factors involved in regulating the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture in cooperation with cAMP elevator and bFGF...
  25. ncbi request reprint Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless mice
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 15:391-9. 2002
    ..These results suggest that the increased proliferative and differentiative activities of mouse epidermal melanocytes from UVB-induced pigmented spots are regulated by keratinocytes, rather than melanocytes...
  26. ncbi request reprint Role of leukemia inhibitory factor in the regulation of the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Cell Physiol 192:315-26. 2002
    ..These results suggest that LIF is one of the keratinocyte-derived factors involved in regulating the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture in cooperation with cAMP elevator and bFGF...
  27. ncbi request reprint Stimulation of the proliferation and differentiation of mouse pink-eyed dilution epidermal melanocytes by excess tyrosine in serum-free primary culture
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    J Cell Physiol 191:162-72. 2002
    ..These results suggest that p/p melanocytes in the primary culture are induced to synthesize eumelanin by excess L-Tyr, but difficult to accumulate them in melanosomes...
  28. ncbi request reprint Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary culture
    T Hirobe
    Division of Biology and Oncology, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    J Investig Dermatol Symp Proc 6:25-31. 2001
    ..These results suggest that ET-1, -2, and -3 are one member of the keratinocyte-derived factors that are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in primary culture...
  29. ncbi request reprint ACTH(4-12) is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary culture
    T Hirobe
    Division of Biology and Oncology, National Institute of Radiological Sciences, Anagawa, Chiba 263 8555, Japan
    J Exp Zool 286:632-40. 2000
    ..The amino acids of Met(4) and Pro(12) are suggested to be important for its potency...
  30. ncbi request reprint Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in culture
    T Hirobe
    Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba, Japan
    Pigment Cell Res 12:147-63. 1999
    ....
  31. ncbi request reprint Hepatocyte growth factor controls the proliferation of cultured epidermal melanoblasts and melanocytes from newborn mice
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 17:51-61. 2004
    ..These results suggest that HGF is a keratinocyte-derived factor involved in regulating the proliferation of epidermal melanoblasts and melanocytes from newborn mice in cooperation with cAMP elevators and/or bFGF...
  32. ncbi request reprint Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls the proliferation and differentiation of mouse epidermal melanocytes from pigmented spots induced by ultraviolet radiation B
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Pigment Cell Res 17:230-40. 2004
    ..These results suggest that GM-CSF is one of the keratinocyte-derived factors involved in regulating the proliferation and differentiation of mouse epidermal melanocytes from UVB-induced pigmented spots...
  33. ncbi request reprint The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Eur J Cell Biol 85:537-49. 2006
    ....
  34. ncbi request reprint Role of keratinocyte-derived factors involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 18:2-12. 2005
    ..Numerous factors may be produced in and released from keratinocytes and be involved in regulating the proliferation and differentiation of mammalian epidermal melanocytes through receptor-mediated signaling pathways...
  35. ncbi request reprint Effects of carbon-ion radiation on the postnatal development of mice and on the yield of white spots in the mid-ventrum and tail tips
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Radiat Res 162:580-4. 2004
    ....
  36. ncbi request reprint The melanocortin receptor-1 gene but not the proopiomelanocortin gene is expressed in melanoblasts and contributes their differentiation in the mouse skin
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 17:627-35. 2004
    ..These results suggest that the expression of the MC1-R gene, but not of the POMC gene, plays an important role in the regulation of melanocyte differentiation in mouse skin...
  37. ncbi request reprint Pheomelanin production in the epidermis from newborn agouti mice is induced by the expression of the agouti gene in the dermis
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba 263 8555, Japan
    Pigment Cell Res 17:506-14. 2004
    ..Pheomelanin production in the epidermis from 3.5- and 5.5-d-old A/A mice may be induced by the expression of the agouti gene in the dermis...
  38. ncbi request reprint Granulocyte-macrophage colony-stimulating factor is a keratinocyte-derived factor involved in regulating the proliferation and differentiation of neonatal mouse epidermal melanocytes in culture
    Tomohisa Hirobe
    Shiseido Research Center, Hayabuchi, Kouhoku, Yokohama 224 8558, Japan
    Exp Cell Res 297:593-606. 2004
    ....
  39. ncbi request reprint Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine
    Tomohisa Hirobe
    Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
    Pigment Cell Res 16:619-28. 2003
    ....
  40. ncbi request reprint Changes in the proliferative activity of epidermal melanocytes in serum-free primary culture during the development of ultraviolet radiation B-induced pigmented spots in hairless mice
    Rikako Furuya
    Shiseido Research Center, Hayabuchi, Kouhoku ku, Yokohama, Japan
    Pigment Cell Res 15:348-56. 2002
    ..These results suggest that the proliferative activity of epidermal melanoblasts and melanocytes in UVB-irradiated skin increases with the development of pigmented spots...
  41. doi request reprint Immunohistochemical survey of the distribution of epidermal melanoblasts and melanocytes during the development of UVB-induced pigmented spots
    Rikako Furuya
    Shiseido Research Center, Fukuura, Kanazawa Ku, Yokohama 236 8643, Japan
    J Dermatol Sci 55:99-107. 2009
    ..Repeated exposures to ultraviolet B radiation (UVB) induce pigmented spots on dorsal skin of (HR-1 x HR/De) F(1) hairless mouse. We showed previously that this mouse is suitable for studies of melanocyte function...
  42. ncbi request reprint Effects of genic substitution at the agouti, brown, albino, dilute, and pink-eyed dilution loci on the proliferation and differentiation of mouse epidermal melanocytes in serum-free culture
    T Hirobe
    Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba, Japan
    Eur J Cell Biol 75:184-91. 1998
    ....
  43. ncbi request reprint Effects of continuous low-dose prenatal irradiation on neuronal migration in mouse cerebral cortex
    Y Hyodo-Taguchi
    Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 38:87-94. 1997
    ..These results suggest that the migration of neuronal cells in mouse cerebral cortex is disturbed by continuous prenatal irradiation at low-dose and some modificational process occurred during the postnatal period...
  44. ncbi request reprint High levels of melanin-related metabolites in plasma from pink-eyed dilution mice
    Kazumasa Wakamatsu
    Pigment Cell Res 20:222-4. 2007