Nobuyoshi Hiraoka

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. pmc Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
    Y Ino
    Division of Molecular Pathology, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 108:914-23. 2013
  2. doi request reprint Tumor-infiltrating lymphocytes and hepatocellular carcinoma: molecular biology
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Int J Clin Oncol 15:544-51. 2010
  3. doi request reprint CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:310-21. 2011
  4. pmc Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation
    N Hiraoka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 103:1057-65. 2010
  5. doi request reprint Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma
    Seiji Oguro
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 37:1030-8. 2013
  6. doi request reprint Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma
    Noriaki Morofuji
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan
    J Proteomics 75:1577-89. 2012
  7. doi request reprint Analysis of 5-year survivors after a macroscopic curative pancreatectomy for invasive ductal adenocarcinoma
    Kazuaki Shimada
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    World J Surg 34:1908-15. 2010
  8. ncbi request reprint CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation
    Yuri Miyazawa
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 70:5136-46. 2010
  9. doi request reprint Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas
    Daisuke Ban
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 34:1025-36. 2010
  10. doi request reprint Clinical significance of frozen section analysis during resection of intraductal papillary mucinous neoplasm: should a positive pancreatic margin for adenoma or borderline lesion be resected additionally?
    Satoshi Nara
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5 1 1Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Am Coll Surg 209:614-21. 2009

Collaborators

Detail Information

Publications53

  1. pmc Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer
    Y Ino
    Division of Molecular Pathology, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 108:914-23. 2013
    ..Conclusion:Tumour-infiltrating CD4(+)T(high)/CD8(+)T(high)/%Treg(low) and %M1(high)/M2(low) are independent prognosticators useful for evaluating the immune microenvironment of PDC...
  2. doi request reprint Tumor-infiltrating lymphocytes and hepatocellular carcinoma: molecular biology
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Int J Clin Oncol 15:544-51. 2010
    ..This review focuses on the mechanisms of lymphocyte trafficking to tumor cells and also discusses the importance of blood vessel for TIL trafficking, especially in relation to hepatocarcinogenesis...
  3. doi request reprint CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 140:310-21. 2011
    ..We investigated when and how the human anti-tumor immune reaction changes during pancreatic tumor development...
  4. pmc Tumour necrosis is a postoperative prognostic marker for pancreatic cancer patients with a high interobserver reproducibility in histological evaluation
    N Hiraoka
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 103:1057-65. 2010
    ..The aim of this study was to investigate whether histological necrosis is a useful predictor of outcome in patients with pancreatic ductal carcinoma (PDC)...
  5. doi request reprint Pancreatic intraglandular metastasis predicts poorer outcome in postoperative patients with pancreatic ductal carcinoma
    Seiji Oguro
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 37:1030-8. 2013
    ..002; hazard ratio=2.239; 95% confidence interval: 1.328-3.773). Our findings suggest that the presence of P-IM in patients with PDC is an independent prognosticator and may represent aggressive tumor behavior...
  6. doi request reprint Macrophage-capping protein as a tissue biomarker for prediction of response to gemcitabine treatment and prognosis in cholangiocarcinoma
    Noriaki Morofuji
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan
    J Proteomics 75:1577-89. 2012
    ..In conclusion, CapG was identified as a novel candidate biomarker to predict response to gemcitabine treatment and survival in cholangiocarcinoma...
  7. doi request reprint Analysis of 5-year survivors after a macroscopic curative pancreatectomy for invasive ductal adenocarcinoma
    Kazuaki Shimada
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    World J Surg 34:1908-15. 2010
    ..Surgical resections for invasive ductal adenocarcinoma of the pancreas can provide the only chance of cure, although the 5-year survivors are not always equated with cure...
  8. ncbi request reprint CUB domain-containing protein 1, a prognostic factor for human pancreatic cancers, promotes cell migration and extracellular matrix degradation
    Yuri Miyazawa
    Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Res 70:5136-46. 2010
    ....
  9. doi request reprint Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas
    Daisuke Ban
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Am J Surg Pathol 34:1025-36. 2010
    ..These findings suggest that a significant proportion of ACC shows IPG, which is potentially linked to less aggressive clinicopathologic characteristics...
  10. doi request reprint Clinical significance of frozen section analysis during resection of intraductal papillary mucinous neoplasm: should a positive pancreatic margin for adenoma or borderline lesion be resected additionally?
    Satoshi Nara
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5 1 1Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Am Coll Surg 209:614-21. 2009
    ....
  11. ncbi request reprint Twenty-six cases of advanced ampullary adenocarcinoma treated with systemic chemotherapy
    Hirokazu Shoji
    Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 44:324-30. 2014
    ..The aim of the present study was to clarify the treatment outcome of systemic chemotherapy in patients with advanced ampullary adenocarcinoma...
  12. doi request reprint Gemcitabine in patients with intraductal papillary mucinous neoplasm with an associated invasive carcinoma of the pancreas
    Taiga Otsuka
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Pancreas 42:889-92. 2013
    ....
  13. doi request reprint Assessment of the interface between retroperitoneal fat infiltration of pancreatic ductal carcinoma and the major artery by multidetector-row computed tomography: surgical outcomes and correlation with histopathological extension
    Yusuke Yamamoto
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Central Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    World J Surg 36:2192-201. 2012
    ..Precise assessment of retroperitoneal invasion is clinically important to allow the achievement of negative margin resections...
  14. doi request reprint Proteomic profiling reveals the prognostic value of adenomatous polyposis coli-end-binding protein 1 in hepatocellular carcinoma
    Tatsuya Orimo
    Proteome Bioinformatics Project, National Cancer Center Hospital, Tokyo, Japan
    Hepatology 48:1851-63. 2008
    ..256; 95% confidence interval, 1.337-3.807; P = 0.002) of patients with HCC after curative surgery. Conclusion: Proteomic profiling revealed the molecular signature behind the progression of HCC, and the prognostic value of EB1 in HCC...
  15. doi request reprint Minimally invasive intraductal papillary-mucinous carcinoma of the pancreas: clinicopathologic study of 104 intraductal papillary-mucinous neoplasms
    Satoshi Nara
    Pathology Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Am J Surg Pathol 32:243-55. 2008
    ..These findings suggest that a category of MI-IPMC provides more accurate and useful information of the stage and the aggressiveness of I-IPMC...
  16. pmc Diagnosis and prognostication of ductal adenocarcinomas of the pancreas based on genome-wide DNA methylation profiling by bacterial artificial chromosome array-based methylated CpG island amplification
    Masahiro Gotoh
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Biomed Biotechnol 2011:780836. 2011
    ..Genome-wide DNA methylation profiling may provide optimal diagnostic markers and prognostic indicators for patients with PCs...
  17. ncbi request reprint Bile duct carcinoma involving the common channel associated with pancreaticobiliary maljunction shows an extension pattern similar to ductal carcinoma of the pancreas
    Nao Yoshida
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 63:415-8. 2013
    ..During the follow-up of patients with PBM, attention should be paid to involvement of the common channel by BD cancer and also to cancer developing silently in the pancreas after extrahepatic BD resection. ..
  18. pmc Arginase II expressed in cancer-associated fibroblasts indicates tissue hypoxia and predicts poor outcome in patients with pancreatic cancer
    Yoshinori Ino
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 8:e55146. 2013
    ..These results indicate that cancer cell-mediated immune suppression through ARG2 expression is not a general event and that the presence of ARG2-expressing CAFs is an indicator of poor prognosis, as well as hypoxia, in PDC tissue...
  19. doi request reprint Definition of T3/4 and regional lymph nodes in gallbladder cancer: which is more valid, the UICC or the Japanese staging system?
    Yoji Kishi
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Ann Surg Oncol 19:3567-73. 2012
    ....
  20. doi request reprint Pancreaticojejunostomy with invagination of the punched pancreatic remnant after medial pancreatectomy and enucleation for multiple metastases of renal cell carcinoma: report of a case
    Yasunori Deguchi
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Surg Today 39:1086-90. 2009
    ....
  21. ncbi request reprint Prognostic value of tumor architecture, tumor-associated vascular characteristics, and expression of angiogenic molecules in pancreatic endocrine tumors
    Yu Takahashi
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 13:187-96. 2007
    ..It is difficult to predict the biological behavior of pancreatic endocrine tumors (PETs). Our aim was to evaluate the prognostic significance of certain variables in PETs...
  22. ncbi request reprint Reappraisal of the clinical significance of tumor size in patients with pancreatic ductal carcinoma
    Kazuaki Shimada
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Pancreas 33:233-9. 2006
    ..Recent advances in diagnostic modalities have made it possible to detect small pancreatic ductal carcinoma and to increase the number of resected cases. However, the postoperative prognosis remains dismal...
  23. ncbi request reprint DNA methylation of multiple tumor-related genes in association with overexpression of DNA methyltransferase 1 (DNMT1) during multistage carcinogenesis of the pancreas
    Dun Fa Peng
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Carcinogenesis 27:1160-8. 2006
    ....
  24. doi request reprint Establishment of six new human biliary tract carcinoma cell lines and identification of MAGEH1 as a candidate biomarker for predicting the efficacy of gemcitabine treatment
    Hidenori Ojima
    Pathology Division, Clinical Trials and Practice Support Division, Center for Cancer Control and Information Services, National Cancer Center, Chuo Ku, Tokyo, Japan
    Cancer Sci 101:882-8. 2010
    ..Negative expression of MAGEH1 protein serves as a potential predictive marker for the effectiveness of gemcitabine therapy in BTC...
  25. doi request reprint Intraductal carcinosarcoma with a heterologous mesenchymal component originating in intraductal papillary-mucinous carcinoma (IPMC) of the pancreas with both carcinoma and osteosarcoma cells arising from IPMC cells
    Jun Okamura
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Clin Pathol 63:266-9. 2010
    ..This is the first report of a carcinosarcoma originating in IPMC. These findings imply that carcinosarcoma with a heterologous mesenchymal component is of ductal origin...
  26. ncbi request reprint Intraductal tubular carcinoma in an adenoma of the main pancreatic duct of the pancreas head
    Keita Itatsu
    Hepato Biliary and Pancreatic Surgery Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    J Gastroenterol 41:702-5. 2006
    ..MPD dilatation is a crucial sign and clue enabling the early detection of tiny pancreatic tumors...
  27. doi request reprint Intrapancreatic nerve invasion as a predictor for recurrence after pancreaticoduodenectomy in patients with invasive ductal carcinoma of the pancreas
    Kazuaki Shimada
    National Cancer Center Hospital, Tokyo, Japan
    Pancreas 40:464-8. 2011
    ..Neural invasion is a distinct route for the spread of pancreatic carcinoma. However, the clinicopathologic significance of neural invasion, with particular reference to intrapancreatic nerve invasion, remains to be elucidated...
  28. doi request reprint Intraductal carcinoma component as a favorable prognostic factor in biliary tract carcinoma
    Hidenori Ojima
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 100:62-70. 2009
    ..Surgeons should not be persistent in trying to achieve a negative surgical margin when the intraoperative frozen section diagnosis is R1 (is), and can choose a safe surgical procedure to avoid postoperative complications...
  29. ncbi request reprint FOXP3+ regulatory T cells affect the development and progression of hepatocarcinogenesis
    Noritoshi Kobayashi
    Pathology Division, National Cancer Center Research Institute, National Cancer Center Hospital, Tokyo, and Gastroenterology Division, Yokohama City University Hospital, Yokohama, Japan
    Clin Cancer Res 13:902-11. 2007
    ..CD4+CD25+FOXP3+ regulatory T cells (Tregs) suppress the immune reaction. The aim of the present study was to investigate the clinicopathologic significance and roles of Tregs and CD8+ T cells during hepatocarcinogenesis...
  30. doi request reprint Solitary hepatic lymphangioma: report of a case
    Takuya Matsumoto
    Pathology Division, National Cancer Center Hospital, Tokyo, Japan
    Surg Today 40:883-9. 2010
    ..This case is presented with details of the pathologic and radiologic findings, because solitary hepatic lymphangioma is an extremely rare tumor and no previous reports have provided details of the immunohistochemical characteristics...
  31. doi request reprint Long-term recurrence-free survival in a patient with primary hepatic carcinosarcoma: case report with a literature review
    Yusuke Yamamoto
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Central Hospital, Tokyo, Japan
    Jpn J Clin Oncol 40:166-73. 2010
    ..Since relatively early-stage hepatic carcinosarcoma rarely seems to present as a small tumor showing a concentric growth pattern, we report this case with a review of the literature...
  32. doi request reprint Adenylate cyclase-associated protein 1 overexpressed in pancreatic cancers is involved in cancer cell motility
    Ken Yamazaki
    Department of Pathology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Lab Invest 89:425-32. 2009
    ..This is the first report demonstrating the overexpression of CAP1 in pancreatic cancers and suggesting the involvement of CAP1 in the aggressive behavior of pancreatic cancer cells...
  33. doi request reprint Role of medial pancreatectomy in the management of intraductal papillary mucinous neoplasms and islet cell tumors of the pancreatic neck and body
    Kazuaki Shimada
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Central Hospital, Tokyo, Japan
    Dig Surg 25:46-51. 2008
    ..However, the role of this procedure remains controversial. We investigate outcomes using this method in 14 patients...
  34. ncbi request reprint Invasive biliary cystic tumor without ovarian-like stroma
    Yuji Ishibashi
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 57:794-8. 2007
    ..On the basis of the World Health Organization histological classification and these pathological findings, the present case was diagnosed as invasive-type biliary cystadenocarcinoma...
  35. ncbi request reprint Prevalence of FOXP3+ regulatory T cells increases during the progression of pancreatic ductal adenocarcinoma and its premalignant lesions
    Nobuyoshi Hiraoka
    Pathology Division, National Cancer Center Research Institute and Division of Hepatobiliary and Pancreatic Surgery, National Cancer Center Central Hospital, Tokyo, Japan
    Clin Cancer Res 12:5423-34. 2006
    ..The aim of this study was to investigate the clinical significance and roles of TR in the progression and multistep carcinogenesis of pancreatic ductal adenocarcinoma...
  36. doi request reprint Intraductal dissemination of papillary adenocarcinoma of the ampulla of Vater in the pancreatic duct
    Akiko Matsubara
    Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 64:39-44. 2014
    ..These results imply that this papillary adenocarcinoma of the ampulla of Vater had disseminated to the pancreatic duct in a retrograde manner and recurred in the remnant pancreas. ..
  37. pmc Mucin-producing carcinoma of the gallbladder: evaluation by magnetic resonance cholangiopancreatography in three cases
    Seiji Ishiguro
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Korean J Radiol 13:637-42. 2012
    ..Thus, gadolinium-enhanced MR imaging is mandatory for the precise diagnosis of the mucin-producing carcinoma of the gallbladder...
  38. doi request reprint Resequencing analysis of the human tyrosine kinase gene family in pancreatic cancer
    Takashi Kubo
    National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Pancreas 38:e200-6. 2009
    ..The tyrosine kinase (TK) gene family, which encodes important regulators of various signal transduction pathways, is one of the most frequently altered gene families in human cancer...
  39. ncbi request reprint Invasive carcinoma originating in an intraductal papillary mucinous neoplasm of the pancreas: a clinicopathologic comparison with a common type of invasive ductal carcinoma
    Kazuaki Shimada
    Department of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Pancreas 32:281-7. 2006
    ..The aim of the present study was to investigate the clinicopathologic difference between invasive IPMN and a common type of invasive ductal carcinoma of the pancreas...
  40. doi request reprint Expression and gene amplification of actinin-4 in invasive ductal carcinoma of the pancreas
    Satoru Kikuchi
    Chemotherapy Division, Cancer Proteomics Project, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Clin Cancer Res 14:5348-56. 2008
    ..Actinin-4 is an actin-binding protein associated with enhanced cell motility, invasive growth, and lymph node metastasis. Actinin-4 might play an important role in the development and progression of pancreatic cancer...
  41. ncbi request reprint Solid-pseudopapillary neoplasms of the pancreas in men and women: do they differ?
    Yu Takahashi
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Virchows Arch 448:561-9. 2006
    ..Nuclear accumulation of beta-catenin appears to be a useful marker of SPN, which allows male SPNs to be correctly diagnosed despite their less typical features...
  42. doi request reprint Prostate stem cell antigen, a presumable organ-dependent tumor suppressor gene, is down-regulated in gallbladder carcinogenesis
    Hiroe Ono
    Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
    Genes Chromosomes Cancer 51:30-41. 2012
    ..These lines of in vivo and in vitro evidence suggest that PSCA is acting as a tumor suppressor in GBC development...
  43. doi request reprint Serous cystic neoplasm in an intrapancreatic accessory spleen
    Shutaro Hori
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 60:681-4. 2010
    ..From these findings, we diagnosed the lesion as SCN in IPAS. This tumor is suggested to develop as a VHL-associated SCN from coexisting pancreatic tissue in IPAS rather than as a metastatic tumor...
  44. ncbi request reprint Increased DNA methyltransferase 1 (DNMT1) protein expression in precancerous conditions and ductal carcinomas of the pancreas
    Dun Fa Peng
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 96:403-8. 2005
    ....
  45. pmc Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis
    Shigeki Sekine
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Gastroenterology 136:2304-2315.e1-4. 2009
    ..We describe experiments to address the physiologic roles of these new regulators of gene expression in the liver that are as of yet largely undefined...
  46. ncbi request reprint Primary adenocarcinoma of the rete testis with preceding diagnosis of pulmonary metastases
    Tohru Nakagawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Int J Urol 13:1532-5. 2006
    ..The diagnosis is often delayed because of non-specific clinical presentation and symptoms. We cannot forget that rete testis is a possible primary site for a primary, unknown metastatic adenocarcinoma...
  47. doi request reprint Preoperative evaluation of invasive and noninvasive intraductal papillary-mucinous neoplasms of the pancreas: clinical, radiological, and pathological analysis of 123 cases
    Satoshi Nara
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital Tokyo, Japan
    Pancreas 38:8-16. 2009
    ..We aimed to investigate preoperative findings that are useful to distinguish intraductal papillary-mucinous neoplasm (IPMN) subtypes...
  48. ncbi request reprint A case of acinar cell adenocarcinoma in the pancreatic tail
    Yoshinori Yamada
    National Cancer Center Central Hospital, Tokyo, Japan
    Jpn J Clin Oncol 36:473. 2006
  49. ncbi request reprint Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma
    Ken Yamazaki
    Department of Pathology, School of Medicine, Keio University, Tokyo, Japan
    Lab Invest 94:683-91. 2014
    ..These findings suggest that SMAD3 in PDAC is involved in the promotion of malignant potential through EMT induction in tumor cells regardless of SMAD4 status and serves as a potential biomarker of poor prognosis. ..
  50. ncbi request reprint Carcinoid tumor arising in a duplication cyst of the duodenum
    Hiroaki Hata
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 56:272-8. 2006
    ....
  51. doi request reprint Cisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas
    Satoru Iwasa
    Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Jpn J Clin Oncol 40:313-8. 2010
    ..However, there were no prior reports limited to the hepatobiliary tract and pancreas as the primary sites...
  52. ncbi request reprint Identification of 27 5' CpG islands aberrantly methylated and 13 genes silenced in human pancreatic cancers
    Atsushi Hagihara
    Carcinogenesis Division, National Cancer Center Research Institute, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Oncogene 23:8705-10. 2004
    ..MSP of 24 primary pancreatic cancers showed that all these genes, except for THBD, were methylated in at least one cancer. Some of those were suggested to be potentially involved in pancreatic cancer development and progression...
  53. doi request reprint A case of neurilemoma at the celiac tripod
    Satoshi Nara
    Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 38:649. 2008