Seishiro Hirano

Summary

Affiliation: National Institute for Environmental Studies
Country: Japan

Publications

  1. ncbi request reprint Transcription of krox-20/egr-2 is upregulated after exposure to fibrous particles and adhesion in rat alveolar macrophages
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, Ibaraki, Japan
    Am J Respir Cell Mol Biol 23:313-9. 2000
  2. ncbi request reprint The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Japan
    Arch Toxicol 80:275-9. 2006
  3. ncbi request reprint Effects of arsenic on modification of promyelocytic leukemia (PML): PML responds to low levels of arsenite
    Seishiro Hirano
    Research Center for Environmental Risk, National Institute for Environmental Studies, Japan Graduate School of Pharmaceutical Sciences, Chiba University, Japan Electronic address
    Toxicol Appl Pharmacol 273:590-9. 2013
  4. doi request reprint Western blot analysis
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Methods Mol Biol 926:87-97. 2012
  5. doi request reprint Macrophage receptor with collagenous structure (MARCO) is a dynamic adhesive molecule that enhances uptake of carbon nanotubes by CHO-K1 cells
    Seishiro Hirano
    Environmental Nanotoxicology Project, RCER, National Institute for Environmental Studies, Japan
    Toxicol Appl Pharmacol 259:96-103. 2012
  6. ncbi request reprint PCR-based subtraction analyses for upregulated gene transcription in cadmium-exposed rat lung type 2 epithelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Biochem Biophys Res Commun 308:133-8. 2003
  7. ncbi request reprint The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compounds
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 198:458-67. 2004
  8. ncbi request reprint [Evaluation of pulmonary toxicity of heavy metal compounds]
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Japan
    Nihon Eiseigaku Zasshi 50:1013-25. 1996
  9. pmc A current overview of health effect research on nanoparticles
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    Environ Health Prev Med 14:223-5. 2009
  10. ncbi request reprint Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:54-61. 2005

Collaborators

Detail Information

Publications68

  1. ncbi request reprint Transcription of krox-20/egr-2 is upregulated after exposure to fibrous particles and adhesion in rat alveolar macrophages
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, Ibaraki, Japan
    Am J Respir Cell Mol Biol 23:313-9. 2000
    ..These results suggest that both krox-20/egr-2 and krox-20H1 are implicated in adhesion and phagocytosis, and that the expression of krox-20 may reflect interaction with foreign substances and adhesion in alveolar macrophages...
  2. ncbi request reprint The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Japan
    Arch Toxicol 80:275-9. 2006
    ..These results suggest that TLR-4 is one of recognition receptors against DEP in the airways...
  3. ncbi request reprint Effects of arsenic on modification of promyelocytic leukemia (PML): PML responds to low levels of arsenite
    Seishiro Hirano
    Research Center for Environmental Risk, National Institute for Environmental Studies, Japan Graduate School of Pharmaceutical Sciences, Chiba University, Japan Electronic address
    Toxicol Appl Pharmacol 273:590-9. 2013
    ..Modification of PML protein occurred faster than activation of the ARE in response to iAs(3+), suggesting that PML was not modified as a consequence of oxidative stress-induced ARE activation...
  4. doi request reprint Western blot analysis
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Methods Mol Biol 926:87-97. 2012
    ..In this chapter the whole process of western blot analysis, from sample preparation to quantitative measurement of target proteins, is described...
  5. doi request reprint Macrophage receptor with collagenous structure (MARCO) is a dynamic adhesive molecule that enhances uptake of carbon nanotubes by CHO-K1 cells
    Seishiro Hirano
    Environmental Nanotoxicology Project, RCER, National Institute for Environmental Studies, Japan
    Toxicol Appl Pharmacol 259:96-103. 2012
    ..1μg/mL and transmission electron microscopic observation indicated that the toxicity of MWCNTs may be due to the incomplete inclusion of MWCNTs by the membrane structure...
  6. ncbi request reprint PCR-based subtraction analyses for upregulated gene transcription in cadmium-exposed rat lung type 2 epithelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Biochem Biophys Res Commun 308:133-8. 2003
    ..AB086193) mRNAs were weakly inducible. The expression of cdig1 increased linearly with time up to 9h, while that of HO-1 reached the maximum value at 4h in response to 10 microM Cd...
  7. ncbi request reprint The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compounds
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 198:458-67. 2004
    ..These results suggest that MMA(III) (GS)(2) is highly toxic compared to other arsenic compounds because of faster accumulation of this species by cells, in addition to having the toxic nature of methylated trivalent organic arsenics...
  8. ncbi request reprint [Evaluation of pulmonary toxicity of heavy metal compounds]
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Japan
    Nihon Eiseigaku Zasshi 50:1013-25. 1996
    ....
  9. pmc A current overview of health effect research on nanoparticles
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, 305 8506, Japan
    Environ Health Prev Med 14:223-5. 2009
    ..3) How has "testing manufactured nanoparticles" been discussed worldwide? (4) What problems have scientists encountered in assessing the health hazard of nanoparticles? and (5) What research is required in the future in nanotoxicology?..
  10. ncbi request reprint Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:54-61. 2005
    ..These results indicate that the inhibition of protein phosphatases as well as the high affinity to cellular components may confer PAO3+ the high toxicity...
  11. doi request reprint Uptake and cytotoxic effects of multi-walled carbon nanotubes in human bronchial epithelial cells
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Toxicol Appl Pharmacol 249:8-15. 2010
    ..Collectively, MWCNT activated NF-κB, enhanced phosphorylation of MAP kinase pathway components, and increased production of proinflammatory cytokines in human bronchial epithelial cells...
  12. ncbi request reprint Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Ibaraki, Japan
    Arch Toxicol 77:305-12. 2003
    ....
  13. ncbi request reprint Oxidative-stress potency of organic extracts of diesel exhaust and urban fine particles in rat heart microvessel endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 187:161-70. 2003
    ....
  14. doi request reprint Multi-walled carbon nanotubes injure the plasma membrane of macrophages
    Seishiro Hirano
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 232:244-51. 2008
    ..These results indicate that MWCNTs probably trigger cytotoxic effects in phagocytotic cells by reacting with MARCO on the plasma membrane and rupturing the plasma membrane...
  15. pmc Exposure, metabolism, and toxicity of rare earths and related compounds
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, Ibaraki, Japan
    Environ Health Perspect 104:85-95. 1996
    ..In this report, we present an overview of the metabolism and health hazards of RE and related compounds, including our recent studies...
  16. ncbi request reprint In vitro and in vivo cytotoxic effects of nitric oxide on metastatic cells
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Cancer Lett 115:57-62. 1997
    ..The increase in NO concentration was accompanied by elevation of concomitant nitric dioxide concentration in exposure chambers and exposure to higher concentration of NO appeared to enhance tumor colony formation in the lung...
  17. ncbi request reprint Inflammatory responses of rat alveolar macrophages following exposure to fluoride
    S Hirano
    Regional Environment Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 0053, Japan
    Arch Toxicol 73:310-5. 1999
    ..Those results suggest that fluoride activates alveolar macrophages, enhances the production of chemokines and proinflammatory cytokines, and causes PMN infiltration in the lung...
  18. ncbi request reprint [Health effects of nanoparticles and nanomaterials (I) recent oveview of health effects of nanoparticles]
    Seishiro Hirano
    Nanotoxicology Section, RCER, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Nihon Eiseigaku Zasshi 63:36-41. 2008
    ..Thus, we should focus more on nano-specific biological interactions and tissue permeability to investigate health effects of manufactured nanoparticles. In this report trend in health effects of nanoparticles is overviewed...
  19. pmc krox-20/egr-2 is up-regulated following non-specific and homophilic adhesion in rat macrophages
    Seishiro Hirano
    Environmental Health Sciences Division and Research Center for Environmental Risk, National Institute for Environmental Studies, Ibaraki, Japan
    Immunology 107:86-92. 2002
    ....
  20. ncbi request reprint Cytotoxic effects of S-(dimethylarsino)-glutathione: a putative intermediate metabolite of inorganic arsenicals
    Seishiro Hirano
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 227:45-52. 2006
    ....
  21. ncbi request reprint Effects of inhaled nanoparticles on acute lung injury induced by lipopolysaccharide in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 238:99-110. 2007
    ..These results suggest that acute exposure to diesel nanoparticles exacerbates lung inflammation induced by LPS...
  22. pmc Effects of airway exposure to nanoparticles on lung inflammation induced by bacterial endotoxin in mice
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan
    Environ Health Perspect 114:1325-30. 2006
    ..Although adverse health effects of particulate matter with a diameter of < 100 nm (nanoparticles) have been proposed, molecular and/or experimental evidence for their facilitation of lung inflammation in vivo is not fully defined...
  23. doi request reprint Analysis of arsenic metabolites in HepG2 and AS3MT-transfected cells
    Takayuki Watanabe
    Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi, Inage, Chiba, 263 8522, Japan
    Arch Toxicol 85:577-88. 2011
    ..Oxidation--reduction of arsenic may be implicated in the toxic effects of arsenite...
  24. ncbi request reprint Effects of acute single intranasal instillation of secondary organic aerosol on neurological and immunological biomarkers in the brain and lung of BALB/c mice
    Tin Tin Win-Shwe
    Center for Environmental Health Sciences, National Institute for Environmental Studies, Ibaraki, Japan
    J Toxicol Sci 38:71-82. 2013
    ..Our present results also clearly indicate that SOA induces inflammatory responses in the lung by modulating proinflammatory cytokines, transcription factor and inflammatory responsive neurotrophins...
  25. doi request reprint Nanoparticle-rich diesel exhaust affects hippocampal-dependent spatial learning and NMDA receptor subunit expression in female mice
    Tin Tin Win-Shwe
    Center for Environmental Risk Research, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Nanotoxicology 6:543-53. 2012
    ..These results indicate that three months of exposure to NRDE affected spatial learning and memory function-related gene expressions in the female mouse hippocampus...
  26. doi request reprint Extrapulmonary translocation of intratracheally instilled fine and ultrafine particles via direct and alveolar macrophage-associated routes
    Akiko Furuyama
    Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Arch Toxicol 83:429-37. 2009
    ....
  27. ncbi request reprint Effects of organic chemicals derived from ambient particulate matter on lung inflammation related to lipopolysaccharide
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506 Ibaraki, Japan
    Arch Toxicol 80:833-8. 2006
    ..These results suggest that the extracted organic chemicals from PM exacerbate infectious lung inflammation. The mechanisms underlying the enhancing effects are not mediated via the enhanced local expression of proinflammatory cytokines...
  28. ncbi request reprint Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Pathol 32:64-72. 2004
    ..This implies that arsenic liver toxicity involves disturbances of some cancer-related molecules...
  29. ncbi request reprint Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Hum Pathol 37:298-311. 2006
    ..In conclusion, a low concentration of As2O3 induces CpG island demethylation of tumor suppressor genes by inhibition of DNMT and reactivates the partially/fully silenced genes in liver cancer cells...
  30. ncbi request reprint Induction of oxidative stress and inhibition of plasminogen activator inhibitor-1 production in endothelial cells following exposure to organic extracts of diesel exhaust particles and urban fine particles
    Akiko Furuyama
    Inhalation Toxicology Team, PM2 5 and DEP Research Project, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506 Tsukuba, Japan
    Arch Toxicol 80:154-62. 2006
    ..These results suggest that exposure to the soluble organic fraction of PM and DEP induced oxidative stress and reduced the PAI-1 production of endothelial cells...
  31. ncbi request reprint cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles
    Eiko Koike
    Department of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan
    Toxicol Sci 67:241-6. 2002
    ..Our results suggest that cDNA microarray analysis is a useful tool to investigate the biological responses to pulmonary toxicants...
  32. doi request reprint Effects of endogenous hydrogen peroxide and glutathione on the stability of arsenic metabolites in rat bile
    Yayoi Kobayashi
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 232:33-40. 2008
    ..These results suggest that H(2)O(2) converts trivalent arsenicals to less toxic pentavalent arsenicals, whereas GSH prevents hydrolysis of As-GSH complexes and the generation of unconjugated toxic trivalent arsenicals...
  33. doi request reprint Mitochondrial electron transport is inhibited by disappearance of metallothionein in human bronchial epithelial cells following exposure to silver nitrate
    Takamitsu Miyayama
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 305:20-9. 2013
    ..These results suggest MT was decomposed by cytosolic H2O2, and then Ag released from MT relocated to insoluble cellular fractions and inhibited electron chain transfer of mitochondrial complexes, which eventually led to cell damage...
  34. doi request reprint Effects of multi-walled carbon nanotubes on a murine allergic airway inflammation model
    Ken ichiro Inoue
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Ibaraki, Japan
    Toxicol Appl Pharmacol 237:306-16. 2009
    ..In addition, the exacerbation may be partly through the inappropriate activation of antigen-presenting cells including DC...
  35. doi request reprint Spatial learning and memory function-related gene expression in the hippocampus of mouse exposed to nanoparticle-rich diesel exhaust
    Tin Tin Win-Shwe
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Neurotoxicology 29:940-7. 2008
    ..These results indicate that co-exposure of NRDE and LTA could affect spatial learning and memory function-related gene expressions in mouse hippocampus...
  36. ncbi request reprint cDNA microarray analysis of rat alveolar epithelial cells following exposure to organic extract of diesel exhaust particles
    Eiko Koike
    Particulate Matter PM2 5 and Diesel Exhaust Particles DEP Research Project, National Institute for Environmental Studies, Tsukuba, Ibaraki, 305 8506, Japan
    Toxicol Appl Pharmacol 201:178-85. 2004
    ..Therefore, an increase in HO-1 and a decrease in TGM-2 might be good markers of the biological response to organic compounds of airborne particulate substances...
  37. pmc Identification of arsenite-and arsenic diglutathione-binding proteins in human hepatocarcinoma cells
    Ayano Mizumura
    Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi, Inage, Chiba 263 8522, Japan
    Toxicol Appl Pharmacol 242:119-25. 2010
    ..These results suggest that although glutathione-conjugation is an important process in the metabolism, excretion, and detoxification of arsenicals, glutathione-conjugated arsenicals can still react with some proteins in hepatic cells...
  38. doi request reprint Metabolism of arsenic and its toxicological relevance
    Takayuki Watanabe
    Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo, Chiba 260 0856, Japan
    Arch Toxicol 87:969-79. 2013
    ..In addition, "being a non-anionic form" also appears to be a determinant of the toxicity of oxo-arsenicals or thioarsenicals. The present review discusses both the metabolism of arsenic and the toxicity of arsenic metabolites...
  39. doi request reprint The role of glutathione in the metabolism of diphenylarsinic acid in rats
    Yayoi Kobayashi
    Center for Environmental Health Sciences, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Metallomics 5:469-78. 2013
    ..As expected, DPA(III) exhibited greater affinity for erythrocyte proteins than did DPAA(V)...
  40. doi request reprint Seasonal differences of the atmospheric particle size distribution in a metropolitan area in Japan
    Yuji Fujitani
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba 305 8506, Japan
    Sci Total Environ 437:339-47. 2012
    ..This leads us to conclude that these particles show distinctly different spatial distributions depending on the season...
  41. ncbi request reprint A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
    Toru Hayakawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:183-91. 2005
    ..Metabolism of iAsIII to methylated arsenicals by Cyt19 was via ATG and MADG rather than by oxidative methylation of iAsIII and MMA(III)...
  42. ncbi request reprint Stability of arsenic metabolites, arsenic triglutathione [As(GS)3] and methylarsenic diglutathione [CH3As(GS)2], in rat bile
    Yayoi Kobayashi
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 211:115-23. 2005
    ..These results suggest that GSH plays an important role in preventing hydrolysis of As-GSH complexes and the generation of well-known toxic trivalent arsenicals...
  43. ncbi request reprint Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 82:478-87. 2004
    ..We are also first to show that DMAV that probably originated from DMAG is excreted into the bile in iAs-po rats...
  44. doi request reprint Theoretical calculations and reaction analysis on the interaction of pentavalent thioarsenicals with biorelevant thiol compounds
    Noriyuki Suzuki
    Graduate School of Pharmaceutical Sciences, Chiba University, Chuo, Chiba 260 8675, Japan
    Chem Res Toxicol 21:550-3. 2008
    ....
  45. doi request reprint Novel object recognition ability in female mice following exposure to nanoparticle-rich diesel exhaust
    Tin Tin Win-Shwe
    Center for Environmental Health Sciences, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 262:355-62. 2012
    ..The present study suggests that genes related to glutamate metabolism may be involved in the NRDE-induced neurotoxicity observed in the present mouse model...
  46. ncbi request reprint A murine scavenger receptor MARCO recognizes polystyrene nanoparticles
    Sanae Kanno
    Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki, Japan
    Toxicol Sci 97:398-406. 2007
    ..These results suggest that macrophages associate with nanoparticles (20 nm) at least in part through MARCO and that MARCO plays a role in clearing nanoparticles which can deposit in the alveolar region...
  47. ncbi request reprint [Arsenic]
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies
    Nihon Rinsho 62:522-5. 2004
  48. ncbi request reprint Extracellular glutamate level and NMDA receptor subunit expression in mouse olfactory bulb following nanoparticle-rich diesel exhaust exposure
    Tin Tin Win-Shwe
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Inhal Toxicol 21:828-36. 2009
    ..This is the first study to show the correlation between glutamate toxicity and memory function-related gene expressions in the mouse olfactory bulb following exposure to NRDE...
  49. ncbi request reprint Characterization of dilution conditions for diesel nanoparticle inhalation studies
    Yuji Fujitani
    National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Japan
    Inhal Toxicol 21:200-9. 2009
    ..We therefore set the secondary dilution ratios for the middle- and low-concentration chambers to 13.5 and 40.5 times, respectively...
  50. ncbi request reprint Distribution and excretion of arsenic in cynomolgus monkey following repeated administration of diphenylarsinic acid
    Yayoi Kobayashi
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Arch Toxicol 82:553-61. 2008
    ..The protein-bound arsenic compounds were presumably trivalent diphenylarsenic compounds, since free DPAA was recovered after treatment of heat-denatured samples with hydrogen peroxide...
  51. ncbi request reprint Effects of the phytoestrogen coumestrol on RANK-ligand-induced differentiation of osteoclasts
    Sanae Kanno
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 203:211-20. 2004
    ..These results suggest that coumestrol has an inhibitory effect on the differentiation of osteoclasts, at least partially via ERK1/2 pathway...
  52. ncbi request reprint Quantitative risk analysis of particulate matter in the air: interspecies extrapolation with bioassay and mathematical models
    Wakae Maruyama
    Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan
    Inhal Toxicol 18:1013-23. 2006
    ..11 to 10.5 x 10(-9) per 1 microg/m3 of particulate matter. The estimated cancer risk for Japanese people in general was estimated as approximately 9-10 persons per 100,000,000 when the particle concentration in the air is 10 microg/m3...
  53. ncbi request reprint [Health effects of nanoparticles and nanomaterials (II) methods for measurement of nanoparticles and their presence in the air]
    Yuji Fujitani
    Environmental Nanotoxicology Section, RCER, National Institute for Environmental Studies, Tsukuba, Japan
    Nihon Eiseigaku Zasshi 63:663-9. 2008
    ..Diesel-powered vehicles are major sources of those nanoparticles in the urban atmosphere. Engineered nanoparticles generate in some occupational settings in the handling processes such as bagging and cleaning with vacuum cleaners...
  54. ncbi request reprint Effects of eicosane, a component of nanoparticles in diesel exhaust, on surface activity of pulmonary surfactant monolayers
    Sanae Kanno
    Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Arch Toxicol 82:841-50. 2008
    ....
  55. ncbi request reprint Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 91:372-81. 2006
    ..In conclusion, iAs(V) exposure increased lung tumor incidence and multiplicity in A/J mice. Epigenetic changes of tumor suppressor genes such as p16INK4a and RASSF1A are involved in the iAs(V)-induced lung carcinogenesis...
  56. ncbi request reprint Arsenic metabolism and thioarsenicals in hamsters and rats
    Hua Naranmandura
    Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
    Chem Res Toxicol 20:616-24. 2007
    ..In addition, arsenic was thiolated more in hamsters than in rats excreting mono and dimethylated thioarsenicals in urine...
  57. ncbi request reprint Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells
    Sanae Kanno
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 196:137-45. 2004
    ....
  58. doi request reprint Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells
    Megumi Yamamoto
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Biochem Mol Toxicol 22:136-46. 2008
    ....
  59. ncbi request reprint Arsenic speciation in the urine and hair of individuals exposed to airborne arsenic through coal-burning in Guizhou, PR China
    Amjad Shraim
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Toxicol Lett 137:35-48. 2003
    ..Females were found to have a higher dimethylarsinic acid but lower percentages of inorganic arsenic and monomethylarsonic acid in their urine than males...
  60. doi request reprint Rapid speciation and quantification of selenium compounds by HPLC-ICP MS using multiple standards labelled with different isotopes
    Yuki Ohta
    Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, Ibaraki, Japan
    Isotopes Environ Health Stud 47:330-40. 2011
    ..Multiple standards labelled with different stable isotopes enable high-throughput identification and quantitative measurements of Se metabolites...
  61. ncbi request reprint [Exposure to nanoparticle-rich diesel exhaust affects hippocampal functions in mice]
    Tin Tin Win-Shwe
    Center for Environmental Risk Research, National Institute for Environmental Studies Ibaraki, Japan
    Nihon Eiseigaku Zasshi 66:628-33. 2011
    ....
  62. ncbi request reprint [Cellular distribution and behavior of metallothionein in mammalian cells following exposure to silver nanoparticles and silver ions]
    Takamitsu Miyayama
    Research Center for Environmental Risk, National Institute for Environmental Studies
    Yakugaku Zasshi 134:723-9. 2014
    ..AgNPs were sequestered by high-molecular weight proteins rather than MT, probably because they were taken up by lysosomes before induction of MT...
  63. ncbi request reprint [Environmental exposure to silver and its health effects]
    Takamitsu Miyayama
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Nihon Eiseigaku Zasshi 67:383-9. 2012
    ..In the present paper, we discuss the absorption, toxicodynamics, and metabolism of both Ag and AgNPs in mammals and their health effects...
  64. ncbi request reprint Expression and activity of arsenic methyltransferase Cyt19 in rat tissues
    Yayoi Kobayashi
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Environ Toxicol Pharmacol 23:115-20. 2007
    ..An intermediate expression of Cyt19 mRNA was observed in the heart and testis. Methylated arsenicals were found to be produced by the liver cytosol using the current HPLC-ICP MS method...
  65. doi request reprint Diphenylarsinic acid increased the synthesis and release of neuroactive and vasoactive peptides in rat cerebellar astrocytes
    Takayuki Negishi
    Department of Chemistry and Biological Science, Aoyama Gakuin University, Chuo Ku, Sagamihara shi, Kanagawa, Japan
    J Neuropathol Exp Neurol 71:468-79. 2012
    ....
  66. ncbi request reprint Oxidative damage to mitochondria is a preliminary step to caspase-3 activation in fluoride-induced apoptosis in HL-60 cells
    C D Anuradha
    Regional Environment Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Free Radic Biol Med 31:367-73. 2001
    ....
  67. ncbi request reprint Myeloperoxidase-associated tyrosine nitration after intratracheal administration of lipopolysaccharide in rats
    Ryuji Hataishi
    Department of Medicine, Kitasato University School of Medicine, Sagamihara, Japan
    Anesthesiology 97:887-95. 2002
    ....
  68. ncbi request reprint Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma
    Xing Cui
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hum Pathol 35:1189-95. 2004
    ..994, P <0.0001, respectively). Most CRCs demonstrate aberrant expression of pRb and/or p16 at resectable stages. Aberrant expression of pRb and p16, alone and in combination, heralds poor prognosis in patients with CRC...