Teruhiko Higuchi

Summary

Affiliation: National Hospital Organization
Country: Japan

Publications

  1. doi request reprint Major depressive disorder treatment guidelines in Japan
    Teruhiko Higuchi
    National Center of Neurology and Psychiatry, Tokyo, Japan
    J Clin Psychiatry 71:e05. 2010
  2. doi request reprint Schizotypy and genetic loading for schizophrenia impact upon neuropsychological status in bipolar II and unipolar major depressive disorders
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Affect Disord 142:225-32. 2012
  3. doi request reprint Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Schizophr Res 139:201-6. 2012
  4. doi request reprint Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 56:613-6. 2011
  5. doi request reprint Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 38:341-4. 2012
  6. pmc Possible association between interleukin-1β gene and schizophrenia in a Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Behav Brain Funct 7:35. 2011
  7. doi request reprint Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 46:555-9. 2012
  8. doi request reprint Support for association between the Ser205Leu polymorphism of p75(NTR) and major depressive disorder
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 56:806-9. 2011
  9. doi request reprint Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1257-63. 2011
  10. doi request reprint Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1439-44. 2011

Collaborators

Detail Information

Publications30

  1. doi request reprint Major depressive disorder treatment guidelines in Japan
    Teruhiko Higuchi
    National Center of Neurology and Psychiatry, Tokyo, Japan
    J Clin Psychiatry 71:e05. 2010
    ..The flowchart shows steps in treatment both for patients who respond to initial treatment and for those who need several trials of treatment. These 3 forms of guidance for managing patients with MDD in Japan are reviewed...
  2. doi request reprint Schizotypy and genetic loading for schizophrenia impact upon neuropsychological status in bipolar II and unipolar major depressive disorders
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Affect Disord 142:225-32. 2012
    ..Although these conditions are known to be associated with neurocognitive impairments, such an association has not been studied in patients with bipolar II disorder (BPII) or unipolar major depressive disorder (UP)...
  3. doi request reprint Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Schizophr Res 139:201-6. 2012
    ..Previous studies also suggest altered oxytocin function in patients with schizophrenia and depression. However, few studies have examined the central oxytocin levels in these disorders...
  4. doi request reprint Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 56:613-6. 2011
    ..These results suggest that IL-1β gene variation may have a role in cognitive functions in aging females as well as males...
  5. doi request reprint Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophrenia
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 38:341-4. 2012
    ..We hypothesized that the Trp64Arg polymorphism may be associated with increased risk of schizophrenia and depression...
  6. pmc Possible association between interleukin-1β gene and schizophrenia in a Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Behav Brain Funct 7:35. 2011
    ..Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms...
  7. doi request reprint Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese population
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 46:555-9. 2012
    ..5, df = 1, p = 0.0037, OR 1.50, 95%CI 1.14-1.98). Our results suggest that the T3435 allele or carrying two copies of this allele confers susceptibility to MDD in the Japanese population...
  8. doi request reprint Support for association between the Ser205Leu polymorphism of p75(NTR) and major depressive disorder
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Hum Genet 56:806-9. 2011
    ....
  9. doi request reprint Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical population
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1257-63. 2011
    ..Our findings further suggest that the mediation model would work better than the bivariate approach in investigating the relationship between sleep, distress and HPA axis reactivity...
  10. doi request reprint Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Psychiatr Res 45:1439-44. 2011
    ..Increased IL-6 levels without alterations in sIL-6R levels may result in excessive IL-6 signaling in schizophrenia...
  11. doi request reprint More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depression
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    J Affect Disord 136:1047-52. 2012
    ..In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls...
  12. pmc Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Behav Brain Funct 7:23. 2011
    ..These findings prompted us to examine the possible association between IL-1β gene polymorphisms and HPA axis function assessed with the DEX/CRH test...
  13. doi request reprint Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/ corticotropin-releasing hormone test
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Neuropsychobiology 63:232-41. 2011
    ....
  14. doi request reprint Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorder
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
    J Psychiatr Res 47:401-6. 2013
    ..The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded...
  15. doi request reprint Addition of antipsychotics to medication regimens during schizophrenic inpatient care
    Asuka Koyama
    National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 62:56-64. 2008
    ..The objective of the present study was to identify schizophrenia inpatients who had their original regimen augmented with additional antipsychotics during acute inpatient care, and to clarify the factors associated with these additions...
  16. pmc Identification of single nucleotide polymorphisms regulating peripheral blood mRNA expression with genome-wide significance: an eQTL study in the Japanese population
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    PLoS ONE 8:e54967. 2013
    ..Further studies are required to clarify how SNPs function in affecting the expression levels in whole blood as well as in other tissues...
  17. doi request reprint Difference in Temperament and Character Inventory scores between depressed patients with bipolar II and unipolar major depressive disorders
    Daimei Sasayama
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    J Affect Disord 132:319-24. 2011
    ..Although some core personality variables are known to be characteristic of unipolar or bipolar depression, few studies have compared the personality profile between these two disorders...
  18. doi request reprint Relationship of temperament and character with cortisol reactivity to the combined dexamethasone/CRH test in depressed outpatients
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
    J Affect Disord 147:128-36. 2013
    ..Another line of research has demonstrated that personality is associated with HPA axis alteration. It is thus hypothesized that different personality pathology in depression would be associated with distinct cortisol reactivity...
  19. doi request reprint The effect of an educational leaflet on depressive patients' attitudes toward treatment
    Kanae Sawamura
    Institute for Health Economics and Policy, No 11 Toyo Kaiji Bldg, 1 5 11, Nishi sinbashi, Minato ku, Tokyo, 105 0003, Japan
    Psychiatry Res 177:184-7. 2010
    ..Our results indicate that the educational leaflet is an effective tool for enhancement of face-to-face education by medical professionals. Trial registration UMIN000002981, www.umin.ac.jp/ctr/index.htm...
  20. doi request reprint Thought disorder and executive dysfunction in patients with schizophrenia
    Toshimi Owashi
    Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
    Int J Neurosci 119:105-23. 2009
    ..No significant correlations were found between parameters of positive thought disorder and executive function. Thought disorder and executive function may play different roles in the pathophysiology of schizophrenia...
  21. doi request reprint Validation of computer-administered clinical rating scale: Hamilton Depression Rating Scale assessment with Interactive Voice Response technology--Japanese version
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 67:253-8. 2013
    ..The aim of this study was to examine the reliability and validity of the Interactive Voice Response (IVR) program to rate the 17-item Hamilton Rating Scale for Depression (HAM-D) score in Japanese depressive patients...
  22. doi request reprint Assessment of cerebral blood flow findings using 99mTc-ECD single-photon emission computed tomography in patients diagnosed with major depressive disorder
    Yuko Nagafusa
    Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Affect Disord 140:296-9. 2012
    ..We used SPECT to verify the cerebral blood flow findings of patients with major depressive disorder (MDD) considering the effect of age on the findings...
  23. doi request reprint Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesia
    Nagahisa Okamoto
    Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
    J ECT 26:223-7. 2010
    ..We conducted an open-label trial of ketamine to determine whether ketamine as the anesthetic during ECT would provide a greater antidepressant effect than the antidepressant effect obtained with propofol...
  24. doi request reprint Possible association of the semaphorin 3D gene (SEMA3D) with schizophrenia
    Takashi Fujii
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    J Psychiatr Res 45:47-53. 2011
    ..Our findings provide strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder...
  25. ncbi request reprint Nurses' collaboration with physicians in managing medication improves patient outcome in acute psychiatric care
    Miharu Nakanishi
    Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 60:196-203. 2006
    ..Nurses' collaboration with physicians in medication management improved patient outcome in acute psychiatric care...
  26. ncbi request reprint Relationships of DEX/CRH and GHRH test results to the outcome of depression--preliminary results suggest the GHRH test may predict relapse after discharge
    Toshimi Owashi
    Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
    J Psychiatr Res 42:356-64. 2008
    ..The findings of this study suggest that results of the GHRH test may be a predictor of future relapse in patients with depression...
  27. doi request reprint Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adults
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    J Psychiatr Res 44:865-73. 2010
    ..These results point to the important role of enhanced suppression of cortisol, or blunted cortisol reactivity, in non-clinical psychopathology such as avoidant coping strategy and greater psychological distress...
  28. doi request reprint Paroxetine controlled-release formulation in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled study in Japan and Korea
    Teruhiko Higuchi
    National Center of Neurology and Psychiatry, Tokyo, Japan
    Psychiatry Clin Neurosci 65:655-63. 2011
    ....
  29. ncbi request reprint Identification and expression of frizzled-3 protein in rat frontal cortex after antidepressant and electroconvulsive treatment
    Misa Yamada
    Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Pharmacol Sci 99:239-46. 2005
    ..In conclusion, the Frz3-mediated signaling cascade may be a component of the molecular machinery targeted by therapeutics commonly used to treat depression...
  30. ncbi request reprint Polypharmacy and excessive dosing: psychiatrists' perceptions of antipsychotic drug prescription
    Hiroto Ito
    National Institute of Mental Health, Kodaira, Tokyo, Japan
    Br J Psychiatry 187:243-7. 2005
    ..Despite extensive research and recommendations regarding the optimal prescription of antipsychotic drugs, polypharmacy and excessive dosing still prevail...