Research Topics
Genomes and GenesSpecies | Teruhiko HiguchiSummaryAffiliation: National Hospital Organization Country: Japan Publications
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Detail Information
Publications
Major depressive disorder treatment guidelines in JapanTeruhiko Higuchi
National Center of Neurology and Psychiatry, Tokyo, Japan
J Clin Psychiatry 71:e05. 2010..The flowchart shows steps in treatment both for patients who respond to initial treatment and for those who need several trials of treatment. These 3 forms of guidance for managing patients with MDD in Japan are reviewed...- Negative correlation between cerebrospinal fluid oxytocin levels and negative symptoms of male patients with schizophreniaDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
Schizophr Res 139:201-6. 2012..Previous studies also suggest altered oxytocin function in patients with schizophrenia and depression. However, few studies have examined the central oxytocin levels in these disorders... - Association of interleukin-1β genetic polymorphisms with cognitive performance in elderly females without dementiaDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
J Hum Genet 56:613-6. 2011..These results suggest that IL-1β gene variation may have a role in cognitive functions in aging females as well as males... - Possible impact of ADRB3 Trp64Arg polymorphism on BMI in patients with schizophreniaDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
Prog Neuropsychopharmacol Biol Psychiatry 38:341-4. 2012..We hypothesized that the Trp64Arg polymorphism may be associated with increased risk of schizophrenia and depression... 
Possible association between interleukin-1β gene and schizophrenia in a Japanese populationDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
Behav Brain Funct 7:35. 2011..Although a number of genetic association studies have been reported, very few have systematically examined gene-wide tagging polymorphisms...- Association between the functional polymorphism (C3435T) of the gene encoding P-glycoprotein (ABCB1) and major depressive disorder in the Japanese populationTakashi Fujii
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
J Psychiatr Res 46:555-9. 2012..5, df = 1, p = 0.0037, OR 1.50, 95%CI 1.14-1.98). Our results suggest that the T3435 allele or carrying two copies of this allele confers susceptibility to MDD in the Japanese population... - Support for association between the Ser205Leu polymorphism of p75(NTR) and major depressive disorderTakashi Fujii
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
J Hum Genet 56:806-9. 2011.... - Poor sleep is associated with exaggerated cortisol response to the combined dexamethasone/CRH test in a non-clinical populationHiroaki Hori
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
J Psychiatr Res 45:1257-63. 2011..Our findings further suggest that the mediation model would work better than the bivariate approach in investigating the relationship between sleep, distress and HPA axis reactivity... - Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patientsDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
J Psychiatr Res 45:1439-44. 2011..Increased IL-6 levels without alterations in sIL-6R levels may result in excessive IL-6 signaling in schizophrenia... - More severe impairment of manual dexterity in bipolar disorder compared to unipolar major depressionDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
J Affect Disord 136:1047-52. 2012..In the present study, manual dexterity was compared between unipolar major depression, bipolar disorder, and healthy controls... - Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adultsDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
Behav Brain Funct 7:23. 2011..These findings prompted us to examine the possible association between IL-1β gene polymorphisms and HPA axis function assessed with the DEX/CRH test... - Schizotypal personality in healthy adults is related to blunted cortisol responses to the combined dexamethasone/ corticotropin-releasing hormone testHiroaki Hori
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
Neuropsychobiology 63:232-41. 2011.... - Increased cerebrospinal fluid interleukin-6 levels in patients with schizophrenia and those with major depressive disorderDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8502, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto 390 8621, Japan
J Psychiatr Res 47:401-6. 2013..The present findings suggest that IL-6 of central origin is associated with the pathophysiology of schizophrenia and MDD, although confounding effect of smoking status can not be entirely excluded... - Addition of antipsychotics to medication regimens during schizophrenic inpatient careAsuka Koyama
National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
Psychiatry Clin Neurosci 62:56-64. 2008..The objective of the present study was to identify schizophrenia inpatients who had their original regimen augmented with additional antipsychotics during acute inpatient care, and to clarify the factors associated with these additions... - Identification of Single Nucleotide Polymorphisms Regulating Peripheral Blood mRNA Expression with Genome-Wide Significance: An eQTL Study in the Japanese PopulationDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan Department of Psychiatry, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
PLoS ONE 8:e54967. 2013..Further studies are required to clarify how SNPs function in affecting the expression levels in whole blood as well as in other tissues... - Difference in Temperament and Character Inventory scores between depressed patients with bipolar II and unipolar major depressive disordersDaimei Sasayama
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
J Affect Disord 132:319-24. 2011..Although some core personality variables are known to be characteristic of unipolar or bipolar depression, few studies have compared the personality profile between these two disorders... - Relationship of temperament and character with cortisol reactivity to the combined dexamethasone/CRH test in depressed outpatientsHiroaki Hori
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo 187 8502, Japan
J Affect Disord 147:128-36. 2013..Another line of research has demonstrated that personality is associated with HPA axis alteration. It is thus hypothesized that different personality pathology in depression would be associated with distinct cortisol reactivity... - The effect of an educational leaflet on depressive patients' attitudes toward treatmentKanae Sawamura
Institute for Health Economics and Policy, No 11 Toyo Kaiji Bldg, 1 5 11, Nishi sinbashi, Minato ku, Tokyo, 105 0003, Japan
Psychiatry Res 177:184-7. 2010..Our results indicate that the educational leaflet is an effective tool for enhancement of face-to-face education by medical professionals. Trial registration UMIN000002981, www.umin.ac.jp/ctr/index.htm... - Thought disorder and executive dysfunction in patients with schizophreniaToshimi Owashi
Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
Int J Neurosci 119:105-23. 2009..No significant correlations were found between parameters of positive thought disorder and executive function. Thought disorder and executive function may play different roles in the pathophysiology of schizophrenia... - Assessment of cerebral blood flow findings using 99mTc-ECD single-photon emission computed tomography in patients diagnosed with major depressive disorderYuko Nagafusa
Department of Psychiatry, National Center of Neurology and Psychiatry, Tokyo, Japan
J Affect Disord 140:296-9. 2012..We used SPECT to verify the cerebral blood flow findings of patients with major depressive disorder (MDD) considering the effect of age on the findings... - Rapid antidepressant effect of ketamine anesthesia during electroconvulsive therapy of treatment-resistant depression: comparing ketamine and propofol anesthesiaNagahisa Okamoto
Department of Psychiatry, National Center Hospital of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
J ECT 26:223-7. 2010..We conducted an open-label trial of ketamine to determine whether ketamine as the anesthetic during ECT would provide a greater antidepressant effect than the antidepressant effect obtained with propofol... 
Relationships of DEX/CRH and GHRH test results to the outcome of depression--preliminary results suggest the GHRH test may predict relapse after dischargeToshimi Owashi
Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan
J Psychiatr Res 42:356-64. 2008..The findings of this study suggest that results of the GHRH test may be a predictor of future relapse in patients with depression...- Nurses' collaboration with physicians in managing medication improves patient outcome in acute psychiatric careMiharu Nakanishi
Department of Social Psychiatry, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
Psychiatry Clin Neurosci 60:196-203. 2006..Nurses' collaboration with physicians in medication management improved patient outcome in acute psychiatric care... - Possible association of the semaphorin 3D gene (SEMA3D) with schizophreniaTakashi Fujii
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
J Psychiatr Res 45:47-53. 2011..Our findings provide strong evidence that SEMA3D confers susceptibility to schizophrenia, which could contribute to the neurodevelopmental impairments in the disorder... - Relationships between psychological distress, coping styles, and HPA axis reactivity in healthy adultsHiroaki Hori
Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
J Psychiatr Res 44:865-73. 2010..These results point to the important role of enhanced suppression of cortisol, or blunted cortisol reactivity, in non-clinical psychopathology such as avoidant coping strategy and greater psychological distress... - Paroxetine controlled-release formulation in the treatment of major depressive disorder: a randomized, double-blind, placebo-controlled study in Japan and KoreaTeruhiko Higuchi
National Center of Neurology and Psychiatry, Tokyo, Japan
Psychiatry Clin Neurosci 65:655-63. 2011.... - Identification and expression of frizzled-3 protein in rat frontal cortex after antidepressant and electroconvulsive treatmentMisa Yamada
Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
J Pharmacol Sci 99:239-46. 2005..In conclusion, the Frz3-mediated signaling cascade may be a component of the molecular machinery targeted by therapeutics commonly used to treat depression... - Polypharmacy and excessive dosing: psychiatrists' perceptions of antipsychotic drug prescriptionHiroto Ito
National Institute of Mental Health, Kodaira, Tokyo, Japan
Br J Psychiatry 187:243-7. 2005..Despite extensive research and recommendations regarding the optimal prescription of antipsychotic drugs, polypharmacy and excessive dosing still prevail...