Makoto Higuchi

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. pmc A Small-Animal Pharmacokinetic/Pharmacodynamic PET Study of Central Serotonin 1A Receptor Occupancy by a Potential Therapeutic Agent for Overactive Bladder
    Yosuke Nakatani
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tsukuba, Ibaraki, Japan Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    PLoS ONE 8:e75040. 2013
  2. pmc Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain
    Takeaki Saijo
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 7:e42589. 2012
  3. doi request reprint PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Curr Top Behav Neurosci 11:45-64. 2012
  4. pmc Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
    Nobuyuki Yamasaki
    Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
    Mol Brain 1:6. 2008
  5. ncbi request reprint Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Curr Alzheimer Res 6:137-43. 2009
  6. ncbi request reprint Animal models of tauopathies
    Makoto Higuchi
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Neuropathology 26:491-7. 2006
  7. doi request reprint In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Chiba 263 8555, Japan
    Biochim Biophys Acta 1802:373-88. 2010
  8. pmc Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies
    Bin Ji
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 28:12255-67. 2008
  9. pmc Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
    Masahiro Maruyama
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Neuron 79:1094-108. 2013
  10. pmc In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders
    Jun Maeda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 31:4720-30. 2011

Detail Information

Publications74

  1. pmc A Small-Animal Pharmacokinetic/Pharmacodynamic PET Study of Central Serotonin 1A Receptor Occupancy by a Potential Therapeutic Agent for Overactive Bladder
    Yosuke Nakatani
    Tsukuba Research Laboratories, Eisai Co, Ltd, Tsukuba, Ibaraki, Japan Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba, Japan Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan
    PLoS ONE 8:e75040. 2013
    ..These findings support the utility of PET RO and plasma pharmacokinetic assays with the aid of adequate mathematical models in determining the in vivo characteristics of a drug acting on 5-HT1A receptors and thereby counteracting OAB. ..
  2. pmc Presynaptic selectivity of a ligand for serotonin 1A receptors revealed by in vivo PET assays of rat brain
    Takeaki Saijo
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    PLoS ONE 7:e42589. 2012
    ....
  3. doi request reprint PET Applications in Animal Models of Neurodegenerative and Neuroinflammatory Disorders
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
    Curr Top Behav Neurosci 11:45-64. 2012
    ....
  4. pmc Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders
    Nobuyuki Yamasaki
    Frontier Technology Center, Kyoto University Graduate School of Medicine, Japan
    Mol Brain 1:6. 2008
    ..Based on these results, we propose that an "immature DG" in adulthood might induce alterations in behavior and serve as a promising candidate endophenotype of schizophrenia and other human psychiatric disorders...
  5. ncbi request reprint Visualization of brain amyloid and microglial activation in mouse models of Alzheimer's disease
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Curr Alzheimer Res 6:137-43. 2009
    ..This motivates our present work aimed at dual monitoring of amyloidosis and microgliosis in living animal models of AD, toward therapeutic regulation of these two processes capable of halting the self-perpetuating cycle...
  6. ncbi request reprint Animal models of tauopathies
    Makoto Higuchi
    Brain Imaging Project, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Neuropathology 26:491-7. 2006
    ..Moreover, visualization of glial responses in living brains may allow sensitive detection of degenerative changes in the central nervous system...
  7. doi request reprint In-vivo visualization of key molecular processes involved in Alzheimer's disease pathogenesis: Insights from neuroimaging research in humans and rodent models
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Chiba 263 8555, Japan
    Biochim Biophys Acta 1802:373-88. 2010
    ....
  8. pmc Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies
    Bin Ji
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 28:12255-67. 2008
    ....
  9. pmc Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls
    Masahiro Maruyama
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Neuron 79:1094-108. 2013
    ..11)C]PBB3-PET data were also consistent with the spreading of tau pathology with AD progression. Furthermore, increased [(11)C]PBB3 signals were found in a corticobasal syndrome patient negative for [(11)C]PIB-PET...
  10. pmc In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders
    Jun Maeda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 31:4720-30. 2011
    ..Our data corroborate the utility of TSPO-PET imaging as a biomarker for tau-triggered toxicity, and as a complement to amyloid scans for diagnostic assessment of tauopathies with and without Aβ pathologies...
  11. doi request reprint Utility of small-animal positron emission tomographic imaging of rats for preclinical development of drugs acting on the serotonin transporter
    Takeaki Saijo
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Neuropsychopharmacol 12:1021-32. 2009
    ....
  12. ncbi request reprint Longitudinal, quantitative assessment of amyloid, neuroinflammation, and anti-amyloid treatment in a living mouse model of Alzheimer's disease enabled by positron emission tomography
    Jun Maeda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    J Neurosci 27:10957-68. 2007
    ....
  13. ncbi request reprint Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
    Jun Maeda
    Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Brain Res 1157:100-11. 2007
    ..The present findings collectively support the utility of PBR in identifying a unique temporal pattern of astrocytic and microglial activation that conventional glial markers hardly pursue...
  14. doi request reprint Increased binding of peripheral benzodiazepine receptor in mild cognitive impairment-dementia converters measured by positron emission tomography with [¹¹C]DAA1106
    Fumihiko Yasuno
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Psychiatry Res 203:67-74. 2012
    ..In vivo detection of microglial activation may provide useful prognostic information with respect to stratifying MCI subjects at increased risk of dementia...
  15. doi request reprint Glial cell-mediated deterioration and repair of the nervous system after traumatic brain injury in a rat model as assessed by positron emission tomography
    Iwae Yu
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Neurotrauma 27:1463-75. 2010
    ....
  16. doi request reprint A traditional medicinal herb Paeonia suffruticosa and its active constituent 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose have potent anti-aggregation effects on Alzheimer's amyloid beta proteins in vitro and in vivo
    Hironori Fujiwara
    Center for Asian Traditional Medicine, Tohoku University Graduate School of Medicine, Sendai, Aoba ku, Japan
    J Neurochem 109:1648-57. 2009
    ..PGG is likely to be a safe and promising lead compound in the development of disease-modifying drugs to prevent and/or cure AD...
  17. ncbi request reprint β-Amyloid in Lewy body disease is related to Alzheimer's disease-like atrophy
    Hitoshi Shimada
    Molecular Imaging Center, Molecular Neuroimaging Program, National Institute of Radiological Sciences, Chiba, Japan
    Mov Disord 28:169-75. 2013
    ..The results suggest that amyloid deposition is associated with AD-like atrophy in DLB/PDD patients. Early intervention against amyloid may prevent or delay AD-like atrophy in DLB/PDD patients with amyloid deposition...
  18. doi request reprint Imaging for metabotropic glutamate receptor subtype 1 in rat and monkey brains using PET with [18F]FITM
    Tomoteru Yamasaki
    Molecular Imaging Centre, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Eur J Nucl Med Mol Imaging 39:632-41. 2012
    ....
  19. doi request reprint In vivo and in vitro imaging of I₂ imidazoline receptors in the monkey brain
    Kazunori Kawamura
    Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 65:452-5. 2011
    ..These results suggest that [¹¹C]FTIMD shows the specific-binging to I₂Rs in the monkey brain as depicted by PET and ARG. We performed the first in vivo imaging of I₂Rs using [¹¹C]FTIMD in the monkey brain...
  20. doi request reprint 18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain
    Joji Yui
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 51:1301-9. 2010
    ....
  21. ncbi request reprint In vivo mapping of substance P receptors in brains of laboratory animals by high-resolution imaging systems
    Eisuke Haneda
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:205-15. 2007
    ....
  22. doi request reprint Characterization of 1-(2-[18F] fluoro-3-pyridyl)-4-(2-isopropyl-1-oxo- isoindoline-5-yl)-5-methyl-1H-1,2,3-triazole, a PET ligand for imaging the metabotropic glutamate receptor type 1 in rat and monkey brains
    Masayuki Fujinaga
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Neurochem 121:115-24. 2012
    ..18) F]FPIT produced in vitro and in vivo signals to visualize mGluR1 expression in rat and monkey brains, suggesting the usefulness of [(18) F]FPIT for imaging mGluR1 in human brain...
  23. doi request reprint Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology
    Ryuichi Harada
    Department of Pharmacology, Tohoku University School of Medicine, 2 1 Seiryo machi, Aoba ku, Sendai, Japan
    Eur J Nucl Med Mol Imaging 40:125-32. 2013
    ..The purpose of this study was to compare the binding properties of [(18)F]THK-523 and other amyloid imaging agents, including PiB, BF-227 and FDDNP, to synthetic protein fibrils and human brain tissue...
  24. ncbi request reprint Quantitative analysis of peripheral benzodiazepine receptor in the human brain using PET with (11)C-AC-5216
    Michie Miyoshi
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Nucl Med 50:1095-101. 2009
    ..The aim of this study was to evaluate a quantification method of (11)C-AC-5216 binding in the human brain...
  25. doi request reprint Increased binding of peripheral benzodiazepine receptor in Alzheimer's disease measured by positron emission tomography with [11C]DAA1106
    Fumihiko Yasuno
    Clinical Neuroimaging Section, Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 64:835-41. 2008
    ..The role of activated microglia in AD is an important topic in the pathophysiology of AD. The aim of this study was to quantify PBR in AD brain with a new high-sensitive PBR ligand, [(11)C]DAA1106...
  26. ncbi request reprint 11C-AC-5216: a novel PET ligand for peripheral benzodiazepine receptors in the primate brain
    Ming Rong Zhang
    Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 48:1853-61. 2007
    ..The aim of this study was to synthesize and evaluate N-benzyl-N-ethyl-2-(7-(11)C-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ((11)C-AC-5216) as a PET ligand for imaging PBR in the primate brain...
  27. doi request reprint Synthesis and evaluation of novel radioligands for positron emission tomography imaging of the orexin-2 receptor
    Norihito Oi
    Tsukuba Research Laboratories, Eisai Co, Ltd, 5 1 3 Tokodai, Tsukuba shi, Ibaraki 300 2635, Japan
    J Med Chem 56:6371-85. 2013
    ..Our approach and findings have provided significant information for development of OX2R PET tracers. ..
  28. doi request reprint Total-body low-dose irradiation of mice induces neither learning disability and memory impairment in Morris water maze test nor Alzheimer's disease-like pathogensis in the brain
    Bing Wang
    National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 55:i20-i21. 2014
    ..10 Gy could hardly induce significant early or late transcriptional alterations in most of the AD-related genes in the hippocampus, learning disability and memory impairment, and AD-like pathological change in the brain in mice [ 3]. ..
  29. ncbi request reprint [Evaluation of imaging biomarker by transgenic mouse models]
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba, 263 8555 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:73-8. 2009
    ..These mechanistic insights, PET assays of Tg mice that we have established here, provide an efficient methodology for preclinical evaluation of emerging diagnostic and therapeutic agents for neurodegenerative and psychiatric illnesses...
  30. pmc Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system
    Masaki Tokunaga
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    J Neurosci 29:1887-96. 2009
    ....
  31. ncbi request reprint [Imaging of glial cells by positron-emitted peripheral benzodiazepine receptor ligands]
    Jun Maeda
    Brain Imaging Project, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 26:17-21. 2006
    ..We concluded that PET imaging by PBR ligands is useful for diagnosis of neurodegenerative disorders...
  32. ncbi request reprint Neuroanatomical correlates of low body weight in Alzheimer's disease: a PET study
    XiaSheng Hu
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 26:1285-9. 2002
    ....
  33. ncbi request reprint Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's beta-amyloid proteins
    Hironori Fujiwara
    Department of Geriatric and Complementary Medicine, Center for Asian Traditional Medicine Research, Tohoku University School of Medicine, Sendai, Japan
    J Neurosci Res 84:427-33. 2006
    ....
  34. doi request reprint Assessment of radioligands for PET imaging of cyclooxygenase-2 in an ischemic neuronal injury model
    Bin Ji
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba, Chiba 263 8555, Japan
    Brain Res 1533:152-62. 2013
    ....
  35. pmc Superiority illusion arises from resting-state brain networks modulated by dopamine
    Makiko Yamada
    Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Proc Natl Acad Sci U S A 110:4363-7. 2013
    ..Our findings help elucidate how this key aspect of the human mind is biologically determined, and identify potential molecular and neural targets for treatment for depressive realism...
  36. pmc Central nervous system drug evaluation using positron emission tomography
    Mizuho Sekine
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan Department of Neuropsychiatry, Nippon Medical School, Tokyo, Japan
    Clin Psychopharmacol Neurosci 9:9-16. 2011
    ..In this article, we focused on rational drug dosing using receptor occupancy and proof-of-concept of drugs in the drug development process using PET...
  37. doi request reprint Molecular imaging of dementia
    Takaaki Mori
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Psychogeriatrics 12:106-14. 2012
    ..Therefore, PET will be of technical importance for both clinical and basic research aimed at prodromal pathologies of Alzheimer's disease...
  38. ncbi request reprint [In-vivo imaging for pursuing molecular cascades in the pathogenesis of neurodegenerative diseases]
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences
    Rinsho Shinkeigaku 49:929-32. 2009
    ..Clarification of these changes in target elements brings mechanistic insights into the molecular etiology of neuropsychiatric disorders...
  39. ncbi request reprint Neuroimaging in dementia: in vivo amyloid imaging
    Tetsuya Suhara
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Tohoku J Exp Med 215:119-24. 2008
    ....
  40. doi request reprint In vivo detection of neuropathologic changes in presymptomatic MAPT mutation carriers: a PET and MRI study
    Michie Miyoshi
    Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Parkinsonism Relat Disord 16:404-8. 2010
    ..Microglial activation and disrupted neurotransmissions may herald symptomatic manifestations in neurodegenerative tauopathies...
  41. ncbi request reprint Cerebrospinal fluid neprilysin is reduced in prodromal Alzheimer's disease
    Masahiro Maruyama
    Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Ann Neurol 57:832-42. 2005
    ....
  42. ncbi request reprint The role of extrastriatal dopamine D2 receptors in schizophrenia
    Hidehiko Takahashi
    Molecular Imaging Center, Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
    Biol Psychiatry 59:919-28. 2006
    ..These notions suggest the need for future investigations of extrastriatal DA D2 receptor function to gain important clues regarding the pathogenesis and of possible treatments for schizophrenia...
  43. pmc Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala
    Ryong Moon Shin
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
    Proc Natl Acad Sci U S A 107:19073-8. 2010
    ....
  44. pmc Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration
    Masaaki Tagawa
    Department of Pharmacology, Tohoku University School of Medicine, Cyclotron and Radioisotope Center, Tohoku University, Japan
    Br J Clin Pharmacol 53:296-304. 2002
    ..In order to evaluate the sedative properties of ebastine, a second-generation antihistamine, its effect on cognitive performance in healthy subjects was compared with placebo and (+)-chlorpheniramine...
  45. ncbi request reprint [Animal models of tauopathies]
    Makoto Higuchi
    Molecular Imaging Center, National Institute of Radiological Sciences
    Rinsho Shinkeigaku 46:928-30. 2006
    ..This technology would greatly facilitate diagnostic workup of patients with suspected tauopathies when combined with appropriate imaging modalities...
  46. ncbi request reprint Measurement of glycine binding site of N-methyl-D-asparate receptors in living human brain using 4-acetoxy derivative of L-703,717, 4-acetoxy-7-chloro-3-[3-(4-[11c] methoxybenzyl) phenyl]-2(1H)-quinolone (AcL703) with positron emission tomography
    Ryohei Matsumoto
    Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Synapse 61:795-800. 2007
    ..This indicates the possibility of in vivo evaluation of NMDA receptors using PET with [11C]AcL703 in living human brain...
  47. ncbi request reprint Pharmacokinetics and brain uptake of lactoferrin in rats
    Bin Ji
    Brain Imaging Project, National Institute of Radiological Sciences, Inage Ku, Chiba shi, 263 8555, Japan
    Life Sci 78:851-5. 2006
    ..Markedly high brain uptake was observed for Lf relative to Tf and OX26. Lf might be useful as a ligand for facilitating drug delivery into the brain...
  48. ncbi request reprint Correlation between quantitative imaging and behavior in unilaterally 6-OHDA-lesioned rats
    Motoki Inaji
    Brain Imaging Project, National Institute of Radiological Science, 4 9 1 Aragawa, Inage, Chiba 305 8555, Japan
    Brain Res 1064:136-45. 2005
    ....
  49. ncbi request reprint Combined Analysis of CSF Tau Levels and [(123)I]Iodoamphetamine SPECT in Mild Cognitive Impairment: Implications for a Novel Predictor of Alzheimer's Disease
    Nobuyuki Okamura
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Miyagi, Japan
    Am J Psychiatry 159:474-6. 2002
    ..The aim of this study was to establish an objective and reliable index to predict the development of Alzheimer's disease in a large pool of elderly patients with mild cognitive impairment...
  50. pmc Total body 100-mGy X-irradiation does not induce Alzheimer's disease-like pathogenesis or memory impairment in mice
    Bing Wang
    Research Center for Radiation Protection, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
    J Radiat Res 55:84-96. 2014
    ..TBI induced early or late transcriptional alteration in only a few AD-related genes but did not significantly affect spatial learning, memory or AD-like pathological change in mice. ..
  51. pmc Nitric oxide signaling exerts bidirectional effects on plasticity inductions in amygdala
    Ryong Moon Shin
    Molecular Imaging Center, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba, Japan
    PLoS ONE 8:e74668. 2013
    ..NO, produced by activation of presynaptic NMDAR in cortical input and postsynaptic NMDAR in thalamic input, may control conditioned fear by suppressing pre-LTP and promoting post-LTP, respectively, in thalamic input to the LA. ..
  52. ncbi request reprint Tau oligomers as potential targets for early diagnosis of tauopathy
    Naruhiko Sahara
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba shi, Chiba, Japan Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, FL, USA
    J Alzheimers Dis 40:S91-6. 2014
    ..While in vivo imaging of mature tangles is now available, imaging biomarkers for tau oligomers would be useful for clarifying their roles in neurotoxicity and for diagnosing early-stage tau pathology. ..
  53. ncbi request reprint Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Bioconjug Chem 19:1135-42. 2008
    ..g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI...
  54. doi request reprint Loss of branched O-mannosyl glycans in astrocytes accelerates remyelination
    Kenji Kanekiyo
    Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN MAX Planck Joint Research Center for Systems Chemical Biology, Global Research Cluster, RIKEN, Saitama 351 0198, Japan
    J Neurosci 33:10037-47. 2013
    ....
  55. ncbi request reprint Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
    Bin Zhang
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 24:4657-67. 2004
    ....
  56. ncbi request reprint A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 102:2118-31. 2007
    ....
  57. ncbi request reprint Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam
    John Q Trojanowski
    The Center for Neurodegenerative Disease Research, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Exp Neurol 176:1-11. 2002
    ..Thus, tau Tg mice recapitulate key phenotypic features of ALS/PDC neuropathology in an ethnic minority on Guam, and these animal models provide new opportunities to discover novel therapies for this and related tauopathies...
  58. ncbi request reprint Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 25:9434-43. 2005
    ..We suggest that similar defects may also occur in sporadic and hereditary human tauopathies with OLG tau pathologies...
  59. ncbi request reprint 19F and 1H MRI detection of amyloid beta plaques in vivo
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako Shi, Saitoma 351 0198, Japan
    Nat Neurosci 8:527-33. 2005
    ..This approach could be used in longitudinal studies in mouse models of Alzheimer disease to search for biomarkers associated with amyloid beta pathology as well as to track disease course after treatment with candidate medications...
  60. ncbi request reprint Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 35:433-46. 2002
    ..Thus, tau-positive glial lesions similar to human FTDs occur in these Tg mice, and these pathologies are linked to glial and axonal degeneration...
  61. ncbi request reprint Tau and axonopathy in neurodegenerative disorders
    Makoto Higuchi
    Neuromolecular Med 2:131-50. 2002
    ....
  62. ncbi request reprint Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model
    Yasumasa Yoshiyama
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    J Neurotrauma 22:1134-41. 2005
    ..The reasons for the augmentation of tau pathologies in only one T44 tau Tg mouse subjected to mrTBI remain to be elucidated...
  63. ncbi request reprint Initiation and synergistic fibrillization of tau and alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine
    Science 300:636-40. 2003
    ..This suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases...
  64. ncbi request reprint Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein
    Jonathan B Macknin
    Smell and Taste Center, Department of Otorhinolaryngology Head and Neck Surgery, University of Pennsylvania School of Medicine, 5 Ravdin Building, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Brain Res 1000:174-8. 2004
    ..Future studies need to similarly assess other pathogenic markers, as well as their distribution within various sectors of the brain, to determine the specificity of this phenomenon...
  65. ncbi request reprint PPARalpha protects proximal tubular cells from acute fatty acid toxicity
    Yuji Kamijo
    Department of Metabolic Regulation, Institute on Aging and Adaptation, Shinshu University School of Medicine, Matsumoto, Japan
    J Am Soc Nephrol 18:3089-100. 2007
  66. ncbi request reprint Relationship between effluent levels of beta(2)-microglobulin and peritoneal injury markers in 7.5% icodextrin-based peritoneal dialysis solution
    Satoshi Minami
    Department of Internal Medicine, Division of Nephrology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan
    Ther Apher Dial 11:296-300. 2007
    ..We propose that the subclinical injury of the peritoneum by ICO treatment may accelerate peritoneal permeability to increase beta(2)MG in effluent. ICO's biocompatibility might not be superior to that of glucose-based solution...
  67. ncbi request reprint Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model
    Yasumasa Yoshiyama
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Neuron 53:337-51. 2007
    ..Thus, hippocampal synaptic pathology and microgliosis may be the earliest manifestations of neurodegenerative tauopathies, and abrogation of tau-induced microglial activation could retard progression of these disorders...
  68. ncbi request reprint Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice
    Runa Araya
    Yamada Research Unit, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neurobiol Dis 24:334-44. 2006
    ..The M5 receptor may represent an attractive novel therapeutic target to ameliorate memory deficits caused by impaired cerebrovascular function...
  69. ncbi request reprint Neprilysin-sensitive synapse-associated amyloid-beta peptide oligomers impair neuronal plasticity and cognitive function
    Shu Ming Huang
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 281:17941-51. 2006
    ..This supports the idea that a strategy to reduce Abeta oligomers in the brain by up-regulating neprilysin activity would contribute to alleviation of these symptoms...
  70. ncbi request reprint Fluoro-substituted and 13C-labeled styrylbenzene derivatives for detecting brain amyloid plaques
    Kumi Sato
    Dojindo Laboratories, Tabaru 2025 5, Mashiki machi, Kumamoto 861 2202, Japan
    Eur J Med Chem 39:573-8. 2004
    ..Because of the possession of a nuclide with a quantized angular momentum, both FSB and [(13)C]BSB are also potential contrast agents for magnetic resonance imaging to locate AD pathologies in vivo...
  71. ncbi request reprint Understanding molecular mechanisms of proteolysis in Alzheimer's disease: progress toward therapeutic interventions
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Biochim Biophys Acta 1751:60-7. 2005
    ....
  72. ncbi request reprint Distinct mechanistic roles of calpain and caspase activation in neurodegeneration as revealed in mice overexpressing their specific inhibitors
    Makoto Higuchi
    Laboratory for Proteolytic Neuroscience, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan
    J Biol Chem 280:15229-37. 2005
    ....
  73. ncbi request reprint Calpain mediates excitotoxic DNA fragmentation via mitochondrial pathways in adult brains: evidence from calpastatin mutant mice
    Jiro Takano
    Laboratories for Proteolytic Neuroscience and Behavioral Genetics, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    J Biol Chem 280:16175-84. 2005
    ..These mutant mice will serve as useful tools for investigating calpain involvement in various diseases...
  74. ncbi request reprint [Therapeutic strategy by manipulating some protease activities for Alzheimer's disease]
    Nobuhisa Iwata
    Nihon Yakurigaku Zasshi 131:320-5. 2008