R Hashimoto

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi request reprint Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 111:217-21. 2004
  2. ncbi request reprint The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder
    Ryota Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Biol Psychiatry 57:1097-102. 2005
  3. ncbi request reprint A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
    T Okada
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Psychiatry 11:695-703. 2006
  4. ncbi request reprint Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 112:303-7. 2005
  5. ncbi request reprint Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
    H Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 113:1569-73. 2006
  6. ncbi request reprint Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 13:2699-708. 2004
  7. ncbi request reprint The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology
    Kiyotaka Nemoto
    Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Neurosci Lett 397:25-9. 2006
  8. ncbi request reprint Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder
    K Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology, and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Neuropsychobiology 50:206-10. 2004
  9. ncbi request reprint The Gem interacting protein (GMIP) gene is associated with major depressive disorder
    Kazuyuki Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Neurogenetics 6:127-33. 2005
  10. ncbi request reprint A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 129:44-6. 2004

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Association analysis of the -308G>A promoter polymorphism of the tumor necrosis factor alpha (TNF-alpha) gene in Japanese patients with schizophrenia
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 111:217-21. 2004
    ..We conclude that the effect of the -308G > A polymorphism on the development of schizophrenia is, if any, weak and the majority of Japanese schizophrenics are unrelated to the -308G > A polymorphism of the TNF-alpha gene...
  2. ncbi request reprint The breakpoint cluster region gene on chromosome 22q11 is associated with bipolar disorder
    Ryota Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Biol Psychiatry 57:1097-102. 2005
    ..The BCR gene encodes a Rho GTPase activating protein, which is known to play important roles in neurite growth and axonal guidance...
  3. ncbi request reprint A complex polymorphic region in the brain-derived neurotrophic factor (BDNF) gene confers susceptibility to bipolar disorder and affects transcriptional activity
    T Okada
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    Mol Psychiatry 11:695-703. 2006
    ..Our results suggest that the BDNF-LCPR is a functional variation that confers susceptibility to bipolar disorder and affects transcriptional activity of the BDNF gene...
  4. ncbi request reprint Association study of the frizzled-3 (FZD3) gene with schizophrenia and mood disorders
    R Hashimoto
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 112:303-7. 2005
    ..We failed to find significant association in the four SNPs or haplotype analysis. The FZD3 gene might not play a role in conferring susceptibility to major psychosis in our sample...
  5. ncbi request reprint Possible association between nonsynonymous polymorphisms of the anaplastic lymphoma kinase (ALK) gene and schizophrenia in a Japanese population
    H Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neural Transm 113:1569-73. 2006
    ..0064, odds ratio 2.4, 95% CI 1.3-4.6). These results suggest that genetic variations of the ALK gene might confer susceptibility to schizophrenia...
  6. ncbi request reprint Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashicho, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 13:2699-708. 2004
    ..Genetic variants associated with impairments of these functions of dysbindin could play an important role in the pathogenesis of schizophrenia...
  7. ncbi request reprint The Val66Met polymorphism of the brain-derived neurotrophic factor gene affects age-related brain morphology
    Kiyotaka Nemoto
    Department of Radiology, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo 187 8551, Japan
    Neurosci Lett 397:25-9. 2006
    ..Furthermore, we suggest that genotype effects of the BDNF gene on brain morphology might differ in female from in male...
  8. ncbi request reprint Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder
    K Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology, and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Neuropsychobiology 50:206-10. 2004
    ..Although the polymorphic region may have an enhancer-like effect on transcriptional activity, we obtained no evidence for allele-dependent differential effects...
  9. ncbi request reprint The Gem interacting protein (GMIP) gene is associated with major depressive disorder
    Kazuyuki Tadokoro
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187 8502, Japan
    Neurogenetics 6:127-33. 2005
    ..Further study needs to be undertaken to validate the association between the GMIP gene and MDD...
  10. ncbi request reprint A missense polymorphism (S205L) of the low-affinity neurotrophin receptor p75NTR gene is associated with depressive disorder and attempted suicide
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, Tokyo, Japan
    Am J Med Genet B Neuropsychiatr Genet 129:44-6. 2004
    ..Our results suggest that the S205L polymorphism of the p75NTR gene is involved in the pathogenesis of depressive disorder and suicidal behavior...
  11. ncbi request reprint No association between the Val66Met polymorphism of the brain-derived neurotrophic factor gene and bipolar disorder in a Japanese population: a multicenter study
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Biol Psychiatry 56:376-8. 2004
    ....
  12. ncbi request reprint Neuronal roles of the integrin-associated protein (IAP/CD47) in developing cortical neurons
    Tadahiro Numakawa
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry of Japan, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    J Biol Chem 279:43245-53. 2004
    ..These observations suggest that the IAP plays important roles in dendritic outgrowth and synaptic transmission in developing cortical neurons through the activation of MAPK...
  13. ncbi request reprint Prepulse inhibition of acoustic startle in Japanese patients with chronic schizophrenia
    Hiroshi Kunugi
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Res 59:23-8. 2007
    ..Our results confirm impaired PPI in chronic schizophrenia patients compared with controls in Japanese...
  14. ncbi request reprint The association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and morphological abnormalities of the brain in chronic schizophrenia
    Takashi Ohnishi
    Department of Radiology, National Center Hospital of Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Kodaira City, Tokyo, Japan
    Brain 129:399-410. 2006
    ..Our findings suggest that the Val158Met polymorphism of the COMT gene might contribute to morphological abnormalities in schizophrenia...
  15. ncbi request reprint Effect of antipsychotic drugs on DISC1 and dysbindin expression in mouse frontal cortex and hippocampus
    S Chiba
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan
    J Neural Transm 113:1337-46. 2006
    ..Our results also suggest a potential role of DISC1 in the therapeutic mechanisms of certain atypical antipsychotics...
  16. doi request reprint Personality in schizophrenia assessed with the Temperament and Character Inventory (TCI)
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Psychiatry Res 160:175-83. 2008
    ....
  17. ncbi request reprint Antipsychotic medication and cognitive function in schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Ogawahigashi, Kodaira, Tokyo, Japan
    Schizophr Res 86:138-46. 2006
    ..Alternatively, poorer cognitive function may be due in part to polypharmacy or excessive dosing. Further investigations are required to draw any conclusions...
  18. ncbi request reprint Enriched environments influence depression-related behavior in adult mice and the survival of newborn cells in their hippocampi
    Satoko Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Behav Brain Res 180:69-76. 2007
    ..Our results suggest that EE, which enhanced the survival of newborn neurons, shows beneficial effects on behavioral despair and habituation to a novel environment...
  19. doi request reprint Impairment of motor dexterity in schizophrenia assessed by a novel finger movement test
    Akira Midorikawa
    Department of Psychology, Chuo University, Tokyo, Japan
    Psychiatry Res 159:281-9. 2008
    ..The present results suggest that impairment in motor dexterity is a major characteristic of schizophrenia, which might be independent of cognitive functions...
  20. ncbi request reprint Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging
    Takeyuki Mori
    Department of Radiology, National Center Hospital for Mental, Nervous, and Muscular Disorders, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira City, Tokyo, 187 8551, Japan
    Psychiatry Res 154:133-45. 2007
    ..Our data confirmed decreased FA in schizophrenics, compared to controls in the widespread WM areas. Such decreased FA values in schizophrenia might be attributable, at least in part, to progressive changes after the onset of the illness...
  21. doi request reprint Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia
    Satoko Hattori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem Biophys Res Commun 373:298-302. 2008
    ..These findings indicate that sdy mice display a number of behavioral abnormalities associated with schizophrenia and suggest that these abnormalities may be mediated by reductions in forebrain dopamine transmission...
  22. doi request reprint IQ decline and memory impairment in Japanese patients with chronic schizophrenia
    Hiroaki Hori
    Department of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1, Ogawahigashi, Kodaira, Tokyo, 187 8502, Japan
    Psychiatry Res 158:251-5. 2008
    ..Our results suggest that schizophrenia patients experience marked IQ decline due to the development of illness and their wide-ranging memory impairments are even more severe than the IQ decline...
  23. ncbi request reprint A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats
    Kyung Won Hong
    The United Graduate School of Agricultural Science, Gifu University, Gifu 501 1193, Japan
    Neurosci Lett 412:195-200. 2007
    ..001), indicating the importance of substitutions in other regions. Our findings on the chimpanzee SNP will be a useful genetic marker in understanding the individual difference in the serotonin-related behavior...
  24. ncbi request reprint A possible association between the -116C/G single nucleotide polymorphism of the XBP1 gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Neuropsychopharmacol 9:83-8. 2006
    ..The association between the -116C/G polymorphism and clinical efficacy of mood stabilizers should be further investigated in a prospective study with a larger sample...
  25. ncbi request reprint Gene expression in the peripheral leukocytes and association analysis of PDLIM5 gene in schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho, Tokushima 770 8503, Japan
    Neurosci Lett 415:28-33. 2007
    ..48), either. We suggest that the higher expression levels of the PDLIM5 mRNA in the peripheral leukocytes may be a candidate marker for medication-free schizophrenic patients...
  26. ncbi request reprint TGFBR2 gene expression and genetic association with schizophrenia
    Shusuke Numata
    Department of Psychiatry, Course of Integrated Brain Sciences, Medical Informatics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 8 15 Kuramoto cho Tokushima 770 8503, Japan
    J Psychiatr Res 42:425-32. 2008
    ..Our results suggest that the TGFBR2 gene itself does not link to schizophrenia but that the TGFBR2 mRNA levels in the peripheral leukocytes may be a potential state marker for schizophrenia...
  27. ncbi request reprint A possible association between missense polymorphism of the breakpoint cluster region gene and lithium prophylaxis in bipolar disorder
    Takuya Masui
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Kita 15 Nishi 7, Kita ku, Sapporo, 060 8638, Hokkaido, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:204-8. 2008
    ..We found that the allele frequency of Ser796 was significantly higher in non-responders than in responders. Further investigation is warranted to confirm our findings...
  28. ncbi request reprint A possible association between the Val158Met polymorphism of the catechol-O-methyl transferase gene and the personality trait of harm avoidance in Japanese healthy subjects
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Lett 428:17-20. 2007
    ..These results suggest that the Val/Met polymorphism of the COMT gene may play a role in HA in Japanese population...
  29. doi request reprint No association between the NDE1 gene and schizophrenia in the Japanese population
    Shusuke Numata
    Schizophr Res 99:367-9. 2008
  30. doi request reprint Failure to replicate the association between NRG1 and schizophrenia using Japanese large sample
    Masashi Ikeda
    Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan
    Schizophr Res 101:1-8. 2008
    ..Moreover, the nature of our results support that two-stage analysis with large sample size is appropriate to examine the susceptibility genes for common diseases...
  31. ncbi request reprint Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity
    Ryota Hashimoto
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Neuropharmacology 43:1173-9. 2002
    ..Taken together, these data suggest that the BDNF/TrkB pathway plays an essential role in mediating the neuroprotective effect of lithium...
  32. ncbi request reprint Neuroprotective effects of lithium in cultured cells and animal models of diseases
    De Maw Chuang
    Section on Molecular Neurobiology, Mood and Anxiety Disorder Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Bipolar Disord 4:129-36. 2002
    ..Our results suggest that lithium might have utility in the treatment of neurodegenerative disorders in addition to its common use for the treatment of bipolar depressive patients...
  33. ncbi request reprint Impact of the DISC1 Ser704Cys polymorphism on risk for major depression, brain morphology and ERK signaling
    Ryota Hashimoto
    Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, D3, 2 2 Yamadaoka, 4 1 1 Suita, Osaka 565 0871, Japan
    Hum Mol Genet 15:3024-33. 2006
    ..A possible biological mechanism of MDD might be implicated by these convergent data that Cys704 DISC1 is associated with the lower biological activity on ERK signaling, reduced brain gray matter volume and an increased risk for MDD...
  34. ncbi request reprint Relationship between XBP1 genotype and personality traits assessed by TCI and NEO-FFI
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo, Hokkaido 060 8638, Japan
    Neurosci Lett 391:7-10. 2005
    ..Further investigations are necessary to examine the relationship in patients with bipolar disorder, or use full version of various self-rating personality assessments...
  35. ncbi request reprint Lithium response and Val66Met polymorphism of the brain-derived neurotrophic factor gene in Japanese patients with bipolar disorder
    Takuya Masui
    Psychiatr Genet 16:49-50. 2006
    ..Our results suggested that the brain-derived neurotrophic factor Val66Met polymorphism might not greatly contribute to the efficacy of lithium in bipolar disorder...
  36. ncbi request reprint Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain
    Cynthia Shannon Weickert
    Clinical Brain Disorders Branch, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Arch Gen Psychiatry 61:544-55. 2004
    ..3) encodes a neuronal protein that binds to beta-dystrobrevin and may be part of the dystrophin protein complex. Little is known about dysbindin expression in normal or schizophrenic brain...
  37. ncbi request reprint Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation
    Ryota Hashimoto
    Section on Molecular Neurobiology, Mood and Anxiety Disorder Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892 1363, USA
    J Neurochem 80:589-97. 2002
    ..This action could also be relevant to its clinical efficacy for bipolar patients...
  38. pmc Genomewide high-density SNP linkage analysis of 236 Japanese families supports the existence of schizophrenia susceptibility loci on chromosomes 1p, 14q, and 20p
    Tadao Arinami
    Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki Ken, 305 8577, Japan
    Am J Hum Genet 77:937-44. 2005
    ....
  39. ncbi request reprint Lack of association between XBP1 genotype and calcium signaling in the platelets of healthy subjects
    Ichiro Kusumi
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, North 15, West 7, Sapporo 060 8638, Japan
    Neurosci Lett 369:1-3. 2004
    ..Further investigations are necessary to examine the relationship in the different peripheral blood cells and/or in larger samples from patients with bipolar disorder...
  40. pmc Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease
    Amanda J Law
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, United Kingdom
    Proc Natl Acad Sci U S A 103:6747-52. 2006
    ..These data implicate variation in isoform expression as a molecular mechanism for the genetic association of NRG1 with schizophrenia...
  41. ncbi request reprint A missense polymorphism (H204R) of a Rho GTPase-activating protein, the chimerin 2 gene, is associated with schizophrenia in men
    Ryota Hashimoto
    Schizophr Res 73:383-5. 2005
  42. ncbi request reprint Identification and characterization of coding single-nucleotide polymorphisms within human protocadherin-alpha and -beta gene clusters
    Rie Miki
    KOKORO Biology Group, Laboratories for Integrated Biology, Graduate School of Frontier Biosciences, Osaka University, Yamadaoka 1 3, Suita 565 0871, Japan
    Gene 349:1-14. 2005
    ..These gene conversions were caused by the unequal crossing-over of homologous sequence regions. Thus, nonsynonymous variations in the Pcdh-alpha and -beta genes are possible contributors to the variations in human brain function...
  43. doi request reprint No association between tagging SNPs of SNARE complex genes (STX1A, VAMP2 and SNAP25) and schizophrenia in a Japanese population
    Kunihiro Kawashima
    Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Am J Med Genet B Neuropsychiatr Genet 147:1327-31. 2008
    ..However, these associations could not be confirmed in the second-set analysis. These results suggest that the SNARE complex-related genes do not play a major role in susceptibility to schizophrenia in the Japanese population...
  44. doi request reprint Dynamin 2 gene is a novel susceptibility gene for late-onset Alzheimer disease in non-APOE-epsilon4 carriers
    Nuripa Jenishbekovna Aidaralieva
    Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    J Hum Genet 53:296-302. 2008
    ..We propose that the DNM2 gene is a novel susceptibility gene for LOAD...
  45. ncbi request reprint Discrepancy of performance among working memory-related tasks in autism spectrum disorders was caused by task characteristics, apart from working memory, which could interfere with task execution
    Takayuki Nakahachi
    Department of Clinical Neuroscience, Osaka University Graduate School of Medicine, Osaka Second Police Hospital, Suita, Osaka, Japan
    Psychiatry Clin Neurosci 60:312-8. 2006
    ..Therefore, to evaluate working memory in ASD, tasks that could stimulate psychopathology specific to ASD should be avoided...
  46. ncbi request reprint Postsynaptic density: a key convergent site for schizophrenia susceptibility factors and possible target for drug development
    Ryota Hashimoto
    The Osaka Hamamatsu Joint Research Center for Child Mental Development, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Drugs Today (Barc) 43:645-54. 2007
    ..PSD may be a promising target for novel classes of drugs to treat schizophrenia...
  47. ncbi request reprint Hyperactivation of midbrain dopaminergic system in schizophrenia could be attributed to the down-regulation of dysbindin
    Natsuko Kumamoto
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 345:904-9. 2006
    ..These data suggest that dysbindin might regulate the dopamine release of the dopaminergic system via modulation of the expression of SNAP25...
  48. ncbi request reprint The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease
    Ryo Kimura
    Department of Psychiatry, Osaka University Graduate School of Medicine, 2 2 D3 Yamadaoka, Suita, Osaka 565 0871, Japan
    Hum Mol Genet 16:15-23. 2007
    ..Our result indicates that DYRK1A could be a key molecule bridging between beta-amyloid production and tau phosphorylation in AD...
  49. ncbi request reprint Psychostimulant-induced attenuation of hyperactivity and prepulse inhibition deficits in Adcyap1-deficient mice
    Kazuhiro Tanaka
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5091-7. 2006
    ....
  50. ncbi request reprint [Neuroprotective actions of lithium]
    Ryota Hashimoto
    Seishin Shinkeigaku Zasshi 105:81-6. 2003
    ..Clearly, mood-stabilizers may have expanded use for treating excitotoxin-related neurodegenerative diseases...
  51. ncbi request reprint High dopamine turnover in the brains of Sandy mice
    Tomotaka Murotani
    Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, 1 7 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neurosci Lett 421:47-51. 2007
    ..These data demonstrate that DA turnover in the specific regions of the brain of the Sdy mouse was increased, and the Sdy mouse is a possible useful candidate animal for studying the pathogenic mechanism of schizophrenia...
  52. ncbi request reprint Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition
    Mi Ra Jeong
    Molecular Neurobiology Section, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 4C 206, 10 Center Dr MSC 1363, Bethesda, MD 20892 1363, USA
    FEBS Lett 542:74-8. 2003
    ..Our results suggest a role of histone deacetylase inhibition in mediating the neuroprotective action of VPA...
  53. ncbi request reprint Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity
    Ryota Hashimoto
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bldg 10, Rm 4C 206, 10 Center Dr MSC 1363, Bethesda, MD 20892 1363, USA
    FEBS Lett 538:145-8. 2003
    ..Our results suggest that lithium-induced inactivation of Src kinase contributes to this drug-induced NMDA receptor inhibition and neuroprotection against excitotoxicity...
  54. ncbi request reprint [Nerve-protective action of lithium]
    Ryota Hashimoto
    Seishin Shinkeigaku Zasshi 106:526-8. 2004
  55. doi request reprint Microarray comparative genomic hybridization analysis of 59 patients with schizophrenia
    Takeshi Mizuguchi
    Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, 236 0004, Japan
    J Hum Genet 53:914-9. 2008
    ..It is noteworthy that 10% of patients with schizophrenia have (sub)microscopic chromosomal abnormalities, indicating that genome-wide copy number survey should be considered in genetic studies of schizophrenia...