Tadashi Hasegawa

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma
    T Hasegawa
    Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Oncology 58:66-74. 2000
  2. ncbi request reprint Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 50:731-8. 2000
  3. ncbi request reprint Adult neuroblastoma of the retroperitoneum and abdomen: clinicopathologic distinction from primitive neuroectodermal tumor
    T Hasegawa
    Department of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Am J Surg Pathol 25:918-24. 2001
  4. ncbi request reprint Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Mod Pathol 14:655-63. 2001
  5. ncbi request reprint Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk
    Tadashi Hasegawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 95:843-51. 2002
  6. ncbi request reprint Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract
    Umio Yamaguchi
    Divisions of Orthopedic Oncology and Pathology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 14:46-51. 2006
  7. pmc Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Cancer Diagnosis Laboratory, Japan Science and Technology Agency Innovation Plaza Hokkaido, Japan Science and Technology Agency, Kita ku, Sapporo, Japan
    PLoS ONE 8:e69095. 2013
  8. ncbi request reprint Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors
    Ukihide Tateishi
    Division of Diagnostic Radiology, Pathology, Orthopedics, and Thoracic Surgery, National Cancer Center Hospital and Institute, 5 1 1, Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Radiographics 23:1491-508. 2003
  9. doi request reprint Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities
    Daisuke Kubota
    Division of Pharmacoproteomics, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 41:1194-202. 2011
  10. ncbi request reprint Expression and function of FERMT genes in colon carcinoma cells
    Kenji Kiriyama
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Anticancer Res 33:167-73. 2013

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma
    T Hasegawa
    Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Oncology 58:66-74. 2000
    ....
  2. ncbi request reprint Angiomatoid (malignant) fibrous histiocytoma: a peculiar low-grade tumor showing immunophenotypic heterogeneity and ultrastructural variations
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Pathol Int 50:731-8. 2000
    ....
  3. ncbi request reprint Adult neuroblastoma of the retroperitoneum and abdomen: clinicopathologic distinction from primitive neuroectodermal tumor
    T Hasegawa
    Department of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Am J Surg Pathol 25:918-24. 2001
    ..Appropriate immunohistochemical studies and laboratory examination enable pathologists to distinguish ANB from other differential diagnoses, especially PNET...
  4. ncbi request reprint Proximal-type epithelioid sarcoma: a clinicopathologic study of 20 cases
    T Hasegawa
    Pathology Division, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Mod Pathol 14:655-63. 2001
    ..These tumors, when arising in proximal locations, have a much worse prognosis than those arising in distal locations...
  5. ncbi request reprint Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk
    Tadashi Hasegawa
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 95:843-51. 2002
    ..The predictive value of histologic grading and staging systems for overall survival in different types of adult soft tissue sarcoma of the extremities and trunk is unclear...
  6. ncbi request reprint Interobserver variability in histologic recognition, interpretation of KIT immunostaining, and determining MIB-1 labeling indices in gastrointestinal stromal tumors and other spindle cell tumors of the gastrointestinal tract
    Umio Yamaguchi
    Divisions of Orthopedic Oncology and Pathology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 14:46-51. 2006
    ....
  7. pmc Ectopically expressed variant form of sperm mitochondria-associated cysteine-rich protein augments tumorigenicity of the stem cell population of lung adenocarcinoma cells
    Akari Takahashi
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan Cancer Diagnosis Laboratory, Japan Science and Technology Agency Innovation Plaza Hokkaido, Japan Science and Technology Agency, Kita ku, Sapporo, Japan
    PLoS ONE 8:e69095. 2013
    ....
  8. ncbi request reprint Chest wall tumors: radiologic findings and pathologic correlation: part 2. Malignant tumors
    Ukihide Tateishi
    Division of Diagnostic Radiology, Pathology, Orthopedics, and Thoracic Surgery, National Cancer Center Hospital and Institute, 5 1 1, Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Radiographics 23:1491-508. 2003
    ..The article reviews the clinical and imaging features of the most common malignant chest wall tumors and presents images collected at a single cancer referral center...
  9. doi request reprint Pfetin as a prognostic biomarker for gastrointestinal stromal tumor: validation study in multiple clinical facilities
    Daisuke Kubota
    Division of Pharmacoproteomics, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 41:1194-202. 2011
    ..There is no biomarker predicting metastasis and/or recurrence of gastrointestinal stromal tumor though imatinib mesylate can improve recurrence-free survival...
  10. ncbi request reprint Expression and function of FERMT genes in colon carcinoma cells
    Kenji Kiriyama
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Anticancer Res 33:167-73. 2013
    ..These findings indicate that FERMT1 is a potential molecular target for cancer therapy...
  11. doi request reprint Pfetin as a prognostic biomarker of gastrointestinal stromal tumors revealed by proteomics
    Yoshiyuki Suehara
    Proteome Bioinformatics Project, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 14:1707-17. 2008
    ..We aimed to develop prognostic biomarkers for gastrointestinal stromal tumors (GIST) using a proteomic approach...
  12. doi request reprint Pfetin as a prognostic biomarker in gastrointestinal stromal tumor: novel monoclonal antibody and external validation study in multiple clinical facilities
    Kazutaka Kikuta
    Proteome Bioinformatics Project, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 40:60-72. 2010
    ..To develop prognostic modalities for GIST patients, we developed a mouse monoclonal antibody against pfetin, the prognostic value of which has been previously reported...
  13. ncbi request reprint Gene expression analysis of soft tissue sarcomas: characterization and reclassification of malignant fibrous histiocytoma
    Robert Nakayama
    Cancer Transcriptome Project, National Cancer Center Research Institute, Tokyo, Japan
    Mod Pathol 20:749-59. 2007
    ..Taken together, gene expression profiling could be a useful tool to unveil the difference in the underlying molecular backgrounds, which leads to a rational taxonomy and diagnosis of a diverse group of soft tissue sarcomas...
  14. doi request reprint Cep55/c10orf3, a tumor antigen derived from a centrosome residing protein in breast carcinoma
    Satoko Inoda
    Department of Pathology, Sapporo Medical University, School of Medicine, Chuo Ku, Sapporo, Japan
    J Immunother 32:474-85. 2009
    ..Monoclonal antibody # 11-55 and the Cep55/c10orf3_193(10) peptides may be useful as part of a therapeutic strategy for hormonal therapy or anti-p185 HER2/neu monoclonal antibody therapy-resistant breast carcinoma patients...
  15. doi request reprint SOX2 is overexpressed in stem-like cells of human lung adenocarcinoma and augments the tumorigenicity
    Munehide Nakatsugawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Lab Invest 91:1796-804. 2011
    ..These observations indicate that SOX2 has a role in maintenance of stemness and tumorigenicity of human lung adenocarcinoma CSCs/CICs and is a potential target for treatment...
  16. ncbi request reprint Distinct gene expression-defined classes of gastrointestinal stromal tumor
    Umio Yamaguchi
    Chemotherapy Division and Cancer Proteomics Project, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    J Clin Oncol 26:4100-8. 2008
    ..GISTs are considered to invariably arise through gain of function KIT or PDGFA mutation of the interstitial cells of Cajal (ICC). However, the genetic basis of the malignant progression of GISTs are poorly understood...
  17. doi request reprint Immunohistochemical expression of HER1, HER3, and HER4 in HER2-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy
    Kan Yonemori
    Breast and Medical Oncology Division, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    J Surg Oncol 101:222-7. 2010
    ....
  18. doi request reprint Contrasting prognostic implications of platelet-derived growth factor receptor-β and vascular endothelial growth factor receptor-2 in patients with angiosarcoma
    Kan Yonemori
    Department of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Ann Surg Oncol 18:2841-50. 2011
    ....
  19. doi request reprint Gene expression profiling of synovial sarcoma: distinct signature of poorly differentiated type
    Robert Nakayama
    Genetics Division, National Cancer Center Research Institute, Keio University School of Medicine, Tokyo, Japan
    Am J Surg Pathol 34:1599-607. 2010
    ..Our results indicate that PDSS tumors constitute a distinct group based on expression profiles...
  20. doi request reprint DNA methyltransferase 1 is essential for initiation of the colon cancers
    Rena Morita
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Mol Pathol 94:322-9. 2013
    ..Taken together, these results indicate that DNMT1 is essential for maintenance of colon CSCs/CICs and that short-term suppression of DNMT1 might be sufficient to disrupt CSCs/CICs...
  21. pmc Cytotoxic T lymphocytes efficiently recognize human colon cancer stem-like cells
    Satoko Inoda
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Am J Pathol 178:1805-13. 2011
    ..These observations suggest that Cep55/c10orf3_193(10) peptide-based cancer vaccine therapy or adoptive cell transfer of the CTL clone is a possible approach for targeting chemotherapy-resistant colon CSCs/TICs...
  22. ncbi request reprint Cytogenetic confirmation of a gastrointestinal stromal tumor and ewing sarcoma/primitive neuroectodermal tumor in a single patient
    Shunsuke Kondo
    Divison of Medical Oncology, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 35:753-6. 2005
    ..Although the cytogenetic correlations of these two tumors are unclear, accurate histologic recognition is of clinical importance because the treatments for these two tumors differ...
  23. ncbi request reprint F-18 fluorodeoxyglucose positron emission tomography finding of Mazabraud syndrome
    Mototaka Miyake
    Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    Clin Nucl Med 31:627-9. 2006
  24. pmc Utility of immunohistochemical analysis for cyclo-oxygenase 2 in the differential diagnosis of osteoblastoma and osteosarcoma
    Ako Hosono
    Division of Paediatric Oncology, National Cancer Center Hospital, Tokyo, Japan
    J Clin Pathol 60:410-4. 2007
    ..To study the immunoexpression of cyclo-oxygenase (COX) 2 in osteoblastomas (OBs) and osteosarcomas (OSs), and to assess the utility of immunohistochemical analysis for COX 2 in the differential diagnosis of the two tumour forms...
  25. ncbi request reprint Cyclooxygenase-2 overexpression associated with a poor prognosis in chondrosarcomas
    Makoto Endo
    Division of Orthopaedic Oncology, National Cancer Centre Hospital, Tokyo, Japan
    Hum Pathol 37:471-6. 2006
    ..001) and a decreased disease-specific survival (P < .001). These findings suggest that COX-2 overexpression in chondrosarcoma is a negative prognostic factor that may be strongly associated with histologic grade...
  26. doi request reprint The feasibility of Cep55/c10orf3 derived peptide vaccine therapy for colorectal carcinoma
    Satoko Inoda
    Department of Pathology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Mol Pathol 90:55-60. 2011
    ..Thus, these peptide vaccination peptide mixture of Cep55/c10orf3_193(10), Cep55/c10orf3_402(11) and Cep55/c10orf3_283(12) might be more effective than a single peptide in the treatment of colorectal carcinoma patients...
  27. ncbi request reprint A case of ganglioneuroma presenting abnormal FDG uptake
    Mototaka Miyake
    Division of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, Tokyo, Japan
    Ann Nucl Med 20:357-60. 2006
    ..Pathological investigation may be needed to differentiate ganglioneuroma from other malignant tumors and, therefore, FDG-PET/CT findings can be helpful for biopsy planning...
  28. ncbi request reprint Disease activity and 18F-FDG uptake in organising pneumonia: semi-quantitative evaluation using computed tomography and positron emission tomography
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 33:906-12. 2006
    ..The present study was conducted to evaluate whether( 18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in combination with computed tomography (CT) reflects disease activity in patients with organising pneumonia...
  29. pmc Macrophage migration inhibitory factor and stearoyl-CoA desaturase 1: potential prognostic markers for soft tissue sarcomas based on bioinformatics analyses
    Hiro Takahashi
    Graduate School of Horticulture, Chiba University, Matsudo, Chiba, Japan Graduate School of Bioscience and Biotechnology, Chubu University, Kasugai, Aichi, Japan Plant Biology Research Center, Chubu University, Kasugai, Aichi, Japan Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
    PLoS ONE 8:e78250. 2013
    ..Furthermore, in vitro cell growth inhibition experiments by MIF and SCD1 inhibitors support the hypothesis. These results suggest that the gene set is useful as a prognostic marker associated with tumor progression. ..
  30. ncbi request reprint HSP DNAJB8 controls tumor-initiating ability in renal cancer stem-like cells
    Satoshi Nishizawa
    Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Cancer Res 72:2844-54. 2012
    ..Together, our findings suggest that DNAJB8 plays a role in CSC maintenance and that it offers a candidate for CSC-targeting immunotherapy in RCC...
  31. ncbi request reprint Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis
    Umio Yamaguchi
    Divisions of Orthopaedic Oncology, Pathology and Clinical Laboratory, National Cancer Centre Hospital and Research Institute, Tokyo, Japan
    Virchows Arch 445:142-50. 2004
    ....
  32. ncbi request reprint The value of MDM2 and CDK4 amplification levels using real-time polymerase chain reaction for the differential diagnosis of liposarcomas and their histologic mimickers
    Shio Shimada
    Department of Pathology, Saitama Medical University School of Medicine, Saitama 350 0495, Japan
    Hum Pathol 37:1123-9. 2006
    ..An analysis of MDM2 and CDK4 amplification using real-time PCR, as well as FISH, is useful for the differential diagnosis of liposarcomas and their histologic mimickers...
  33. ncbi request reprint Diaphyseal medullary stenosis with pleomorphic malignant fibrous histiocytoma of the bone: 99mTc hydroxymethylenediphosphonate and 201Tl chloride scintigraphy findings
    Mototaka Miyake
    Division of Diagnostic Radiology and Nuclear Medicinea, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    Ann Nucl Med 20:233-6. 2006
    ..The mechanism of the uptake of 99mTc HMDP to the extraosseous lesion was not clear. On 201Tl chloride scintigraphy, the increased uptake of the periphery of the mass seemed to reflect the aggressiveness of invasion and the cellularity...
  34. ncbi request reprint Glut-1 expression and enhanced glucose metabolism are associated with tumour grade in bone and soft tissue sarcomas: a prospective evaluation by [18F]fluorodeoxyglucose positron emission tomography
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 33:683-91. 2006
    ....
  35. ncbi request reprint Proteomic signatures corresponding to histological classification and grading of soft-tissue sarcomas
    Yoshiyuki Suehara
    Proteome Bioinformatics Project, National Cancer Center Research Institute, Tokyo, Japan
    Proteomics 6:4402-9. 2006
    ....
  36. ncbi request reprint Gastrointestinal stromal tumor: consistent CD117 immunostaining for diagnosis, and prognostic classification based on tumor size and MIB-1 grade
    Tadashi Hasegawa
    Pathology and Clinical Laboratory Divisions, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Hum Pathol 33:669-76. 2002
    ....
  37. ncbi request reprint Gastrointestinal stromal tumor. Correlation of computed tomography findings with tumor grade and mortality
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Institute, Tokyo, Japan
    J Comput Assist Tomogr 27:792-8. 2003
    ..To assess computed tomography (CT) findings to assist in the distinction of low- and high-grade gastrointestinal stromal tumors (GISTs) and to estimate their relative risk (RR) for mortality...
  38. ncbi request reprint Primary dedifferentiated liposarcoma of the retroperitoneum. Prognostic significance of computed tomography and magnetic resonance imaging features
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    J Comput Assist Tomogr 27:799-804. 2003
    ..To describe computed tomography (CT) and magnetic resonance (MR) imaging findings and to determine the prognostic significance of radiologic appearances in primary dedifferentiated liposarcoma of the retroperitoneum...
  39. ncbi request reprint Chest wall tumors: radiologic findings and pathologic correlation: part 1. Benign tumors
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Institute, 5 1 1, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Radiographics 23:1477-90. 2003
    ..Both aneurysmal bone cysts and giant cell tumors typically manifest as expansile osteolytic lesions and occasionally show fluid-fluid levels suggestive of diagnosis...
  40. doi request reprint Malignant pulmonary epithelioid hemangioendothelioma with hilar lymph node metastasis
    Naobumi Tochigi
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Ann Diagn Pathol 15:207-12. 2011
    ....
  41. ncbi request reprint Primary retroperitoneal spindle cell liposarcoma: pathological and immunohistochemical findings
    Yoshihiro Shioi
    Division of Molecular Diagnostic Pathology, Department of Pathology, Iwate Medical University School of Medicine, Uchimaru, Morioka, Japan
    Pathol Int 60:472-6. 2010
    ..Accumulation of cases of SCLS is necessary to facilitate a more accurate evaluation of the pathology and clinical behavior of this tumor...
  42. ncbi request reprint Expression of insulin-like growth factor 1 receptor in primary breast cancer: immunohistochemical analysis
    Chikako Shimizu
    Department of Medical Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Hum Pathol 35:1537-42. 2004
    ..Though its prognostic value in breast cancer is limited, immunohistochemical evaluation of IGF-1R by using this monoclonal antibody may be useful in translational research using archived material...
  43. doi request reprint Secernin-1 as a novel prognostic biomarker candidate of synovial sarcoma revealed by proteomics
    Yoshiyuki Suehara
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Japan
    J Proteomics 74:829-42. 2011
    ..These results indicate that secernin-1 may be used as a biomarker to predict the overall and metastasis-free survival in synovial sarcoma patients...
  44. pmc Ovarian cancer stem cells are enriched in side population and aldehyde dehydrogenase bright overlapping population
    Kazuyo Yasuda
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    PLoS ONE 8:e68187. 2013
    ..Taken together, use of the SP and ALDH(Br) overlapping population is a promising approach to isolate highly purified CSCs/CICs and SOX2 might be a novel functional marker for ovarian CSCs/CICs. ..
  45. ncbi request reprint Quantitative immunohistochemical evaluation of MIB-1 labeling index in adult soft-tissue sarcomas by computer-assisted image analysis
    Tadashi Hasegawa
    Division of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Pathol Int 52:433-7. 2002
    ....
  46. ncbi request reprint Validity and reproducibility of histologic diagnosis and grading for adult soft-tissue sarcomas
    Tadashi Hasegawa
    Division of Pathology, National Cancer Center Research Institute and Hospital, Tokyo, Japan
    Hum Pathol 33:111-5. 2002
    ....
  47. ncbi request reprint Ossifying fibromyxoid tumor: invariable ultrastructural features and diverse immunophenotypic expression
    Takanori Hirose
    Department of Pathology, Saitama Medical School, Saitama, Japan
    Ultrastruct Pathol 31:233-9. 2007
    ..The salient and invariable ultrastructural features included reduplicated basal laminas, which seem to be crucial for the diagnosis...
  48. ncbi request reprint Bronchial granular cell tumor: a case presenting secondary obstructive changes on CT
    Mototaka Miyake
    Division of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, Tokyo, Japan
    Radiat Med 24:154-7. 2006
    ..Bronchial granular cell tumor is an uncommon benign tumor that causes pulmonary complications due to obstruction of the airways. We report a case presenting bronchial obstruction on high resolution (HR) computed tomography (CT)...
  49. ncbi request reprint Myxoinflammatory Fibroblastic Sarcoma: MR Appearance and Pathologic Correlation
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Institute, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    AJR Am J Roentgenol 184:1749-53. 2005
    ..This lesion manifests on MR images as a poorly circumscribed mass involving the underlying tendon sheath in the distal extremities...
  50. ncbi request reprint Alternating sequential chemotherapy with high-dose ifosfamide and doxorubicin/cyclophosphamide for adult non-small round cell soft tissue sarcomas
    Akira Kawai
    Division of Orthopaedic Surgery, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    J Orthop Sci 10:258-63. 2005
    ..Sequential administration of high-dose ifosfamide and doxorubicin/cyclophosphamide has promising activity with manageable side effects in patients with advanced adult non-small round cell soft tissue sarcomas...
  51. ncbi request reprint CT and MRI findings in KIT-weak or KIT-negative atypical gastrointestinal stromal tumors
    Ukihide Tateishi
    Division of Diagnostic Radiololgy and Nuclear Medicine, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Eur Radiol 16:1537-43. 2006
    ..Despite the relatively small number of patients CT and MRI findings of atypical GIST are a submucosal mass with soft tissue elements and cystic regions...
  52. ncbi request reprint MR features of angiosarcoma in a patient with Maffucci's syndrome
    Mototaka Miyake
    Division of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, Tokyo, Japan
    Radiat Med 23:508-12. 2005
    ..We report a rare case of Maffucci's syndrome with soft tissue angiosarcoma of the leg to illustrate MRI findings with pathologic correlations...
  53. doi request reprint A case of urothelial carcinoma, lipid cell variant
    Yui Kojima
    Department of Pathology, Sapporo Medical University, Sapporo, Japan
    Pathol Int 63:183-7. 2013
    ..This is the first report in which the presence of lipid in vacuoles of the lipid cell variant has been verified by immunohistochemistry...
  54. doi request reprint Detection of HEY1-NCOA2 fusion by fluorescence in-situ hybridization in formalin-fixed paraffin-embedded tissues as a possible diagnostic tool for mesenchymal chondrosarcoma
    Robert Nakayama
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Pathol Int 62:823-6. 2012
    ..The current study adds further support for the use of HEY1-NCOA2 fusion as a valid diagnostic marker for MC...
  55. doi request reprint High expression of ALDH1 and SOX2 diffuse staining pattern of oral squamous cell carcinomas correlates to lymph node metastasis
    Yoshitaka Michifuri
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Pathol Int 62:684-9. 2012
    ..These results indicate that high expression rates of ALDH1 and SOX2 diffuse staining patterns might be novel prediction markers for OSCC lymph node metastasis...
  56. ncbi request reprint Disruption of the blood brain barrier by brain metastases of triple-negative and basal-type breast cancer but not HER2/neu-positive breast cancer
    Kan Yonemori
    Breast and Medical Oncology Division, National Cancer Center Hospital, Tokyo, Japan
    Cancer 116:302-8. 2010
    ..Generally, the blood-brain barrier (BBB) of brain metastasis was thought to be disrupted...
  57. ncbi request reprint Novel spliced form of a lens protein as a novel lung cancer antigen, Lengsin splicing variant 4
    Munehide Nakatsugawa
    Department of Pathology, Sapporo Medical University School of Medicine, Chuo Ku, Sapporo, Japan
    Cancer Sci 100:1485-93. 2009
    ..Hence, Lengsin splicing variant 4 might be an immunogenic lung cancer-specific antigen that is suitable as a diagnostic marker and for molecular targeting therapy, including immunotherapy...
  58. ncbi request reprint Low-grade fibromyxoid sarcoma arising in the big toe
    Tomomi Kusumi
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki, Japan
    Pathol Int 55:802-6. 2005
    ..LGFMS may become more common with time, and unique cases may accumulate...
  59. ncbi request reprint Myxoid epithelioid gastrointestinal stromal tumor (GIST) with mast cell infiltrations: a subtype of GIST with mutations of platelet-derived growth factor receptor alpha gene
    Shinji Sakurai
    Department of Pathology, Jichi Medical School, Tochigi, Japan
    Hum Pathol 35:1223-30. 2004
    ....
  60. ncbi request reprint Inflammatory myofibroblastic tumor of the lung
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, 104 0045, Tokyo, Japan
    Eur J Cardiothorac Surg 25:155-9. 2004
    ..In this retrospective study, we reviewed clinicopathological characteristics and prognoses for all patients with surgically resected IMT of the lung at our institute...
  61. ncbi request reprint Malignant glomus tumor of the lung
    Tomoyuki Hishida
    Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 53:632-6. 2003
    ..We believe that this is the fourth reported case of malignant glomus tumor of the lung...
  62. ncbi request reprint Identification of 20 genes aberrantly methylated in human breast cancers
    Kazuaki Miyamoto
    Carcinogenesis Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Int J Cancer 116:407-14. 2005
    ..This may serve as markers for early-stage breast cancers and suggests that aberrant methylation targets transcriptionally inactive genes in vivo...
  63. ncbi request reprint Bizarre parosteal osteochondromatous proliferation with a t(1;17) translocation
    Makoto Endo
    Division of Orthopaedic Oncology, National Cancer Centre Hospital and Research Institute, Tokyo, Japan
    Virchows Arch 447:99-102. 2005
    ..These results suggest that t(1;17) is a distinct translocation of BPOP and that BPOP is a neoplastic lesion, rather than a reactive proliferative process...
  64. ncbi request reprint CD56-positive small round cell tumor: osseous plasmacytoma manifested in osteolytic tumors of the iliac bone and femora
    Tsutomu Kouno
    Hematology Division, National Cancer Center Hospital 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 35:90-3. 2005
    ..Locally infiltrating osteolytic bone tumors should be examined for surface immunoglobulin light chains as well as CD56 expression when plasmacytoma is suspected...
  65. ncbi request reprint Prediction of response and prognostic factors for Ewing family of tumors in a low incidence population
    Kan Yonemori
    Breast and Medical Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Cancer Res Clin Oncol 134:389-95. 2008
    ..This study analyzed the prediction of response and prognostic factors for Ewing family of tumors (EFTs) in an Asian population with a low incidence...
  66. ncbi request reprint Incidence of multiple primary malignancies in a cohort of adult patients with soft tissue sarcoma
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Jpn J Clin Oncol 35:444-52. 2005
    ..The current study was performed to quantify the risk of development of multiple primary malignancies in adult patients with soft tissue sarcoma...
  67. ncbi request reprint Histological grade, p53, HER2 and hormone receptor status of synchronous bilateral breast carcinoma
    Kaneyuki Matsuo
    Department of Surgical Oncology, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Breast Cancer 9:127-33. 2002
    ..We analyzed the clinicopathological characteristics and tumor biology with regard to histological grade (HG), p53, HER2 and hormone receptor status to address this question...
  68. ncbi request reprint Intracystic papillary carcinoma of the breast in a male patient diagnosed by core needle biopsy: a case report
    Takayuki Kinoshita
    Surgical Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Breast 14:322-4. 2005
    ..So the patient underwent simple mastectomy without axillary node biopsy. From the final pathological result, no invasion was identified...
  69. ncbi request reprint Favorable outcome in patients with breast cancer in the presence of pathological response after neoadjuvant endocrine therapy
    Sadako Akashi-Tanaka
    Division of Breast Surgery, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Breast 16:482-8. 2007
    ..Multivariate analysis of relapse-free survival indicated that pathological response was independent. Therefore, pathological response may be a favorable prognostic factor after NAET...
  70. ncbi request reprint Synovial sarcoma of the soft tissues: prognostic significance of imaging features
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Comput Assist Tomogr 28:140-8. 2004
    ..This study assessed the prognostic value of computed tomography (CT) and magnetic resonance (MR) imaging features in synovial sarcoma of the soft tissues...
  71. ncbi request reprint Desmoplastic small round cell tumor: imaging findings associated with clinicopathologic features
    Ukihide Tateishi
    Division of Diagnostic Ridiology, National Cancer Hospital and Reseach Institute, Tokyo, USA
    J Comput Assist Tomogr 26:579-83. 2002
    ..To describe imaging findings of desmoplastic small round cell tumor (DSCRT) and to clarify the relation between radiologic appearances and clinicopathologic features...
  72. ncbi request reprint Primary malignant fibrous histiocytoma of the chest wall: CT and MR appearance
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    J Comput Assist Tomogr 26:558-63. 2002
    ..The purpose of this work is to describe the CT and MR appearance of primary malignant fibrous histiocytoma (MFH) of the chest wall...
  73. ncbi request reprint CT and MRI features of low-grade fibromyxoid sarcoma in the shoulder of a pediatric patient
    Mototaka Miyake
    Division of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Radiat Med 24:511-4. 2006
    ....
  74. ncbi request reprint MRI features of extraskeletal myxoid chondrosarcoma
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Skeletal Radiol 35:27-33. 2006
    ..To describe the MRI features of extraskeletal myxoid chondrosarcoma in comparison with clinicopathologic findings...
  75. pmc Cancer diagnosis marker extraction for soft tissue sarcomas based on gene expression profiling data by using projective adaptive resonance theory (PART) filtering method
    Hiro Takahashi
    Department of Biotechnology, School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    BMC Bioinformatics 7:399. 2006
    ..To accomplish this objective, it is important to establish a sophisticated algorithm that can deal with large quantities of data such as gene expression profiles obtained by DNA microarray analysis...
  76. doi request reprint Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy
    Kan Yonemori
    Breast and Medical Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Med Oncol 26:344-9. 2009
    ..Except among patients with pathological complete remission, the persistent over-expression of HER2/neu may be a poor prognostic factor...
  77. ncbi request reprint Correlation of p53 and MIB-1 expression with both the systemic recurrence and survival in cases of phyllodes tumors of the breast
    Kan Yonemori
    Breast and Medical Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Tokyo 104 0045, Japan
    Pathol Res Pract 202:705-12. 2006
    ..p53 expression status and MIB-1 index may be significant prognostic factors in patients with phyllodes tumors, and careful postoperative follow-up may be important in those cases showing positive expression of p53 and/or MIB-1 index...
  78. ncbi request reprint Acral myxoinflammatory fibroblastic sarcoma: a report of five cases and review of the literature
    Mika Sakaki
    Department of Pathology, University of Tokushima School of Medicine, 3 18 15 Kuramoto cho, Tokushima, 770 8503, Japan
    Virchows Arch 442:25-30. 2003
    ....
  79. pmc The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma
    Michiko Ishida
    Genter for Medical Genomics, Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji Chuo ku, Tokyo 104 0045, Japan
    Mol Cell Biol 27:1348-55. 2007
    ..Increased COM1 expression resulted in induced apoptosis and in reduced cell growth and colony formation activity. Our results suggested that restoration of COM1 expression may be of therapeutic benefit in synovial sarcoma...
  80. ncbi request reprint Adult neuroblastoma: radiologic and clinicopathologic features
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    J Comput Assist Tomogr 27:321-6. 2003
    ..The purpose of the current study was to define the imaging findings of adult neuroblastoma (ANB) and correlate them with clinicopathologic features...
  81. pmc The use of contrast-enhanced computed tomography before neoadjuvant chemotherapy to identify patients likely to be treated safely with breast-conserving surgery
    Sadako Akashi-Tanaka
    Division of Breast Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Surg 239:238-43. 2004
    ..To select suitable candidates for breast-conserving treatment (BCT) after neoadjuvant chemotherapy (NAC), based on the classification of tumors into localized or diffuse types using contrast-enhanced computed tomography (CE-CT)...
  82. ncbi request reprint Accuracy in estimating tumor extension according to mammographic subtypes in patients with ductal carcinoma in situ
    Masahiko Sato
    Breast Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 32:157-61. 2002
    ..The purpose of this study was to investigate the relationship between tumor extension on mammography, by stratifying four subtypes, and histopathological tumor size in patients with ductal carcinoma in situ...
  83. ncbi request reprint Methylation-associated silencing of heparan sulfate D-glucosaminyl 3-O-sulfotransferase-2 (3-OST-2) in human breast, colon, lung and pancreatic cancers
    Kazuaki Miyamoto
    National Cancer Center Research Institute, Tokyo, Japan
    Oncogene 22:274-80. 2003
    ..From the high incidence, silencing of the 3-OST-2 gene is expected to have high diagnostic, and potentially therapeutic, values...
  84. ncbi request reprint Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas: a clinicopathologic study of 281 cases
    Osamu Sato
    Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan
    Cancer 103:1881-90. 2005
    ..Verification of the presence of an association with prognosis was performed...
  85. ncbi request reprint Extraskeletal myxoid chondrosarcoma: a Multi-Institutional Study of 42 Cases in Japan
    Satoshi Kawaguchi
    Department of Orthopaedic Surgery, Sapporo Medical University, Sapporo, Japan
    Cancer 97:1285-92. 2003
    ..Despite a consensus for the distinct clinicopathologic entity of EMC, its clinical features remain controversial. In addition, most studies have contained a small number of patients who underwent definitive surgical treatment...
  86. ncbi request reprint Large benign rheumatoid nodules of the trunk in an elderly patient: radiologic appearance mimicking a soft-tissue sarcoma
    Toshihisa Osanai
    Department of Orthopaedic Surgery, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata, 990 9585, Japan
    Mod Rheumatol 16:312-5. 2006
    ..The final diagnosis was benign rheumatoid nodules. Recognition of this rare clinical entity is important to avoid unnecessary examination and treatment...
  87. ncbi request reprint Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature
    Ko Hashimoto
    Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 208:157-62. 2006
    ..However, given the aggressiveness of the malignant tumor, this is unlikely. The recurrence of pain and aggravation of bone destruction many years after the primary treatment suggest malignant transformation of GCT...
  88. ncbi request reprint Concordance in pathological response to neoadjuvant chemotherapy between invasive and noninvasive components of primary breast carcinomas
    Kaneyuki Matsuo
    Department of Surgical Oncology, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Breast Cancer 9:75-81. 2002
    ....
  89. ncbi request reprint Histological and immunohistochemical analysis of apocrine breast carcinoma
    Kaneyuki Matsuo
    Department of Surgical Oncology, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Breast Cancer 9:43-9. 2002
    ..We analyzed the histopathological characteristics and tumor biology of apocrine breast carcinomas with regard to histological grade, p53, HER2, bcl-2, MIB-1 and hormone receptor status...
  90. ncbi request reprint Nodular mucinosis of the breast: a case report with clinical and imaging findings
    Norimasa Koide
    Surgical Oncology Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Breast Cancer 9:261-4. 2002
    ..Nodular mucinosis, simulating mucinous carcinoma or phyllodes tumor on clinical and imaging examinations, should be included in the differential diagnosis in cases of mucinous lesions occurring near the nipple in a young woman...
  91. ncbi request reprint Extraskeletal osteosarcoma: extensive tumor thrombus on fused PET-CT images
    Ukihide Tateishi
    Division of Diagnostic Radiology and Nuclear Medicine, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Ann Nucl Med 19:729-32. 2005
    ..PET study in our patient provided information concerning disease extent and viability of tumor thrombus...
  92. ncbi request reprint Sclerosing perineurioma: a clinicopathological study of five cases and diagnostic utility of immunohistochemical staining for GLUT1
    Umio Yamaguchi
    Division of Orthopedic Oncology, National Cancer Center Hospital and Research Institute, 5 1 1 Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    Virchows Arch 443:159-63. 2003
    ..We also observed that the tumor cells were positive for the human erythrocyte glucose transporter (GLUT1) antigen, suggesting that GLUT1 may be a useful marker for the identification of sclerosing perineurioma...
  93. ncbi request reprint CT and MRI features of recurrent tumors and second primary neoplasms in pediatric patients with retinoblastoma
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, 5 1 1, Tsukiji, Chuo Ku, 104 0045 Tokyo, Japan
    AJR Am J Roentgenol 181:879-84. 2003
    ..The aim of our study was to describe the CT and MRI findings of recurrent tumors and second primary (malignant and benign) neoplasms in patients with retinoblastoma and to evaluate imaging features to assist in distinguishing them...
  94. ncbi request reprint Frequent KIT and epidermal growth factor receptor overexpressions in undifferentiated-type breast carcinomas with 'stem-cell-like' features
    Hitoshi Tsuda
    Department of Pathology II, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama 359 8513, Japan
    Cancer Sci 96:333-9. 2005
    ..0002). The undifferentiated-type breast carcinomas appeared to show mammary epithelial stem cell-like features, and they could be identified by KIT and/or EGFR overexpressions...
  95. ncbi request reprint Bone scanning--who needs it among patients with newly diagnosed prostate cancer?
    Megumi Hirobe
    Department of Urology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    Jpn J Clin Oncol 37:788-92. 2007
    ..We evaluated the relationship between serum PSA and clinical variables to eliminate bone scanning in patients with prostate cancer having a low probability of bone metastasis...
  96. ncbi request reprint Osteosarcomas after the age of 50: a clinicopathologic study of 64 cases--an experience in northern Japan
    Kyoji Okada
    Department of Orthopedic Surgery, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543 Japan
    Ann Surg Oncol 11:998-1004. 2004
    ..The clinicopathologic profile and prognostic factors of osteosarcomas after the age of 50 years have been obscure...
  97. ncbi request reprint Primitive neuroectodermal tumor of the breast: immunohistochemistry and fluorescence in situ hybridization
    Gen Tamura
    Department of Pathology and Laboratory Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan
    Pathol Int 57:509-12. 2007
    ..The patient has been disease free for 6 months after surgery followed by chemoradiation therapy. FISH is extremely useful for accurate diagnosis of EFT, especially in cases of unusual locations...
  98. ncbi request reprint [Pathological evaluation of soft tissue sarcoma for diagnosis, prognosis and treatment]
    Umio Yamaguchi
    Division of Orthopedic Oncology, National Cancer Center Hospital
    Gan To Kagaku Ryoho 31:1340-5. 2004
    ....
  99. ncbi request reprint Prognostic significance of MRI findings in patients with myxoid-round cell liposarcoma
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Research Institute, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    AJR Am J Roentgenol 182:725-31. 2004
    ..The aims of this study were to determine the prognostic significance of MRI findings in patients with myxoid-round cell liposarcomas and to clarify which MRI features best indicate tumors with adverse clinical behavior...
  100. ncbi request reprint Primary hepatic angiosarcoma on coregistered FDG PET and CT images
    Tetsuo Maeda
    Division of Diagnostic Radiology, National Cancer Center Hospital, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    AJR Am J Roentgenol 188:1615-7. 2007
  101. ncbi request reprint Histological grading and MIB-1 labeling index of soft-tissue sarcomas
    Tadashi Hasegawa
    Department of Surgical Pathology, Sapporo Medical University School of Medicine, South 1 West 16 Chuo Ku, Sapporo 060 8543, Japan
    Pathol Int 57:121-5. 2007
    ....