Tomoyuki Hanaoka

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Active and passive smoking and breast cancer risk in middle-aged Japanese women
    Tomoyuki Hanaoka
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Int J Cancer 114:317-22. 2005
  2. doi request reprint Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Cancer Sci 100:927-33. 2009
  3. doi request reprint Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Nutr Cancer 62:466-75. 2010
  4. ncbi request reprint Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan
    Tetsuya Otani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tsukjii, Tokyo
    Nutr Cancer 53:42-50. 2005
  5. ncbi request reprint Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples
    Ying Liu
    Epidemiology and Prevention Division, Research Center of Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    J Hum Genet 50:62-8. 2005
  6. ncbi request reprint Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 15:1341-7. 2006
  7. ncbi request reprint Atrophic gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study
    Ai Machida-Montani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Helicobacter 12:328-32. 2007
  8. doi request reprint Serum organochlorines and breast cancer risk in Japanese women: a case-control study
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Causes Control 20:567-80. 2009
  9. doi request reprint A case-control study of the association between urinary cadmium concentration and endometriosis in infertile Japanese women
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Sci Total Environ 402:171-5. 2008
  10. ncbi request reprint Generalizability of relative risk estimates from a well-defined population to a general population
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Eur J Epidemiol 21:253-62. 2006

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Active and passive smoking and breast cancer risk in middle-aged Japanese women
    Tomoyuki Hanaoka
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Int J Cancer 114:317-22. 2005
    ..6; 95% CI = 1.3-5.2) but not in postmenopausal women (RR = 0.7; 95% CI = 0.4-1.0). We conclude that tobacco smoking increases the risk of female breast cancer in premenopausal women...
  2. doi request reprint Isoflavone, polymorphisms in estrogen receptor genes and breast cancer risk in case-control studies in Japanese, Japanese Brazilians and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Cancer Sci 100:927-33. 2009
    ..21, respectively). We found no remarkable difference for the other four polymorphisms. Our findings suggest that polymorphisms in the estrogen receptor beta gene may modify the association between isoflavone intake and breast cancer risk...
  3. doi request reprint Dietary isoflavone intake, polymorphisms in the CYP17, CYP19, 17beta-HSD1, and SHBG genes, and risk of breast cancer in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Nutr Cancer 62:466-75. 2010
    ..06-0.77). We found no remarkable difference for the rs743572 and rs10046 polymorphisms. Our findings suggest that polymorphisms in the 17beta-HSD1 and SHBG genes may modify the association between isoflavone intake and breast cancer risk...
  4. ncbi request reprint Folate, vitamin B6, vitamin B12, and vitamin B2 intake, genetic polymorphisms of related enzymes, and risk of colorectal cancer in a hospital-based case-control study in Japan
    Tetsuya Otani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tsukjii, Tokyo
    Nutr Cancer 53:42-50. 2005
    ..02) with colorectal cancer, although the other polymorphisms did not interact with any nutrient intake. In conclusion, the study did not support the existing hypothesis of gene-nutrient interaction in colorectal carcinogenesis...
  5. ncbi request reprint Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples
    Ying Liu
    Epidemiology and Prevention Division, Research Center of Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    J Hum Genet 50:62-8. 2005
    ..The findings of the present study suggest that polymorphism in associated candidate genes plays a role in the habitual use of tobacco and alcohol among Japanese men...
  6. ncbi request reprint Effect of Helicobacter pylori infection combined with CagA and pepsinogen status on gastric cancer development among Japanese men and women: a nested case-control study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 15:1341-7. 2006
    ..Possible effect modification by CagA status, and serum pepsinogen status, as a marker of atrophic gastritis, was also considered to see its effect on developing gastric cancer. Subjects and..
  7. ncbi request reprint Atrophic gastritis, Helicobacter pylori, and colorectal cancer risk: a case-control study
    Ai Machida-Montani
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Helicobacter 12:328-32. 2007
    ..However, the correlation between H. pylori and colorectal cancer (CRC) is controversial. The aim of this study was to examine the correlation between H. pylori, serum gastrin level, and atrophic gastritis with CRC...
  8. doi request reprint Serum organochlorines and breast cancer risk in Japanese women: a case-control study
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Causes Control 20:567-80. 2009
    ..Here, we examined these associations in Japanese women in the largest study in Asian women to date...
  9. doi request reprint A case-control study of the association between urinary cadmium concentration and endometriosis in infertile Japanese women
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Sci Total Environ 402:171-5. 2008
    ..86 (0.30 to 2.49, P for trend=0.79). Our results do not support the hypothesis that higher urinary cadmium concentration is associated with the risk of endometriosis...
  10. ncbi request reprint Generalizability of relative risk estimates from a well-defined population to a general population
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Chuo Ku, Tokyo, Japan
    Eur J Epidemiol 21:253-62. 2006
    ..06). Our results suggest that even for RRs, the extrapolation of estimates for a sample from a well-defined population to a general population may not be possible...
  11. ncbi request reprint Effect of soy isoflavones on endometriosis: interaction with estrogen receptor 2 gene polymorphism
    Masaki Tsuchiya
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Epidemiology 18:402-8. 2007
    ..We examined associations among soy isoflavone intake, estrogen receptor 2 (ESR2) gene polymorphisms and risk of endometriosis...
  12. doi request reprint Dietary isoflavone intake and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians
    Motoki Iwasaki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Breast Cancer Res Treat 116:401-11. 2009
    ..In addition, women may benefit from risk reduction if they consume at least moderate amounts of isoflavones...
  13. ncbi request reprint hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations
    Hiromasa Tsukino
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Cancer Sci 95:977-83. 2004
    ..The results of the present study suggest that patients with atrophic gastritis in conjunction with the hOGG1 Cys allele might have a higher susceptibility to gastric cancer...
  14. doi request reprint Urinary phthalate monoesters and endometriosis in infertile Japanese women
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Sci Total Environ 408:37-42. 2009
    ..23-0.90). Our results do not support the hypothesis that higher urinary concentrations of phthalate metabolites are associated with the risk of endometriosis in infertile Japanese women...
  15. ncbi request reprint Validity of a self-administered food frequency questionnaire in the assessment of heterocyclic amine intake using 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) levels in hair
    Minatsu Kobayashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Mutat Res 630:14-9. 2007
    ..The present study indicates that HCA intake estimated from this FFQ provides a reasonable ranking of individuals to allow the analysis of associations between HCA intake and risk of cancer in large-scale epidemiological studies...
  16. ncbi request reprint Fish, long-chain n-3 polyunsaturated fatty acids, and risk of colorectal cancer in middle-aged Japanese: the JPHC study
    Minatsu Kobayashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan
    Nutr Cancer 49:32-40. 2004
    ..This study does not support the role of fish and Ln-3 PUFA in the etiology of colon and rectal cancer in this population whose fish consumption was high and the variation in Ln-3 PUFA consumption was large...
  17. ncbi request reprint Green tea consumption and subsequent risk of gastric cancer by subsite: the JPHC Study
    Shizuka Sasazuki
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Causes Control 15:483-91. 2004
    ..To investigate the relationship between green tea consumption and subsequent risk of gastric cancer at different anatomical subsites in a population-based prospective study...
  18. ncbi request reprint Impact of tobacco smoking on subsequent cancer risk among middle-aged Japanese men and women: data from a large-scale population-based cohort study in Japan--the JPHC study
    Manami Inoue
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 104 0045 Tokyo, Japan
    Prev Med 38:516-22. 2004
    ..The present study aimed to obtain a relevant epidemiological index of the impact of tobacco smoking on the subsequent risk of cancer in Japan...
  19. pmc Urinary bisphenol-A concentration in infertile Japanese women and its association with endometriosis: A cross-sectional study
    Hiroaki Itoh
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, 104 0045, Tokyo, Japan
    Environ Health Prev Med 12:258-64. 2007
    ..Humans are widely exposed to BPA. We investigated the urinary concentration of BPA in infertile Japanese women and its possible association with endometriosis...
  20. ncbi request reprint Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation
    Hiroyasu Esumi
    Investigative Treatment Division, National Cancer Center Research Institute East, Kashiwa, Chiba 277 8577, Japan
    Cancer Sci 95:685-90. 2004
    ..These findings indicate that PP may be useful for anticancer therapy and that anti-austerity therapy could be a novel strategy for anticancer therapy...
  21. ncbi request reprint Cytochrome P450 1B1 mRNA levels in peripheral blood cells and exposure to polycyclic aromatic hydrocarbons in Chinese coke oven workers
    Tomoyuki Hanaoka
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa shi, Chiba, Japan
    Sci Total Environ 296:27-33. 2002
    ..Our preliminary study suggests that PAH exposure in coke ovens and smoking maybe associated with CYP1B1 mRNA levels in peripheral blood cells although mRNA is generally unstable and could be expressed following exposure to other agents...
  22. ncbi request reprint Urinary level of 1,N(6) -ethenodeoxyadenosine, a marker of oxidative stress, is associated with salt excretion and omega 6-polyunsaturated fatty acid intake in postmenopausal Japanese women
    Tomoyuki Hanaoka
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan
    Int J Cancer 100:71-5. 2002
    ..08). Results from this pilot study suggest urinary epsilon dA as a potential biomarker of DNA damage possibly derived from salt-induced inflammation and LPO; further exploration of epsilon dA in human biomonitoring studies is warranted...
  23. ncbi request reprint 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) level in human hair as biomarkers for dietary grilled/stir-fried meat and fish intake
    Minatsu Kobayashi
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104 0045, Japan
    Mutat Res 588:136-42. 2005
    ..28). These observations were made of hair with and without melanin adjustment. The present study indicates that the PhIP level in hair can be used as a biological indicator of dietary intake of HCAs...
  24. ncbi request reprint Associations between serum levels of selected organochlorine compounds and endometriosis in infertile Japanese women
    Hiromasa Tsukino
    Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center Tsukiji, Tokyo, Japan
    Environ Res 99:118-25. 2005
    ..06). The results of this study provide some evidence that serum levels of these organochlorine compounds are not associated with an increased risk of endometriosis in infertile Japanese women...
  25. ncbi request reprint Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate genes for gene-environment studies on cancer: data from population-based Japanese random samples
    Kimio Yoshimura
    Cancer Information and Epidemiology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Hum Genet 48:654-8. 2003
    ..In the present study, the Japanese allele frequencies were verified by using nationwide population samples...
  26. ncbi request reprint Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan
    Minatsu Kobayashi
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Kashiwa, Chiba 277 8577, Japan
    Mutat Res 506:233-41. 2002
    ..Our study suggests that grilled fish are the major dietary sources of HCAs in Japanese, except those in Okinawa Island...
  27. ncbi request reprint Risk factors for stomach cancer in Brazil (I): a case-control study among non-Japanese Brazilians in São Paulo
    Ines Nobuko Nishimoto
    Research Center, Hospital do Cancer A C Camargo, Sao Paulo, Brazil
    Jpn J Clin Oncol 32:277-83. 2002
    ..Nevertheless, there are no reports of analytical epidemiological study on stomach cancer in Brazil...
  28. ncbi request reprint Background characteristics of basic health examination participants: the JPHC Study Baseline Survey
    Motoki Iwasaki
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    J Epidemiol 13:216-25. 2003
    ..The aim of this study is to clarify the background characteristics of participants and to discuss their impact on epidemiologic studies...
  29. ncbi request reprint Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan
    Megumi Hara
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan
    Nutr Cancer 46:138-47. 2003
    ..These findings suggest that cruciferous vegetables decrease the risk of both stomach and colorectal cancer, and that mushrooms are associated with a decreased risk of stomach cancer...
  30. ncbi request reprint Association between CDH1 haplotypes and gastric cancer risk in a Japanese population
    Hidetaka Yamada
    First Department of Pathology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan
    Scand J Gastroenterol 42:1479-85. 2007
    ....
  31. ncbi request reprint Alcohol consumption, smoking, and subsequent risk of colorectal cancer in middle-aged and elderly Japanese men and women: Japan Public Health Center-based prospective study
    Tetsuya Otani
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, Chiba, Japan
    Cancer Epidemiol Biomarkers Prev 12:1492-500. 2003
    ..In conclusion, approximately half of the colorectal cancer cases may be preventable by tobacco and alcohol controls in middle-aged and elderly Japanese men...
  32. ncbi request reprint Risk factors for stomach cancer in Brazil (II): a case-control study among Japanese Brazilians in São Paulo
    Gerson Shigueaki Hamada
    Nikkei Disease Prevention Center, Santa Cruz Hospital, Sao Paulo, Brazil
    Jpn J Clin Oncol 32:284-90. 2002
    ..Although stomach cancer is the most frequent cancer among Japanese Brazilians, the risk factor of this cancer has not been investigated among them...
  33. ncbi request reprint Mortality of iron-steel workers in Anshan, China: a retrospective cohort study
    Tsutomu Hoshuyama
    Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi, Kitakyushu 807 8555, Japan
    Int J Occup Environ Health 12:193-202. 2006
    ..Combined exposure to polycyclic aromatic hydrocarbons and two or more dusts increased the risks of lung cancer (SRR = 654; 95% CI: 113-3,780) and other malignancies. Foundry work has adverse health effects, including carcinogenic risks...
  34. ncbi request reprint Association of Helicobacter pylori infection and environmental factors in non-cardia gastric cancer in Japan
    Ai Machida-Montani
    Epidemiology and Biostatistics Division, National Cancer Center Research Institute East, 6 5 1 Kashiwanoha, Kashiwa, Chiba 277 8577, Japan
    Gastric Cancer 7:46-53. 2004
    ..pylori infection, and to investigate the effects of the interaction between environmental factors and H. pylori infection...
  35. ncbi request reprint A novel splice-site variant of the base excision repair gene MYH is associated with production of an aberrant mRNA transcript encoding a truncated MYH protein not localized in the nucleus
    Hong Tao
    First Department of Pathology, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Carcinogenesis 25:1859-66. 2004
    ....
  36. ncbi request reprint A retrospective cohort study among iron-steel workers in Anshan, China: exposure assessment
    Tsutomu Hoshuyama
    Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J UOEH 28:253-63. 2006
    ....
  37. ncbi request reprint Development of the adductome approach to detect DNA damage in humans
    Robert A Kanaly
    Department of Technology and Ecology, Graduate School of Global Environmental Studies, Kyoto University, Kyoto, Japan
    Antioxid Redox Signal 8:993-1001. 2006
    ..The future applications of this method are discussed...
  38. ncbi request reprint Prevalence of substance abuse among patients with physical diseases seen in an emergency room in Japan
    Naotsugu Hirabayashi
    National Center Hospital for Mental, Nervous, and Muscular Disorders, Tokyo 187 8551, Japan
    Am J Addict 13:398-404. 2004
    ..2%). It is necessary to look at the methodological differences between this study and previous studies; however, this finding supports the lower point prevalence of methamphetamine in an ER in Japan than in an ER in the United States...
  39. ncbi request reprint Male reproductive health in relation to occupational exposure to endocrine disrupting and other potent chemicals, a review of the epidemiologic literature
    Ken Takahashi
    Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J UOEH 26:23-40. 2004
    ..There is thus a need for convergence of knowledge and a widening of the scope of epidemiological research targeting occupationally exposed populations under a carefully-designed protocol...
  40. ncbi request reprint Psychosocial factors associated with quality of life in Japanese patients with human immunodeficiency virus infection
    Naotsugu Hirabayashi
    Department of Psychiatry, Tokyo Medical University, Tokyo, Japan
    Psychosomatics 43:16-23. 2002
    ..Patients with hemophilia had a significantly weaker Fighting Spirit than patients with sexually transmitted infection...
  41. pmc Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China
    Guowei Pan
    Department of Environmental Epidemiology, Liaoning Provincial Center for Disease Prevention and Control, Shenyang, People s Republic of China
    Environ Health Perspect 114:1643-8. 2006
    ..Observations of adverse developmental and reproductive effects in laboratory animals and wildlife have fueled increasing public concern regarding the potential for various chemicals to impair human fertility...
  42. ncbi request reprint Application of the adductome approach to assess intertissue DNA damage variations in human lung and esophagus
    Robert A Kanaly
    Department of Technology and Ecology, Graduate School of Global Environmental Studies, Kyoto University, Kyoto 606 8501, Japan
    Mutat Res 625:83-93. 2007
    ....