Keerthi S Guruge

Summary

Affiliation: National Institute of Agrobiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Accumulation status of persistent organochlorines in albatrosses from the North Pacific and the Southern Ocean
    K S Guruge
    Laboratory of Toxico-Pharmacology, Department of Feed Safety, National Institute of Animal Health, Kannon-dai 3-1-1, Tsukuba 305-0856, Japan
    Environ Pollut 114:389-98. 2001
  2. ncbi request reprint Detection of corn intrinsic and recombinant DNA fragments and Cry1Ab protein in the gastrointestinal contents of pigs fed genetically modified corn Bt11
    E H Chowdhury
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Anim Sci 81:2546-51. 2003
  3. ncbi request reprint Perfluorinated organic compounds in human blood serum and seminal plasma: a study of urban and rural tea worker populations in Sri Lanka
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    J Environ Monit 7:371-7. 2005
  4. ncbi request reprint Occurrence of perfluorinated acids and fluorotelomers in waters from Sri Lanka
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Mar Pollut Bull 54:1667-72. 2007
  5. doi request reprint Species-specific concentrations of perfluoroalkyl contaminants in farm and pet animals in Japan
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 73:S210-5. 2008
  6. ncbi request reprint Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA)
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Toxicol Sci 89:93-107. 2006
  7. ncbi request reprint Polychlorinated dibenzo-p-dioxins, -dibenzofurans, and biphenyls in domestic animal food stuff and their fat
    K S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 58:883-9. 2005
  8. ncbi request reprint Accumulation of polychlorinated naphthalenes in domestic animal related samples
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Japan
    J Environ Monit 6:753-7. 2004
  9. ncbi request reprint Polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like biphenyls in biota from Sri Lankan coast
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba 305 0856, Japan
    Mar Pollut Bull 48:1004-8. 2004
  10. doi request reprint Profiles of nonylphenol isomers in surface waters from Sri Lanka
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Mar Pollut Bull 62:870-3. 2011

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Accumulation status of persistent organochlorines in albatrosses from the North Pacific and the Southern Ocean
    K S Guruge
    Laboratory of Toxico-Pharmacology, Department of Feed Safety, National Institute of Animal Health, Kannon-dai 3-1-1, Tsukuba 305-0856, Japan
    Environ Pollut 114:389-98. 2001
    ..Species-specific accumulation patterns of OCs in albatrosses were closely related with their feeding, migration, age and geographical ranges...
  2. ncbi request reprint Detection of corn intrinsic and recombinant DNA fragments and Cry1Ab protein in the gastrointestinal contents of pigs fed genetically modified corn Bt11
    E H Chowdhury
    National Institute of Animal Health, Tsukuba, Ibaraki 305 0856, Japan
    J Anim Sci 81:2546-51. 2003
    ..These results suggest that ingested corn DNA and Cry1Ab protein were not totally degraded in the gastrointestinal tract, as shown by their presence in a form detectable by PCR or immunological tests...
  3. ncbi request reprint Perfluorinated organic compounds in human blood serum and seminal plasma: a study of urban and rural tea worker populations in Sri Lanka
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    J Environ Monit 7:371-7. 2005
    ..The novel finding of FOCs in human seminal plasma implies that further studies are needed to determine whether long-term exposure in humans can result in reproductive impairments...
  4. ncbi request reprint Occurrence of perfluorinated acids and fluorotelomers in waters from Sri Lanka
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Mar Pollut Bull 54:1667-72. 2007
  5. doi request reprint Species-specific concentrations of perfluoroalkyl contaminants in farm and pet animals in Japan
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 73:S210-5. 2008
    ..Elevated concentrations of both PFOS (25 ng/ml) and perfluorohexane sulfonate (PFHxS; 10 ng/ml) were found in dog sera, indicating that further studies are needed to identify PFC sources in the human environment...
  6. ncbi request reprint Gene expression profiles in rat liver treated with perfluorooctanoic acid (PFOA)
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Toxicol Sci 89:93-107. 2006
    ..Several other genes involved in apoptosis; regulation of hormones; metabolism; and G-protein coupled receptor protein signaling pathways were significantly suppressed...
  7. ncbi request reprint Polychlorinated dibenzo-p-dioxins, -dibenzofurans, and biphenyls in domestic animal food stuff and their fat
    K S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 58:883-9. 2005
    ..Biomagnification factors for both mono- and non-ortho coplanar PCBs were greater in chicken fat compared to those in pig fat...
  8. ncbi request reprint Accumulation of polychlorinated naphthalenes in domestic animal related samples
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Japan
    J Environ Monit 6:753-7. 2004
    ..033 and 0.011 pg g(-1) lipid wt, respectively. Based on predicted luciferase inducing potency for each PCN congener, the estimated PCN-TEQs in feed ingredients and animal fat were similar to those that were estimated from selected PCNs...
  9. ncbi request reprint Polychlorinated dibenzo-p-dioxins, dibenzofurans and dioxin-like biphenyls in biota from Sri Lankan coast
    Keerthi S Guruge
    Toxico Biochemistry Section, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba 305 0856, Japan
    Mar Pollut Bull 48:1004-8. 2004
  10. doi request reprint Profiles of nonylphenol isomers in surface waters from Sri Lanka
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Mar Pollut Bull 62:870-3. 2011
    ..The spatial differences in NP concentrations suggest that NP contamination in Sri Lanka may be widespread, and comprehensive study is vital...
  11. doi request reprint Occurrence and exposure assessment of perchlorate, iodide and nitrate ions from dairy milk and water in Japan and Sri Lanka
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, 3 1 5 Kannondai, Tsukuba, Ibaraki 305 0856, Japan
    J Environ Monit 13:2312-20. 2011
    ..Therefore, further studies of risk associated with perchlorate may need to reconsider co-existence of iodine and other iodide transport inhibitors in food...
  12. doi request reprint Differential induction of cytochrome P450 1A1 and 1B1 mRNA in primary cultured bovine hepatocytes treated with TCDD, PBDD/Fs and feed ingredients
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 205 0856, Japan
    Toxicol Lett 185:193-6. 2009
    ..The data suggested that quantification of biomarker regulations in primary cultured hepatocytes could represent an effective tool for both the screening and study of various chemical entities in larger animals...
  13. doi request reprint Fluorinated alkyl compounds including long chain carboxylic acids in wild bird livers from Japan
    Keerthi S Guruge
    Safety Research Team, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 83:379-84. 2011
    ..However, the current FAC concentrations found in livers may suggest that these compounds alone would not cause a severe toxic effect in these species...
  14. ncbi request reprint Differential expression of chicken hepatic genes responsive to PFOA and PFOS
    Leo W Y Yeung
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Toxicology 237:111-25. 2007
    ..Specifically, the gene expressions of CYP8B and NOV were studied...
  15. ncbi request reprint Effects of feeding calves genetically modified corn bt11: a clinico-biochemical study
    Nobuaki Shimada
    Safety Research Team, National Institute of Animal Health, Ibaraki, Japan
    J Vet Med Sci 68:1113-5. 2006
    ..The results suggest that the transgenic Bt11 has no negative clinico-biochemical effects on calves...
  16. doi request reprint Comparison of total fluorine, extractable organic fluorine and perfluorinated compounds in the blood of wild and pefluorooctanoate (PFOA)-exposed rats: evidence for the presence of other organofluorine compounds
    Leo W Y Yeung
    National Institute of Advanced Industrial Science and Technology, 16 1 Onogawa, Tsukuba, Ibaraki 305 8569, Japan
    Anal Chim Acta 635:108-14. 2009
    ..The mass balance analysis of the different forms of fluorine in blood suggested the presence of other forms of organic fluorine in addition to known PFCs...
  17. ncbi request reprint Determination of PCDD/Fs and dioxin-like PCBs in fish oils for feed ingredients by congener-specific chemical analysis and CALUX bioassay
    Jun Hasegawa
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Chemosphere 69:1188-94. 2007
    ..84, 0.89, and 0.90 for PCDD/Fs, DL-PCBs, and the sum, respectively. These results suggest that the CALUX assay is a very useful method for the screening of dioxin-related compounds in fish oils...
  18. doi request reprint Biochemical responses and accumulation properties of long-chain perfluorinated compounds (PFOS/PFDA/PFOA) in juvenile chickens (Gallus gallus)
    Leo W Y Yeung
    Safety Research Team, National Institute of Animal Health, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan
    Arch Environ Contam Toxicol 57:377-86. 2009
    ..These results indicate that exposure to a 1.0-mg mixture of PFOS/PFDA/PFOA/kg b.w. has no adverse effect on juvenile chickens...
  19. doi request reprint An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods
    Leo W Y Yeung
    National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    J Chromatogr A 1216:4950-6. 2009
    ..Separation of possible inferences such as taurodeoxycholic acid (TDC) was accomplished using an ion exchange JJ50-2D column, and this separation was validated using whole blood of different animals...
  20. ncbi request reprint Concentration and toxic potential of polychlorinated biphenyl congeners in migratory oceanic birds from the North Pacific and the Southern Ocean
    K S Guruge
    Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan
    Mar Environ Res 52:271-88. 2001
    ..01). The calculated hazard indices indicated that black-footed and Laysan albatrosses inhabiting in the North Pacific had similar threshold levels which were known to cause toxic effects in some populations of fish-eating birds...
  21. doi request reprint Profiles of perfluoroalkyl substances in the liver and serum of patients with liver cancer and cirrhosis in Australia
    Leo W Y Yeung
    Pathology and Pathophysiology Research Division, National Institute of Animal Health, National Agriculture and Food Research Organization, Kannondai 3 1 5, Tsukuba, Ibaraki 305 0856, Japan Potential Pollutants Group, National Institute of Advanced Industrial Science and Technology, Onogawa 16 1, Tsukuba, Japan
    Ecotoxicol Environ Saf 96:139-46. 2013
    ..The present study demonstrates, for the first time, the detection and comparison of a range of PFASs in the liver of patients with liver cancer and/or liver cirrhosis. ..
  22. ncbi request reprint Fate of maize intrinsic and recombinant genes in calves fed genetically modified maize Bt11
    Emdadull H Chowdhury
    Department of Safety Research, National Institute of Animal Health, Kannondai, Tsukuba, Ibaraki, 305 0856 Japan
    J Food Prot 67:365-70. 2004
    ..These results also suggest that the recombinant cry1Ab genes were not transferred to the PBMC and tissues of calves fed Bt11 maize...