Petr Gruz

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. ncbi request reprint Exclusive induction of G:C to A:T transitions by 3-azido-1,2-propanediol in yeast
    Petr Gruz
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 760:73-6. 2014
  2. pmc Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus
    Petr Gruz
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Nucleic Acids Res 31:4024-30. 2003
  3. doi request reprint Origins of age-related DNA damage and dietary strategies for its reduction
    Petr Gruz
    Division of Genetic and Mutagenesis II, National Institute of Health Sciences, Tokyo, Japan
    Rejuvenation Res 13:285-7. 2010
  4. doi request reprint Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa
    Akira Sassa
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 718:10-7. 2011
  5. pmc Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides
    Atsushi Katafuchi
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Nucleic Acids Res 38:859-67. 2010
  6. ncbi request reprint Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta
    Masatomi Shimizu
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Biochemistry 46:5515-22. 2007
  7. doi request reprint The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase kappa
    Naoko Niimi
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Biochemistry 48:4239-46. 2009
  8. pmc Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains
    Masami Yamada
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Mol Microbiol 86:1364-75. 2012
  9. doi request reprint In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ
    Akira Sassa
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji shi, Tokyo 192 0392, Japan
    DNA Repair (Amst) 15:21-8. 2014
  10. pmc Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli
    Masami Yamada
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Bacteriol 188:4992-5. 2006

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Exclusive induction of G:C to A:T transitions by 3-azido-1,2-propanediol in yeast
    Petr Gruz
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan Electronic address
    Mutat Res Genet Toxicol Environ Mutagen 760:73-6. 2014
    ..AZG also induced reversions to tryptophan prototrophy by base-pair substitutions in a dose-dependent manner. This unusual mutational specificity may be shared by other organic azido compounds. ..
  2. pmc Processing of DNA lesions by archaeal DNA polymerases from Sulfolobus solfataricus
    Petr Gruz
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Nucleic Acids Res 31:4024-30. 2003
    ..Additionally, we reveal that the deaminated bases can be introduced into DNA enzymatically, since both PolB1 and PolY1 are able to incorporate the aberrant DNA precursors dUTP and dITP...
  3. doi request reprint Origins of age-related DNA damage and dietary strategies for its reduction
    Petr Gruz
    Division of Genetic and Mutagenesis II, National Institute of Health Sciences, Tokyo, Japan
    Rejuvenation Res 13:285-7. 2010
    ..This may be particularly beneficial to the aging organism, which has progressively impaired natural protective systems...
  4. doi request reprint Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa
    Akira Sassa
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 718:10-7. 2011
    ..These results suggest that F171 functions as a molecular brake for TLS across BPDE-N(2)-dG by Pol κ and that the F171A derivative of Pol κ bypasses these DNA lesions more actively than does the wild-type enzyme...
  5. pmc Critical amino acids in human DNA polymerases eta and kappa involved in erroneous incorporation of oxidized nucleotides
    Atsushi Katafuchi
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Nucleic Acids Res 38:859-67. 2010
    ..These results suggested that amino acids at distinct positions in the active sites of Poleta and Polkappa might enhance 8-oxo-dGTP to favor the syn conformation, and thus direct its misincorporation into DNA...
  6. ncbi request reprint Efficient and erroneous incorporation of oxidized DNA precursors by human DNA polymerase eta
    Masatomi Shimizu
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Biochemistry 46:5515-22. 2007
    ..We propose that human DNA polymerase eta may participate in oxidative mutagenesis through the efficient and erroneous incorporation of oxidized dNTPs during DNA synthesis...
  7. doi request reprint The steric gate amino acid tyrosine 112 is required for efficient mismatched-primer extension by human DNA polymerase kappa
    Naoko Niimi
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Biochemistry 48:4239-46. 2009
    ..We conclude that the steric gate of hPolkappa is a major fidelity factor that regulates extension reactions from mismatched primer termini...
  8. pmc Escherichia coli DNA polymerase III is responsible for the high level of spontaneous mutations in mutT strains
    Masami Yamada
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Mol Microbiol 86:1364-75. 2012
    ..coli mutT compared with the mammalian counterparts lacking the 8-oxo-dGTP hydrolysing activities...
  9. doi request reprint In vivo evidence that phenylalanine 171 acts as a molecular brake for translesion DNA synthesis across benzo[a]pyrene DNA adducts by human DNA polymerase κ
    Akira Sassa
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji shi, Tokyo 192 0392, Japan
    DNA Repair (Amst) 15:21-8. 2014
    ....
  10. pmc Involvement of Y-family DNA polymerases in mutagenesis caused by oxidized nucleotides in Escherichia coli
    Masami Yamada
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    J Bacteriol 188:4992-5. 2006
    ..Mutator phenotypes in sod/fur strains were substantially diminished by deletion of dinB and/or umuDC. DNA polymerases IV and V may be involved in mutagenesis caused by incorporation of the oxidized deoxynucleoside triphosphates...
  11. doi request reprint Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases
    Manabu Yasui
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    J Mol Biol 377:1015-23. 2008
    ..Thus, the dI adduct is a highly miscoding lesion capable of generating A-->G transition. This ()NO-induced adduct may play an important role in initiating inflammation-driven carcinogenesis...
  12. pmc Erroneous incorporation of oxidized DNA precursors by Y-family DNA polymerases
    Masatomi Shimizu
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    EMBO Rep 4:269-73. 2003
    ..We also report that human DNA polymerase eta, a human Y-family DNA polymerase, incorporates the oxidized dNTPs in a similar erroneous manner...