Katsuhide Fujita

Summary

Affiliation: National Institute of Advanced Industrial Science and Technology
Country: Japan

Publications

  1. ncbi request reprint [Significance of comprehensive gene expression analysis for evaluation of biological effects of manufactured nanomaterials]
    Katsuhide Fujita
    National Institute of Advanced Industrial Science and Technology, Japan
    Nihon Eiseigaku Zasshi 67:390-5. 2012
  2. doi request reprint Identification of potential biomarkers from gene expression profiles in rat lungs intratracheally instilled with C(60) fullerenes
    Katsuhide Fujita
    Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology AIST, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicology 274:34-41. 2010
  3. doi request reprint Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion
    Katsuhide Fujita
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicol Lett 191:109-17. 2009
  4. doi request reprint Gene expression profiles in rat lung after inhalation exposure to C60 fullerene particles
    Katsuhide Fujita
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicology 258:47-55. 2009
  5. ncbi request reprint The genome-wide screening of yeast deletion mutants to identify the genes required for tolerance to ethanol and other alcohols
    Katsuhide Fujita
    JBA Daicel Chemical Industries, Tsukuba, Ibaraki, Japan
    FEMS Yeast Res 6:744-50. 2006
  6. ncbi request reprint Comprehensive gene expression analysis of the response to straight-chain alcohols in Saccharomyces cerevisiae using cDNA microarray
    K Fujita
    Japan Bioindustry Association JBA, Daicel Chemical Industries, Ltd, Branch, Tsukuba, Japan
    J Appl Microbiol 97:57-67. 2004
  7. ncbi request reprint Yeast pheromone signaling pathway as a bioassay to assess the effect of chemicals on mammalian peptide hormones
    K Fujita
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, 1 1 Higashi 1, Tsukuba, 305 8566, Ibaraki, Japan
    Ecotoxicol Environ Saf 56:358-66. 2003
  8. doi request reprint Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells
    Masanori Horie
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Environ Toxicol 28:61-75. 2013
  9. pmc Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies
    Yasuo Morimoto
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Part Fibre Toxicol 7:4. 2010
  10. doi request reprint Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells
    Masanori Horie
    Health Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biochem 150:461-71. 2011

Collaborators

Detail Information

Publications28

  1. ncbi request reprint [Significance of comprehensive gene expression analysis for evaluation of biological effects of manufactured nanomaterials]
    Katsuhide Fujita
    National Institute of Advanced Industrial Science and Technology, Japan
    Nihon Eiseigaku Zasshi 67:390-5. 2012
    ..In this review, we introduce an outline of the project, and discuss about the significance of comparative gene expression analysis for evaluation of the biological effects of MNs...
  2. doi request reprint Identification of potential biomarkers from gene expression profiles in rat lungs intratracheally instilled with C(60) fullerenes
    Katsuhide Fujita
    Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology AIST, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicology 274:34-41. 2010
    ..We propose that these genes are useful for identifying potential biomarkers in acute-phase or persistent responses to C(60) fullerenes in the lung tissue...
  3. doi request reprint Effects of ultrafine TiO2 particles on gene expression profile in human keratinocytes without illumination: involvement of extracellular matrix and cell adhesion
    Katsuhide Fujita
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicol Lett 191:109-17. 2009
    ..These results suggest that the ultrafine TiO(2) particles without illumination have no significant impact on ROS-associated oxidative damage, but affect the cell-matrix adhesion in keratinocytes for extracellular matrix remodeling...
  4. doi request reprint Gene expression profiles in rat lung after inhalation exposure to C60 fullerene particles
    Katsuhide Fujita
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Onogawa 16 1, Tsukuba, Ibaraki 305 8569, Japan
    Toxicology 258:47-55. 2009
    ..We suggest that C(60) fullerene might not have a severe pulmonary toxicity under the inhalation exposure condition...
  5. ncbi request reprint The genome-wide screening of yeast deletion mutants to identify the genes required for tolerance to ethanol and other alcohols
    Katsuhide Fujita
    JBA Daicel Chemical Industries, Tsukuba, Ibaraki, Japan
    FEMS Yeast Res 6:744-50. 2006
    ..A global screening approach of yeast deletion library mutants was useful in elucidating the mechanisms of alcohol tolerance based on different lipophilicities...
  6. ncbi request reprint Comprehensive gene expression analysis of the response to straight-chain alcohols in Saccharomyces cerevisiae using cDNA microarray
    K Fujita
    Japan Bioindustry Association JBA, Daicel Chemical Industries, Ltd, Branch, Tsukuba, Japan
    J Appl Microbiol 97:57-67. 2004
    ..The purpose of this study was to examine the gene expression profiles of yeast Saccharomyces cerevisiae subjected to straight-chain alcohols...
  7. ncbi request reprint Yeast pheromone signaling pathway as a bioassay to assess the effect of chemicals on mammalian peptide hormones
    K Fujita
    Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology AIST, 1 1 Higashi 1, Tsukuba, 305 8566, Ibaraki, Japan
    Ecotoxicol Environ Saf 56:358-66. 2003
    ..Analysis of the yeast pheromone signaling pathway helps to establish chemical toxicity assay models for mammalian peptide signal transduction pathways...
  8. doi request reprint Chromium(III) oxide nanoparticles induced remarkable oxidative stress and apoptosis on culture cells
    Masanori Horie
    Health Research Institute, National Institute of Advanced Industrial Science and Technology, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Environ Toxicol 28:61-75. 2013
    ..The cellular influences of Cr(2)O(3) nanoparticles matched those of hexavalent chromium. In conclusion, Cr(2)O(3) nanoparticles have a high cytotoxic potential...
  9. pmc Inflammogenic effect of well-characterized fullerenes in inhalation and intratracheal instillation studies
    Yasuo Morimoto
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Part Fibre Toxicol 7:4. 2010
    ..The inflammatory responses and gene expression of cytokine-induced neutrophil chemoattractants (CINCs) were examined in rat lungs in both studies...
  10. doi request reprint Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells
    Masanori Horie
    Health Research Institute, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biochem 150:461-71. 2011
    ..These results suggest that CeO(2) nanoparticles have a potential to induce intracellular oxidative stress and increase the intracellular Ca(2+) level, but these influences are small...
  11. doi request reprint Characterization of fullerene colloidal suspension in a cell culture medium for in vitro toxicity assessment
    Haruhisa Kato
    Polymer Standards Section Japan PSSJ, National Metrology Institute of Japan NMIJ, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 5, Higashi 1 1 1, Tsukuba, Ibaraki, 305 8565 Japan
    Mol Biosyst 6:1238-46. 2010
    ..Since carbon nanomaterials with different geometric structures exhibit quite different cytotoxicity and bioactivity, these results are important for in vitro toxicity assessment...
  12. doi request reprint Dispersion characteristics of various metal oxide secondary nanoparticles in culture medium for in vitro toxicology assessment
    Haruhisa Kato
    Polymer Standards Section Japan, National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, Higashi 1 1 1, Tsukuba, Ibaraki 305 8565, Japan
    Toxicol In Vitro 24:1009-18. 2010
    ..The estimation of particle dynamics in culture medium using this method would be significant to recognize the inherent toxicity of nanoparticles...
  13. doi request reprint Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion
    Masanori Horie
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka 807 8555, Japan
    Metallomics 3:1244-52. 2011
    ..These results suggest that the physically and chemically inactive cellular influences of platinum nanoparticles are small...
  14. doi request reprint Cellular responses by stable and uniform ultrafine titanium dioxide particles in culture-medium dispersions when secondary particle size was 100 nm or less
    Masanori Horie
    Health Technology Research Center HTRC, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Toxicol In Vitro 24:1629-38. 2010
    ..As a result, although the ultrafine TiO(2) particles induce some cellular responses, these cellular responses to ultrafine TiO(2) are weaker than those of other cytotoxic ultrafine metal oxide particles, such as nickel oxide...
  15. doi request reprint Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung
    Hiroko Fukui
    Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, Ikeda, Osaka, Japan
    Chem Biol Interact 198:29-37. 2012
    ..Intracellular ROS level had a high correlation with intracellular Zn(2+) level. ZnO nanoparticles will stay in the lung and continually release zinc ion, and thus stronger oxidative stress is induced...
  16. doi request reprint Protein adsorption of ultrafine metal oxide and its influence on cytotoxicity toward cultured cells
    Masanori Horie
    Health Technology Research Center HTRC, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Chem Res Toxicol 22:543-53. 2009
    ..In conclusion, the adsorption ability of metal oxide nanoparticles is an important factor for the estimation of cytotoxicity in vitro for low-toxicity materials...
  17. doi request reprint In vitro evaluation of cellular responses induced by stable fullerene C60 medium dispersion
    Masanori Horie
    Health Research Institute HRI, National Institute of Advanced Industrial Science and Technology AIST, 1 8 31 Midorigaoka, Ikeda, Osaka 563 8577, Japan
    J Biochem 148:289-98. 2010
    ..The results obtained from this study indicate that C60 has oxidative stress induction potential. Further examinations including in vivo studies are necessary for a more accurate evaluation of biological influences by C60...
  18. doi request reprint Ultrafine NiO particles induce cytotoxicity in vitro by cellular uptake and subsequent Ni(II) release
    Masanori Horie
    Health Technology Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Chem Res Toxicol 22:1415-26. 2009
    ..Taken together, the present results suggest that the intracellular Ni(2+) release could be an important factor that determines the cytotoxicity of NiO. Ultrafine NiO is more cytotoxic than fine NiO in vitro...
  19. doi request reprint Reliable size determination of nanoparticles using dynamic light scattering method for in vitro toxicology assessment
    Haruhisa Kato
    Polymer Standards Section Japan, National Metrology Institute of Japan, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, Tsukuba, Ibaraki 305 8565, Japan
    Toxicol In Vitro 23:927-34. 2009
    ..Furthermore, TiO(2) secondary nanoparticle suspensions are well dispersed with slow gravity settling, no agglomeration, with the diffusion process as the primary transport mode of particles to cells...
  20. doi request reprint Biopersistence of inhaled MWCNT in rat lungs in a 4-week well-characterized exposure
    Takako Oyabu
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Inhal Toxicol 23:784-91. 2011
    ..The clearance was not delayed, but a slight increase in lung weight at 3 days after the inhalation was observed...
  21. doi request reprint Expression of cytokine-induced neutrophil chemoattractant in rat lungs by intratracheal instillation of nickel oxide nanoparticles
    Kenichiro Nishi
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka, Japan
    Inhal Toxicol 21:1030-9. 2009
    ..In lung tissue, infiltration of mainly neutrophils and alveolar macrophages was observed from day 3 to 6 months in alveoli. These results suggest that CINC was involved in lung injury by nickel oxide nanoparticles...
  22. doi request reprint Dispersant affects the cellular influences of single-wall carbon nanotube: the role of CNT as carrier of dispersants
    Masanori Horie
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Toxicol Mech Methods 23:315-22. 2013
    ..These results suggest that the adsorbed dispersant reagents on the surface of the CNT affect its cellular influences, particularly the induction of oxidative stress...
  23. doi request reprint Physical properties of single-wall carbon nanotubes in cell culture and their dispersal due to alveolar epithelial cell response
    Katsuhide Fujita
    Research Institute of Science for Safety and Sustainability, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba, Ibaraki 305 8569, Japan
    Toxicol Mech Methods 23:598-609. 2013
    ..Additionally, the residual metals associated with the manufacturing of SWCNTs may not be a definitive parameter for intracellular ROS generation in A549 cells...
  24. doi request reprint Comparison of acute oxidative stress on rat lung induced by nano and fine-scale, soluble and insoluble metal oxide particles: NiO and TiO2
    Masanori Horie
    Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Inhal Toxicol 24:391-400. 2012
    ..Ni(2+) release from NiO nanoparticles is an important factor inoxidative stress-related toxicity, not only in vitro but also in vivo...
  25. doi request reprint Induction of adaptive response and enhancement of PC12 cell tolerance by lipopolysaccharide primarily through the upregulation of glutathione S-transferase A3 via Nrf2 activation
    Yo Omata
    Human Stress Signal Research Center, National Institute of Advanced Industrial Science and Technology, 1 8 31, Midorigaoka, Ikeda, Osaka 563 8577, Japan
    Free Radic Biol Med 45:1437-45. 2008
    ....
  26. ncbi request reprint Genome-wide expression analysis of yeast response during exposure to 4 degrees C
    Yoshinori Murata
    International Patent Organism Depositary, National Institute of Advanced Industrial Science Technology, Central 6, Tsukuba, Japan
    Extremophiles 10:117-28. 2006
    ..The genes with these functions may provide the ability of cold tolerance and adaptation to yeast cells...
  27. ncbi request reprint Evaluation of acute oxidative stress induced by NiO nanoparticles in vivo and in vitro
    Masanori Horie
    Health Research Institute, Ikeda, Osaka, Japan
    J Occup Health 53:64-74. 2011
    ..In the present study, we focused on the oxidative stress caused by NiO nanoparticles by examining and comparing in vitro and in vivo acute responses induced by NiO nanoparticles...
  28. ncbi request reprint Lcb4p sphingoid base kinase localizes to the Golgi and late endosomes
    Nitai C Hait
    Department of Molecular and Cellular Biochemistry, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    FEBS Lett 532:97-102. 2002
    ..These results indicate that LCBs made in the endoplasmic reticulum must transit to the Golgi to be converted into LCBPs, which must then return to the endoplasmic reticulum to be degraded...