Takao Fujisawa

Summary

Affiliation: National Hospital Organization
Country: Japan

Publications

  1. ncbi request reprint Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils
    Takao Fujisawa
    Department of Pediatrics and Allergy, National Mie Hospital, Tsu City, Japan
    J Asthma 39:21-7. 2002
  2. ncbi request reprint Serum measurement of thymus and activation-regulated chemokine/CCL17 in children with atopic dermatitis: elevated normal levels in infancy and age-specific analysis in atopic dermatitis
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Pediatr Allergy Immunol 20:633-41. 2009
  3. doi request reprint Biomarkers for allergen immunotherapy in cedar pollinosis
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    Allergol Int 58:163-70. 2009
  4. doi request reprint House dust mite extract induces interleukin-9 expression in human eosinophils
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, Tsu, Mie, Japan
    Allergol Int 57:141-6. 2008
  5. ncbi request reprint [Allergens--the alpha and the omega of allergology]
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital
    Arerugi 57:803-6. 2008
  6. ncbi request reprint Role of oxygen radicals on bronchial asthma
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, 357 Osato kubota, Tsu, Mie 514 0125, Japan
    Curr Drug Targets Inflamm Allergy 4:505-9. 2005
  7. doi request reprint Allergen-induced basophil CD203c expression as a biomarker for rush immunotherapy in patients with Japanese cedar pollinosis
    Mizuho Nagao
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    Int Arch Allergy Immunol 146:47-53. 2008
  8. doi request reprint Differential activation of eosinophils by bacteria associated with asthma
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 161:16-22. 2013
  9. doi request reprint Staphylococcus aureus directly activates eosinophils via platelet-activating factor receptor
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    J Leukoc Biol 92:333-41. 2012
  10. ncbi request reprint Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils
    Yoshiko Kato
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 137:17-20. 2005

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils
    Takao Fujisawa
    Department of Pediatrics and Allergy, National Mie Hospital, Tsu City, Japan
    J Asthma 39:21-7. 2002
    ..The inhibition was comparable to that with dexamethasone at 10(-9) M. Our results suggest that a combination of low-dose theophylline and procaterol exhibits antiinflammatory effects in asthma by inhibiting eosinophil-effector functions...
  2. ncbi request reprint Serum measurement of thymus and activation-regulated chemokine/CCL17 in children with atopic dermatitis: elevated normal levels in infancy and age-specific analysis in atopic dermatitis
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Pediatr Allergy Immunol 20:633-41. 2009
    ..The serum level of TARC/CCL17 reflects the severity and therapeutic response in AD. The high normal levels in infants should be taken into account when assaying TARC/CCL17...
  3. doi request reprint Biomarkers for allergen immunotherapy in cedar pollinosis
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    Allergol Int 58:163-70. 2009
    ..In patients who received rush immunotherapy for Japanese cedar pollinosis, reduction in CD203c expression after the therapy was observed, suggesting the utility of the test for monitoring immunotherapy...
  4. doi request reprint House dust mite extract induces interleukin-9 expression in human eosinophils
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, Tsu, Mie, Japan
    Allergol Int 57:141-6. 2008
    ..We investigated cytokine production from eosinophils through direct interaction with a major allergen, house dust mite (HDM) ...
  5. ncbi request reprint [Allergens--the alpha and the omega of allergology]
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital
    Arerugi 57:803-6. 2008
  6. ncbi request reprint Role of oxygen radicals on bronchial asthma
    Takao Fujisawa
    Institute for Clinical Research, Mie National Hospital, 357 Osato kubota, Tsu, Mie 514 0125, Japan
    Curr Drug Targets Inflamm Allergy 4:505-9. 2005
    ..Therapeutic interventions that reduce oxidant stress and enhance antioxidant defense may be useful in the treatment of asthma...
  7. doi request reprint Allergen-induced basophil CD203c expression as a biomarker for rush immunotherapy in patients with Japanese cedar pollinosis
    Mizuho Nagao
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    Int Arch Allergy Immunol 146:47-53. 2008
    ..CD203c is a basophil activation marker known to be upregulated by cross-linking of the FcepsilonRIalpha receptor and may serve as a useful marker...
  8. doi request reprint Differential activation of eosinophils by bacteria associated with asthma
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 161:16-22. 2013
    ..This study investigated whether bacteria exert differential effects on the functions of eosinophils, major effector cells in airway inflammation in asthma...
  9. doi request reprint Staphylococcus aureus directly activates eosinophils via platelet-activating factor receptor
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    J Leukoc Biol 92:333-41. 2012
    ..A PAFR-blocking peptide and two PAFR antagonists completely inhibited those reactions. In conclusion, SA directly induced eosinophil activation via PAFR. Blockade of PAFR may be a novel, therapeutic approach for AD colonized by SA...
  10. ncbi request reprint Leukotriene D4 induces production of transforming growth factor-beta1 by eosinophils
    Yoshiko Kato
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 137:17-20. 2005
    ..The results suggested that CysLTs stimulate eosinophils to induce TGF-beta1 production in allergic inflammation where IL-5 and GM-CSF are abundant and may be involved in the pathogenesis of airway remodeling...
  11. doi request reprint Antigen-induced expression of CD203c on basophils predicts IgE-mediated wheat allergy
    Reiko Tokuda
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    Allergol Int 58:193-9. 2009
    ..Oral food challenge, the gold standard for the diagnosis, is accompanied by a risk of severe induced reactions. Reliable in vitro tests are needed to be developed for safe indication for oral challenge...
  12. ncbi request reprint Differential activation of eosinophils by 'probiotic' Bifidobacterium bifidum and 'pathogenic' Clostridium difficile
    Koa Hosoki
    Institute for Clinical Research, Mie University Hospital, Tsu, Japan
    Int Arch Allergy Immunol 152:83-9. 2010
    ..However, the underlying mechanisms are not well known, especially in relation to eosinophils, the major effector cells of these inflammatory diseases...
  13. doi request reprint 1,25-Dihydroxyvitamin D3 upregulates functional C-x-C chemokine receptor type 4 expression in human eosinophils
    Yukiko Hiraguchi
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 158:51-7. 2012
    ..Objectives: To test whether 1,25-dihydroxyvitamin D(3) [1,25-(OH)(2)D(3) or calcitriol], the active metabolite of vitamin D, acts directly on eosinophils to induce upregulation of CXCR4...
  14. doi request reprint Inhibition of eosinophil activation mediated by a Toll-like receptor 7 ligand with a combination of procaterol and budesonide
    Yukiko Hiraguchi
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 155:85-9. 2011
    ..We investigated the effect of a β(2)-agonist, i.e. procaterol, and a corticosteroid, i.e. budesonide, that are commonly used for viral-induced asthma, on TLR7 ligand-induced activation of eosinophils in vitro...
  15. doi request reprint Neutrophil Proteases Activate Eosinophil Function in vitro
    Yukiko Hiraguchi
    Institute for Clinical Research, Mie National Hospital, Mie, Japan
    Int Arch Allergy Immunol 146:16-21. 2008
    ..Mechanisms for interaction between neutrophils and eosinophils are still to be understood. Since eosinophils express protease-activated receptor 2, neutrophil-derived serine proteases may activate eosinophils...
  16. doi request reprint High prevalence and young onset of allergic rhinitis in children with bronchial asthma
    Sawako Masuda
    Department of Otorhinolaryngology, Mie National Hospital, Tsu, Japan
    Pediatr Allergy Immunol 19:517-22. 2008
    ..These results demonstrate that allergic rhinitis manifested early in life in the majority of the asthmatic children. Persistent nasal symptoms in infancy may point to subsequent development of asthma and possible early intervention...
  17. pmc Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells
    Atsushi Yasukawa
    Department of Immunology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 8:e64281. 2013
    ..Treatment with anti-TGF-β1 antibody blocked EMT in bronchial epithelial cells. Eosinophils induced EMT in bronchial epithelial cells, suggesting their contribution to the pathogenesis of airway remodelling...
  18. ncbi request reprint [Factors related to recurrent wheezing after hospitalization with RSV infection with the children who were aged three years old or younger: a questionnaire survey]
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital
    Arerugi 58:1513-20. 2009
    ..These results suggest that some host factors susceptible to wheezing and chance of infection due to attending a daycare may be related to recurrent wheezing possibly onset of bronchial asthma, after RSV infection...
  19. doi request reprint An 8-year-old boy with hypereosinophilic syndrome
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 155:117-22. 2011
    ..HES is extraordinary rare in children and the long-term prognosis in pediatric HES is not well known. Comprehensive diagnostic procedures are vital for the early detection and management of complications in pediatric HES...
  20. ncbi request reprint Montelukast suppresses epithelial to mesenchymal transition of bronchial epithelial cells induced by eosinophils
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital, Japan Department of Immunology, Mie University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 449:351-6. 2014
    ..This study showed that montelukast suppresses eosinophils-induced EMT of airway epithelial cells. This finding may explain the mechanism of montelukast-mediated amelioration of airway remodeling in bronchial asthma. ..
  21. ncbi request reprint Presence of high contents of thymus and activation-regulated chemokine in platelets and elevated plasma levels of thymus and activation-regulated chemokine and macrophage-derived chemokine in patients with atopic dermatitis
    Takao Fujisawa
    Department of Pediatrics and Allergy, National Mie Hospital, Tsu, Japan
    J Allergy Clin Immunol 110:139-46. 2002
    ..T(H)2 cells and eosinophils selectively express CC chemokine receptor 4 and CCR3, respectively, and their chemokine ligands are likely to play important roles in the pathogenesis of atopic dermatitis (AD)...
  22. ncbi request reprint [Prevalence of allergy in patients with severe motor and intellectual disabilities (SMID)]
    Koa Hosoki
    Institute for Clinical Research, Mie National Hospital
    Arerugi 60:823-33. 2011
    ..Patients with SMID have complex problems involving multiple organs and multidisciplinary approach is mandatory. However, prevalence of allergic diseases in SMID patients is not known...
  23. doi request reprint Elevated numbers of cells producing interleukin-5 and interleukin-10 in a boy with Kimura disease
    Koa Hosoki
    Institute for Clinical Research, and Department of Pediatrics, Mie National Hospital, Tsu, Japan
    Int Arch Allergy Immunol 158:70-4. 2012
    ..Immunohistochemical evaluation, however, did not detect IL-5 in the tissue. Possible cytokine dysregulation in Kimura disease was suggested, but the pathogenesis remains unclear...
  24. ncbi request reprint [Prevalence of sensitization of Japanese cedar pollen in children from infancy to adolescence]
    Sawako Masuda
    Department of Otorhinolaryngology, National Mie Hospital
    Arerugi 55:1312-20. 2006
    ..In Japan, morbidity of Japanese cedar pollinosis has dramatically increased, especially in children. However, little is known about the prevalence of pollinosis and sensitization to Japanese cedar pollen (JCP) in young children...
  25. ncbi request reprint [A case of primary ciliary dyskinesia who had been treated as asthma]
    Koa Hosoki
    Department of Pediatrics, Mie National Hospital and Electron Microscopy Research Center, Mie University
    Arerugi 59:847-54. 2010
    ..Recurrent wheeze with chronic rhinosinusitis, chronic otitis media, and brochiectasis may warrant detailed investigations for PCD, especially with nasal NO measurement...
  26. doi request reprint Higher allergenicity of high molecular weight hydrolysed wheat protein in cosmetics for percutaneous sensitization
    Yuko Chinuki
    Department of Dermatology, Shimane University, Izumo, Shimane, Japan
    Contact Dermatitis 68:86-93. 2013
    ..Several cases of contact urticaria following exposure to hydrolysed wheat protein (HWP) in cosmetics or of anaphylaxis caused by deamidated gluten in food or non-food products have been described...
  27. ncbi request reprint 'Benifuuki' green tea containing o-methylated catechin reduces symptoms of Japanese cedar pollinosis: a randomized, double-blind, placebo-controlled trial
    Sawako Masuda
    Department of Clinical Research, Mie National Hospital, Mie, Japan Department of Otorhinolaryngology, Mie National Hospital, Mie, Japan
    Allergol Int 63:211-7. 2014
    ..We evaluated the efficacy of 'Benifuuki' green tea, which contains O-methylated epigallocatechin-3-O-[3-O-methyl] gallate (O-methylated EGCG), in alleviating Japanese cedar pollinosis (JCP)...
  28. ncbi request reprint A new strategy for healthcare-associated pneumonia: a 2-year prospective multicenter cohort study using risk factors for multidrug-resistant pathogens to select initial empiric therapy
    Takaya Maruyama
    Department of Respiratory Medicine, National Hospital Organization, Mie National Hospital, Tsu
    Clin Infect Dis 57:1373-83. 2013
    ..Optimal empiric therapy for hospitalized patients with healthcare-associated pneumonia (HCAP) is uncertain...
  29. ncbi request reprint A functional study on CysLT(1) receptors in human eosinophils
    Nobuharu Ohshima
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 129:67-75. 2002
    ..The cysteinyl leukotrienes (CysLTs) mediate their biological actions through two receptors: CysLT(1) receptor and CysLT(2) receptor...
  30. ncbi request reprint Comparative effects of basophil-directed growth factors
    Chitose Yoshimura-Uchiyama
    Department of Allergy and Rheumatology, University of Tokyo, Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 302:201-6. 2003
    ..Our results indicate that IL-3 is the most potent activator of human basophils, and that the rank order of potency of hemopoietic growth factors virtually corresponded to their receptor expression levels in both cell types...
  31. doi request reprint Blocking antibody is generated in allergic rhinitis patients during specific immunotherapy using standardized Japanese cedar pollen extract
    Ayako Kawakami
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 146:54-60. 2008
    ..In this study, we assessed the induction of blocking antibody during specific immunotherapy (SIT) using a recently standardized allergen extract from Japanese cedar pollen...
  32. ncbi request reprint [A questionnaire survey of asthma in children with co-morbid allergic rhinitis]
    Sawako Masuda
    Department of Otorhinolaryngology, National Mie Hospital
    Arerugi 55:566-73. 2006
    ..Bronchial asthma is often complicated with allergic rhinitis (AR)...
  33. ncbi request reprint [Eosinophilic inflammation in bronchial asthma: its re-evaluation]
    Takao Fujisawa
    Nihon Naika Gakkai Zasshi 95:1564-71. 2006
  34. ncbi request reprint ASK family proteins in stress response and disease
    Takao Fujisawa
    Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Mol Biotechnol 37:13-8. 2007
    ..Here, we highlight the roles of members of the ASK family, which consists of ASK1 and newly characterized ASK2, in ROS signaling with their possible involvement in human diseases...
  35. doi request reprint Eosinophils in allergy and related diseases. Preface
    Takao Fujisawa
    Int Arch Allergy Immunol 146:1. 2008
  36. ncbi request reprint Liver-expressed chemokine/CC chemokine ligand 16 attracts eosinophils by interacting with histamine H4 receptor
    Takashi Nakayama
    Department of Microbiology, Kinki University School of Medicine, Osaka, Japan
    J Immunol 173:2078-83. 2004
    ..Collectively, CCL16 is a novel functional ligand for H4 and may have a role in trafficking of eosinophils...