Affiliation: National Institute of Advanced Industrial Science and Technology
Ema M, Naya M, Yoshida K, Nagaosa R. Reproductive and developmental toxicity of degradation products of refrigerants in experimental animals. Reprod Toxicol. 2010;29:1-9 pubmed publisher
..Rat multiple-generation studies revealed that NaF caused retarded ossification and degenerative changes in the lung and kidney in offspring. There is a lack of information about the toxicity of TFA and FA. ..
Ema M, Matsuda A, Kobayashi N, Naya M, Nakanishi J. Dermal and ocular irritation and skin sensitization studies of fullerene C60 nanoparticles. Cutan Ocul Toxicol. 2013;32:128-34 pubmed publisher
..Further information is needed to clarify the potential for toxicity given the complex nature of fullerenes and their derivatives. ..
Ema M, Naya M, Horimoto M, Kato H. Developmental toxicity of diesel exhaust: a review of studies in experimental animals. Reprod Toxicol. 2013;42:1-17 pubmed publisher
Ema M, Gamo M, Honda K. A review of toxicity studies of single-walled carbon nanotubes in laboratory animals. Regul Toxicol Pharmacol. 2016;74:42-63 pubmed publisher
..To further clarify their toxicity and risk assessment, studies should be conducted using well-characterized SWCNTs, standard protocols, and the relevant route and doses of human exposure. ..
Ema M, Gamo M, Honda K. Developmental toxicity of engineered nanomaterials in rodents. Toxicol Appl Pharmacol. 2016;299:47-52 pubmed publisher
Ema M, Okuda H, Gamo M, Honda K. A review of reproductive and developmental toxicity of silver nanoparticles in laboratory animals. Reprod Toxicol. 2017;67:149-164 pubmed publisher
..Further studies using state-of-the-art methodologies and the relevant routes and doses for human exposure are required. ..
Ema M, Kobayashi N, Naya M, Hanai S, Nakanishi J. Reproductive and developmental toxicity studies of manufactured nanomaterials. Reprod Toxicol. 2010;30:343-52 pubmed publisher
Ema M, Gamo M, Honda K. A review of toxicity studies on graphene-based nanomaterials in laboratory animals. Regul Toxicol Pharmacol. 2017;85:7-24 pubmed publisher
..To fill the data gap, further studies should be performed using laboratory mammals exposed using the route and dose anticipated for human exposure scenarios. ..