Xing Cui

Summary

Affiliation: National Institute for Environmental Studies
Country: Japan

Publications

  1. ncbi request reprint Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer
    Xing Cui
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    Curr Med Chem 15:2293-304. 2008
  2. ncbi request reprint Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 91:372-81. 2006
  3. ncbi request reprint Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Hum Pathol 37:298-311. 2006
  4. ncbi request reprint Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 82:478-87. 2004
  5. ncbi request reprint Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Pathol 32:64-72. 2004
  6. ncbi request reprint Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Ibaraki, Japan
    Arch Toxicol 77:305-12. 2003
  7. ncbi request reprint A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
    Toru Hayakawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:183-91. 2005
  8. ncbi request reprint Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:54-61. 2005
  9. ncbi request reprint Stability of arsenic metabolites, arsenic triglutathione [As(GS)3] and methylarsenic diglutathione [CH3As(GS)2], in rat bile
    Yayoi Kobayashi
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 211:115-23. 2005
  10. ncbi request reprint PCR-based subtraction analyses for upregulated gene transcription in cadmium-exposed rat lung type 2 epithelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Biochem Biophys Res Commun 308:133-8. 2003

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancer
    Xing Cui
    Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
    Curr Med Chem 15:2293-304. 2008
    ..We also summarize the clinical use of arsenic trioxide (As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors...
  2. ncbi request reprint Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 91:372-81. 2006
    ..In conclusion, iAs(V) exposure increased lung tumor incidence and multiplicity in A/J mice. Epigenetic changes of tumor suppressor genes such as p16INK4a and RASSF1A are involved in the iAs(V)-induced lung carcinogenesis...
  3. ncbi request reprint Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
    Hum Pathol 37:298-311. 2006
    ..In conclusion, a low concentration of As2O3 induces CpG island demethylation of tumor suppressor genes by inhibition of DNMT and reactivates the partially/fully silenced genes in liver cancer cells...
  4. ncbi request reprint Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in rats
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Sci 82:478-87. 2004
    ..We are also first to show that DMAV that probably originated from DMAG is excreted into the bile in iAs-po rats...
  5. ncbi request reprint Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Pathol 32:64-72. 2004
    ..This implies that arsenic liver toxicity involves disturbances of some cancer-related molecules...
  6. ncbi request reprint Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Ibaraki, Japan
    Arch Toxicol 77:305-12. 2003
    ....
  7. ncbi request reprint A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19
    Toru Hayakawa
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:183-91. 2005
    ..Metabolism of iAsIII to methylated arsenicals by Cyt19 was via ATG and MADG rather than by oxidative methylation of iAsIII and MMA(III)...
  8. ncbi request reprint Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Arch Toxicol 79:54-61. 2005
    ..These results indicate that the inhibition of protein phosphatases as well as the high affinity to cellular components may confer PAO3+ the high toxicity...
  9. ncbi request reprint Stability of arsenic metabolites, arsenic triglutathione [As(GS)3] and methylarsenic diglutathione [CH3As(GS)2], in rat bile
    Yayoi Kobayashi
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicology 211:115-23. 2005
    ..These results suggest that GSH plays an important role in preventing hydrolysis of As-GSH complexes and the generation of well-known toxic trivalent arsenicals...
  10. ncbi request reprint PCR-based subtraction analyses for upregulated gene transcription in cadmium-exposed rat lung type 2 epithelial cells
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Biochem Biophys Res Commun 308:133-8. 2003
    ..AB086193) mRNAs were weakly inducible. The expression of cdig1 increased linearly with time up to 9h, while that of HO-1 reached the maximum value at 4h in response to 10 microM Cd...
  11. ncbi request reprint The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compounds
    Seishiro Hirano
    Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Appl Pharmacol 198:458-67. 2004
    ..These results suggest that MMA(III) (GS)(2) is highly toxic compared to other arsenic compounds because of faster accumulation of this species by cells, in addition to having the toxic nature of methylated trivalent organic arsenics...
  12. doi request reprint Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cells
    Megumi Yamamoto
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    J Biochem Mol Toxicol 22:136-46. 2008
    ....
  13. ncbi request reprint Arsenic speciation in the urine and hair of individuals exposed to airborne arsenic through coal-burning in Guizhou, PR China
    Amjad Shraim
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
    Toxicol Lett 137:35-48. 2003
    ..Females were found to have a higher dimethylarsinic acid but lower percentages of inorganic arsenic and monomethylarsonic acid in their urine than males...
  14. doi request reprint Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats
    Xing Cui
    Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki 305 8506, Japan
    Food Chem Toxicol 46:3646-50. 2008
    ..These data indicate that arsenic is widely distributed and significantly accumulated in various organs and influences on other trace elements, and also modulates MT-1 expression in the liver and kidney...
  15. ncbi request reprint Inhibition of beta-amyloid precursor protein gene in SK-N-SH cells by piperlonguminine/dihydropiperlonguminine components separated from Chinese herbal medicine Futokadsura stem
    Wen Xia
    Department of Cerebrovascular Disease, Qilu Hospital, Shandong University, Jinan 250012, Shandong, People s Republic of China
    Chin J Physiol 50:157-63. 2007
    ..These data suggest that piperlonguminine/dihydropiperlonguminine components are the effective components in Futokadsura stem which can inhibit the expression of APP gene...
  16. doi request reprint Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosis
    Taiji Tamura
    Department of Radiation Emergency Medicine, The Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba City, Chiba 263 8555, Japan
    Food Chem Toxicol 46:3080-9. 2008
    ....
  17. ncbi request reprint Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinoma
    Xing Cui
    Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
    Hum Pathol 35:1189-95. 2004
    ..994, P <0.0001, respectively). Most CRCs demonstrate aberrant expression of pRb and/or p16 at resectable stages. Aberrant expression of pRb and p16, alone and in combination, heralds poor prognosis in patients with CRC...
  18. ncbi request reprint Liver regeneration enhanced by orally administered ursodesoxycholic acid is mediated by immunosuppression in partially hepatectomized rats
    Lili Liu
    The First Department of Surgery, Niigata University School of Medicine, Japan
    Am J Chin Med 30:119-26. 2002
    ..It was also noted that UDCA did not affect serum parameters indicating liver and kidney function. These findings suggest that liver regeneration can be modified by orally administered UDCA through a change in immunoactivity...