Research Topics
Species | Xing CuiSummaryAffiliation: National Institute for Environmental Studies Country: Japan Publications
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Detail Information
Publications
Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancerXing Cui
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
Curr Med Chem 15:2293-304. 2008..We also summarize the clinical use of arsenic trioxide (As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors...- Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J miceXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Sci 91:372-81. 2006..In conclusion, iAs(V) exposure increased lung tumor incidence and multiplicity in A/J mice. Epigenetic changes of tumor suppressor genes such as p16INK4a and RASSF1A are involved in the iAs(V)-induced lung carcinogenesis... - Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cellsXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki 305 8506, Japan
Hum Pathol 37:298-311. 2006..In conclusion, a low concentration of As2O3 induces CpG island demethylation of tumor suppressor genes by inhibition of DNMT and reactivates the partially/fully silenced genes in liver cancer cells... - Arsenic speciation in bile and urine following oral and intravenous exposure to inorganic and organic arsenics in ratsXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Sci 82:478-87. 2004..We are also first to show that DMAV that probably originated from DMAG is excreted into the bile in iAs-po rats... - Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liverXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Pathol 32:64-72. 2004..This implies that arsenic liver toxicity involves disturbances of some cancer-related molecules... - Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cellsSeishiro Hirano
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, 305 8506, Tsukuba, Ibaraki, Japan
Arch Toxicol 77:305-12. 2003.... - A new metabolic pathway of arsenite: arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19Toru Hayakawa
Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-8506, Ibaraki, Japan
Arch Toxicol 79:183-91. 2005..Metabolism of iAsIII to methylated arsenicals by Cyt19 was via ATG and MADG rather than by oxidative methylation of iAsIII and MMA(III)... - Accumulation and toxicity of monophenyl arsenicals in rat endothelial cellsSeishiro Hirano
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
Arch Toxicol 79:54-61. 2005..These results indicate that the inhibition of protein phosphatases as well as the high affinity to cellular components may confer PAO3+ the high toxicity... - Stability of arsenic metabolites, arsenic triglutathione [As(GS)3] and methylarsenic diglutathione [CH3As(GS)2], in rat bileYayoi Kobayashi
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicology 211:115-23. 2005..These results suggest that GSH plays an important role in preventing hydrolysis of As-GSH complexes and the generation of well-known toxic trivalent arsenicals... - PCR-based subtraction analyses for upregulated gene transcription in cadmium-exposed rat lung type 2 epithelial cellsSeishiro Hirano
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Biochem Biophys Res Commun 308:133-8. 2003..AB086193) mRNAs were weakly inducible. The expression of cdig1 increased linearly with time up to 9h, while that of HO-1 reached the maximum value at 4h in response to 10 microM Cd... - The accumulation and toxicity of methylated arsenicals in endothelial cells: important roles of thiol compoundsSeishiro Hirano
Environmental Health Sciences Division, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
Toxicol Appl Pharmacol 198:458-67. 2004..These results suggest that MMA(III) (GS)(2) is highly toxic compared to other arsenic compounds because of faster accumulation of this species by cells, in addition to having the toxic nature of methylated trivalent organic arsenics... 
Selective activation of NF-kappaB and E2F by low concentration of arsenite in U937 human monocytic leukemia cellsMegumi Yamamoto
Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
J Biochem Mol Toxicol 22:136-46. 2008....- Arsenic speciation in the urine and hair of individuals exposed to airborne arsenic through coal-burning in Guizhou, PR ChinaAmjad Shraim
Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, 305 8506, Ibaraki, Japan
Toxicol Lett 137:35-48. 2003..Females were found to have a higher dimethylarsinic acid but lower percentages of inorganic arsenic and monomethylarsonic acid in their urine than males... - Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of ratsXing Cui
Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki 305 8506, Japan
Food Chem Toxicol 46:3646-50. 2008..These data indicate that arsenic is widely distributed and significantly accumulated in various organs and influences on other trace elements, and also modulates MT-1 expression in the liver and kidney... - Inhibition of beta-amyloid precursor protein gene in SK-N-SH cells by piperlonguminine/dihydropiperlonguminine components separated from Chinese herbal medicine Futokadsura stemWen Xia
Department of Cerebrovascular Disease, Qilu Hospital, Shandong University, Jinan 250012, Shandong, People s Republic of China
Chin J Physiol 50:157-63. 2007..These data suggest that piperlonguminine/dihydropiperlonguminine components are the effective components in Futokadsura stem which can inhibit the expression of APP gene... - Ginsenoside Rd prevents and rescues rat intestinal epithelial cells from irradiation-induced apoptosisTaiji Tamura
Department of Radiation Emergency Medicine, The Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba City, Chiba 263 8555, Japan
Food Chem Toxicol 46:3080-9. 2008.... - Aberrant expression of pRb and p16(INK4), alone or in combination, indicates poor outcome after resection in patients with colorectal carcinomaXing Cui
Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata City, Japan
Hum Pathol 35:1189-95. 2004..994, P <0.0001, respectively). Most CRCs demonstrate aberrant expression of pRb and/or p16 at resectable stages. Aberrant expression of pRb and p16, alone and in combination, heralds poor prognosis in patients with CRC... - Liver regeneration enhanced by orally administered ursodesoxycholic acid is mediated by immunosuppression in partially hepatectomized ratsLili Liu
The First Department of Surgery, Niigata University School of Medicine, Japan
Am J Chin Med 30:119-26. 2002..It was also noted that UDCA did not affect serum parameters indicating liver and kidney function. These findings suggest that liver regeneration can be modified by orally administered UDCA through a change in immunoactivity...