R Bakalova

Summary

Affiliation: National Institute of Radiological Sciences
Country: Japan

Publications

  1. ncbi request reprint Enhancement of the photoluminescence of CdSe quantum dots during long-term UV-irradiation: privilege or fault in life science research?
    Zhivko Zhelev
    Natural Substance Composed Materials Group, National Institute for Advanced Industrial Science and Technology, AIST Kyushu, Tosu, Saga ken, Japan
    J Photochem Photobiol B 75:99-105. 2004
  2. ncbi request reprint Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Bioconjug Chem 19:1135-42. 2008
  3. pmc Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Nanomedicine 6:1719-32. 2011
  4. doi request reprint Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer
    Rumiana Bakalova
    Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Clin Cancer Res 19:2503-17. 2013
  5. pmc Fluorescent imaging for assessment of the effect of combined application of electroporation and rifampicin on HaCaT cells as a new therapeutic approach for psoriasis
    Biliana Nikolova
    Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad G Bonchev Str, Bl 21, Sofia 1113, Bulgaria
    Sensors (Basel) 13:3625-34. 2013
  6. ncbi request reprint Cell-penetrating nitroxides as molecular sensors for imaging of cancer in vivo, based on tissue redox activity
    Zhivko Zhelev
    Diagnostic Imaging Program, Molecular Imaging Center, NIRS Chiba, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Mol Biosyst 8:2733-40. 2012
  7. ncbi request reprint RNA interference--about the reality to be exploited in cancer therapy
    R Bakalova
    Department of Biophysics, Molecular Imaging Center, NIRS, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Methods Find Exp Clin Pharmacol 29:417-21. 2007
  8. ncbi request reprint Modified 27-nt dsRNAs with dramatically enhanced stability in serum and long-term RNAi activity
    Takanori Kubo
    On site Sensing and Diagnosis Research Laboratory, AIST Kyushu, Tosu, Japan
    Oligonucleotides 17:445-64. 2007
  9. ncbi request reprint Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect
    Takanori Kubo
    On site Sensing and Diagnosis Research Laboratory, National Institute of Advanced Industrial Science and Technology AIST, 807 1 Shuku machi, Tosu 841 0052, Japan
    Biochem Biophys Res Commun 365:54-61. 2008
  10. ncbi request reprint Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    Anal Chem 78:5925-32. 2006

Collaborators

  • Ichio Aoki
  • Tsuneo Saga
  • Makoto Higuchi
  • Kazuto Masamoto
  • Takayuki Obata
  • Zhivko Zhelev
  • Hideki Ohba
  • Yoshinobu Baba
  • Mitsuru Ishikawa
  • Takanori Kubo
  • Rajan Jose
  • Biliana Nikolova
  • Ashraf Ewis
  • Yasuo Shinohara
  • Genoveva Zlateva
  • Toshimi Nagase
  • Hannah Schröder-Borm
  • Iana Tsoneva
  • Anelia Kostadinova
  • Borislav Dimitrov
  • Veselina Gadjeva
  • Iwao Kanno
  • Yusuke Imai
  • Jörg Andrä
  • Sawako Moriwaki
  • Seiji Yasuda
  • Toshiro Omori
  • Nobuyuki Yamasaki
  • Vera Hadjimitova
  • Michiro Muraki

Detail Information

Publications32

  1. ncbi request reprint Enhancement of the photoluminescence of CdSe quantum dots during long-term UV-irradiation: privilege or fault in life science research?
    Zhivko Zhelev
    Natural Substance Composed Materials Group, National Institute for Advanced Industrial Science and Technology, AIST Kyushu, Tosu, Saga ken, Japan
    J Photochem Photobiol B 75:99-105. 2004
    ..The results are discussed in the context of application of CdSe nanocrystals as novel fluorophores in life science experiments...
  2. ncbi request reprint Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effects
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Bioconjug Chem 19:1135-42. 2008
    ..g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI...
  3. pmc Chemical nature and structure of organic coating of quantum dots is crucial for their application in imaging diagnostics
    Rumiana Bakalova
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Int J Nanomedicine 6:1719-32. 2011
    ..The aim of the present study was to clarify whether the composition and structure of organic coating of nanoparticles are crucial for their application in vivo...
  4. doi request reprint Tissue redox activity as a hallmark of carcinogenesis: from early to terminal stages of cancer
    Rumiana Bakalova
    Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Clin Cancer Res 19:2503-17. 2013
    ..The study aimed to clarify the dynamics of tissue redox activity (TRA) in cancer progression and assess the importance of this parameter for therapeutic strategies...
  5. pmc Fluorescent imaging for assessment of the effect of combined application of electroporation and rifampicin on HaCaT cells as a new therapeutic approach for psoriasis
    Biliana Nikolova
    Institute of Biophysics and Biomedical Engineering, Bulgarian Academy of Sciences, Acad G Bonchev Str, Bl 21, Sofia 1113, Bulgaria
    Sensors (Basel) 13:3625-34. 2013
    ..The future application of this electrochemotherapeutic approach for combined local treatment of psoriasis may have serous benefits because of a high possibility to avoid side-effects of conventional chemotherapy...
  6. ncbi request reprint Cell-penetrating nitroxides as molecular sensors for imaging of cancer in vivo, based on tissue redox activity
    Zhivko Zhelev
    Diagnostic Imaging Program, Molecular Imaging Center, NIRS Chiba, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Mol Biosyst 8:2733-40. 2012
    ..We provide direct evidence that the nitroxide redox cycle could be used as a sensing platform for functional imaging of different pathologies, based on changes in cellular and tissue redox activity, as in the case of cancer...
  7. ncbi request reprint RNA interference--about the reality to be exploited in cancer therapy
    R Bakalova
    Department of Biophysics, Molecular Imaging Center, NIRS, 4 9 1 Anagawa, Inage Ku, Chiba, Japan
    Methods Find Exp Clin Pharmacol 29:417-21. 2007
    ....
  8. ncbi request reprint Modified 27-nt dsRNAs with dramatically enhanced stability in serum and long-term RNAi activity
    Takanori Kubo
    On site Sensing and Diagnosis Research Laboratory, AIST Kyushu, Tosu, Japan
    Oligonucleotides 17:445-64. 2007
    ..The 5' sense conjugation with cholesterol approved this assumption...
  9. ncbi request reprint Chemically modified symmetric and asymmetric duplex RNAs: an enhanced stability to nuclease degradation and gene silencing effect
    Takanori Kubo
    On site Sensing and Diagnosis Research Laboratory, National Institute of Advanced Industrial Science and Technology AIST, 807 1 Shuku machi, Tosu 841 0052, Japan
    Biochem Biophys Res Commun 365:54-61. 2008
    ..After a direct transfection in cells, the cholesterol-conjugated 27nt dsRNA possessed a higher RNAi activity than cholesterol-conjugated 21nt siRNA...
  10. ncbi request reprint Silica-shelled single quantum dot micelles as imaging probes with dual or multimodality
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    Anal Chem 78:5925-32. 2006
    ..g., fluorescent imaging and functional magnetic resonance imaging)...
  11. ncbi request reprint Inhibition of bcr-abl and/or c-abl gene expression by small interfering, double-stranded RNAs: cross-talk with cell proliferation factors and other oncogenes
    Hideki Ohba
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, Takamatsu, Kagawa, Japan
    Cancer 101:1390-403. 2004
    ..Short, 21-mer, double-stranded/small interfering RNAs (ds/siRNAs) were designed to target bcr-abl mRNA in chronic myelogenous leukemia (CML) with a potential also to target c-abl mRNA...
  12. ncbi request reprint Suppression of bcr-abl synthesis by siRNAs or tyrosine kinase activity by Glivec alters different oncogenes, apoptotic/antiapoptotic genes and cell proliferation factors (microarray study)
    Zhivko Zhelev
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    FEBS Lett 570:195-204. 2004
    ....
  13. ncbi request reprint Antisense inhibition of Bcr-Abl/c-Abl synthesis promotes telomerase activity and upregulates tankyrase in human leukemia cells
    Rumiana Bakalova
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    FEBS Lett 564:73-84. 2004
    ..These data provide evidence that the inhibition of Bcr-Abl or c-Abl synthesis keeps a potential to restore or induce cell proliferation through telomere lengthening control and telomerase activation...
  14. ncbi request reprint Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia
    Zhivko Zhelev
    National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, 761 0395 Takamatsu, Kagawa, Japan
    Cancer Chemother Pharmacol 53:267-75. 2004
    ....
  15. ncbi request reprint Cross-talk between Bcr-Abl tyrosine kinase, protein kinase C and telomerase-a potential reason for resistance to Glivec in chronic myelogenous leukaemia
    Rumiana Bakalova
    National Institute of Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, 761 0395 Takamatsu, Japan
    Biochem Pharmacol 66:1879-84. 2003
    ..Experimental preclinical data are given in confirmation of this hypothesis...
  16. ncbi request reprint Relationships between degree of binding, cytotoxicity and cytoagglutinating activity of plant-derived agglutinins in normal lymphocytes and cultured leukemic cell lines
    Hideki Ohba
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, Takamatsu, 761 0395, Kagawa, Japan
    Cancer Chemother Pharmacol 51:451-8. 2003
    ..To clarify the relationships between the degree of lectin-cell binding, cytotoxicity and cytoagglutinating activity of plant-derived lectins in normal lymphocytes and cultured leukemic cell lines...
  17. ncbi request reprint Single quantum dot-micelles coated with silica shell as potentially non-cytotoxic fluorescent cell tracers
    Zhivko Zhelev
    On site Sensing and Diagnosis Research Laboratory, National Institute of Advanced Industrial Science and Technology, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    J Am Chem Soc 128:6324-5. 2006
    ..The nanoparticles show ability for intracellular delivery and are noncytotoxic during long-term incubation with viable cells in the absence of light exposure, which makes them appropriate for cell tracing and drug delivery...
  18. ncbi request reprint Precise size control and synchronized synthesis of six colors of CdSe quantum dots in a slow-increasing temperature gradient
    Genoveva Zlateva
    Department of Physics and Biophysics, Medical University, Sofia, Bulgaria
    Inorg Chem 46:6212-4. 2007
    ..The method is environmentally friendly as it ensures almost complete utilization of the precursors and productive yield approximately 95%...
  19. ncbi request reprint Fluorescent molecular sensors and multi-photon microscopy in brain studies
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, AIST Kyushy, 807 1 Shuku machi, Tosu, Saga 841 0052, Japan
    Brain Res Bull 73:150-3. 2007
    ....
  20. ncbi request reprint Dual-labeled telomere sensing probes for quantification of telomerase activity assay
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    J Biochem Biophys Methods 70:503-6. 2007
    ....
  21. ncbi request reprint Self-surface passivation of CdX (X = Se, Te) quantum dots
    Rajan Jose
    Nano Bioanalysis Team, Health Technology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Hayashi cho 2217 14, Takamatsu 761 0395, Japan
    J Nanosci Nanotechnol 6:618-23. 2006
    ..The X-ray diffraction measurements of RT-synthesized CdSe QDs and that subsequently aged in 1-butanol showed that crystallinity of the samples was improved on aging...
  22. ncbi request reprint The cyclooxygenase inhibitors indomethacin and Rofecoxib reduce regional cerebral blood flow evoked by somatosensory stimulation in rats
    Rumiana Bakalova
    Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels, Akita 010 0874, Japan
    Exp Biol Med (Maywood) 227:465-73. 2002
    ..Neither COX inhibitor significantly affected the baseline level of CBF. The results suggest a participation of COX products in the regulation of evoked rCBF in response to somatosensory stimulation in the brain...
  23. ncbi request reprint Cytoagglutination and cytotoxicity of Wheat Germ Agglutinin isolectins against normal lymphocytes and cultured leukemic cell lines--relationship between structure and biological activity
    Hideki Ohba
    Natural Substance Composed Materials Group, Institute for Structural and Engineering Materials, National Institute of Advanced Industrial Science and Technology, AIST Kyushu, 807 1 Shuku, Tosu, Saga, Kyushu 841 0052, Japan
    Biochim Biophys Acta 1619:144-50. 2003
    ..01). The results suggest that the WGA-isolectins, structurally distinguishable in only several amino acid sequences, interacted in different degrees with leukemic cells and manifested different cytoagglutinating and cytotoxic activity...
  24. ncbi request reprint Plant-derived abrin-a induces apoptosis in cultured leukemic cell lines by different mechanisms
    Hideki Ohba
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    Toxicol Appl Pharmacol 195:182-93. 2004
    ....
  25. ncbi request reprint Quantum dots as photosensitizers?
    Rumiana Bakalova
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, 2217 14 Hayashi Cho, Takamatsu 761 0395, Japan
    Nat Biotechnol 22:1360-1. 2004
  26. ncbi request reprint Quantum dot-based western blot technology for ultrasensitive detection of tracer proteins
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    J Am Chem Soc 127:9328-9. 2005
    ..The present study describes two quantum dot-based Western blotting protocols for ultrasensitive detection of "tracer" proteins in cell lysates...
  27. ncbi request reprint Role of free cadmium and selenium ions in the potential mechanism for the enhancement of photoluminescence of CdSe quantum dots under ultraviolet irradiation
    Rumiana Bakalova
    Single Molecule Bioanalysis Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, Takamatsu, Kagawa 761 0395, Japan
    J Nanosci Nanotechnol 5:887-94. 2005
    ....
  28. ncbi request reprint Nonradioactive telomerase activity assay by microchip electrophoresis: privileges to the classical gel electrophoresis assay
    Zhivko Zhelev
    Single Molecule Bioanalysis Laboratory SMBL, National Institute for Advanced Industrial Science and Technology, AIST Shikoku, Takamatsu, Japan
    Electrophoresis 26:3021-4. 2005
    ..We try to clarify the interpretation of the results obtained by both electrophoretic procedures and to avoid misinterpretation as a result of PCR-dependent artefacts...
  29. ncbi request reprint Quantum dot-conjugated hybridization probes for preliminary screening of siRNA sequences
    Rumiana Bakalova
    On site Sensing and Diagnosis Research Laboratory, National Institute for Advanced Industrial Science and Technology, AIST Kyushu, 807 1 Shuku machi, Tosu 841 0052, Japan
    J Am Chem Soc 127:11328-35. 2005
    ..Moreover, the amplitude of the FRET signal significantly correlated with the specific effect of siRNA on the expression of the target mRNA and protein, determined in native cells by RT-PCR and immunoblot analysis, respectively...
  30. ncbi request reprint The NK-lysin derived peptide NK-2 preferentially kills cancer cells with increased surface levels of negatively charged phosphatidylserine
    Hannah Schröder-Borm
    Department of Biochemistry and Molecular Biology, University of Hamburg, D 20146 Hamburg, Germany
    FEBS Lett 579:6128-34. 2005
    ..This is underlined by the specific intercalation of the peptide into PS-containing liposomes analyzed by fluorescence-resonance energy transfer spectroscopy...
  31. ncbi request reprint Uncoated, broad fluorescent, and size-homogeneous CdSe quantum dots for bioanalyses
    Zhivko Zhelev
    On site Sensing and Diagnosis Research Laboratory, AIST Kyushu, 807 1 Shuku machi, Tosu, Japan
    Anal Chem 78:321-30. 2006
    ..These QDs were further conjugated with antibodies and applied in several biochemical analyses...
  32. ncbi request reprint Decrease of resistance to imatinib in leukaemia
    Rumiana Bakalova
    Lancet 359:1776-7. 2002