Hisao Asamura

Summary

Affiliation: National Cancer Center
Country: Japan

Publications

  1. ncbi request reprint Mechanical vascular division in lung resection
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Eur J Cardiothorac Surg 21:879-82. 2002
  2. doi request reprint Radiographically determined noninvasive adenocarcinoma of the lung: survival outcomes of Japan Clinical Oncology Group 0201
    Hisao Asamura
    National Cancer Center Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 146:24-30. 2013
  3. doi request reprint Minimally invasive approach to early, peripheral adenocarcinoma with ground-glass opacity appearance
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 85:S701-4. 2008
  4. doi request reprint A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 3:46-52. 2008
  5. ncbi request reprint Neuroendocrine neoplasms of the lung: a prognostic spectrum
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Clin Oncol 24:70-6. 2006
  6. ncbi request reprint How should the TNM staging system for lung cancer be revised? A simulation based on the Japanese Lung Cancer Registry populations
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 132:316-9. 2006
  7. ncbi request reprint A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, and Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Ann Thorac Surg 76:1016-22. 2003
  8. doi request reprint Minimally invasive open surgery approach for the surgical resection of thoracic malignancies
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Thorac Surg Clin 18:269-73, vi. 2008
  9. doi request reprint c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas
    Koji Tsuta
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 7:331-9. 2012
  10. ncbi request reprint Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity
    Yukihiro Yoshida
    Cancer Genomics Project, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 37:907-12. 2007

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Mechanical vascular division in lung resection
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Eur J Cardiothorac Surg 21:879-82. 2002
    ..This study was intended to demonstrate the feasibility of pulmonary vascular division by staplers...
  2. doi request reprint Radiographically determined noninvasive adenocarcinoma of the lung: survival outcomes of Japan Clinical Oncology Group 0201
    Hisao Asamura
    National Cancer Center Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 146:24-30. 2013
    ..The study objective was to evaluate the long-term survival of patients with radiographically determined noninvasive lung adenocarcinomas...
  3. doi request reprint Minimally invasive approach to early, peripheral adenocarcinoma with ground-glass opacity appearance
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 85:S701-4. 2008
  4. doi request reprint A Japanese Lung Cancer Registry study: prognosis of 13,010 resected lung cancers
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 3:46-52. 2008
    ..The validation of tumor, node, metastasis staging system in terms of prognosis is an indispensable part of establishing a better staging system in lung cancer...
  5. ncbi request reprint Neuroendocrine neoplasms of the lung: a prognostic spectrum
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Clin Oncol 24:70-6. 2006
    ..Their clinicopathologic profiles and relative grade of malignancy have not been defined...
  6. ncbi request reprint How should the TNM staging system for lung cancer be revised? A simulation based on the Japanese Lung Cancer Registry populations
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Cardiovasc Surg 132:316-9. 2006
    ..Among these, the overlapping survival of stages IB and IIA is the most serious. We performed this retrospective study to test a revised TNM staging system for lung cancer...
  7. ncbi request reprint A clinicopathological study of resected subcentimeter lung cancers: a favorable prognosis for ground glass opacity lesions
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, and Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Ann Thorac Surg 76:1016-22. 2003
    ..However their clinicopathological characteristics with special reference to the proper surgical mode are not fully described so far...
  8. doi request reprint Minimally invasive open surgery approach for the surgical resection of thoracic malignancies
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Thorac Surg Clin 18:269-73, vi. 2008
    ..Overall, it is respected as a technically feasible alternative to conventional lobectomy by way of open thoracotomy with an acceptable range of morbidity or mortality...
  9. doi request reprint c-MET/phospho-MET protein expression and MET gene copy number in non-small cell lung carcinomas
    Koji Tsuta
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 7:331-9. 2012
    ..The aim of this study was to examine the correlations between c-MET/phospho-MET expression as well as MET gene copy number alterations and overall survival (OS) in non-small cell lung carcinomas (NSCLCs)...
  10. ncbi request reprint Molecular markers and changes of computed tomography appearance in lung adenocarcinoma with ground-glass opacity
    Yukihiro Yoshida
    Cancer Genomics Project, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 37:907-12. 2007
    ..There is no consensus on the strategy for follow-up. Identification of the molecular mechanisms that are associated with the natural history of lung adenocarcinoma should provide useful information...
  11. doi request reprint Results of T4 surgical cases in the Japanese Lung Cancer Registry Study: should mediastinal fat tissue invasion really be included in the T4 category?
    Shun ichi Watanabe
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 8:759-65. 2013
    ..The present study aimed to investigate how different invasive features of T4 disease impacted prognosis, and what types of patients with T4 disease could benefit most from surgical treatment...
  12. ncbi request reprint Hypermethylation of the TSLC1/IGSF4 promoter is associated with tobacco smoking and a poor prognosis in primary nonsmall cell lung carcinoma
    Shinji Kikuchi
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Cancer 106:1751-8. 2006
    ..The purpose of this study was to investigate the possible association of TSLC1/IGSF4 methylation with tobacco smoking as well as with the clinical characteristics of tumors using a large number of primary NSCLC...
  13. doi request reprint Comprehensive histologic analysis of ALK-rearranged lung carcinomas
    Akihiko Yoshida
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 35:1226-34. 2011
    ..ALK-positive cancers commonly showed coexpression of thyroid transcription factor-1 and p63, and its significance is currently unclear...
  14. doi request reprint Visceral pleura invasion impact on non-small cell lung cancer patient survival: its implications for the forthcoming TNM staging based on a large-scale nation-wide database
    Junji Yoshida
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 4:959-63. 2009
    ..The purpose of this study was to evaluate the impact of VPI on survival and propose a method of incorporating VPI status into the TNM classification...
  15. doi request reprint Phase II trial of preoperative chemoradiotherapy followed by surgical resection in patients with superior sulcus non-small-cell lung cancers: report of Japan Clinical Oncology Group trial 9806
    Hideo Kunitoh
    Department of Medical Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Clin Oncol 26:644-9. 2008
    ..To evaluate the safety and efficacy of preoperative chemoradiotherapy followed by surgical resection for superior sulcus tumors (SSTs)...
  16. doi request reprint Prognostic impact of pleural invasion in 1488 patients with surgically resected non-small cell lung carcinoma
    Mayumi Oyama
    Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Jpn J Clin Oncol 43:540-6. 2013
    ..This study aimed to verify the prognostic impact of pleural invasion according to the revised TNM classification, seventh edition...
  17. doi request reprint Clinicopathologic analysis of multiple (five or more) atypical adenomatous hyperplasias (AAHs) of the lung: evidence for the AAH-adenocarcinoma sequence
    Akiko Miyagi Maeshima
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 5:466-71. 2010
    ..Clarification of the clinicopathologic characteristics of patients with multiple atypical adenomatous hyperplasias (AAHs)...
  18. ncbi request reprint Epidermal growth factor receptor mutation status and clinicopathological features of combined small cell carcinoma with adenocarcinoma of the lung
    Tomoya Fukui
    Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukuji, Chuo Ku, Tokyo, Japan
    Cancer Sci 98:1714-9. 2007
    ..In addition to the clinicopathological characteristics of this rare histological type of lung cancer, these findings provide useful information for better understanding the biology, natural history and clinical management of SCLC...
  19. doi request reprint Visceral pleural invasion classification in non-small-cell lung cancer in the 7th edition of the tumor, node, metastasis classification for lung cancer: validation analysis based on a large-scale nationwide database
    Akikazu Kawase
    Division of Thoracic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
    J Thorac Oncol 8:606-11. 2013
    ..To validate this, we analyzed the survival of non-small-cell lung cancer patients from a nationwide database and evaluated the prognostic impact of VPI...
  20. doi request reprint A prospective radiological study of thin-section computed tomography to predict pathological noninvasiveness in peripheral clinical IA lung cancer (Japan Clinical Oncology Group 0201)
    Kenji Suzuki
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 6:751-6. 2011
    ..Pathological noninvasiveness needs to be precisely predicted in preoperative radiological examinations of patients with early lung cancer for the application of limited surgery...
  21. doi request reprint Steroid receptor expression in thymomas and thymic carcinomas
    Takahiro Mimae
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Cancer 117:4396-405. 2011
    ....
  22. doi request reprint Insulin-like growth factor-1 receptor protein expression and gene copy number alterations in non-small cell lung carcinomas
    Koji Tsuta
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Hum Pathol 44:975-82. 2013
    ..IGF-1R is highly expressed in SCC and mucinous ADC, although copy number alterations in the IGF-1R gene were rare. These findings may have important implications for future anti-IGF-1R therapeutic approaches...
  23. doi request reprint ROS1-rearranged lung cancer: a clinicopathologic and molecular study of 15 surgical cases
    Akihiko Yoshida
    Division of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 37:554-62. 2013
    ..Fluorescence in situ hybridization signal patterns were unrelated to 5' fusion partner genes. All ROS1 fusion-positive tumors lacked alteration of EGFR, KRAS, HER2, ALK, and RET genes...
  24. doi request reprint Cathepsin D as a potential prognostic marker for lung adenocarcinoma
    Takahiro Mimae
    Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Res Pract 208:534-40. 2012
    ..Cathepsin D expression is indicated to be a possible prognostic marker for lung AD and to correlate with a more poorly differentiated form...
  25. ncbi request reprint Multiple lung adenocarcinomas showing ground-glass opacities on thoracic computed tomography
    Yukio Tsushima
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Chuo Ku, Japan
    Ann Thorac Surg 82:1508-10. 2006
    ..A ground-glass opacity appearance on computed tomographic scan could be interpreted as supportive evidence for multiple primary lung adenocarcinoma rather than pulmonary metastases...
  26. doi request reprint Clinicopathological characteristics of screen-detected lung cancers
    Riken Kawachi
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 4:615-9. 2009
    ..The purpose of the present study was to retrospectively analyze and characterize the clinicopathological features of screen-detected (SCR) lung cancer in comparison with lung cancers detected by other means...
  27. doi request reprint Bright-field dual-color chromogenic in situ hybridization for diagnosing echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase-positive lung adenocarcinomas
    Akihiko Yoshida
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Japan
    J Thorac Oncol 6:1677-86. 2011
    ..In this study, we explored the potential of the ALK-break-apart chromogenic in situ hybridization (CISH) method to detect ALK-rearranged lung cancer...
  28. ncbi request reprint Development and validation of diagnostic prediction model for solitary pulmonary nodules
    Kan Yonemori
    Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
    Respirology 12:856-62. 2007
    ..The aim of this study was to develop a simple prediction model for the underlying diagnosis of solitary pulmonary nodules (SPN) based on clinical characteristics and thin-section CT findings...
  29. doi request reprint Prospective study of the accuracy of EGFR mutational analysis by high-resolution melting analysis in small samples obtained from patients with non-small cell lung cancer
    Tomoya Fukui
    Division of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
    Clin Cancer Res 14:4751-7. 2008
    ..In this study, we verified the accuracy of EGFR mutation analysis in small samples by high-resolution melting analysis (HRMA), which is a rapid method using PCR amplification with a dye to analyze the melting curves in NSCLC...
  30. ncbi request reprint Characteristics of loss of heterozygosity in large cell neuroendocrine carcinomas of the lung and small cell lung carcinomas
    Tomoyo Takeuchi
    Department of Pathology, Institute of Basic Medical Science, University of Tsukuba, Tsukuba, and Department of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 56:434-9. 2006
    ..4%). LCNEC and SCLC had different characteristics of LOH patterns at 3p14.2 and 22q13.3. The combined analysis of the LOH at 3p14.2 and 22q13.3 is thought to be useful for differential diagnosis between LCNEC and SCLC...
  31. ncbi request reprint Radiologic classification of small adenocarcinoma of the lung: radiologic-pathologic correlation and its prognostic impact
    Kenji Suzuki
    Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 81:413-9. 2006
    ..A new radiologic classification for small adenocarcinoma is necessary for discussions of limited surgical resection for peripheral lung cancer...
  32. ncbi request reprint Combined resection of superior vena cava for lung carcinoma: prognostic significance of patterns of superior vena cava invasion
    Kenji Suzuki
    Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 78:1184-9; discussion 1184-9. 2004
    ..We attempted to clarify the surgical outcome of combined resection and reconstruction of the SVC for lung carcinoma...
  33. ncbi request reprint Clinical responses of large cell neuroendocrine carcinoma of the lung to cisplatin-based chemotherapy
    Shigeo Yamazaki
    Division of Thoracic Oncology and Internal Medicine, National Cancer Center Hospital, Tsukiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
    Lung Cancer 49:217-23. 2005
    ..The efficacy of chemotherapy in patients with large cell neuroendocrine carcinoma of the lung (LCNEC) remains unclear...
  34. ncbi request reprint Clinicopathologic features of peripheral squamous cell carcinoma of the lung
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 78:222-7. 2004
    ..In this retrospective study, we investigated the clinicopathologic characteristics of patients with peripheral squamous cell carcinomas...
  35. doi request reprint The impact of residual tumor morphology on prognosis, recurrence, and fistula formation after lung cancer resection
    Takeshi Kawaguchi
    Division of Thoracic Surgery, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    J Thorac Oncol 3:599-603. 2008
    ..The prognosis and proper management of patients with microscopic residual tumor at the bronchial resection margins (bronchial R1) remain unclear...
  36. ncbi request reprint Malignant glomus tumor of the lung
    Tomoyuki Hishida
    Thoracic Surgery Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 53:632-6. 2003
    ..We believe that this is the fourth reported case of malignant glomus tumor of the lung...
  37. doi request reprint Malignant pulmonary epithelioid hemangioendothelioma with hilar lymph node metastasis
    Naobumi Tochigi
    Pathology Division, National Cancer Center Research Institute, Tokyo 104 0045, Japan
    Ann Diagn Pathol 15:207-12. 2011
    ....
  38. doi request reprint Histological scoring for small lung adenocarcinomas 2 cm or less in diameter: a reliable prognostic indicator
    Akiko Miyagi Maeshima
    Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuoku, 104 0045 Tokyo, Japan
    J Thorac Oncol 5:333-9. 2010
    ..Lung adenocarcinomas 2 cm or less in diameter were studied to develop histologic criteria predicting the outcome...
  39. doi request reprint Histological evaluation of the effect of smoking on peripheral small adenocarcinomas of the lung
    Akiko Miyagi Maeshima
    Clinical Laboratory and double daggerThoracic Surgery Divisions, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 3:698-703. 2008
    ..As there is little information on the histologic characteristics of adenocarcinoma in smokers, we histologically examined the effect of smoking on the carcinogenesis and progression of peripheral small lung adenocarcinomas...
  40. doi request reprint Comparison of different clones (WT49 versus 6F-H2) of WT-1 antibodies for immunohistochemical diagnosis of malignant pleural mesothelioma
    Koji Tsuta
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Appl Immunohistochem Mol Morphol 17:126-30. 2009
    ..Furthermore, the positive reaction of clone WT49 was restricted to nucleus without cytoplasmic staining, which is seen in conventionally used WT-1 antibodies...
  41. doi request reprint Utility of 10 immunohistochemical markers including novel markers (desmocollin-3, glypican 3, S100A2, S100A7, and Sox-2) for differential diagnosis of squamous cell carcinoma from adenocarcinoma of the Lung
    Koji Tsuta
    Division of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 6:1190-9. 2011
    ..Recent clinical trials revealed that accurate histologic typing of non-small cell lung cancer, especially squamous cell carcinoma (SCC), is essential...
  42. doi request reprint Survival differences by gender for resected non-small cell lung cancer: a retrospective analysis of 12,509 cases in a Japanese Lung Cancer Registry study
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    J Thorac Oncol 5:1594-601. 2010
    ..Women with non-small cell lung cancer (NSCLC) are more likely to have better survival than men. This study intended to assess gender differences in the survival of these patients in a large registry population...
  43. ncbi request reprint Surgical treatment of pulmonary metastasis from hepatocellular carcinoma
    Norimasa Koide
    Division of Thoracic Surgery, National Cancer Center Hospital, Japan
    Hepatogastroenterology 54:152-6. 2007
    ..The lung is one of the most common sites of extrahepatic spread from hepatocellular carcinoma (HCC). The aim of this study was to evaluate the efficacy of surgical management in patients with pulmonary metastasis from HCC...
  44. ncbi request reprint Immunohistochemical KIT (CD117) expression in thymic epithelial tumors
    Kazuo Nakagawa
    Department of Pathology, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Chest 128:140-4. 2005
    ..The expression of KIT (CD117) in thymic epithelial tumors was investigated in order to evaluate its usefulness as a marker supporting differential diagnosis and choice of therapy...
  45. ncbi request reprint Immunohistochemical detection of GLUT-1 can discriminate between reactive mesothelium and malignant mesothelioma
    Yasufumi Kato
    Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Mod Pathol 20:215-20. 2007
    ..On the other hand, no RM cases were positive for GLUT-1. GLUT-1 is a sensitive and specific immunohistochemical marker enabling differential diagnosis of RM from MPM, whereas it cannot discriminate MPM from lung carcinoma...
  46. ncbi request reprint Grade of stromal invasion in small adenocarcinoma of the lung: histopathological minimal invasion and prognosis
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Am J Surg Pathol 28:198-206. 2004
    ..Therefore, tumors with grade 1 and grade 2 invasion could be considered "minimally invasive" or "early" adenocarcinomas...
  47. doi request reprint Differences in the prognosis of resected lung adenocarcinoma according to the histological subtype: a retrospective analysis of Japanese lung cancer registry data
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Eur J Cardiothorac Surg 45:100-7. 2014
    ..This study intended to assess the clinicopathological features of the histological subtypes of adenocarcinoma of the lung in a large registry population...
  48. ncbi request reprint Problems in diagnosis and surgical management of clinical N1 non-small cell lung cancer
    Shun ichi Watanabe
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 79:1682-5. 2005
    ..We evaluated the surgical and pathologic results of cN1 NSCLC patients to reveal the problems in diagnosis and surgical management for this subset...
  49. ncbi request reprint "Early" peripheral lung cancer: prognostic significance of ground glass opacity on thin-section computed tomographic scan
    Kenji Suzuki
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 74:1635-9. 2002
    ..The concept of peripherally located "early lung cancer" remains controversial...
  50. doi request reprint Prognostic implication of metastasis limited to segmental (level 13) and/or subsegmental (level 14) lymph nodes in patients with surgically resected nonsmall cell lung carcinoma and pathologic N1 lymph node status
    Akiko Miyagi Maeshima
    Department of Pathology and Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Cancer 118:4512-8. 2012
    ....
  51. pmc A randomised phase II trial of preoperative chemotherapy of cisplatin-docetaxel or docetaxel alone for clinical stage IB/II non-small-cell lung cancer results of a Japan Clinical Oncology Group trial (JCOG 0204)
    H Kunitoh
    Department of Medical Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Br J Cancer 99:852-7. 2008
    ..Preoperative DP was associated with encouraging resection rate and DFS data, and phase III trials for c-stage IB/II NSCLC are warranted...
  52. ncbi request reprint Left pneumonectomy for lung cancer after correction of contralateral partial anomalous pulmonary venous return
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 79:1778-80. 2005
    ..Therefore his partial anomalous pulmonary venous return was corrected first under cardiopulmonary bypass, and 3 weeks later he underwent successful radical left pneumonectomy...
  53. doi request reprint Analysis of expression patterns of breast cancer-specific markers (mammaglobin and gross cystic disease fluid protein 15) in lung and pleural tumors
    Yuji Takeda
    Clinical Laboratory Department, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Arch Pathol Lab Med 132:239-43. 2008
    ..Although it is often difficult to make a clear-cut differential diagnosis between the two, distinguishing primary lung carcinoma from breast carcinoma metastatic to the lung is important because the treatment modalities are different...
  54. ncbi request reprint Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Cancer Sci 98:985-91. 2007
    ....
  55. doi request reprint Aberrant anaplastic lymphoma kinase expression in high-grade pulmonary neuroendocrine carcinoma
    Harumi Nakamura
    Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, Tokyo, Japan
    J Clin Pathol 66:705-7. 2013
    ..In the present report, we describe aberrant ALK expression in a small proportion of pulmonary neuroendocrine carcinomas (NECs) that do not have ALK gene alteration...
  56. ncbi request reprint Recent results of postoperative mortality for surgical resections in lung cancer
    Shun ichi Watanabe
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 78:999-1002; discussion 1002-3. 2004
    ..Changes in the postoperative mortality rates and causes of death for lung cancer surgery at the specialized hospital for cancer in Tokyo, Japan during the last 16 years were investigated...
  57. doi request reprint The utility of the proposed IASLC/ATS/ERS lung adenocarcinoma subtypes for disease prognosis and correlation of driver gene alterations
    Koji Tsuta
    Division of Pathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Lung Cancer 81:371-6. 2013
    ....
  58. doi request reprint High-grade lung adenocarcinoma with fetal lung-like morphology: clinicopathologic, immunohistochemical, and molecular analyses of 17 cases
    Shigeki Morita
    Department of Pathology and Clinical Laboratories, Thoracic Surgery Division, National Cancer Center Hospital, Japan
    Am J Surg Pathol 37:924-32. 2013
    ....
  59. doi request reprint Proteomic study of malignant pleural mesothelioma by laser microdissection and two-dimensional difference gel electrophoresis identified cathepsin D as a novel candidate for a differential diagnosis biomarker
    Mutsumi Hosako
    Division of Pharmacoproteomics, National Cancer Center Research Institute, Japan
    J Proteomics 75:833-44. 2012
    ..In conclusion, we examined the protein expression profile of MPM and other lung malignancies, and identified cathepsin D to distinguish MPM from most popular lung cancer such as lung adenocarcinoma...
  60. ncbi request reprint Thymoma: a clinicopathologic study based on the new World Health Organization classification
    Kazuo Nakagawa
    Divisions of Thoracic Surgery, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    J Thorac Cardiovasc Surg 126:1134-40. 2003
    ..This study explored the relationship between the histologic subtype of thymoma according to the new World Health Organization histologic classification and the clinical findings, as well as the prognostic significance of the classification...
  61. ncbi request reprint Management of primary malignant germ cell tumor of the mediastinum
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Jpn J Clin Oncol 34:386-92. 2004
    ..Although multimodality treatment is a standard therapeutic strategy in mediastinal GCTs, the clinical implications of surgical intervention remain unclear...
  62. doi request reprint The usefulness of mutation-specific antibodies in detecting epidermal growth factor receptor mutations and in predicting response to tyrosine kinase inhibitor therapy in lung adenocarcinoma
    Yoshiki Kozu
    Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Lung Cancer 73:45-50. 2011
    ..The ability to detecting such mutations using immunohistochemistry (IHC) would be advantageous...
  63. doi request reprint Which is the better prognostic factor for resected non-small cell lung cancer: the number of metastatic lymph nodes or the currently used nodal stage classification?
    Shenhai Wei
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 6:310-8. 2011
    ....
  64. ncbi request reprint Large cell neuroendocrine carcinoma of the lung: a clinicopathologic study of eighty-seven cases
    Hidefumi Takei
    Clinical Laboratory Division and Thoracic Surgery Division, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    J Thorac Cardiovasc Surg 124:285-92. 2002
    ..The clinical characteristics and optimal treatment of patients with large cell carcinomas are not yet established. The aim of this study was to define the clinicopathologic characteristics of large cell neuroendocrine carcinoma...
  65. ncbi request reprint Successful pulmonary resection of lung cancer in a patient with partial anomalous pulmonary venous connection: report of a case
    Hidefumi Takei
    Thoracic Surgery Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Surg Today 32:899-901. 2002
    ..We successfully performed a left lower lobectomy for lung cancer in a patient with abnormal venous drainage in the left upper lobe, with simultaneous correction of a PAPVC...
  66. doi request reprint Cytological features of signet-ring cell carcinoma of the lung: comparison with the goblet-cell-type adenocarcinoma of the lung
    Koji Tsuta
    Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
    Diagn Cytopathol 37:159-63. 2009
    ..The cytological features of SRCC were the presence of single tumor cells and nuclear pleomorphism, whereas that of GCA were the presence of abundant mucin and significant inflammation in the background, and a honeycomb-like cluster...
  67. ncbi request reprint Array-based comparative genomic hybridization analysis of high-grade neuroendocrine tumors of the lung
    Wei Xia Peng
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Cancer Sci 96:661-7. 2005
    ..These results will be valuable for evaluating clinical status, including patient prognosis, and for identifying novel molecular targets for effective therapies...
  68. ncbi request reprint Lung adenocarcinoma with mixed bronchioloalveolar and invasive components: clinicopathological features, subclassification by extent of invasive foci, and immunohistochemical characterization
    Hiroshi Terasaki
    Thoracic Surgery Division, National Hospital, Tokyo, Japan
    Am J Surg Pathol 27:937-51. 2003
    ....
  69. ncbi request reprint Mutations of the epidermal growth factor receptor gene in atypical adenomatous hyperplasia and bronchioloalveolar carcinoma of the lung
    Yukihiro Yoshida
    Pathology Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Lung Cancer 50:1-8. 2005
    ..In all cases each lesion had a different mutation status. This finding suggests that the genetic alterations responsible for the development of lung adenocarcinoma occur randomly even under exposure to the same carcinogen...
  70. doi request reprint Clinical application of costal coaptation pins made of hydroxyapatite and poly-L-lactide composite for posterolateral thoracotomy
    Riken Kawachi
    Thoracic Surgery Division, National Cancer Center Hospital, 1 1 Tsukiji 5 chome, Chuo Ku, Tokyo 104 0045, Japan
    Eur J Cardiothorac Surg 34:510-3. 2008
    ..The objective of this study was to evaluate rib fixation achieved by HA/PLLA costal coaptation pins...
  71. doi request reprint Minute pulmonary meningothelial-like nodules: clinicopathologic analysis of 121 patients
    Eiki Mizutani
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo 104 0045, Japan Thoracic Surgery Division, National Cancer Center Hospital, Tokyo 104 0045, Japan
    Hum Pathol 40:678-82. 2009
    ..4% versus 4.5%; odds ratio, 2.33; 95% confidence interval, 1.35-4.02; P < .01). There was no significant difference in clinicopathologic factors between patients with single and multiple MPMNs, except for the size of each nodule...
  72. pmc Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
    Tatsuhiro Shibata
    Cancer Genomics Project, Pathology Division, Center for Medical Genomics, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Proc Natl Acad Sci U S A 105:13568-73. 2008
    ..Congruously, the present study also provides in vivo validation of the two-site substrate recognition model for Nrf2 activation by the Keap1-Cul3-based E3 ligase...
  73. doi request reprint Clinicopathological analysis of primary lung carcinoma with heterotopic ossification
    Hidehiko Kuribayashi
    Clinical Laboratory Division, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    Lung Cancer 64:160-5. 2009
    ..The present study suggested that IHO associated with adenocarcinomas and BMP-2 production in the tumor cells, whereas EHO was not associated with the biology of the carcinoma...
  74. doi request reprint Superior and basal segment lung cancers in the lower lobe have different lymph node metastatic pathways and prognosis
    Shun ichi Watanabe
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Ann Thorac Surg 85:1026-31. 2008
    ..The aim of this study was to reveal differences in the metastatic pathway to the mediastinum and in prognosis of N2 disease between lung cancers originating from superior and basal segment of the lower lobe...
  75. doi request reprint Computed tomographic findings and prognosis in thymic epithelial tumor patients
    Satomi Yakushiji
    Divisions of Medical Oncology, National Cancer Center Hospital and Research Institute, Tokyo, Japan
    J Comput Assist Tomogr 32:799-805. 2008
    ..To determine which computed tomographic findings are associated with high-risk thymic epithelial tumors and a poor prognosis...
  76. ncbi request reprint Histologic prognostic factors for small-sized squamous cell carcinomas of the peripheral lung
    Akiko Miyagi Maeshima
    Pathology Division, National Cancer Center Research Institute, Tokyo, Japan
    Lung Cancer 52:53-8. 2006
    ..The aim of this study is to identify clinicopathologic prognostic factors...
  77. doi request reprint Lymph node dissection for lung cancer: significance, strategy, and technique
    Shun ichi Watanabe
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    J Thorac Oncol 4:652-7. 2009
    ..In this manuscript, the significance, recent strategy, and technique of lymph node dissection for lung cancer are described...
  78. ncbi request reprint Mucin-producing adenocarcinoma of the lung: thin-section computed tomography findings in 48 patients and their effect on prognosis
    Ukihide Tateishi
    Division of Diagnostic Radiology, National Cancer Center Hospital and Institute, Tokyo, Japan
    J Comput Assist Tomogr 29:361-8. 2005
    ..To determine the prognostic value of thin-section computed tomography (CT) findings in patients with mucin-producing adenocarcinoma (MPA) of the lung...
  79. ncbi request reprint Promoter methylation of DAL-1/4.1B predicts poor prognosis in non-small cell lung cancer
    Shinji Kikuchi
    Tumor Suppression and Functional Genomics Project, National Cancer Center Research Institute, Tokyo, Japan
    Clin Cancer Res 11:2954-61. 2005
    ..The purpose of this study is to understand the molecular mechanisms and clinical significance of DAL-1 inactivation in lung cancer...
  80. ncbi request reprint Prognostic factors for malignant pericardial effusion treated by pericardial drainage in solid-malignancy patients
    Kan Yonemori
    Division of Medical Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Med Oncol 24:425-30. 2007
    ..The purpose of this study was to identify prognostic factors for cytology-positive malignant pericardial effusion in patients treated by pericardial drainage...
  81. ncbi request reprint [Practice guidelines for lung cancer invading the neighboring anatomic structures]
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital Tokyo, Japan
    Nihon Geka Gakkai Zasshi 105:408-11. 2004
    ..The further refinement of scientific evidence that justifies the therapeutic strategy is necessary, especially for these tumor categories...
  82. ncbi request reprint Inflammatory myofibroblastic tumor of the lung
    Hiroyuki Sakurai
    Division of Thoracic Surgery, National Cancer Center Hospital, 1 1, Tsukiji 5 chome, Chuo Ku, 104 0045, Tokyo, Japan
    Eur J Cardiothorac Surg 25:155-9. 2004
    ..In this retrospective study, we reviewed clinicopathological characteristics and prognoses for all patients with surgically resected IMT of the lung at our institute...
  83. ncbi request reprint [The process of the revision of staging system for lung cancer(UICC-7)]
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Gan To Kagaku Ryoho 36:2502-7. 2009
    ..The new staging system (UICC-7) is scheduled to take effect as of from January, 2010...
  84. ncbi request reprint [Modern radical resection for lung cancer; a critique on the video-assisted radical resection]
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Kyobu Geka 59:710-3. 2006
    ..Since their differences are solely concerned about the route of the approach into the thoracic cavity, the oncological difference reasonably does not seem to exist...
  85. ncbi request reprint [Operative vascular techniques in lung resections for cancer]
    Hisao Asamura
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 107:243-4. 2006
  86. ncbi request reprint Primary mediastinal large B-cell lymphoma: a single-institution clinical study in Japan
    Naohiro Sekiguchi
    Hematology Division, National Cancer Center Hospital, Tokyo, Japan
    Int J Hematol 79:465-71. 2004
    ..Because this investigation was a single-institution study with a limited number of patients, however, multicenter confirmatory studies are needed...
  87. ncbi request reprint Immunohistochemical expression of TTF-1 in various cytological subtypes of primary lung adenocarcinoma, with special reference to intratumoral heterogeneity
    Akiko M Maeshima
    Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan
    Pathol Int 58:31-7. 2008
    ..BSE and POR in both groups had a different phenotype, possibly reflecting their different natural history. In group C 80% of cases were TTF-1 positive, suggesting that the majority were derived from group A tumors...
  88. ncbi request reprint [Controversies of video-assisted thoracic surgery (VATS)]
    Shun ichi Watanabe
    Division of Thoracic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Nihon Geka Gakkai Zasshi 106:313-9. 2005
  89. ncbi request reprint [Standard surgical procedures in lung cancer]
    Haruhiko Kondo
    Thoracic Surgery Division, National Cancer Center Hospital
    Nihon Rinsho 60:388-91. 2002
  90. ncbi request reprint Prognosis of 6644 resected non-small cell lung cancers in Japan: a Japanese lung cancer registry study
    Tomoyuki Goya
    Department of Surgery, Kyorin University, 6 20 2, Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Lung Cancer 50:227-34. 2005
    ..Otherwise, the present TNM staging system seemed to well characterize the stage-specific prognosis in non-small cell lung cancer. The future revision should focus on the subdivision of stages I and II...
  91. ncbi request reprint Treatment of choice for stage I non-small cell lung cancer: surgery or radiotherapy?
    Hisao Asamura
    J Thorac Oncol 1:766-7. 2006
  92. ncbi request reprint hASH1 expression is closely correlated with endocrine phenotype and differentiation extent in pulmonary neuroendocrine tumors
    Shi Xu Jiang
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Mod Pathol 17:222-9. 2004
    ..Finally, hASH1 expression correlated with a significantly shortened survival in small-cell carcinoma patients (P=0.041)...
  93. ncbi request reprint CT findings of surgically resected large cell neuroendocrine carcinoma of the lung in 38 patients
    Yasuji Oshiro
    Department of Radiology, University of Ryukyus School of Medicine, 207 Uehara, Nishihara cho, Okinawa Prefecture 903 0215, Japan
    AJR Am J Roentgenol 182:87-91. 2004
    ..We sought to assess the CT features of surgically resected large cell neuroendocrine carcinoma of the lung...
  94. ncbi request reprint [Neuroendocrine tumors of the lung]
    Hidefumi Takei
    Thoracic Surgery Division, Yokohama Rosai Hospital
    Nihon Rinsho 62:877-82. 2004
    ..It is not clear how these patients should be treated. Further collaborative accumulation of clinicopathological data is strongly required...
  95. ncbi request reprint Divergent cyclin B1 expression and Rb/p16/cyclin D1 pathway aberrations among pulmonary neuroendocrine tumors
    Toru Igarashi
    Department of Pathology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan
    Mod Pathol 17:1259-67. 2004
    ..Neither cyclins B1 and D1, Rb, p16, nor Ki-67 correlated with patient survival in individual tumor categories, suggesting that the prognostic significance of these factors is tumor-type specific...
  96. ncbi request reprint Consensus report IASLC workshop Bruges, September 2002: pretreatment minimal staging for non-small cell lung cancer
    Pieter E Postmus
    Department of Pulmonary Diseases, Vrije Universiteit Medical Cetner, Amsterdam, Netherlands
    Lung Cancer 42:S3-6. 2003
  97. ncbi request reprint Intrapulmonary lymph nodes: thin-section CT features of 19 nodules
    Yasuji Oshiro
    Department of Radiology, University of Ryukyu School fo Medicine, Okinawa Prefecture, Japan
    J Comput Assist Tomogr 26:553-7. 2002
    ..The purpose of this study was to describe the thin-section CT features of intrapulmonary lymph nodes that accompanied primary or metastatic lung tumors...