K Aoki

Summary

Affiliation: National Institute of Technology and Evaluation
Country: Japan

Publications

  1. ncbi request reprint Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7
    Y Kawarabayasi
    National Institute of Technology and Evaluation, Shibuya, Tokyo, Japan
    DNA Res 8:123-40. 2001
  2. doi request reprint Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob
    T Nishimoto
    Section for Studies on Host Immune Response, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Gene Ther 16:669-80. 2009
  3. ncbi request reprint Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX
    K Aoki
    Department of Immunology, National Institute of Health, Shinjuku ku, Tokyo, Japan
    FEBS Lett 401:109-12. 1997
  4. ncbi request reprint Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin
    G Meng
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    Gene 242:59-64. 2000
  5. ncbi request reprint Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob
    Y Miura
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gene Ther 14:1448-60. 2007
  6. doi request reprint In vivo delivery of interferon-α gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts
    K Narumi
    Division of Gene and Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan
    Gene Ther 19:34-48. 2012
  7. ncbi request reprint Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X
    G Meng
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    J Hum Genet 45:305-8. 2000
  8. pmc Adenovirus-mediated interferon alpha gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer
    M Ohashi
    Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Br J Cancer 93:441-9. 2005
  9. ncbi request reprint Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA
    M Nakano
    Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
    Mol Ther 3:491-9. 2001
  10. ncbi request reprint RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression
    K Aoki
    Department of Immunology, Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan
    J Biol Chem 273:26698-704. 1998

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Complete genome sequence of an aerobic thermoacidophilic crenarchaeon, Sulfolobus tokodaii strain7
    Y Kawarabayasi
    National Institute of Technology and Evaluation, Shibuya, Tokyo, Japan
    DNA Res 8:123-40. 2001
    ..The result suggests that this strain is closer to eukaryotes among the archaea strains so far sequenced. The data presented in this paper are also available on the internet homepage (http://www.bio.nite.go.jp/E-home/genome_list-e.html/)...
  2. doi request reprint Oncolytic virus therapy for pancreatic cancer using the adenovirus library displaying random peptides on the fiber knob
    T Nishimoto
    Section for Studies on Host Immune Response, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Gene Ther 16:669-80. 2009
    ..The results showed that a tumor-targeting strategy using an adenovirus library is promising for optimizing the safety and efficacy of oncolytic adenovirus therapy...
  3. ncbi request reprint Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX
    K Aoki
    Department of Immunology, National Institute of Health, Shinjuku ku, Tokyo, Japan
    FEBS Lett 401:109-12. 1997
    ..The TRAX protein was established to contain bipartite nuclear targeting sequences in its N-terminal region, suggesting a possible role in the selective nuclear transport of Translin protein lacking any nuclear targeting motifs...
  4. ncbi request reprint Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin
    G Meng
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    Gene 242:59-64. 2000
    ..Chromosomal mapping by fluorescence in situ hybridization analysis allowed localization of the rp58 gene to human chromosome 1q44 ter, a genetic region associated with a number of human malignancies and neurological disorders...
  5. ncbi request reprint Direct selection of targeted adenovirus vectors by random peptide display on the fiber knob
    Y Miura
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gene Ther 14:1448-60. 2007
    ..This vector-screening system can facilitate the development of a targeted adenovirus vector for a variety of applications in medicine...
  6. doi request reprint In vivo delivery of interferon-α gene enhances tumor immunity and suppresses immunotolerance in reconstituted lymphopenic hosts
    K Narumi
    Division of Gene and Immune Medicine, National Cancer Center Research Institute, Tokyo, Japan
    Gene Ther 19:34-48. 2012
    ....
  7. ncbi request reprint Genomic structure and chromosomal localization of the gene encoding TRAX, a Translin-associated factor X
    G Meng
    Department of Immunology, National Institute of Infectious Diseases, Tokyo, Japan
    J Hum Genet 45:305-8. 2000
    ..7kb, and its distribution in various tissues was like that of Translin. Chromosomal mapping by fluorescence in situ hybridization (FISH) analysis allowed localization of the TRAX gene to human chromosome lq41...
  8. pmc Adenovirus-mediated interferon alpha gene transfer induces regional direct cytotoxicity and possible systemic immunity against pancreatic cancer
    M Ohashi
    Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Br J Cancer 93:441-9. 2005
    ..This study suggested that a local IFN-alpha gene therapy is a promising therapeutic strategy for pancreatic cancer, due to its dual mechanisms of antitumour activities and lack of significant toxicity...
  9. ncbi request reprint Suppression of colorectal cancer growth using an adenovirus vector expressing an antisense K-ras RNA
    M Nakano
    Genetics Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan
    Mol Ther 3:491-9. 2001
    ..This study shows that the adenovirus-mediated in vivo gene transfer of the antisense K-ras construct may be a useful therapeutic strategy for colorectal cancer...
  10. ncbi request reprint RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression
    K Aoki
    Department of Immunology, Division of Genetic Resources, National Institute of Infectious Diseases, Tokyo, Japan
    J Biol Chem 273:26698-704. 1998
    ..We suggest that RP58 may be involved in a molecular link between sequence-specific transcriptional repression and the organization of chromosomes in the nucleus...
  11. ncbi request reprint GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling
    N Saeki
    Center for Medical Genomics, Genetics Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, Japan
    Oncogene 26:6488-98. 2007
    ..The present data suggest that TGF-beta, LMO1, possibly RUNX3, and GSDM form a regulatory pathway for directing the pit cells to apoptosis...
  12. doi request reprint The influence of mechanical stimulation on osteoclast localization in the mouse maxilla: bone histomorphometry and finite element analysis
    K Fujiki
    Department of Removable Partial Prosthodontics, Graduate School, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo, Tokyo, 113 8549, Japan
    Biomech Model Mechanobiol 12:325-33. 2013
    ..0μ strain for the high stimulation group. The result suggests that the osteoclastic resorption is location-dependent and is also sensitive to the local strain intensity...
  13. ncbi request reprint Indispensability of transmembrane domains of Golgi UDP-galactose transporter as revealed by analysis of genetic defects in UDP-galactose transporter-deficient murine had-1 mutant cell lines and construction of deletion mutants
    N Ishida
    Department of Physiological Chemistry, The Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo, 113 8613, Japan
    J Biochem 126:1107-17. 1999
    ..Our results demonstrate the importance of the transmembrane core region of the UDP-galactose transporter protein...
  14. ncbi request reprint Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model
    K Suzuki
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gene Ther 10:765-73. 2003
    ..The study suggested for the first time the advantage and feasibility of IFN-alpha gene therapy for LC...
  15. ncbi request reprint Genomic structure and chromosomal localization of the gene encoding translin, a recombination hotspot binding protein
    K Aoki
    Department of Immunology, National Institute of Health, Shinjuku ku, Tokyo, Japan
    Genomics 43:237-41. 1997
    ..In situ hybridization and physical mapping of somatic cell hybrids allowed localization of the gene to human chromosome 2q21.1...
  16. doi request reprint Defective nuclear factor-κB-inducing kinase in aly/aly mice prevents bone resorption induced by local injection of lipopolysaccharide
    N S Soysa
    Section of Pharmacology, Department of Hard Tissue Engineering, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Periodontal Res 46:280-4. 2011
    ..Nevertheless, the role of NIK in pathological bone resorption is not well investigated. The present study was undertaken to investigate the role of NIK in lipopolysaccharide (LPS)-induced inflammatory bone resorption using aly/aly mice...
  17. ncbi request reprint Participation of CYP2A in cocaine-induced hepatotoxicity in female mice
    K Aoki
    School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Pharmacol Toxicol 87:26-32. 2000
    ..These results suggest that cocaine-induced hepatotoxicity in female mice was mediated in part by CYP2A, participating in cocaine N-demethylation...