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Monkeys quickly learn and generalize visual categories without lateral prefrontal cortexTakafumi Minamimoto
Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Neuron 66:501-7. 2010..These results strongly indicate that visual categorization occurs at some earlier stage of feed-forward processing, presumably in temporal cortex, without top-down information from LPFC...
The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancerMayumi Iwakawa
RadGenomics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan
Cancer Biol Ther 6:905-11. 2007..To identify changes in gene expression related to the concurrent use of platinum compounds with radiotherapy, in the treatment of cervical cancer...
Dose effect for South Serbians due to 238U in natural drinking waterS K Sahoo
Department of Radiation Dosimetry, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Radiat Prot Dosimetry 127:407-10. 2007..00698 to 0.00745. These findings indicate that uranium in water was a mixture of natural and anthropogenic origin. The annual effective dose due to 238U was estimated to be in the range 9.2 x 10(-5)-2.1 x 10(-3) mSv...
Precise determination of Pu isotopes in a seawater reference material using ID-SF-ICP-MS combined with two-stage anion-exchange chromatographyJian Zheng
Nakaminato Laboratory for Marine Radioecology, Environmental Radiation Effects Research Group, National Institute of Radiological Sciences, Japan
Anal Sci 23:611-5. 2007..6%) provided by the IAEA certification report. The precise determination of Pu isotopes in this seawater reference material will be useful for the validation of analytical methods for the study of radionuclides in the marine environment...
The conserved role of Smu1 in splicing is characterized in its mammalian temperature-sensitive mutantKimihiko Sugaya
Radiation Effect Mechanisms Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba 263 8555, Japan
J Cell Sci 119:4944-51. 2006..Comparison of the results of perlecan RT-PCR analysis with those of analysis of four other genes suggested that the splicing defect in the perlecan gene is unique and that it is conserved through evolution...
Removal of technetium from solution by algal flagellate Euglena gracilisNobuyoshi Ishii
Office of Biospheric Assessment for Waste Disposal, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, 263 8555 Japan
J Environ Qual 35:2017-20. 2006..These results suggested that intracellular uptake of (99)Tc by E. gracilis occurred. These results are the first documented example of significant removal of (99)Tc by planktonic microalgae...
Analysis of non-genetic risk factors for adverse skin reactions to radiotherapy among 284 breast cancer patientsMayumi Iwakawa
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
Breast Cancer 13:300-7. 2006....
The extremely high 137Cs inventory in the Sulu Sea: a possible mechanismMasatoshi Yamada
Nakaminato Laboratory for Marine Radioecology, Environmental Radiation Effects Research Group, National Institute of Radiological Sciences, Isozaki 3609, Hitachinaka, Ibaraki 311 1202, Japan
J Environ Radioact 90:163-71. 2006....
Noise properties for three weighted Feldkamp algorithms using a 256-detecotor row CT-scanner: case study for hepatic volumetric cine imagingShinichiro Mori
Department of Medical Physics, National Institute of Radiological Sciences, Chiba 263 8555, Japan
Eur J Radiol 59:289-94. 2006..We concluded that, considering the trade-off between image quality and temporal resolution, the NHS-FDK algorithm is useful in volumetric cine imaging for the abdomen...
Physical evaluation of CT scan methods for radiation therapy planning: comparison of fast, slow and gating scan using the 256-detector row CT scannerShinichiro Mori
Department of Medical Physics, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba, Japan
Phys Med Biol 51:587-600. 2006..FSCT-ave is a satisfactory radiotherapy planning alternative if RGCT is not available...
Radiosensitivity of hypoxic and proliferating clonogen in a human lung cancer grown in nude miceTadaaki Miyamoto
Research Center Hospital for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba 263 8555, Japan
Oncol Rep 14:1421-8. 2005....
Development of high-radiation-sensitive polymer gel for magnetic resonance imaging in three-dimensional dosimetryShinichiro Mori
Department of Medical Physics, National Institute of Radiological Sciences, 4 9 1, Anagawa, Chiba, Japan, 263 8555
Magn Reson Imaging 23:691-4. 2005..Since the present gel has higher sensitivity and it is synthesized more easily at lower cost than conventional polymer gels, we expect to see improved three-dimensional (3D) dosimetry using it...
Distribution coefficient of selenium in Japanese agricultural soilsYasuo Nakamaru
Office of Biospheric Assessment for Waste Disposal, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba shi 263 8555, Japan
Chemosphere 58:1347-54. 2005..The high values of Kd seemed to be caused mainly by the adsorption of Se onto active-Al in Japanese soils...
Strain dependent differences in a histological study of CD44 and collagen fibers with an expression analysis of inflammatory response-related genes in irradiated murine lungMayumi Iwakawa
RadGenomics Project, Frontier Research Center, National Institute of Radiological Sciences, Chiba shi, Japan
J Radiat Res 45:423-33. 2004..The expression analysis showed that the several genes are potentially involved in interstrain differences in inflammatory response causing radiation-induced lung fibrosis...
Optimization for fast-scanning irradiation in particle therapyTaku Inaniwa
Medical Physics Research Group, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Med Phys 34:3302-11. 2007..A typical treatment time with the proposed method is about 15 s for the irradiation of a spherical target with an 80 mm diameter at 3 GyE...
Evaluating glycogen signal contamination in muscle by (13)C MRS of the liverMoyoko Tomiyasu
Department of Biophysics, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba 263 8555, Japan
Magn Reson Imaging 26:572-6. 2008....
Relationship between baseline cerebral blood flow and vascular responses to changes in PaCO2 measured by positron emission tomography in humans: implication of inter-individual variations of cerebral vascular toneH Ito
Department of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels, Akita, Japan
Acta Physiol (Oxf) 193:325-30. 2008..In the present study, the relationship between CBF and cerebral vascular tone to inter-individual variation at rest condition was investigated using positron emission tomography (PET)...
Ultrafast LC method for purification and metabolite analysis of PET probesRyuji Nakao
Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
Nucl Med Biol 37:67-72. 2010....
Low-cost metaphase finder systemAkira Furukawa
National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Health Phys 98:269-75. 2010..The scanning speed was 14.5 to 18.1 min cm2. The system was slower than several commercial metaphase finders, but there were few false positives. This system is economical and satisfactory for practical use...
The effect of long-running severe selenium-deficiency on the amount of iron and zinc in the organs of ratsKen Ichiro Matsumoto
Department of Physical Chemistry, Showa Pharmaceutical University, Tokyo, Japan
Molecules 14:4440-53. 2009..Fluctuations of Fe and Zn in the liver of Se-deficient rats were observed. The amount of redox-relating minerals, such as Fe and Zn, in SeD rat organs is changeable depending on the age...
Low-dose radiation attenuates chemical mutagenesis in vivoShizuko Kakinuma
Experimental Biology for Children s Health Research Group, National Institute of Radiological Sciences, Chiba, Japan
J Radiat Res (Tokyo) 50:401-5. 2009....
Responses of selected neutron monitors to cosmic radiation at aviation altitudesHiroshi Yasuda
Environmental Radiation Exposure Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Health Phys 96:655-60. 2009..These results indicate that careful attention must be paid to the dosimetric properties of a detector employed for verification of cosmic neutron dose...
Development of a multi-layer ionization chamber for heavy-ion radiotherapyKaori Yajima
Toho University Graduate School of Science, 2 2 1, Miyama, Funabashi, Chiba 274 8510, Japan
Phys Med Biol 54:N107-14. 2009..For carbon-ion beams, the PMMA type MLIC has the capability to measure depth dose distributions in the water phantom with less than 2% error, including the fragment tail region...
Preliminary study on potential of the jPET-D4 human brain scanner for small animal imagingTaiga Yamaya
Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Ann Nucl Med 23:183-90. 2009..In this article, we investigate the jPET-D4's potential for small animal imaging by comparing it with the microPET Focus220, a state-of-the-art PET scanner dedicated to small animals...
Optimal scan time of oxygen-15-labeled gas inhalation autoradiographic method for measurement of cerebral oxygen extraction fraction and cerebral oxygen metabolic rateMiho Shidahara
Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba, 263 8555, Japan
Ann Nucl Med 22:667-75. 2008..Our objective in this study was to optimize the scan time for 15O2 gas study for accurate estimation of OEF and CMRO2...
Roles of the thalamic CM-PF complex-Basal ganglia circuit in externally driven rebias of actionTakafumi Minamimoto
Department of Physiology, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
Brain Res Bull 78:75-9. 2009..This model provides a framework for how the thalamic CM-PF complex and the basal ganglia function together in general for unexpected situations...
Metabolism and the paradoxical effects of arsenic: carcinogenesis and anticancerXing Cui
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Chiba 263 8555, Japan
Curr Med Chem 15:2293-304. 2008..We also summarize the clinical use of arsenic trioxide (As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors...
Rapid and simple method for quantitative evaluation of neurocytotoxic effects of radiation on developing medaka brainTakako Yasuda
Environmental Radiation Effects Research Group, Research Center for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
J Radiat Res (Tokyo) 49:533-40. 2008..The results show that medaka embryos are useful for quantitative evaluation of developmental neurocytotoxic effects of radiation...
Multimodal silica-shelled quantum dots: direct intracellular delivery, photosensitization, toxic, and microcirculation effectsRumiana Bakalova
Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
Bioconjug Chem 19:1135-42. 2008..g., heart rate, blood pressure, diameter and shape of blood vessels), which makes it appropriate for tracing of blood circulation and in vivo multimodal imaging using fluorescent confocal microscopy, two-photon microscopy, and MRI...
Enhanced activation in the extrastriate body area by goal-directed actionsHidehiko Takahashi
Department of Molecular Neuroimaging, National Institute of Radiological Sciences, Chiba, Japan
Psychiatry Clin Neurosci 62:214-9. 2008..The aim of the present study was to investigate the role of EBA in processing goal-directed actions...
Differences in pO2 peaks of a murine fibrosarcoma between carbon-ion and X-ray irradiationTakeshi Fukawa
Institute of Biomedical Engineering, Keio University, Yokohama, Japan
J Radiat Res 45:303-8. 2004..It is concluded that carbon-ion irradiation reoxygenated the NFSa fibrosarcomas earlier in time and deeper in space than the X-ray irradiation did...
Effect of high-level natural radiation on chromosomes of residents in southern ChinaI Hayata
National Institute of Radiological Sciences, Chiba, Japan
Cytogenet Genome Res 104:237-9. 2004..But the increase of translocations in HBRA was within the range of individual variation in the controls...
Impairment of spermatogenesis in rats by methylmercury: involvement of stage- and cell- specific germ cell apoptosisS Homma-Takeda
Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
Toxicology 169:25-35. 2001..Our results suggest that methylmercury impairs spermatogenesis by germ cell deletion via cell- and stage- specific apoptosis...
A mutation in the largest (catalytic) subunit of RNA polymerase II and its relation to the arrest of the cell cycle in G(1) phaseK Sugaya
Genome Research Group, National Institute of Radiological Sciences, 4 9 1, Anagawa, Chiba, 263 8555, Japan
Gene 274:77-81. 2001..Aligning the amino acid sequences from various species reveals that ala(315) is highly conserved in eukaryotes...
Design of synchrotron light source and its beamline dedicated to dual-energy x-ray computed tomographyM Torikoshi
National Institute of Radiological Sciences, Anagawa 4 9 1, Inage, Chiba 263 8555, Japan
J Biomed Opt 6:371-7. 2001A synchrotron light source dedicated to medical applications has been designed at National Institute of Radiological Sciences. The storage ring, with circumference of 80 m, is designed for acceleration of 2...
Glow-peak stability in 6LiF:Mg,Ti (TLD-600) exposed to a Fe-ion beamH Yasuda
Int Space Radiation Laboratory, National Institute of Radiological Sciences 4 9 1 Anagawa, Inage ku Chiba 263 8555, Japan
J Radiat Res 42:69-78. 2001..These facts suggest that peaks 3-5 in TLD-600 comprised both stable and unstable luminescent centers, and that the latter part would be easily depleted in highly dense ionization...
Quantitative comparison of two types of planar lipid bilayers--folded and painted--with respect to fusion with vesiclesK Anzai
Bioregulation Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Inage, Japan
J Biochem Biophys Methods 48:283-91. 2001..For the study of single channel behavior, the painted bilayer could have an advantage because simply stopping the stirring prevents excess fusion...
Tumor uptake of radioiodinated anti-human pulmonary surfactant-associated protein monoclonal antibody PE10 in nude mice bearing human pulmonary adenocarcinoma in combination with an unlabeled preloadN Watanabe
Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
Nucl Med Biol 27:723-31. 2000....
Determination of the spatial distribution of major elements in the rat brain with X-ray fluorescence analysisS Takahashi
Environmental and Toxicological Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, 263 8555, Chiba
J Neurosci Methods 100:53-62. 2000....
Phosphatase inhibitors and premature chromosome condensation in human peripheral lymphocytes at different cell-cycle phasesR Kanda
Division of Radiobiology and Biodosimetry, National Institute of Radiological Sciences, Chiba, Japan
Somat Cell Mol Genet 25:1-8. 1999..It was found that calcium ionophore A23187 increased frequencies of G0-PCC induced by calyculin A, although a further refinement is necessary to obtain a suitable morphology of G0-PCC for cytogenetic studies...
Determination of major and trace elements in the liver of Wistar rats by inductively coupled plasma-atomic emission spectrometry and mass spectrometryS Takahashi
Environmental and Toxicological Research Group, National Institute of Radiological Sciences, Chiba, Japan
Lab Anim 34:97-105. 2000....
Localization of indium-111 in human malignant tumor xenografts and control by chelatorsN Watanabe
Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
Nucl Med Biol 26:853-8. 1999..Pre- and postadministration of CaNa3DTPA could remove (111)In-nonspecific localization in tumors when (111)In is released from the radiolabeled agents...
Genetic and epigenetic control of the proliferation and differentiation of mouse epidermal melanocytes in cultureT Hirobe
Division of Biology and Oncology, National Institute of Radiological Sciences, Chiba, Japan
Pigment Cell Res 12:147-63. 1999....
Radiation-induced tumorigenesis of mammary glands in pituitary transplanted rats ovariectomized before onset of estrous cycleH Inano
The First Research Group, National Institute of Radiological Sciences, Chiba shi, Japan
Cancer Lett 138:93-100. 1999....
Muscarinic receptor occupancy by biperiden in living human brainY Sudo
Division of Advanced Technology for Medical Imaging, National Institute of Radiological Sciences, Chiba, Japan
Life Sci 64:PL99-104. 1999..mAchR occupancy was 10-45% in the frontal cortex three hours after the oral administration of 4 mg of biperiden. The occupancy correlated with the plasma concentration of biperiden in a curvilinear manner...
Endothelins are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in serum-free primary cultureT Hirobe
Division of Biology and Oncology, National Institute of Radiological Sciences, Anagawa, Chiba, Japan
J Investig Dermatol Symp Proc 6:25-31. 2001..These results suggest that ET-1, -2, and -3 are one member of the keratinocyte-derived factors that are involved in regulating the proliferation and differentiation of mouse epidermal melanocytes in primary culture...
Bioassay for neutron-dose estimations of three patients in the JCO criticality accident in Tokai-mura by measuring beta-ray emittersH Takeda
Environmental and Toxicological Sciences Research Group, National Institute of Radiological Sciences, Chiba, Japan
J Radiat Res (Tokyo) 42:S129-35. 2001....
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptorsTerushi Haradahira
Department of Medical Imaging, National Institute of Radiological Sciences, Chiba 263 8555, Japan
Nucl Med Biol 29:517-25. 2002..Thus, the present studies point to the possibility that the polyamines and cations behave as endogenous inhibitors for (+/-)[11C]1 binding, leading to the loss of the specific binding in vivo...
Cross-calibration of ionization chambers in proton and carbon beamsTatsuaki Kanai
National Institute of Radiological Sciences, 9 1, Anagawa 4 chome, Inage Ku, Chiba shi, 263 8555 Chiba, Japan
Phys Med Biol 49:771-81. 2004..5% lower than those obtained using 400 MeV/u beams. The calibration coefficient obtained by the first method agreed roughly with the results obtained by SOBP beams...
Biokinetics of radiotellurium in ratsY Nishimura
National Institute of Radiological Sciences, 4 9 1, Anagawa, Inage Ku, Chiba shi, 263 8555, Japan
Radiat Prot Dosimetry 105:285-90. 2003..The C(F)/C(M) ratio was dependent on the stage of gestation and ranged from 0.2 to 0.5. A little 123mTe was transferred to the suckling rats through the mother's milk when the isotope was administered intravenously to the mother...
Quality control of CT system for treatment planning using the polybinary calibration methodNobuyuki Kanematsu
Department of Medical Physics, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba shi, Chiba ken, 263 8555, Japan
Igaku Butsuri 23:140-6. 2003..Practical procedures for commissioning and constancy testing are documented along with the methodologies against various sources of uncertainty. We propose this guideline for quality assurance of heavy charged particle radiotherapy...
Different radiation susceptibility among five strains of mice detected by a skin reactionMayumi Iwakawa
Frontier Research Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba shi, Chiba ken 263 8555, Japan
J Radiat Res (Tokyo) 44:7-13. 2003....
A simplified system for reading time-resolved photoluminescenceHiroshi Yasuda
National Institute of Radiological Sciences, Anagawa 4 9 1, Inage, Chiba shi 263 8555, Japan
J Radiat Res (Tokyo) 43:S63-5. 2002..It is thus expected that this system will be conveniently used for searching new PL materials that would be more suitable for space radiation dosimetry...
A CT calibration method based on the polybinary tissue model for radiotherapy treatment planningNobuyuki Kanematsu
Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
Phys Med Biol 48:1053-64. 2003....
Time resolved photoluminescence from a phosphate glass (GD-300) irradiated with heavy ions and gamma raysHiroshi Yasuda
National Institute of Radiological Sciences, Anagawa 4 9 1, Inage, Chiba shi 263 8555, Japan
Health Phys 84:373-5. 2003..In contrast, the photoluminescence afterglows for the heavy ions were stable over the whole range after excitation. These results indicate that the process of photoluminescence-center formation is different for heavy ions and gamma rays...
Dose estimation by ESR on tooth enamel from two workers exposed to radiation due to the JCO accidentKunio Shiraishi
Environmental Radiation Protection System Research Group, National Institute of Radiological Sciences, Japan
J Radiat Res 43:331-5. 2002..3 +/- 3.4 and 10.8 +/- 3.3 Gy, 11.7 +/- 3.5 and 11.4 +/- 3.4 Gy, respectively. The estimated doses were found to be similar and not dependent on the tooth positions, whether the buccal or lingual sides in each tooth...
Gamma-irradiation effect: variation of photosynthetic activity of EuglenaT Sakashita
National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage, Chiba 263 8555, Japan
Biomed Environ Sci 15:261-7. 2002....
Analysis of alpha- and beta-tubulin genes of Bombyx mori using an EST databaseHideki Kawasaki
Faculty of Agriculture, Utsunomiya University, 350 Mine, Utsunomiya, 321 8505, Tochigi, Japan
Insect Biochem Mol Biol 33:131-7. 2003....
Inhibition of DNA-double strand break repair by antimony compoundsSentaro Takahashi
Environmental and Toxicological Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, 263 8555, Chiba, Japan
Toxicology 180:249-56. 2002..This is the first report to indicate that antimony compounds may inhibit the repair of radiation-induced DNA DSB...
Histological and elemental changes in the rat brain after local irradiation with carbon ion beamsSentaro Takahashi
Environmental and Toxicological Research Group, National Institute of Radiological Sciences, Anagawa 4 9 1, Inage Ku, Chiba shi, Chiba 263 8555, Japan
J Radiat Res 43:143-52. 2002....
Keratinocytes control the proliferation and differentiation of cultured epidermal melanocytes from ultraviolet radiation B-induced pigmented spots in the dorsal skin of hairless miceTomohisa Hirobe
Radiation Hazards Research Group, National Institute of Radiological Sciences, Anagawa, Inage Ku, Chiba, Japan
Pigment Cell Res 15:391-9. 2002..These results suggest that the increased proliferative and differentiative activities of mouse epidermal melanocytes from UVB-induced pigmented spots are regulated by keratinocytes, rather than melanocytes...
Radio-sensitive murine thymoma cell line 3SB: characterization of its apoptosis-resistant variants induced by repeated X-irradiationH Hama-Inaba
Bioregulation Research Group, National Institute of Radiological Sciences, Chiba, Japan
Mutat Res 403:85-94. 1998..Present result suggests that the induction of X-ray resistance by repeated X-irradiation might be achieved, at least partly, by the enhanced resistance to the ceramide-mediated apoptosis...
