Masahito Uemura

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. pmc Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Int J Hepatol 2011:759047. 2011
  2. doi Pivotal role of ADAMTS13 function in liver diseases
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara Nara, 634 8522, Japan
    Int J Hematol 91:20-9. 2010
  3. ncbi Decreased activity of plasma ADAMTS13 may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Alcohol Clin Exp Res 29:264S-71S. 2005
  4. doi Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Thromb Haemost 99:1019-29. 2008
  5. ncbi Potential role of ADAMTS13 in the progression of alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, 634 8522, Japan
    Curr Drug Abuse Rev 1:188-96. 2008
  6. ncbi Impact of insulin resistance on the progression of chronic liver diseases
    Kosuke Kaji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Int J Mol Med 22:801-8. 2008
  7. doi Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 51:315-21. 2009
  8. ncbi Synergistic inhibition of hepatocellular carcinoma growth and hepatocarcinogenesis by combination of 5-fluorouracil and angiotensin-converting enzyme inhibitor via anti-angiogenic activities
    Koji Yanase
    Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 17:441-6. 2007
  9. ncbi Interferon augments the anti-fibrotic activity of an angiotensin-converting enzyme inhibitor in patients with refractory chronic hepatitis C
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 12:6786-91. 2006
  10. doi Branched-chain amino acids suppress insulin-resistance-based hepatocarcinogenesis in obese diabetic rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Gastroenterol 44:483-91. 2009

Collaborators

Detail Information

Publications62

  1. pmc Determination of ADAMTS13 and Its Clinical Significance for ADAMTS13 Supplementation Therapy to Improve the Survival of Patients with Decompensated Liver Cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Int J Hepatol 2011:759047. 2011
    ..Such treatments may improve the survival of patients with decompensated LC...
  2. doi Pivotal role of ADAMTS13 function in liver diseases
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara Nara, 634 8522, Japan
    Int J Hematol 91:20-9. 2010
    ..These results promise to bring further understanding of the pathophysiology of liver diseases, and offer new insight for development of therapeutic strategies...
  3. ncbi Decreased activity of plasma ADAMTS13 may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Alcohol Clin Exp Res 29:264S-71S. 2005
    ..The aim of this study was to explore the potential role of ADAMTS13 on the development of liver disturbance and multiorgan failure in AH...
  4. doi Comprehensive analysis of ADAMTS13 in patients with liver cirrhosis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Thromb Haemost 99:1019-29. 2008
    ..An imbalance between the decreased ADAMTS13:AC and its increased substrate may reflect the predisposing state for platelet thrombi formation in patients with advanced LC...
  5. ncbi Potential role of ADAMTS13 in the progression of alcoholic hepatitis
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, 634 8522, Japan
    Curr Drug Abuse Rev 1:188-96. 2008
    ..The determination of ADAMTS13:AC and its substrate will give us new insights into the pathophysiology of acute alcoholic liver injury and help to elucidate additional therapeutic strategies for this disease...
  6. ncbi Impact of insulin resistance on the progression of chronic liver diseases
    Kosuke Kaji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Int J Mol Med 22:801-8. 2008
    ....
  7. doi Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 51:315-21. 2009
    ....
  8. ncbi Synergistic inhibition of hepatocellular carcinoma growth and hepatocarcinogenesis by combination of 5-fluorouracil and angiotensin-converting enzyme inhibitor via anti-angiogenic activities
    Koji Yanase
    Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 17:441-6. 2007
    ..Since both 5-FU and ACE-I are widely used in clinical practice, this combination therapy may be an effective new therapeutic strategy against HCC in the future...
  9. ncbi Interferon augments the anti-fibrotic activity of an angiotensin-converting enzyme inhibitor in patients with refractory chronic hepatitis C
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 12:6786-91. 2006
    ..To evaluate the effect of combination treatment with the interferon (IFN) and angiotensin-converting enzyme inhibitor (ACE-I) on several fibrotic indices in patients with refractory chronic hepatitis C (CHC)...
  10. doi Branched-chain amino acids suppress insulin-resistance-based hepatocarcinogenesis in obese diabetic rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Gastroenterol 44:483-91. 2009
    ..However, the possible mechanism is still obscure. The aim of the present study was to examine the effect of BCAAs, especially in conjunction with angiogenesis, on hepatocarcinogenesis under the condition of IR...
  11. ncbi Leptin-mediated neovascularization is a prerequisite for progression of nonalcoholic steatohepatitis in rats
    Mitsuteru Kitade
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Hepatology 44:983-91. 2006
    ..In conclusion, these results suggest that leptin-mediated neovascularization coordinated with VEGF plays an important role in the development of liver fibrosis and hepatocarcinogenesis in NASH...
  12. doi Plasma ADAMTS13 activity parallels the APACHE II score, reflecting an early prognostic indicator for patients with severe acute pancreatitis
    Chie Morioka
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Scand J Gastroenterol 43:1387-96. 2008
    ..The purpose of the study was to investigate the potential role of ADAMTS13:AC in the severity of SAP...
  13. pmc Crosstalk between angiogenesis, cytokeratin-18, and insulin resistance in the progression of non-alcoholic steatohepatitis
    Mitsuteru Kitade
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 15:5193-9. 2009
    ..To elucidate the possible crosstalk between angiogenesis, cytokeratin-18 (CK-18), and insulin resistance (IR) especially in patients with non-alcoholic steatohepatitis (NASH)...
  14. ncbi Amelioration of carcinogenesis and tumor growth in the rat liver by combination of vitamin K2 and angiotensin-converting enzyme inhibitor via anti-angiogenic activities
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Japan
    Oncol Rep 15:155-9. 2006
    ..Since both VK and ACE-I are widely used in clinical practice without serious side effects, this combination therapy may be an effective new therapeutic strategy against hepatocarcinogenesis and HCC growth in the future...
  15. pmc Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138
    Tatsuhiro Tsujimoto
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    World J Gastroenterol 15:5533-40. 2009
    ..To investigate the possible use of the multiple cytokine production modulator, Y-40138, as a novel immunotherapy in the rat nonalcoholic steatohepatitis (NASH) model...
  16. ncbi Combined treatment of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates hepatic dysplastic nodule in a patient with liver cirrhosis
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 13:3259-61. 2007
    ..Since both VK and ACE-I are widely used without serious side effects, this combined regimen may become a new strategy for chemoprevention against HCC...
  17. doi Combination of branched-chain amino acids and angiotensin-converting enzyme inhibitor suppresses the cumulative recurrence of hepatocellular carcinoma: a randomized control trial
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Oncol Rep 26:1547-53. 2011
    ..Moreover, sVEGFR2 may become a useful clinical predictive marker of this combination treatment...
  18. ncbi Amelioration of liver fibrogenesis by dual inhibition of PDGF and TGF-beta with a combination of imatinib mesylate and ACE inhibitor in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    Int J Mol Med 17:899-904. 2006
    ..Since both agents are widely used in clinical practice, this combination therapy may provide a new strategy against liver fibrosis in the future...
  19. pmc Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet
    Hideto Kawaratani
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 14:6655-61. 2008
    ..To investigate the innate immune reactivity of tumor necrosis factor-alpha (TNF-alpha), Toll-like receptor 4 (TLR4), and CD14 in the liver of non-alcoholic steatohepatitis (NASH) model rats...
  20. ncbi Different tumoricidal effects of interferon subclasses and p53 status on hepatocellular carcinoma development and neovascularization
    Ryuichi Noguchi
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Int J Oncol 32:193-9. 2008
    ..A cautious approach may be also required in the clinical practice since even in a same IFN subclass (class-I), IFN-alpha and IFN-beta exert tumoricidal effects of different magnitudes on HCC...
  21. doi Potential role of enhanced cytokinemia and plasma inhibitor on the decreased activity of plasma ADAMTS13 in patients with alcoholic hepatitis: relationship to endotoxemia
    Masatoshi Ishikawa
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Alcohol Clin Exp Res 34:S25-33. 2010
    ..The aim of this study was to explore the potential mechanism to reduce the activity of plasma ADAMTS13...
  22. ncbi Renin-angiotensin system inhibitors as therapeutic alternatives in the treatment of chronic liver diseases
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Curr Med Chem 14:2749-54. 2007
    ..Since RAS inhibitors are widely used in the clinical practice without serious side effects, they may represent a potential new therapeutic strategy against the progression of chronic liver diseases...
  23. pmc Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model
    Tatsuhiro Tsujimoto
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 14:6036-43. 2008
    ..To investigate Kupffer cell dynamics and phagocytic activity, using a rat nonalcoholic steatohepatitis (NASH) model...
  24. ncbi Increased von Willebrand factor over decreased ADAMTS13 activity may contribute to the development of liver disturbance and multiorgan failure in patients with alcoholic hepatitis
    Tomomi Matsuyama
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    Alcohol Clin Exp Res 31:S27-35. 2007
    ..We investigated the relationship of ADAMTS13 and von Willebrand factor antigen (VWF:Ag) with the clinical features of AH and SAH...
  25. pmc Branched-chain amino acids suppress the cumulative recurrence of hepatocellular carcinoma under conditions of insulin-resistance
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Oncol Rep 30:545-52. 2013
    ..Moreover, our findings suggest that sVEGFR2 may be a useful clinical predictive marker for BCAA treatment under IR conditions...
  26. doi Combination of branched-chain amino acid and angiotensin-converting enzyme inhibitor improves liver fibrosis progression in patients with cirrhosis
    Hitoshi Yoshiji
    The Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    Mol Med Rep 5:539-44. 2012
    ....
  27. ncbi Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis
    Hideyuki Kojima
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Alcohol Clin Exp Res 31:S61-6. 2007
    ..This study aimed to investigate the role of mitochondrial abnormality in NASH in relation to oxidative stress...
  28. ncbi Suppression of renin-angiotensin system attenuates hepatocarcinogenesis via angiogenesis inhibition in rats
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Anticancer Res 25:3335-40. 2005
    ..These results suggested that RAS plays an important role in hepatocarcinogenesis, at least partly through VEGF-mediated angiogenesis...
  29. ncbi Crosstalk between high-molecular-weight adiponectin and T-cadherin during liver fibrosis development in rats
    Kiyoshi Asada
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Int J Mol Med 20:725-9. 2007
    ..Collectively, since the specific ligand and receptor were augmented together, crosstalk between HMW adiponectin and T-cadherin may play an important role during liver fibrosis development in rats...
  30. ncbi Salvage effect of the vascular endothelial growth factor on chemically induced acute severe liver injury in rats
    Tadashi Namisaki
    Third Department of Internal Medicine, Nara Medical University, School of Medicine, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 44:568-75. 2006
    ..The aims of the current study were to investigate the role of VEGF, and to find out whether VEGF can improve the outcome of ALI in rats...
  31. doi Therapeutic effects of cytokine modulator Y-40138 in the rat alcoholic liver disease model
    Hideto Kawaratani
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    J Gastroenterol Hepatol 26:775-83. 2011
    ..Y-40138 is known to suppress the pro-inflammatory cytokines and augment the anti-inflammatory cytokines. We investigated whether or not Y-40138 may be effective as a novel immunotherapy in the rat ALD model...
  32. ncbi Cryptogenic cirrhosis in the region where obesity is not prevalent
    Hideyuki Kojima
    Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    World J Gastroenterol 12:2080-5. 2006
    ..Recent studies have demonstrated that obesity is the common feature of cryptogenic cirrhosis (CC) and non-alcoholic steatohepatitis. However, there is little information on CC in the region where obesity is not prevalent...
  33. ncbi Eosinophilic cholecystitis along with pericarditis caused by Ascaris lumbricoides: a case report
    Kosuke Kaji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    World J Gastroenterol 13:3760-2. 2007
    ..We report herein a rare case of simultaneous onset of acute cholecystitis and pericarditis associated with a marked eosinophilia caused by parasitic infection...
  34. ncbi Effect of prostaglandin E receptor subtype EP4 selective agonist on the secretion of tumor necrosis factor-alpha by macrophages in acute ethanol-loaded rats
    Yoshihiro Nakatani
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Alcohol Clin Exp Res 28:123S-128S. 2004
    ..We examined the efficacy of an EP4 agonist ONO-AE1-437 on tumor necrosis factor-alpha (TNF-alpha) secretion of Kupffer cells, splenic macrophages, and alveolar macrophages in acute ethanol-loaded rats...
  35. ncbi Glucocorticoid therapy ameliorated hypoglycemia in insulin-like growth factor-II-producing solitary fibrous tumor
    Kiminori Tsuro
    Third Department of Internal Medicine, Nara Medical University, Kashihara
    Intern Med 45:525-9. 2006
    ..Glucocorticoid dramatically and continuously abolished hypoglycemia. In cases of inoperable IGF-II-producing tumor, glucocorticoid therapy may be promising for hypoglycemia...
  36. ncbi Localization of ADAMTS13 to the stellate cells of human liver
    Masahito Uemura
    Third Department of Internal Medicine, Department of Anatomy, Nara Medical University, 840 Shijo Cho, Kashihara City, Nara, 634 8522, Japan
    Blood 106:922-4. 2005
    ..These results suggest that HSCs may be major cells producing ADAMTS13 in human liver...
  37. ncbi Intrahepatic cholangiocarcinoma associated with central calcification and arterio-portal shunt
    Mitsuteru Kitade
    Third Department of Internal Medicine, Nara Medical University, Japan
    Intern Med 44:825-8. 2005
    ..The postoperative histopathological examination revealed a cholangiocarcinoma. Herein, we report this case of IHC that was very difficult to diagnose due to the simultaneous association with central calcification and A-P shunt...
  38. doi Innate immune reactivity of the ileum-liver axis in nonalcoholic steatohepatitis
    Tatsuhiro Tsujimoto
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Dig Dis Sci 57:1144-51. 2012
    ..Over-proliferation and bacterial translocation of Gram-negative bacilli within the intestinal flora, and increased portal venous levels of endotoxins, are involved in nonalcoholic steatohepatitis (NASH)...
  39. ncbi The production of tumor necrosis factor-alpha by macrophages in rats with acute alcohol loading
    Toshiyuki Kitazawa
    Third Department of Internal Medicine, Nara Medical University, Kashihara shi, Nara, Japan
    Alcohol Clin Exp Res 27:72S-75S. 2003
    ....
  40. pmc A histologically proven case of progressive liver sarcoidosis with variceal rupture
    Hitoshi Yoshiji
    Hitoshi Yoshiji, Kou Kitagawa, Ryuichi Noguchi, Masahito Uemura, Yasuhide Ikenaka, Yosuke Aihara, Keisuke Nakanishi, Yusaku Shirai, Chie Morioka, Hiroshi Fukui, Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8522, Japan
    World J Hepatol 3:271-4. 2011
    ..Although significant liver dysfunction with portal hypertension is rarely seen in sarcoidosis, this case indicates that we have to consider the possibility that sarcoidosis may cause end-stage liver cirrhosis...
  41. pmc Development of hepatocellular carcinoma in a patient 13 years after sustained virological response to interferon against chronic hepatitis C: a case report
    Tsuyoshi Mashitani
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Cases J 2:18. 2009
    ..abstract:..
  42. pmc A case of severe acalculous cholecystitis associated with sorafenib treatment for advanced hepatocellular carcinoma
    Yosuke Aihara
    Yosuke Aihara, Hitoshi Yoshiji, Masaharu Yamazaki, Yasuhide Ikenaka, Ryuichi Noguchi, Chie Morioka, Kosuke Kaji, Haruki Tastumi, Keisuke Nakanishi, Maiko Nakamura, Junichi Yamao, Masahisa Toyohara, Akira Mitoro, Masayoshi Sawai, Motoyuki Yoshida, Masao Fujimoto, Masahito Uemura, Hiroshi Fukui, Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    World J Gastrointest Oncol 4:115-8. 2012
    ..In summary, we herein report a rare case of acute severe acalculous cholecystitis associated with sorafenib in the patient with advanced HCC...
  43. ncbi ADAMTS13 activity may predict the cumulative survival of patients with liver cirrhosis in comparison with the Child-Turcotte-Pugh score and the Model for End-Stage Liver Disease score
    Hiroaki Takaya
    Third Department of Internal Medicine Departments of Blood Transfusion Medicine Community Health and Epidemiology, Nara Medical University, Kashihara, Nara, Japan
    Hepatol Res 42:459-72. 2012
    ..This activity may be a useful prognostic marker that is equal or superior to the CTP score and the MELD score to predict not only the short-term prognosis but also the long-term survival of the cirrhotic patients...
  44. ncbi [A case of intrahepatic splenosis]
    Masatoshi Ishikawa
    Third Department of Internal Medicine, Nara Medical University
    Nihon Shokakibyo Gakkai Zasshi 104:1758-65. 2007
    ..Histopathological examination of this specimen confirmed the diagnosis. As there have been only 19 previous reported cases of intrahepatic splenosis, we hereby present this valuable case with a review of the literature...
  45. pmc Salvage living donor liver transplantation after percutaneous transluminal angioplasty for recurrent Budd-Chiari syndrome: a case report
    Yusaku Shirai
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    J Med Case Reports 5:124. 2011
    ..abstract:..
  46. ncbi Disturbed colocalization of multidrug resistance protein 2 and radixin in human cholestatic liver diseases
    Hideyuki Kojima
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    J Gastroenterol Hepatol 23:e120-8. 2008
    ..This study aimed to investigate the role of radixin in the altered localization of MRP2 in various human cholestatic liver diseases...
  47. ncbi Plasma ADAMTS13 activity may predict early adverse events in living donor liver transplantation: observations in 3 cases
    Saiho Ko
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Liver Transpl 12:859-69. 2006
    ..Our findings not only suggest a novel mechanism for thrombocytopenia, but also provide a useful tool for diagnosis of graft dysfunction in the early stage after transplantation...
  48. ncbi Difference and similarity between non-alcoholic steatohepatitis and alcoholic liver disease
    Hideyuki Kojima
    Third Department of Internal Medicine, Nara Medical University, Japan
    Alcohol Clin Exp Res 29:259S-63S. 2005
    ..Non-alcoholic steatohepatitis (NASH) and alcoholic liver disease (ALD) are extremely similar in the pathologic findings and pathogenesis. This study aimed to elucidate the difference and similarity between these diseases...
  49. ncbi Rapid onset of glycogen storage hepatomegaly in a type-2 diabetic patient after a massive dose of long-acting insulin and large doses of glucose
    Tatsuhiro Tsujimoto
    Third Department of Internal Medicine, Nara Medical University, Kashihara
    Intern Med 45:469-73. 2006
    ..When hepatic dysfunction or hepatomegaly is detected during treatment with insulin, the possibility of hepatic glycogen deposition should be considered. CT scanning and liver biopsy were useful in diagnosing this case...
  50. ncbi Clinical features of liver disturbance in rheumatoid diseases: clinicopathological study with special reference to the cause of liver disturbance
    Hideyuki Kojima
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara 634 8522, Japan
    J Gastroenterol 37:617-25. 2002
    ..This study aimed to elucidate the clinical features of liver disturbance in rheumatoid diseases, focusing on the cause of this disturbance...
  51. ncbi Disappearance of hepatic encephalopathy and improvement of liver function after surgical treatment of portal-systemic shunt in a patient with liver cirrhosis
    Kei Moriya
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara shi, Nara 634 8522, Japan
    Hepatogastroenterology 50:1128-32. 2003
    ..7 to 3.4 g/dL, respectively. This case supports the effectiveness of shunt resection for hepatic encephalopathy and the deteriorated liver function in cirrhotic patients with large portal-systemic shunt...
  52. ncbi Recent developments in the treatment of alcoholic chronic pancreatitis
    Tatsuhiro Tsujimoto
    Third Department of Internal Medicine, Nara Medical University, Nara, Japan
    Curr Drug Abuse Rev 1:197-202. 2008
    ....
  53. ncbi The role of radixin in altered localization of canalicular conjugate export pump Mrp2 in cholestatic rat liver
    Hideyuki Kojima
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan
    Hepatol Res 38:202-10. 2008
    ....
  54. ncbi Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats
    Shinya Sakurai
    Third Department of Internal Medicine, Nara Medical University, Nara 634 8522, Japan
    World J Gastroenterol 12:2095-102. 2006
    ..To investigate whether adrenomedullin, a potent vasodilator peptide, plays a role in the circulatory disturbance in cirrhosis...
  55. ncbi Cysteinyl leukotrienes in the bile of patients with obstructive jaundice
    Masahito Uemura
    Third Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara 634 8521, Japan
    J Gastroenterol 37:821-30. 2002
    ..To explore the clinical significance of biliary cysteinyl LTs, we determined their concentration changes in bile during treatment in patients with obstructive jaundice...
  56. doi Acute myocardial infarction as a systemic prothrombotic condition evidenced by increased von Willebrand factor protein over ADAMTS13 activity in coronary and systemic circulation
    Manabu Horii
    First Department of Internal Medicine, Nara Medical University, 840 Shijo Cho, Kashihara, 634 8521, Japan
    Heart Vessels 23:301-7. 2008
    ....
  57. ncbi Different cascades in the signaling pathway of two vascular endothelial growth factor (VEGF) receptors for the VEGF-mediated murine hepatocellular carcinoma development
    Hitoshi Yoshiji
    The Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    Oncol Rep 13:853-7. 2005
    ..These results suggested that both VEGFR-1 and VEGFR-2 play important roles, and lie in the different signaling cascades by which VEGF augments HCC development and angiogenesis...
  58. ncbi Effect of alcohol on the secretion of tumor necrosis factor-alpha by macrophages in the presence of rat serum
    Yoshihiro Nakatani
    Third Department of Internal Medicine, Nara Medical University, Kashihara shi, Japan
    Alcohol Clin Exp Res 26:81S-85S. 2002
    ....
  59. ncbi Changes in the expression and localization of hepatocellular transporters and radixin in primary biliary cirrhosis
    Hideyuki Kojima
    Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    J Hepatol 39:693-702. 2003
    ..Expression and localization of human hepatocellular transporters and of radixin, cross-linking actin with some membrane transporters, may change in cholestatic liver diseases...
  60. ncbi Development of ADAMTS13 inhibitor in a patient with hepatitis C virus-related liver cirrhosis causes thrombotic thrombocytopenic purpura
    Masato Yagita
    J Hepatol 42:420-1. 2005
  61. pmc Two mechanistic pathways for thienopyridine-associated thrombotic thrombocytopenic purpura: a report from the SERF-TTP Research Group and the RADAR Project
    Charles L Bennett
    VA Center for Management of Complex Chronic Care at Jesse Brown VA Medical Center, Division of Hematology Oncology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Coll Cardiol 50:1138-43. 2007
    ..We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP)...
  62. ncbi Thrombotic thrombocytopenic purpura associated with pegylated-interferon alpha-2a by an ADAMTS13 inhibitor in a patient with chronic hepatitis C
    Kiyoshi Kitano
    Department of Internal Medicine, Matsumoto National Hospital, Matsumoto, Japan
    Haematologica 91:ECR34. 2006
    ..Serial determination of ADAMTS13 activity and its inhibitor may provide useful information for the diagnosis and treatment of IFN-associated TTP, as well as its pathogenesis...