Masayuki Sho

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. doi request reprint Novel postoperative adjuvant strategy prevents early hepatic recurrence after resection of pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 18:235-9; discussion 239-40. 2011
  2. doi request reprint Postoperative prognosis of pancreatic cancer with para-aortic lymph node metastasis: a multicenter study on 822 patients
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    J Gastroenterol 50:694-702. 2015
  3. doi request reprint Optimal indication of neoadjuvant chemoradiotherapy for pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Langenbecks Arch Surg 400:477-85. 2015
  4. pmc Clinical importance of B7-H3 expression in human pancreatic cancer
    I Yamato
    Department of Surgery, Nara Medical University, Nara 634 8522, Japan
    Br J Cancer 101:1709-16. 2009
  5. pmc Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma
    K Hotta
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Br J Cancer 105:1191-6. 2011
  6. doi request reprint Pathological and clinical impact of neoadjuvant chemoradiotherapy using full-dose gemcitabine and concurrent radiation for resectable pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 20:197-205. 2013
  7. ncbi request reprint Function of the vascular endothelial growth factor receptors Flt-1 and Flk-1/KDR in the alloimmune response in vivo
    Masayuki Sho
    Department of Surgery, Nara Medical University, Nara, Japan
    Transplantation 80:717-22. 2005
  8. ncbi request reprint [A case of postoperative multiple liver metastases of pancreatic cancer successfully treated by combination chemotherapy with weekly high-dose 5-FU hepatic arterial infusion plus systemic infusion of gemcitabine]
    Jin Doh
    Department of Surgery, Nara Medical University
    Gan To Kagaku Ryoho 36:2087-9. 2009
  9. ncbi request reprint Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    Takeo Nomi
    Department of Surgery, Second Department of Internal Medicine, First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Clin Cancer Res 13:2151-7. 2007
  10. ncbi request reprint A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection
    Satoru Akashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Transplantation 80:378-84. 2005

Collaborators

Detail Information

Publications73

  1. doi request reprint Novel postoperative adjuvant strategy prevents early hepatic recurrence after resection of pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 18:235-9; discussion 239-40. 2011
    ..However, the efficacy was limited and further studies are required to improve the prognosis. In particular, postoperative hepatic recurrence often occurs even after gemcitabine treatment...
  2. doi request reprint Postoperative prognosis of pancreatic cancer with para-aortic lymph node metastasis: a multicenter study on 822 patients
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    J Gastroenterol 50:694-702. 2015
    ..The aim of this study was to reevaluate the postoperative prognostic value of PALN metastasis in pancreatic cancer and to determine the validity of pancreatic surgery...
  3. doi request reprint Optimal indication of neoadjuvant chemoradiotherapy for pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Langenbecks Arch Surg 400:477-85. 2015
    ..The purpose of this study was to define the optimal indication of neoadjuvant chemoradiotherapy (NACRT) for pancreatic cancer...
  4. pmc Clinical importance of B7-H3 expression in human pancreatic cancer
    I Yamato
    Department of Surgery, Nara Medical University, Nara 634 8522, Japan
    Br J Cancer 101:1709-16. 2009
    ..However, the role of B7-H3 in tumour immunity is largely unknown. The purpose of this study was to evaluate the clinical significance of B7-H3 expression in human pancreatic cancer and the therapeutic potential for cancer immunotherapy...
  5. pmc Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma
    K Hotta
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Br J Cancer 105:1191-6. 2011
    ..However, their role in actual human cancer remains largely unknown. In this study, we tried to reveal the clinical importance of tumour-infiltrating CD45RO+ memory T cells in renal cell carcinoma (RCC)...
  6. doi request reprint Pathological and clinical impact of neoadjuvant chemoradiotherapy using full-dose gemcitabine and concurrent radiation for resectable pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 20:197-205. 2013
    ..In this study, we have retrospectively evaluated its impact on pathology and the perioperative clinical course in addition to its safety...
  7. ncbi request reprint Function of the vascular endothelial growth factor receptors Flt-1 and Flk-1/KDR in the alloimmune response in vivo
    Masayuki Sho
    Department of Surgery, Nara Medical University, Nara, Japan
    Transplantation 80:717-22. 2005
    ..VEGF binds two major VEGF receptors: VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR). Here, we wished to investigate the expression and function of VEGF receptors in the process of acute allograft rejection in vivo...
  8. ncbi request reprint [A case of postoperative multiple liver metastases of pancreatic cancer successfully treated by combination chemotherapy with weekly high-dose 5-FU hepatic arterial infusion plus systemic infusion of gemcitabine]
    Jin Doh
    Department of Surgery, Nara Medical University
    Gan To Kagaku Ryoho 36:2087-9. 2009
    ..He survived for 34 months after surgery. It has been suggested that this combined chemotherapy might be an effective treatment to control liver metastases of pancreatic cancer...
  9. ncbi request reprint Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    Takeo Nomi
    Department of Surgery, Second Department of Internal Medicine, First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Clin Cancer Res 13:2151-7. 2007
    ..In this study, we tried to reveal the clinical importance and therapeutic potential of the PD-L/PD-1 pathway in pancreatic cancer, which is one of the most aggressive and intractable malignant tumors...
  10. ncbi request reprint A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection
    Satoru Akashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Transplantation 80:378-84. 2005
    ..Among them, CC chemokine receptor 5 (CCR5) and CXC chemokine receptor 3 (CXCR3) have been reported to play important roles in alloimmune responses and may be potential targets for posttransplant immunosuppression...
  11. doi request reprint Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma
    Kazuhiro Migita
    Department of Surgery, Nara Medical University, Nara, Japan
    Cancer 120:808-17. 2014
    ..The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions...
  12. ncbi request reprint Importance of peroxisome proliferator-activated receptor-gamma in hepatic ischemia/reperfusion injury in mice
    Takahiro Akahori
    Department of Surgery, Nara Medical University, Nara, Japan
    J Hepatol 47:784-92. 2007
    ..However, the precise role of PPARgamma in acute liver injury remains unknown...
  13. ncbi request reprint Intra-arterial chemoinfusion prior to chemoradiotherapy with full-dose systemic gemcitabine for management of locally advanced pancreatic cancer
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, 840 Shijo cho Kashihara, 634 8522, Japan
    Anticancer Res 31:3909-12. 2011
    ..We are currently developing a novel therapeutic technique to conduct neoadjuvant treatments of intra-arterial chemoinfusion prior to chemoradiotherapy with the aim of tumor volume reduction...
  14. ncbi request reprint Significance and therapeutic potential of prostaglandin E2 receptor in hepatic ischemia/reperfusion injury in mice
    Yukiyasu Kuzumoto
    Department of Surgery, Nara Medical University, Nara, Japan
    Hepatology 42:608-17. 2005
    ..In sharp contrast, 80% of mice treated with the EP4 agonist survived. In conclusion, the PGE2-EP4 signaling pathway has an inhibitory role in hepatic I/R injury. An EP4 agonist effectively protects against ischemic injury...
  15. doi request reprint Safety and optimal management of hepatic arterial infusion chemotherapy after pancreatectomy for pancreatobiliary cancer
    Aya Hashimoto
    Department of Radiology, Nara Medical University, Kashihara City, Japan
    AJR Am J Roentgenol 198:923-30. 2012
    ..The purpose of this study was to assess the safety of hepatic arterial infusion (HAI) chemotherapy after pancreatectomy for pancreatobiliary cancer...
  16. ncbi request reprint [Resection of the remnant pancreas for recurrent pancreatic cancer after distal pancreatectomy-a case report]
    Shoichi Kinoshita
    Dept of Surgery, Nara Medical University, Japan
    Gan To Kagaku Ryoho 39:1883-5. 2012
    ..The pathological findings showed moderately differentiated adenocarcinoma, morphologically similar to the primary pancreatic cancer. Six months following surgery, there are no signs of recurrence at present...
  17. ncbi request reprint Dual role of vascular endothelial growth factor in hepatic ischemia-reperfusion injury
    Yoshikazu Tsurui
    Department of Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Transplantation 79:1110-5. 2005
    ..In the present study, we evaluated the expression of VEGF in hepatic warm ischemia-reperfusion (I/R) injury and examined the effect of recombinant human (rh)VEGF administration in an established murine model...
  18. ncbi request reprint Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection
    Hisanori Kashizuka
    Department of Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Transplantation 79:1045-50. 2005
    ..Recent studies indicated that the ICOS-B7h pathway plays an important role in alloimmune responses. We further investigated the role of the ICOS pathway in the pathologic process of chronic rejection in vivo...
  19. doi request reprint Unresectable pancreatic cancer: arterial embolization to achieve a single blood supply for intraarterial infusion of 5-fluorouracil and full-dose IV gemcitabine
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, Kashihara, Japan
    AJR Am J Roentgenol 198:1445-52. 2012
    ..The purposes of this phases 1 and 2 study of intraarterial therapy were to ascertain the recommended dose of intraarterial chemoinfusion and to evaluate the efficacy and safety of this therapy...
  20. doi request reprint Pharmacokinetic evaluation of pancreatic arterial infusion chemotherapy after unification of the blood supply in an animal model
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, Kashihara, Japan
    J Vasc Interv Radiol 21:116-21. 2010
    ....
  21. doi request reprint Factors associated with failure to complete adjuvant chemotherapy in pancreatic cancer
    Takahiro Akahori
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Nara, 634 8522, Japan
    Am J Surg 211:787-92. 2016
    ..The importance of completing adjuvant chemotherapy in pancreatic cancer is becoming recognized. However, the clinicopathological factors associated with failure to complete adjuvant chemotherapy remain unclear...
  22. doi request reprint Do pancrelipase delayed-release capsules have a protective role against nonalcoholic fatty liver disease after pancreatoduodenectomy in patients with pancreatic cancer? A randomized controlled trial
    Sohei Satoi
    Department of Surgery, Kansai Medical University, Hirakata, Osaka, Japan
    J Hepatobiliary Pancreat Sci 23:167-73. 2016
    ....
  23. doi request reprint Prognosis after surgical treatment for pancreatic cancer in patients aged 80 years or older: a multicenter study
    Masayuki Sho
    Department of Surgery, Nara Medical University, Nara, Japan
    J Hepatobiliary Pancreat Sci 23:188-97. 2016
    ..The optimal therapeutic strategy for very elderly pancreatic cancer patients remains to be determined. The aim of this study was to clarify the role of pancreatic resection in patients 80 years of age or older...
  24. doi request reprint Impact of Smoking on Pancreatic Cancer Patients Receiving Current Chemotherapy
    Chihiro Kawaguchi
    From the Departments of Surgery and Radiology, Nara Medical University, Nara, Japan
    Pancreas 44:1155-60. 2015
    ..The aim of this study was to clarify how smoking totally affected patients with PC receiving current chemotherapy...
  25. doi request reprint Impact of Preoperative Biliary Drainage on Long-Term Survival in Resected Pancreatic Ductal Adenocarcinoma: A Multicenter Observational Study
    Kenichiro Uemura
    Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
    Ann Surg Oncol 22:1238-46. 2015
    ..This study aimed to evaluate the impact of preoperative biliary drainage (PBD) on the long-term survival of patients with pancreatic ductal adenocarcinoma (PDAC) who underwent pancreaticoduodenectomy (PD)...
  26. doi request reprint Importance of resectability status in neoadjuvant treatment for pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    J Hepatobiliary Pancreat Sci 22:563-70. 2015
    ..Much attention has been paid to neoadjuvant treatment (NAT) as a new strategy especially for borderline resectable pancreatic cancer (BRPC). However, the optimal indication of NAT remains undetermined...
  27. ncbi request reprint Significant efficacy of new transcatheter arterial chemoembolization technique for hepatic metastases of pancreatic neuroendocrine tumors
    Takahiro Akahori
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Anticancer Res 33:3355-8. 2013
    ..The liver is the most frequent site of metastasis of pancreatic neuroendocrine tumors (PNETs). Moreover, hepatic metastasis is a strong prognostic factor for patients with advanced PNETs and is often difficult to treat and cure...
  28. doi request reprint Potential role of surgical resection for pancreatic cancer in the very elderly
    Shoichi Kinoshita
    Department of Surgery, Nara Medical University, Japan
    Pancreatology 15:240-6. 2015
    ..However, the available clinical data are limited, and the optimal treatment is still controversial. The aim of this study was to evaluate the benefit of pancreatic resection in pancreatic cancer patients over the age of 80...
  29. doi request reprint Impact of preoperative asymptomatic renal dysfunction on clinical course after pancreatoduodenectomy
    Minako Nagai
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Japan
    J Hepatobiliary Pancreat Sci 22:810-8. 2015
    ....
  30. doi request reprint Prognostic Significance of Muscle Attenuation in Pancreatic Cancer Patients Treated with Neoadjuvant Chemoradiotherapy
    Takahiro Akahori
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    World J Surg 39:2975-82. 2015
    ..The aim of this study was to evaluate the impact of MA on the prognosis of pancreatic cancer patients treated with neoadjuvant chemoradiotherapy (NACRT)...
  31. doi request reprint Reappraisal of peritoneal washing cytology in 984 patients with pancreatic ductal adenocarcinoma who underwent margin-negative resection
    Sohei Satoi
    Department of Surgery, Kansai Medical University, Osaka, Japan
    J Gastrointest Surg 19:6-14; discussion 14. 2015
    ..The objective of the present study was to reappraise the clinical value of peritoneal washing cytology (CY) in 984 pancreatic ductal adenocarcinoma patients who underwent margin-negative resection...
  32. pmc Nectin-4 expression contributes to tumor proliferation, angiogenesis and patient prognosis in human pancreatic cancer
    Satoshi Nishiwada
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    J Exp Clin Cancer Res 34:30. 2015
    ..Recent studies have also suggested some roles for Nectin-4 in several human cancers. However, the precise roles and clinical relevance of Nectin-4 in tumors are largely unknown...
  33. ncbi request reprint Clinical significance of CD155 expression in human pancreatic cancer
    Satoshi Nishiwada
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Anticancer Res 35:2287-97. 2015
    ..CD155 is expressed in many types of human cells and has diverse functions. We herein evaluated the clinical importance of CD155 in pancreatic cancer...
  34. doi request reprint Adult hepatoblastoma successfully treated with multimodal treatment
    Shinji Nakamura
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Langenbecks Arch Surg 395:1165-8. 2010
    ..To date, no therapeutic strategy has been established. We report here a rare case of adult hepatoblastoma successfully treated with multimodal treatment...
  35. doi request reprint Transcatheter arterial chemoembolization using cisplatin powder mixed with degradable starch microspheres for colorectal liver metastases after FOLFOX failure: results of a phase I/II study
    Hideyuki Nishiofuku
    Department of Radiology, Nara Medical University, 840 Shijo Cho, Kashihara, 634 8522, Nara, Japan
    J Vasc Interv Radiol 24:56-65. 2013
    ....
  36. doi request reprint Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury
    Kiyohiko Hotta
    Department of Surgery, Nara Medical University, Nara, Japan
    Kidney Int 79:179-88. 2011
    ..Thus, we conclude that Fn14 is a critical mediator in the pathogenesis of ischemia reperfusion injury...
  37. doi request reprint National Comprehensive Cancer Network Resectability Status for Pancreatic Carcinoma Predicts Overall Survival
    Yoshiaki Murakami
    Department of Surgery, Institute of Biomedical and Health Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima, 734 8551, Japan
    World J Surg 39:2306-14. 2015
    ..The aim of this study was to evaluate the validity of preoperative resectability status, as defined by the National Comprehensive Cancer Network (NCCN), from the viewpoint of overall survival...
  38. doi request reprint SALL4 positive fetal gut-like adenocarcinoma of the duodenum
    Shoichi Kinoshita
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Pathol Int 64:581-4. 2014
    ..For postoperative therapy, S-1 was administered. The patient is alive with no recurrence, 83 months postoperatively. This case may contribute to further elucidate the disease entity of SALL4 positive, fetal-type carcinomas...
  39. doi request reprint PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis
    Ichiro Yamato
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Cancer Res 72:4829-39. 2012
    ..Our results establish PCA-1/ALKBH3 as important gene in pancreatic cancer with potential utility as a therapeutic target in this fatal disease...
  40. doi request reprint Clinical significance of prostate stem cell antigen expression in non-small cell lung cancer
    Takeshi Kawaguchi
    Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Kashihara, Nara, Japan
    Jpn J Clin Oncol 40:319-26. 2010
    ..In this study, we investigated the clinical significance and therapeutic potential of prostate stem cell antigen expression in non-small cell lung cancer...
  41. ncbi request reprint A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model
    Yasue Suzaki
    Second Department of Internal Medicine, Nara Medical University, Nara, Tokyo
    J Allergy Clin Immunol 116:1220-7. 2005
    ..Clinical studies suggest a role for angiogenesis in the development and persistence of chronic asthma, but whether angiogenic mediators contribute to acute asthma has not been fully studied...
  42. doi request reprint Phase I study assessing the feasibility of the triple combination chemotherapy of SOXIRI (S-1/oxaliplatin/irinotecan) in patients with unresectable pancreatic ductal adenocarcinoma
    Hiroaki Yanagimoto
    Department of Surgery, Kansai Medical University, 2 5 1, Shin Machi, Hirakata, 573 1010, Japan
    Cancer Chemother Pharmacol 77:35-41. 2016
    ..The objective of this study was to determine the recommended dose (RD) of a biweekly S-1, oxaliplatin, and irinotecan (SOXIRI) regimen in patients with unresectable pancreatic ductal adenocarcinoma...
  43. doi request reprint Clinical significance and therapeutic potential of prostate cancer antigen-1/ALKBH3 in human renal cell carcinoma
    Kiyohiko Hotta
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Oncol Rep 34:648-54. 2015
    ..Furthermore, its knockdown has a therapeutic efficacy on RCC. Taken together, both our clinical and experimental data strongly suggest that PCA-1/ALKBH3 may be functionally important and a novel molecular target for human RCC...
  44. doi request reprint Erythropoietin attenuates intestinal inflammation and promotes tissue regeneration
    Shinji Nakamura
    Department of Surgery, Nara Medical University, Nara, Japan
    Scand J Gastroenterol 50:1094-102. 2015
    ..The aim of this study was to investigate the therapeutic potential of erythropoietin (EPO) for the treatment of IBD...
  45. ncbi request reprint HVEM expression contributes to tumor progression and prognosis in human colorectal cancer
    Takashi Inoue
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Anticancer Res 35:1361-7. 2015
    ..Herpesvirus entry mediator (HVEM) has been recently suggested to play certain roles in cancer biology. We examined HVEM expression in human colorectal cancer (CRC) to reveal its clinical importance...
  46. doi request reprint Clinical impact of herpesvirus entry mediator expression in human hepatocellular carcinoma
    Daisuke Hokuto
    Department of Surgery, Nara Medical University, Nara 6348522, Japan
    Eur J Cancer 51:157-65. 2015
    ..Although HVEM is also suggested to be a critical regulator in tumours, actual roles in human cancer are largely unknown. This study aimed to clarify clinical importance of HVEM in human hepatocellular carcinoma (HCC)...
  47. doi request reprint Simple technique for gasless transumbilical single-incisional laparoscopic-assisted appendectomy
    Naoya Ikeda
    Department of Surgery, Nara Prefectural Mimuro Hospital, 1 14 16 Mimuro, Sango cho, Ikoma Gun, Nara, Nara, 636 0802, Japan
    Langenbecks Arch Surg 399:359-66. 2014
    ..We developed a novel simple technique of gasless transumbilical single-incisional laparoscopic-assisted appendectomy (TUSILAA) and retrospectively analyzed our initial experience...
  48. doi request reprint A novel interventional radiology technique for arterial infusion chemotherapy against advanced pancreatic cancer
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, 840 Shijo Cho, Kashihara 634 8522, Japan
    AJR Am J Roentgenol 192:W168-77. 2009
    ..We are currently developing a new interventional radiology technique to unify the pancreatic blood supply for chemoinfusion. In this article, we evaluated the feasibility, therapeutic potential, and limitations of this technique...
  49. doi request reprint Effects of pancrelipase on nonalcoholic fatty liver disease after pancreaticoduodenectomy
    Minako Nagai
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 21:186-92. 2014
    ..Furthermore, the optimal treatment has not been established. The aim of this prospective study was to clarify whether pancrelipase, which contains digestive pancreatic enzymes, could reverse NAFLD...
  50. ncbi request reprint Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    Yuichiro Ohigashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Clin Cancer Res 11:2947-53. 2005
    ..In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery...
  51. doi request reprint Clinical impact of tumor-infiltrating CD45RO⁺ memory T cells on human gastric cancer
    Kohei Wakatsuki
    Department of Surgery, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 29:1756-62. 2013
    ..In conclusion, tumor-infiltrating CD45RO(+) memory T cells are functional and have significant prognostic value in human gastric cancer. Our data suggest that adaptive immune response is clinically critical in gastric cancer...
  52. doi request reprint Influence of preoperative anti-cancer therapy on resectability and perioperative outcomes in patients with pancreatic cancer: project study by the Japanese Society of Hepato-Biliary-Pancreatic Surgery
    Fuyuhiko Motoi
    Division of Gastroenterological Surgery, Department of Surgery, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, 980 8574, Japan
    J Hepatobiliary Pancreat Sci 21:148-58. 2014
    ..Little is known about the effects of neoadjuvant therapy on outcomes in patients with pancreatic cancer. This study evaluated the effects of neoadjuvant therapy on resectability and perioperative outcomes...
  53. ncbi request reprint Bone marrow chimerism and tolerance induced by single-dose cyclophosphamide
    Junji Okayama
    First Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Surg Res 120:102-10. 2004
    ..We evaluated the efficacy of a simple protocol using cyclophosphamide (CYP) on induction of chimerism and organ transplant tolerance across major histocompatibility complex (MHC) barriers in the rat...
  54. doi request reprint Safety and feasibility for single-incision laparoscopic cholecystectomy in local community hospital: a retrospective comparison with conventional 4-port laparoscopic cholecystectomy
    Naoya Ikeda
    Department of Surgery, Nara Prefectural Mimuro Hospital, Nara, Japan
    Surg Laparosc Endosc Percutan Tech 23:33-6. 2013
    ..The aim of this study was to evaluate the safety and feasibility for single-incision laparoscopic cholecystectomy (SILC) by retrospective comparison with conventional laparoscopic cholecystectomy (CLC) in a local community hospital...
  55. doi request reprint Malignant potential of intraductal papillary mucinous neoplasms of the pancreas
    Yoshiyuki Nakajima
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Surg Today 40:816-24. 2010
    ..This review focuses on the malignant potential, including the postoperative recurrence of IPMN, coincidence of IPMN with PDAC, and extrapancreatic malignancy that may affect the long-term survival of the patients rather than IPMN itself...
  56. ncbi request reprint Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer
    Akihisa Fukumoto
    First Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara City, Nara 634 8522, Japan
    Oncol Rep 11:277-84. 2004
    ..Cell cycle control targeting p27Kip1 might be a promising future therapeutic modality against pancreatic cancer...
  57. doi request reprint Role of adjuvant surgery for patients with initially unresectable pancreatic cancer with a long-term favorable response to non-surgical anti-cancer treatments: results of a project study for pancreatic surgery by the Japanese Society of Hepato-Biliary-Pan
    Sohei Satoi
    Department of Surgery, Kansai Medical University, Moriguchi, Japan
    J Hepatobiliary Pancreat Sci 20:590-600. 2013
    ..A multicenter survey was conducted to explore the role of adjuvant surgery for initially unresectable pancreatic cancer with a long-term favorable response to non-surgical cancer treatments...
  58. doi request reprint Improved survival with combined gemcitabine and S-1 for locally advanced pancreatic cancer: pooled analysis of three randomized studies
    Hiroaki Yanagimoto
    Department of Surgery, Kansai Medical University, 2 5 1 Shin machi, Hirakata, 573 1010, Japan
    J Hepatobiliary Pancreat Sci 21:761-6. 2014
    ..A pooled analysis based on published data examined whether Gem with S-1 (GS) is superior to Gem alone in overall survival (OS) in patients with locally advanced PC...
  59. ncbi request reprint [Current status and prospect of T cell costimulatory blockade in transplantation]
    Masayuki Sho
    First Department of Surgery, Nara Medical University, Nara, Japan
    Nihon Geka Gakkai Zasshi 104:853-7. 2003
    ....
  60. pmc Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population
    Atsushi Kubo
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    PLoS ONE 6:e24058. 2011
    ....
  61. ncbi request reprint [Genetic alterations in biliary tract carcinoma]
    Masayuki Sho
    Department of Surgery, Nara Medical University
    Nihon Rinsho 64:358-61. 2006
  62. ncbi request reprint [A case of resected endocrine cell carcinoma in the remnant stomach]
    Takashi Inoue
    Department of Surgery, Nara Medical University
    Nihon Shokakibyo Gakkai Zasshi 107:1139-45. 2010
    ..Although adjuvant chemotherapy was given, multiple liver metastases and lymph node recurrence were found 13 months after the second surgery. A new regimen of chemotherapy was not effective and he died 18 months after surgery...
  63. pmc Proinflammatory functions of vascular endothelial growth factor in alloimmunity
    Marlies E J Reinders
    Division of Nephrology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:1655-65. 2003
    ..Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. Together, these observations provide mechanistic insight into the proinflammatory function of VEGF in immunity...
  64. ncbi request reprint T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection
    Hillary K Rolls
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114 2500, USA
    Transplantation 74:1053-7. 2002
    ..This response contributes to transplant rejection in that its modulation affects cardiac graft survival. This study investigates whether anti-CM T cells undergo activation and expansion in mice with chronic cardiac allograft rejection...
  65. pmc New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs
    Masayuki Sho
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Surg 236:667-75. 2002
    ..To determine the precise in vivo interaction between T-cell costimulatory blockade and conventional immunosuppression in transplantation...
  66. ncbi request reprint Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size
    Masayuki Sho
    Department of Medicine, Children s Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:3744-51. 2002
    ..These data demonstrate that cytokine regulation, CTLA-4 negative signaling, and T cell apoptosis play critical roles in regulating alloimmunity, especially under conditions where the alloreactive T cell clone size is relatively small...
  67. ncbi request reprint Allograft rejection in a new allospecific CD4+ TCR transgenic mouse
    Mohamed H Sayegh
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 3:381-9. 2003
    ..The results indicate that a complex interplay between responder frequency, priming and repertoire dictates the occurrence, or lack thereof, of acute and chronic rejection...
  68. ncbi request reprint CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy
    Masayuki Sho
    Department of Medicine, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 75:1142-6. 2003
    ..We evaluated the in vivo effect of anti-CD45RB monoclonal antibody (mAb) treatment in combination with conventional immunosuppression or costimulatory blockade strategies as a therapeutic modality for future clinical application...
  69. pmc The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity
    Hiroshi Harada
    Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 112:234-43. 2003
    ..These data define the complex functions of the ICOS-B7h pathway in regulating alloimmune responses in vivo...
  70. pmc Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance
    Koji Kishimoto
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:1471-9. 2002
    ..These data have implications for the design of tolerance strategies in transplant recipients with varying degrees of MHC mismatching...
  71. ncbi request reprint Proangiogenic function of CD40 ligand-CD40 interactions
    Marlies E J Reinders
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:1534-41. 2003
    ..These observations imply that ligation of CD40 at a peripheral inflammatory site is of pathophysiological importance as a mediator of both angiogenesis and inflammation...
  72. ncbi request reprint CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo
    Akira Yamada
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:1357-64. 2005
    ..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
  73. pmc Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
    Masayuki Sho
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13230-5. 2005
    ..These results provide insight into the mechanisms of tolerance in stringent models and provide a rational basis for innovative tolerogenic strategies in humans...