Masayuki Sho

Summary

Affiliation: Nara Medical University
Country: Japan

Publications

  1. doi request reprint Novel postoperative adjuvant strategy prevents early hepatic recurrence after resection of pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 18:235-9; discussion 239-40. 2011
  2. pmc Clinical importance of B7-H3 expression in human pancreatic cancer
    I Yamato
    Department of Surgery, Nara Medical University, Nara 634 8522, Japan
    Br J Cancer 101:1709-16. 2009
  3. pmc Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma
    K Hotta
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Br J Cancer 105:1191-6. 2011
  4. ncbi request reprint Pathological and clinical impact of neoadjuvant chemoradiotherapy using full-dose gemcitabine and concurrent radiation for resectable pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 20:197-205. 2013
  5. ncbi request reprint Function of the vascular endothelial growth factor receptors Flt-1 and Flk-1/KDR in the alloimmune response in vivo
    Masayuki Sho
    Department of Surgery, Nara Medical University, Nara, Japan
    Transplantation 80:717-22. 2005
  6. ncbi request reprint Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    Takeo Nomi
    Department of Surgery, Second Department of Internal Medicine, First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Clin Cancer Res 13:2151-7. 2007
  7. ncbi request reprint A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection
    Satoru Akashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Transplantation 80:378-84. 2005
  8. ncbi request reprint Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma
    Kazuhiro Migita
    Department of Surgery, Nara Medical University, Nara, Japan
    Cancer 120:808-17. 2014
  9. ncbi request reprint Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection
    Hisanori Kashizuka
    Department of Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Transplantation 79:1045-50. 2005
  10. ncbi request reprint Importance of peroxisome proliferator-activated receptor-gamma in hepatic ischemia/reperfusion injury in mice
    Takahiro Akahori
    Department of Surgery, Nara Medical University, Nara, Japan
    J Hepatol 47:784-92. 2007

Collaborators

Detail Information

Publications49

  1. doi request reprint Novel postoperative adjuvant strategy prevents early hepatic recurrence after resection of pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 18:235-9; discussion 239-40. 2011
    ..However, the efficacy was limited and further studies are required to improve the prognosis. In particular, postoperative hepatic recurrence often occurs even after gemcitabine treatment...
  2. pmc Clinical importance of B7-H3 expression in human pancreatic cancer
    I Yamato
    Department of Surgery, Nara Medical University, Nara 634 8522, Japan
    Br J Cancer 101:1709-16. 2009
    ..However, the role of B7-H3 in tumour immunity is largely unknown. The purpose of this study was to evaluate the clinical significance of B7-H3 expression in human pancreatic cancer and the therapeutic potential for cancer immunotherapy...
  3. pmc Prognostic significance of CD45RO+ memory T cells in renal cell carcinoma
    K Hotta
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Br J Cancer 105:1191-6. 2011
    ..However, their role in actual human cancer remains largely unknown. In this study, we tried to reveal the clinical importance of tumour-infiltrating CD45RO+ memory T cells in renal cell carcinoma (RCC)...
  4. ncbi request reprint Pathological and clinical impact of neoadjuvant chemoradiotherapy using full-dose gemcitabine and concurrent radiation for resectable pancreatic cancer
    Masayuki Sho
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 20:197-205. 2013
    ..In this study, we have retrospectively evaluated its impact on pathology and the perioperative clinical course in addition to its safety...
  5. ncbi request reprint Function of the vascular endothelial growth factor receptors Flt-1 and Flk-1/KDR in the alloimmune response in vivo
    Masayuki Sho
    Department of Surgery, Nara Medical University, Nara, Japan
    Transplantation 80:717-22. 2005
    ..VEGF binds two major VEGF receptors: VEGFR-1 (flt-1) and VEGFR-2 (flk-1/KDR). Here, we wished to investigate the expression and function of VEGF receptors in the process of acute allograft rejection in vivo...
  6. ncbi request reprint Clinical significance and therapeutic potential of the programmed death-1 ligand/programmed death-1 pathway in human pancreatic cancer
    Takeo Nomi
    Department of Surgery, Second Department of Internal Medicine, First Department of Internal Medicine, Nara Medical University, Nara, Japan
    Clin Cancer Res 13:2151-7. 2007
    ..In this study, we tried to reveal the clinical importance and therapeutic potential of the PD-L/PD-1 pathway in pancreatic cancer, which is one of the most aggressive and intractable malignant tumors...
  7. ncbi request reprint A novel small-molecule compound targeting CCR5 and CXCR3 prevents acute and chronic allograft rejection
    Satoru Akashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Transplantation 80:378-84. 2005
    ..Among them, CC chemokine receptor 5 (CCR5) and CXC chemokine receptor 3 (CXCR3) have been reported to play important roles in alloimmune responses and may be potential targets for posttransplant immunosuppression...
  8. ncbi request reprint Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma
    Kazuhiro Migita
    Department of Surgery, Nara Medical University, Nara, Japan
    Cancer 120:808-17. 2014
    ..The objective of the current study was to clarify the clinical significance of HVEM in human esophageal squamous cell carcinoma as well as its in vivo functions...
  9. ncbi request reprint Role of the ICOS-B7h costimulatory pathway in the pathophysiology of chronic allograft rejection
    Hisanori Kashizuka
    Department of Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Transplantation 79:1045-50. 2005
    ..Recent studies indicated that the ICOS-B7h pathway plays an important role in alloimmune responses. We further investigated the role of the ICOS pathway in the pathologic process of chronic rejection in vivo...
  10. ncbi request reprint Importance of peroxisome proliferator-activated receptor-gamma in hepatic ischemia/reperfusion injury in mice
    Takahiro Akahori
    Department of Surgery, Nara Medical University, Nara, Japan
    J Hepatol 47:784-92. 2007
    ..However, the precise role of PPARgamma in acute liver injury remains unknown...
  11. ncbi request reprint [A case of postoperative multiple liver metastases of pancreatic cancer successfully treated by combination chemotherapy with weekly high-dose 5-FU hepatic arterial infusion plus systemic infusion of gemcitabine]
    Jin Doh
    Department of Surgery, Nara Medical University
    Gan To Kagaku Ryoho 36:2087-9. 2009
    ..He survived for 34 months after surgery. It has been suggested that this combined chemotherapy might be an effective treatment to control liver metastases of pancreatic cancer...
  12. ncbi request reprint Intra-arterial chemoinfusion prior to chemoradiotherapy with full-dose systemic gemcitabine for management of locally advanced pancreatic cancer
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, 840 Shijo cho Kashihara, 634 8522, Japan
    Anticancer Res 31:3909-12. 2011
    ..We are currently developing a novel therapeutic technique to conduct neoadjuvant treatments of intra-arterial chemoinfusion prior to chemoradiotherapy with the aim of tumor volume reduction. Case..
  13. ncbi request reprint Significance and therapeutic potential of prostaglandin E2 receptor in hepatic ischemia/reperfusion injury in mice
    Yukiyasu Kuzumoto
    Department of Surgery, Nara Medical University, Nara, Japan
    Hepatology 42:608-17. 2005
    ..In sharp contrast, 80% of mice treated with the EP4 agonist survived. In conclusion, the PGE2-EP4 signaling pathway has an inhibitory role in hepatic I/R injury. An EP4 agonist effectively protects against ischemic injury...
  14. doi request reprint Safety and optimal management of hepatic arterial infusion chemotherapy after pancreatectomy for pancreatobiliary cancer
    Aya Hashimoto
    Department of Radiology, Nara Medical University, Kashihara City, Japan
    AJR Am J Roentgenol 198:923-30. 2012
    ..The purpose of this study was to assess the safety of hepatic arterial infusion (HAI) chemotherapy after pancreatectomy for pancreatobiliary cancer...
  15. ncbi request reprint [Resection of the remnant pancreas for recurrent pancreatic cancer after distal pancreatectomy-a case report]
    Shoichi Kinoshita
    Dept of Surgery, Nara Medical University, Japan
    Gan To Kagaku Ryoho 39:1883-5. 2012
    ..The pathological findings showed moderately differentiated adenocarcinoma, morphologically similar to the primary pancreatic cancer. Six months following surgery, there are no signs of recurrence at present...
  16. ncbi request reprint Dual role of vascular endothelial growth factor in hepatic ischemia-reperfusion injury
    Yoshikazu Tsurui
    Department of Surgery, Nara Medical University School of Medicine, Kashihara, Nara, Japan
    Transplantation 79:1110-5. 2005
    ..In the present study, we evaluated the expression of VEGF in hepatic warm ischemia-reperfusion (I/R) injury and examined the effect of recombinant human (rh)VEGF administration in an established murine model...
  17. doi request reprint Unresectable pancreatic cancer: arterial embolization to achieve a single blood supply for intraarterial infusion of 5-fluorouracil and full-dose IV gemcitabine
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, Kashihara, Japan
    AJR Am J Roentgenol 198:1445-52. 2012
    ..The purposes of this phases 1 and 2 study of intraarterial therapy were to ascertain the recommended dose of intraarterial chemoinfusion and to evaluate the efficacy and safety of this therapy...
  18. doi request reprint Pharmacokinetic evaluation of pancreatic arterial infusion chemotherapy after unification of the blood supply in an animal model
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, Kashihara, Japan
    J Vasc Interv Radiol 21:116-21. 2010
    ....
  19. doi request reprint PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis
    Ichiro Yamato
    Department of Surgery, Nara Medical University, Kashihara, Nara, Japan
    Cancer Res 72:4829-39. 2012
    ..Our results establish PCA-1/ALKBH3 as important gene in pancreatic cancer with potential utility as a therapeutic target in this fatal disease...
  20. doi request reprint Adult hepatoblastoma successfully treated with multimodal treatment
    Shinji Nakamura
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Langenbecks Arch Surg 395:1165-8. 2010
    ..To date, no therapeutic strategy has been established. We report here a rare case of adult hepatoblastoma successfully treated with multimodal treatment...
  21. doi request reprint Transcatheter arterial chemoembolization using cisplatin powder mixed with degradable starch microspheres for colorectal liver metastases after FOLFOX failure: results of a phase I/II study
    Hideyuki Nishiofuku
    Department of Radiology, Nara Medical University, 840 Shijo Cho, Kashihara, 634 8522, Nara, Japan
    J Vasc Interv Radiol 24:56-65. 2013
    ....
  22. doi request reprint Direct targeting of fibroblast growth factor-inducible 14 protein protects against renal ischemia reperfusion injury
    Kiyohiko Hotta
    Department of Surgery, Nara Medical University, Nara, Japan
    Kidney Int 79:179-88. 2011
    ..Thus, we conclude that Fn14 is a critical mediator in the pathogenesis of ischemia reperfusion injury...
  23. ncbi request reprint Significant efficacy of new transcatheter arterial chemoembolization technique for hepatic metastases of pancreatic neuroendocrine tumors
    Takahiro Akahori
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara, 634 8522, Japan
    Anticancer Res 33:3355-8. 2013
    ..The liver is the most frequent site of metastasis of pancreatic neuroendocrine tumors (PNETs). Moreover, hepatic metastasis is a strong prognostic factor for patients with advanced PNETs and is often difficult to treat and cure...
  24. ncbi request reprint A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model
    Yasue Suzaki
    Second Department of Internal Medicine, Nara Medical University, Nara, Tokyo
    J Allergy Clin Immunol 116:1220-7. 2005
    ..Clinical studies suggest a role for angiogenesis in the development and persistence of chronic asthma, but whether angiogenic mediators contribute to acute asthma has not been fully studied...
  25. doi request reprint Clinical significance of prostate stem cell antigen expression in non-small cell lung cancer
    Takeshi Kawaguchi
    Department of Thoracic and Cardiovascular Surgery, Nara Medical University, Kashihara, Nara, Japan
    Jpn J Clin Oncol 40:319-26. 2010
    ..In this study, we investigated the clinical significance and therapeutic potential of prostate stem cell antigen expression in non-small cell lung cancer...
  26. doi request reprint Simple technique for gasless transumbilical single-incisional laparoscopic-assisted appendectomy
    Naoya Ikeda
    Department of Surgery, Nara Prefectural Mimuro Hospital, 1 14 16 Mimuro, Sango cho, Ikoma Gun, Nara, Nara, 636 0802, Japan
    Langenbecks Arch Surg 399:359-66. 2014
    ..We developed a novel simple technique of gasless transumbilical single-incisional laparoscopic-assisted appendectomy (TUSILAA) and retrospectively analyzed our initial experience...
  27. ncbi request reprint Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer
    Yuichiro Ohigashi
    Department of Surgery, Nara Medical University School of Medicine, Nara, Japan
    Clin Cancer Res 11:2947-53. 2005
    ..In this study, we investigated the expression of PD-L1 and PD-L2 in human esophageal cancer to define their clinical significance in patients' prognosis after surgery...
  28. doi request reprint A novel interventional radiology technique for arterial infusion chemotherapy against advanced pancreatic cancer
    Toshihiro Tanaka
    Department of Radiology, Nara Medical University, 840 Shijo Cho, Kashihara 634 8522, Japan
    AJR Am J Roentgenol 192:W168-77. 2009
    ..We are currently developing a new interventional radiology technique to unify the pancreatic blood supply for chemoinfusion. In this article, we evaluated the feasibility, therapeutic potential, and limitations of this technique...
  29. doi request reprint Clinical impact of tumor-infiltrating CD45RO⁺ memory T cells on human gastric cancer
    Kohei Wakatsuki
    Department of Surgery, Nara Medical University, Nara 634 8522, Japan
    Oncol Rep 29:1756-62. 2013
    ..In conclusion, tumor-infiltrating CD45RO(+) memory T cells are functional and have significant prognostic value in human gastric cancer. Our data suggest that adaptive immune response is clinically critical in gastric cancer...
  30. ncbi request reprint Bone marrow chimerism and tolerance induced by single-dose cyclophosphamide
    Junji Okayama
    First Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Surg Res 120:102-10. 2004
    ..We evaluated the efficacy of a simple protocol using cyclophosphamide (CYP) on induction of chimerism and organ transplant tolerance across major histocompatibility complex (MHC) barriers in the rat...
  31. doi request reprint Safety and feasibility for single-incision laparoscopic cholecystectomy in local community hospital: a retrospective comparison with conventional 4-port laparoscopic cholecystectomy
    Naoya Ikeda
    Department of Surgery, Nara Prefectural Mimuro Hospital, Nara, Japan
    Surg Laparosc Endosc Percutan Tech 23:33-6. 2013
    ..The aim of this study was to evaluate the safety and feasibility for single-incision laparoscopic cholecystectomy (SILC) by retrospective comparison with conventional laparoscopic cholecystectomy (CLC) in a local community hospital...
  32. doi request reprint Malignant potential of intraductal papillary mucinous neoplasms of the pancreas
    Yoshiyuki Nakajima
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    Surg Today 40:816-24. 2010
    ..This review focuses on the malignant potential, including the postoperative recurrence of IPMN, coincidence of IPMN with PDAC, and extrapancreatic malignancy that may affect the long-term survival of the patients rather than IPMN itself...
  33. doi request reprint Effects of pancrelipase on nonalcoholic fatty liver disease after pancreaticoduodenectomy
    Minako Nagai
    Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8522, Japan
    J Hepatobiliary Pancreat Sci 21:186-92. 2014
    ..Furthermore, the optimal treatment has not been established. The aim of this prospective study was to clarify whether pancrelipase, which contains digestive pancreatic enzymes, could reverse NAFLD...
  34. ncbi request reprint Prognostic significance of localized p27Kip1 and potential role of Jab1/CSN5 in pancreatic cancer
    Akihisa Fukumoto
    First Department of Surgery, Nara Medical University, 840 Shijo Cho, Kashihara City, Nara 634 8522, Japan
    Oncol Rep 11:277-84. 2004
    ..Cell cycle control targeting p27Kip1 might be a promising future therapeutic modality against pancreatic cancer...
  35. ncbi request reprint [Current status and prospect of T cell costimulatory blockade in transplantation]
    Masayuki Sho
    First Department of Surgery, Nara Medical University, Nara, Japan
    Nihon Geka Gakkai Zasshi 104:853-7. 2003
    ....
  36. pmc Pdx1 and Ngn3 overexpression enhances pancreatic differentiation of mouse ES cell-derived endoderm population
    Atsushi Kubo
    First Department of Internal Medicine, Nara Medical University, Kashihara, Nara, Japan
    PLoS ONE 6:e24058. 2011
    ....
  37. ncbi request reprint [Genetic alterations in biliary tract carcinoma]
    Masayuki Sho
    Department of Surgery, Nara Medical University
    Nihon Rinsho 64:358-61. 2006
  38. ncbi request reprint [A case of resected endocrine cell carcinoma in the remnant stomach]
    Takashi Inoue
    Department of Surgery, Nara Medical University
    Nihon Shokakibyo Gakkai Zasshi 107:1139-45. 2010
    ..Although adjuvant chemotherapy was given, multiple liver metastases and lymph node recurrence were found 13 months after the second surgery. A new regimen of chemotherapy was not effective and he died 18 months after surgery...
  39. pmc Proinflammatory functions of vascular endothelial growth factor in alloimmunity
    Marlies E J Reinders
    Division of Nephrology, Department of Medicine, Children s Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    J Clin Invest 112:1655-65. 2003
    ..Thus, VEGF appears to be functional in acute allograft rejection via its effects on leukocyte trafficking. Together, these observations provide mechanistic insight into the proinflammatory function of VEGF in immunity...
  40. pmc Requirements for induction and maintenance of peripheral tolerance in stringent allograft models
    Masayuki Sho
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:13230-5. 2005
    ..These results provide insight into the mechanisms of tolerance in stringent models and provide a rational basis for innovative tolerogenic strategies in humans...
  41. ncbi request reprint Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size
    Masayuki Sho
    Department of Medicine, Children s Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:3744-51. 2002
    ..These data demonstrate that cytokine regulation, CTLA-4 negative signaling, and T cell apoptosis play critical roles in regulating alloimmunity, especially under conditions where the alloreactive T cell clone size is relatively small...
  42. ncbi request reprint T-cell response to cardiac myosin persists in the absence of an alloimmune response in recipients with chronic cardiac allograft rejection
    Hillary K Rolls
    Schepens Eye Research Institute and Department of Ophthalmology, Harvard Medical School, Boston, MA 02114 2500, USA
    Transplantation 74:1053-7. 2002
    ..This response contributes to transplant rejection in that its modulation affects cardiac graft survival. This study investigates whether anti-CM T cells undergo activation and expansion in mice with chronic cardiac allograft rejection...
  43. pmc New insights into the interactions between T-cell costimulatory blockade and conventional immunosuppressive drugs
    Masayuki Sho
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Ann Surg 236:667-75. 2002
    ..To determine the precise in vivo interaction between T-cell costimulatory blockade and conventional immunosuppression in transplantation...
  44. ncbi request reprint Allograft rejection in a new allospecific CD4+ TCR transgenic mouse
    Mohamed H Sayegh
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 3:381-9. 2003
    ..The results indicate that a complex interplay between responder frequency, priming and repertoire dictates the occurrence, or lack thereof, of acute and chronic rejection...
  45. ncbi request reprint CD45RB-targeting strategies for promoting long-term allograft survival and preventingchronic allograft vasculopathy
    Masayuki Sho
    Department of Medicine, Children s Hospital, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 75:1142-6. 2003
    ..We evaluated the in vivo effect of anti-CD45RB monoclonal antibody (mAb) treatment in combination with conventional immunosuppression or costimulatory blockade strategies as a therapeutic modality for future clinical application...
  46. pmc The role of the ICOS-B7h T cell costimulatory pathway in transplantation immunity
    Hiroshi Harada
    Department of Medicine, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 112:234-43. 2003
    ..These data define the complex functions of the ICOS-B7h pathway in regulating alloimmune responses in vivo...
  47. ncbi request reprint Proangiogenic function of CD40 ligand-CD40 interactions
    Marlies E J Reinders
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 171:1534-41. 2003
    ..These observations imply that ligation of CD40 at a peripheral inflammatory site is of pathophysiological importance as a mediator of both angiogenesis and inflammation...
  48. ncbi request reprint CD70 signaling is critical for CD28-independent CD8+ T cell-mediated alloimmune responses in vivo
    Akira Yamada
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:1357-64. 2005
    ..These novel findings have important implications for the development of transplantation tolerance-inducing strategies in primates and humans, in which CD8(+) T cell depletion is currently mandatory...
  49. pmc Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance
    Koji Kishimoto
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 109:1471-9. 2002
    ..These data have implications for the design of tolerance strategies in transplant recipients with varying degrees of MHC mismatching...